X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
chemistry, organic (12) 12
index medicus (11) 11
drug discovery (9) 9
chemistry, medicinal (7) 7
chemistry, multidisciplinary (7) 7
humans (7) 7
inhibitors (7) 7
chemistry (6) 6
combinatorial chemistry (6) 6
molecular structure (5) 5
organic chemistry (5) 5
analysis (4) 4
discovery (4) 4
heterocyclic compounds (4) 4
models, molecular (4) 4
protein binding (4) 4
protein-protein interactions (4) 4
solid-phase synthesis (4) 4
activation (3) 3
acyclic, carbocyclic or heterocyclic compounds containingelements other than carbon, hydrogen, halogen, oxygen, nitrogen,sulfur, selenium or tellurium (3) 3
analogs (3) 3
animals (3) 3
bcr-abl (3) 3
design (3) 3
human necessities (3) 3
hygiene (3) 3
letter (3) 3
ligands (3) 3
medical or veterinary science (3) 3
metallurgy (3) 3
mice (3) 3
peptides (3) 3
peptides - chemistry (3) 3
potent (3) 3
preparations for medical, dental, or toilet purposes (3) 3
protein (3) 3
proteins (3) 3
protein–protein interactions (3) 3
structure-activity relationship (3) 3
wirkstoffentwicklung (3) 3
active pharmaceutical ingredients (2) 2
acylations (2) 2
administration, oral (2) 2
agent-development (2) 2
allosteric regulation - drug effects (2) 2
allosteric site - drug effects (2) 2
amides (2) 2
amino acid sequence (2) 2
amp397 (2) 2
binding (2) 2
biological availability (2) 2
c-abl (2) 2
candidates (2) 2
chemical reactions (2) 2
chronic myeloid-leukemia (2) 2
derivatives (2) 2
drug evaluation, preclinical - methods (2) 2
drugs (2) 2
efficacy (2) 2
enzyme inhibitors - pharmacology (2) 2
furans (2) 2
generation (2) 2
geranyltranstransferase - antagonists & inhibitors (2) 2
imatinib (2) 2
insulin-like growth factor 1 receptor (2) 2
libraries (2) 2
magnetic resonance spectroscopy (2) 2
michaelis-menten kinetics (2) 2
michaelis–menten kinetics (2) 2
molecular sequence data (2) 2
nitrogen-containing bisphosphonates (2) 2
organic-synthesis (2) 2
osteoporosis (2) 2
peptide (2) 2
pharmacology & pharmacy (2) 2
phosphorylation (2) 2
phosphotransferases (2) 2
protein kinase inhibitors - chemistry (2) 2
quinazolines (2) 2
specific therapeutic activity of chemical compounds ormedicinal preparations (2) 2
substrate specificity (2) 2
synthesis (2) 2
systems (2) 2
tyrosine (2) 2
tyrosine kinase (2) 2
usage (2) 2
1,3-disubstituted 2,4-quinazolinediones (1) 1
1st example (1) 1
absorption (1) 1
adenosine triphosphate - chemistry (1) 1
adult (1) 1
aged (1) 1
agonists (1) 1
aldose reductase inhibitors (1) 1
allosteric inhibitor (1) 1
allosteric inhibitors (1) 1
allosteric regulation (1) 1
alpha-diazoketones (1) 1
amino functions (1) 1
aminobisphosphonates (1) 1
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Nature, ISSN 0028-0836, 03/2017, Volume 543, Issue 7647, pp. 733 - 737
Journal Article
ISSN 1359-7345, 6/2017, Volume 53, Issue 49, pp. 6649 - 6652
We report an automated flow chemistry platform that can efficiently perform a wide range of chemistries, including single/multi-phase and single/multi-step,... 
Journal Article
Chemical communications (Cambridge, England), ISSN 1359-7345, 06/2017, Volume 53, Issue 49, pp. 6649 - 6652
We report an automated flow chemistry platform that can efficiently perform a wide range of chemistries, including single/multi-phase and single/multi-step,... 
Journal Article
Chemical Communications, ISSN 1359-7345, 2017, Volume 53, Issue 49, pp. 6649 - 6652
We report an automated flow chemistry platform that can efficiently perform a wide range of chemistries, including single/multi-phase and single/multi-step,... 
DRUG DISCOVERY | SYSTEMS | GENERATION | INHIBITORS | CANDIDATES | CHEMISTRY, MULTIDISCIPLINARY | ACTIVE PHARMACEUTICAL INGREDIENTS | Platforms | Synthesis (chemistry) | Automation | Chemical reactions | Oscillating | Droplets | Compatibility
Journal Article
Current Topics in Medicinal Chemistry, ISSN 1568-0266, 2005, Volume 5, Issue 8, pp. 751 - 762
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2018, Volume 61, Issue 18, pp. 8120 - 8135
Chronic myelogenous leukemia (CML) arises from the constitutive activity of the BCR-ABL1 oncoprotein. Tyrosine kinase inhibitors (TKIs) that target the... 
CHEMISTRY, MEDICINAL | MANAGEMENT | C-ABL | BCR-ABL | DRUG DISCOVERY | IMATINIB | RESISTANCE | BINDING-SITE | PATCH-CLAMP | CHRONIC MYELOID-LEUKEMIA
Journal Article
Journal Article
ChemMedChem, ISSN 1860-7179, 11/2015, Volume 10, Issue 11, pp. 1884 - 1891
Journal Article
Chimia, ISSN 0009-4293, 12/2013, Volume 67, Issue 12, pp. 899 - 904
In view of our more comprehensive understanding with respect to intracellular pathways and their regulation, a vast number of interesting drug targets appear... 
Peptide synthesis | Permeability | Intracellular delivery | Protein-protein interactions | ACTIVATION | ABSORPTION | N-METHYLATION | CHEMISTRY, MULTIDISCIPLINARY | CYCLIC-PEPTIDES | Molecular Sequence Data | Amino Acid Sequence | Peptides - chemistry | Peptides - administration & dosage
Journal Article
Synlett, ISSN 0936-5214, 2/2005, Volume 2005, Issue 3, pp. 496 - 500
Abstract A novel and straightforward synthesis of malondiamides on solid-phase has been developed. These compounds, which are obtained in good yield and... 
letter | Combinatorial chemistry | Amides | Peptides | Solid-phase synthesis | Acylations | amides | acylations | PEPTIDE ANALOGS | CHEMISTRY, ORGANIC | peptides | combinatorial chemistry | solid-phase synthesis
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 07/2015, Volume 6, Issue 7, pp. 776 - 781
The discovery of inhibitors targeting novel allosteric kinase sites is very challenging. Such compounds, however, once identified could offer exquisite levels... 
PAK1 | p21 activated kinase | allosteric inhibitor | tool compound | dibenzodiazepine | ACTIVATION | CHEMISTRY, MEDICINAL | MECHANISM | CANCER | P21-ACTIVATED KINASES | DISCOVERY | SMALL-MOLECULE INHIBITOR | FRAGILE-X-SYNDROME | MICE | AUTOPHOSPHORYLATION
Journal Article
Synthesis, ISSN 0039-7881, 2005, Volume 2005, Issue 12, pp. 2015 - 2021
Journal Article
Synlett, ISSN 0936-5214, 2005, Issue 16, pp. 2441 - 2444
Journal Article
Journal of Organic Chemistry, ISSN 0022-3263, 02/1998, Volume 63, Issue 3, pp. 723 - 727
The value of alpha,beta-unsaturated ketones as key intermediates for the combinatorial assembly of four different templates on the solid phase, namely... 
LIBRARIES | CHEMISTRY, ORGANIC | ORGANIC-SYNTHESIS | PEPTIDE | DISCOVERY | Biochemical templates | Research | Ketones | Heterocyclic compounds
Journal Article
ChemMedChem, ISSN 1860-7179, 11/2015, Volume 10, Issue 11, pp. 1884 - 1891
Farnesyl pyrophosphate synthase (FPPS) is an established target for the treatment of bone diseases, but also shows promise as an anticancer and anti-infective... 
Journal Article
No results were found for your search.

Cannot display more than 1000 results, please narrow the terms of your search.