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Orphanet Journal of Rare Diseases, ISSN 1750-1172, 09/2018, Volume 13, Issue 1, pp. 152 - 15
Journal Article
Annals of the New York Academy of Sciences, ISSN 0077-8923, 05/2016, Volume 1371, Issue 1, pp. 15 - 29
Journal Article
Orphanet Journal of Rare Diseases, ISSN 1750-1172, 04/2018, Volume 13, Issue 1
Infantile and late infantile neuronal ceroid lipofuscinoses (NCLs) are lysosomal storage diseases affecting the central nervous system (CNS). The infantile NCL... 
Enzymes | Neuronal ceroid-lipofuscinosis | Care and treatment | Usage | Gene mutations | Stem cells | Tocopherols | Cyclodextrins | Dosage and administration | Research | Health aspects
Journal Article
Science, ISSN 0036-8075, 4/2011, Volume 332, Issue 6027, pp. 358 - 361
Transforming growth factor—β (TGFβ) signaling drives aneurysm progression in multiple disorders, including Marfan syndrome (MFS), and therapies that inhibit... 
Transcriptional regulatory elements | Echocardiography | Aortic diseases | Root growth | REPORTS | Placebos | Aneurysms | Aorta | Mice | Aortic aneurysm | Marfan syndrome | PATHOGENESIS | CELLS | ACTIVATION | VALSALVA | MULTIDISCIPLINARY SCIENCES | N-TERMINAL KINASE | MOUSE MODEL | NOONANS-SYNDROME | RECEPTOR | MUTATIONS | INHIBITOR | Diphenylamine - pharmacology | Aortic Aneurysm - metabolism | Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Anthracenes - therapeutic use | MAP Kinase Signaling System | Diphenylamine - analogs & derivatives | Marfan Syndrome - drug therapy | Smad4 Protein - genetics | Transforming Growth Factor beta - antagonists & inhibitors | Aortic Aneurysm - pathology | Aortic Aneurysm - prevention & control | Disease Models, Animal | Transforming Growth Factor beta - immunology | Diphenylamine - therapeutic use | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 8 - metabolism | Aortic Aneurysm - physiopathology | Losartan - pharmacology | Smad2 Protein - metabolism | Sulfonamides - pharmacology | Anthracenes - pharmacology | Disease Progression | Aorta - pathology | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Sulfonamides - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Losartan - therapeutic use | Marfan Syndrome - metabolism | Marfan Syndrome - pathology | Protein Kinase Inhibitors - pharmacology | Smad4 Protein - deficiency | Enzyme Activation | Transforming Growth Factor beta - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2014, Volume 57, Issue 8, pp. 3450 - 3463
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 01/2013, Volume 288, Issue 1, pp. 296 - 296
Journal Article
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 08/2019, p. fj201901046R
Fibrosis is an underlying cause of cirrhosis and hepatic failure resulting in end stage liver disease with limited pharmacological options. The beneficial... 
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JOURNAL OF NEUROSCIENCE, ISSN 0270-6474, 07/2016, Volume 36, Issue 29, pp. 7693 - 7706
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 9472 - 16
Assessment of the interactions between a drug and its protein target in a physiologically relevant cellular environment constitutes a major challenge in the... 
POTENT | PROTEIN | PERMEABILITY | SMALL-MOLECULE INHIBITORS | STABILIZATION | MULTIDISCIPLINARY SCIENCES | DRUG TARGET ENGAGEMENT | BINDING | DEHYDROGENASE | DISCOVERY | LIVING CELLS | High-throughput screening | Phenotypes | Drug discovery | Thermal stability
Journal Article
STEM CELLS Translational Medicine, ISSN 2157-6564, 12/2016, Volume 5, Issue 12, pp. 1644 - 1655
Journal Article
Antimicrobial Agents & Chemotherapy, ISSN 0066-4804, 01/2011, Volume 55, Issue 2, pp. 667 - 675
The human pathogen Giardia lamblia is an anaerobic protozoan parasite that causes giardiasis, one of the most common diarrheal diseases worldwide. Although... 
Journal Article
Science Translational Medicine, ISSN 1946-6234, 12/2014, Volume 6, Issue 268, pp. 268ra178 - ra178
Journal Article
Science (Washington), ISSN 0036-8075, 04/2011, Volume 332, Issue 6027, pp. 358 - 361
Transforming growth factor- beta (TGF beta ) signaling drives aneurysm progression in multiple disorders, including Marfan syndrome (MFS), and therapies that... 
Therapy | Progressions | Pathways | Strategy | Activation | Mice | Inhibition | Kinases
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 2968 - 14
Journal Article