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Journal of Clinical Investigation, ISSN 0021-9738, 05/2015, Volume 125, Issue 5, pp. 1857 - 1872
Myelodysplastic syndromes and chronic myelomonocytic leukemia (CMML) are characterized by mutations in genes encoding epigenetic modifiers and aberrant DNA... 
MEDICINE, RESEARCH & EXPERIMENTAL | DNA METHYLATION | MALIGNANT HEMATOPOIESIS | 5-AZA-2'-DEOXYCYTIDINE DECITABINE | METHYLTRANSFERASE GENE EZH2 | CHROMOSOME CONFORMATION | ACUTE MYELOID-LEUKEMIA | EXPRESSION PROFILES | MYELODYSPLASTIC SYNDROMES | RAF/MEK/ERK PATHWAY | EPIGENETIC CHANGES | Genes, Neoplasm | Humans | Leukemia, Myelomonocytic, Chronic - genetics | Middle Aged | Male | Gene Expression Profiling | Leukemia, Myelomonocytic, Chronic - drug therapy | Leukemia, Myelomonocytic, Chronic - metabolism | beta-Thromboglobulin - biosynthesis | DNA Mutational Analysis | Aged, 80 and over | Antimetabolites, Antineoplastic - pharmacology | Female | Platelet Factor 4 - biosynthesis | Neoplasm Proteins - genetics | Gene Expression Regulation, Neoplastic - genetics | Platelet Factor 4 - genetics | Neoplasm Proteins - biosynthesis | beta-Thromboglobulin - genetics | Azacitidine - analogs & derivatives | Treatment Outcome | beta-Thromboglobulin - physiology | DNA, Intergenic - genetics | Azacitidine - pharmacology | Antimetabolites, Antineoplastic - therapeutic use | Drug Resistance, Neoplasm - genetics | Platelet Factor 4 - physiology | Bone Marrow - pathology | Aged | Enhancer Elements, Genetic - genetics | DNA Methylation - drug effects | Azacitidine - therapeutic use | Research | Gene expression | Methylation | Drug therapy | Chronic myelomonocytic leukemia | Enzymes | Clinical trials | Cancer therapies | Generalized linear models | Studies | Medical prognosis | DNA methylation | Epigenetics | Mutation | Deoxyribonucleic acid--DNA | Cancer | Apoptosis | Genetics | Oncology | Immunology | Hematology | Therapeutics
Journal Article
Blood, ISSN 0006-4971, 12/2016, Volume 128, Issue 22, pp. 5129 - 5129
Abstract Introduction: Azacitidine is at present the standard of treatment of myelodysplastic syndromes (MDS). We demonstrated that MDS patients responsive to... 
Journal Article
Clinical Lymphoma, Myeloma and Leukemia, ISSN 2152-2650, 09/2019, Volume 19, pp. S347 - S347
Journal Article
Blood, ISSN 0006-4971, 12/2015, Volume 126, Issue 23, pp. 4753 - 4753
Abstract Introduction: Myelodysplastic Syndromes (MDS) are clonal neoplasms. Whether the transforming event occurs in a myeloid committed cell or in earlier... 
Journal Article
Blood, ISSN 0006-4971, 11/2012, Volume 120, Issue 21, pp. 4615 - 4615
Abstract Abstract 4615 Introduction. Alterations in chromatin organization are a common mechanism of leukemogenesis. Drugs affecting epigenetics have been... 
Journal Article
Stem Cells International, ISSN 1687-966X, 2017, Volume 2017, pp. 1 - 8
Previous studies based on low oxygen concentrations in the incubation atmosphere revealed that metabolic factors govern the maintenance of normal hematopoietic... 
Cell culture | Medical research | Oxygen | Incubation | Leukemia | Minimal residual disease | Biology | Maintenance | Metabolism | Kinases | Tissues | Biological activity | Proteins | Signaling | Addiction | Thermal resistance | Rodents | Stem cells | Hypoxia | Physiology | Niches | Cancer
Journal Article
Blood, ISSN 0006-4971, 12/2015, Volume 126, Issue 23, pp. 355 - 355
Abstract Introduction: Accumulating evidence implicates innate immune activation in the pathobiology of myelodysplastic syndromes (MDS) and its inflammatory... 
Journal Article
Journal Article
Blood, ISSN 0006-4971, 11/2012, Volume 120, Issue 21, pp. 4747 - 4747
Abstract Abstract 4747 Introduction: Myelodysplastic Syndromes (MDS) are clonal neoplasms. Whether the transforming event occurs in a myeloid committed cell or... 
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 05/2015, Volume 125, Issue 5, pp. 1857 - 1857
Myelodysplastic syndromes and chronic myelomonocytic leukemia (CMML) are characterized by mutations in genes encoding epigenetic modifiers and aberrant DNA... 
Journal Article
Stem Cells International, ISSN 1687-966X, 06/2017, Volume 2017, p. 4979474
Previous studies based on low oxygen concentrations in the incubation atmosphere revealed that metabolic factors govern the maintenance of normal hematopoietic... 
PROGENITOR CELLS | MAINTENANCE | IN-VITRO | MOUSE FEMUR | SCID-REPOPULATING CELLS | COLONY-FORMING CELL | MURINE BONE-MARROW | IMATINIB | LOW OXYGEN-TENSION | CHRONIC MYELOID-LEUKEMIA | CELL & TISSUE ENGINEERING | Analysis | Stem cells | Cancer cells | Cell metabolism | Cellular signal transduction | Research | Gene expression | Oncogenes
Journal Article
Blood, ISSN 0006-4971, 12/2014, Volume 124, Issue 21, pp. 4598 - 4598
Abstract Myelodysplastic syndromes (MDS) and the related disorder chronic myelomonocytic leukemia (CMML) are characterized by abnormal DNA hypermethylation and... 
Journal Article
Oncotarget, ISSN 1949-2553, 2018, Volume 9, Issue 12, pp. 10561 - 10571
Myelodysplastic Syndromes (MDS) are clonal neoplasms where stem/progenitor cells endowed with self-renewal and capable of perpetuating the disease have been... 
Mice transplantation | Hypoxia | High risk MDS | MDS | Stem cells
Journal Article
Blood, ISSN 0006-4971, 11/2012, Volume 120, Issue 21, pp. 2810 - 2810
Abstract Abstract 2810 Azacitidine is a pyrimidine nucleoside analogue of cytidine and it is at present the standard treatment for myelodysplastic syndromes... 
Journal Article
Journal Article
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