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1. Full Text Synaptotagmin-1, -2, and -9: Ca2+ Sensors for Fast Release that Specify Distinct Presynaptic Properties in Subsets of Neurons
by Xu, Jun and Mashimo, Tomoyuki and Südhof, Thomas C
Neuron (Cambridge, Mass.), ISSN 0896-6273, 05/2007, Volume 54, Issue 4, pp. 567 - 581
PROTEINS | MOLNEURO | SIGNALING | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Studies | Genotype & phenotype | Sensors | Neurons | Experiments
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2. Full Text 2-Hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas
by Choi, Changho and Ganji, Sandeep K and DeBerardinis, Ralph J and Hatanpaa, Kimmo J and Rakheja, Dinesh and Kovacs, Zoltan and Yang, Xiao-Li and Mashimo, Tomoyuki and Raisanen, Jack M and Marin-Valencia, Isaac and Pascual, Juan M and Madden, Christopher J and Mickey, Bruce E and Malloy, Craig R and Bachoo, Robert M and Maher, Elizabeth A
Nature medicine, ISSN 1078-8956, 04/2012, Volume 18, Issue 4, pp. 624 - 629
Choline - metabolism | Magnetic Resonance Spectroscopy | Glutarates | Humans | Brain - enzymology | Brain Neoplasms - genetics | Isocitrate Dehydrogenase - genetics | Male | Statistics as Topic | Mutation - genetics | Brain Neoplasms - metabolism | Glioma - metabolism | Glioma - genetics | Algorithms | Creatine - metabolism | Brain Mapping | Aspartic Acid - metabolism | Female | Aspartic Acid - analogs & derivatives | Enzymes | Medical imaging | Mutation | Gene expression | Brain cancer | Spectrum analysis | Index Medicus
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3. Full Text Acetate Is a Bioenergetic Substrate for Human Glioblastoma and Brain Metastases
by Mashimo, Tomoyuki and Pichumani, Kumar and Vemireddy, Vamsidhara and Hatanpaa, Kimmo J and Singh, Dinesh Kumar and Sirasanagandla, Shyam and Nannepaga, Suraj and Piccirillo, Sara G and Kovacs, Zoltan and Foong, Chan and Huang, Zhiguang and Barnett, Samuel and Mickey, Bruce E and DeBerardinis, Ralph J and Tu, Benjamin P and Maher, Elizabeth A and Bachoo, Robert M
Cell (Cambridge), ISSN 0092-8674, 12/2014, Volume 159, Issue 7, pp. 1603 - 1614
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Acetates - metabolism | Humans | Brain Neoplasms - pathology | Brain Neoplasms - metabolism | Citric Acid Cycle | Brain Neoplasms - secondary | Animals | Acetate-CoA Ligase - genetics | Acetate-CoA Ligase - metabolism | Neoplasm Metastasis - pathology | Glioblastoma - pathology | Glioblastoma - metabolism | Glutamic Acid - metabolism | Mice | Disease Models, Animal | Glucose metabolism | Ligases | Metastasis | Glucose | Acetates | Dextrose | Citric acid | Glutamine | Index Medicus
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4. Full Text ASCL1 regulates neurodevelopmental transcription factors and cell cycle genes in brain tumors of glioma mouse models
by Vue, Tou Yia and Kollipara, Rahul K and Borromeo, Mark D and Smith, Tyler and Mashimo, Tomoyuki and Burns, Dennis K and Bachoo, Robert M and Johnson, Jane E
Glia, ISSN 0894-1491, 12/2020, Volume 68, Issue 12, pp. 2613 - 2630
brain tumor | mouse model | ASCL1 | transcription factor function | glioma development | Chromatin | RNA | Genes | Brain tumors | DNA binding proteins | Prevention | Gene mutations | Gliomas | Analysis | Stem cells | Cell cycle | Models | Genetic aspects | Cancer | ASCL1 protein | Brain | Transcription factors | Animal models | Brain cancer | Ribonucleic acid--RNA | Glial stem cells | Neuronal-glial interactions | Heterogeneity | Glioma | Neural stem cells | Mutation | Tumors | Index Medicus
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5. Full Text In vivo MRS measurement of 2‐hydroxyglutarate in patient‐derived IDH‐mutant xenograft mouse models versus glioma patients
by Tiwari, Vivek and Mashimo, Tomoyuki and An, Zhongxu and Vemireddy, Vamsidhara and Piccirillo, Sara and Askari, Pegah and Hulsey, Keith M and Zhang, Shanrong and Graaf, Robin A and Patel, Toral R and Pan, Edward and Mickey, Bruce E and Maher, Elizabeth A and Bachoo, Robert M and Choi, Changho
Magnetic resonance in medicine, ISSN 0740-3194, 09/2020, Volume 84, Issue 3, pp. 1152 - 1160
point‐resolved spectroscopy | 2HG | mouse | isocitrate dehydrogenase | patient‐derived xenograft | 1H magnetic resonance spectroscopy | 2‐hydroxyglutarate | PDX | IDH mutation | gliomas | PRESS | MRS | point-resolved spectroscopy | patient-derived xenograft | H magnetic resonance spectroscopy | 2-hydroxyglutarate | Life Sciences & Biomedicine | Radiology, Nuclear Medicine & Medical Imaging | Science & Technology | Animal models | Computer simulation | Brain tumors | Xenotransplantation | Metabolism | Patients | Mutants | Glioma | Metabolites | Xenografts | Biocompatibility | In vivo methods and tests | Mutation | Isocitrate dehydrogenase | Tumors | Index Medicus
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6. Full Text 2-hydroxyglutarate detection by magnetic resonance spectroscopy in subjects with IDH-mutated gliomas
by Choi, Changho and Ganji, Sandeep K and DeBerardinis, Ralph J and Hatanpaa, Kimmo J and Rakheja, Dinesh and Kovacs, Zoltan and Yang, Xiao-Li and Mashimo, Tomoyuki and Raisanen, Jack M and Marin-Valencia, Isaac and Pascual, Juan M and Madden, Christopher J and Mickey, Bruce E and Malloy, Craig R and Bachoo, Robert M and Maher, Elizabeth A
Nature medicine, ISSN 1078-8956, 04/2012, Volume 18, Issue 4, pp. 624 - 629
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Care and treatment | Usage | Gene mutations | Magnetic resonance imaging | Gliomas | Physiological aspects | Genetic aspects | Diagnosis
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7. Full Text IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma
by Kofuji, Satoshi and Hirayama, Akiyoshi and Eberhardt, Alexander Otto and Kawaguchi, Risa and Sugiura, Yuki and Sampetrean, Oltea and Ikeda, Yoshiki and Warren, Mikako and Sakamoto, Naoya and Kitahara, Shuji and Yoshino, Hirofumi and Yamashita, Daisuke and Sumita, Kazutaka and Wolfe, Kara and Lange, Lisa and Ikeda, Satsuki and Shimada, Hiroko and Minami, Noriaki and Malhotra, Akshiv and Morioka, Shin and Ban, Yuki and Asano, Maya and Flanary, Victoria L and Ramkissoon, Annmarie and Chow, Lionel M. L and Kiyokawa, Juri and Mashimo, Tomoyuki and Lucey, Greg and Mareninov, Sergey and Ozawa, Tatsuya and Onishi, Nobuyuki and Okumura, Koichi and Terakawa, Jumpei and Daikoku, Takiko and Wise-Draper, Trisha and Majd, Nazanin and Kofuji, Kaori and Sasaki, Mika and Mori, Masaru and Kanemura, Yonehiro and Smith, Eric P and Anastasiou, Dimitrios and Wakimoto, Hiroaki and Holland, Eric C and Yong, William H and Horbinski, Craig and Nakano, Ichiro and DeBerardinis, Ralph J and Bachoo, Robert M and Mischel, Paul S and Yasui, Wataru and Suematsu, Makoto and Saya, Hideyuki and Soga, Tomoyoshi and Grummt, Ingrid and Bierhoff, Holger and Sasaki, Atsuo T
Nature cell biology, ISSN 1465-7392, 08/2019, Volume 21, Issue 8, pp. 1003 - 1014
Life Sciences & Biomedicine | Science & Technology | Cell Biology | IMP Dehydrogenase - metabolism | Cell Nucleolus - metabolism | Humans | Cell Proliferation - physiology | Cell Line, Tumor | RNA, Ribosomal - metabolism | Glioblastoma - metabolism | Carcinogenesis - metabolism | Cell Transformation, Neoplastic - metabolism | IMP Dehydrogenase - genetics | Physiological aspects | Nucleolus organizer region | Development and progression | Oxidoreductases | Glioblastoma multiforme | Health aspects | Cell proliferation | Brain | GTP-binding protein | Deactivation | Dehydrogenases | tRNA | Transcription | rRNA | p53 Protein | Glioblastoma | IMP dehydrogenase | Biosynthesis | Nucleotides | Dehydrogenase | Inactivation | Nucleostemin | Guanine | Nucleoli | Tumorigenesis | Glioblastoma cells | Hypertrophy | Index Medicus
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8. Full Text Oncogenes Activate an Autonomous Transcriptional Regulatory Circuit That Drives Glioblastoma
by Singh, Dinesh K and Kollipara, Rahul K and Vemireddy, Vamsidara and Yang, Xiao-Li and Sun, Yuxiao and Regmi, Nanda and Klingler, Stefan and Hatanpaa, Kimmo J and Raisanen, Jack and Cho, Steve K and Sirasanagandla, Shyam and Nannepaga, Suraj and Piccirillo, Sara and Mashimo, Tomoyuki and Wang, Shan and Humphries, Caroline G and Mickey, Bruce and Maher, Elizabeth A and Zheng, Hongwu and Kim, Ryung S and Kittler, Ralf and Bachoo, Robert M
Cell reports (Cambridge), ISSN 2211-1247, 01/2017, Volume 18, Issue 4, pp. 961 - 976
stem cells | targeted therapy | transcription factor | glioblastoma | cancer | brain | oncogene | astrocyte | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Receptor, Epidermal Growth Factor - genetics | Brain - diagnostic imaging | Brain Neoplasms - diagnostic imaging | Humans | Brain Neoplasms - pathology | SOXB1 Transcription Factors - antagonists & inhibitors | Zinc Finger E-box-Binding Homeobox 1 - genetics | Zinc Finger E-box-Binding Homeobox 1 - metabolism | SOXB1 Transcription Factors - metabolism | Brain - metabolism | Glioblastoma - diagnostic imaging | Receptor, Epidermal Growth Factor - metabolism | Neoplasm Grading | RNA Interference | SOXB1 Transcription Factors - genetics | Oligodendrocyte Transcription Factor 2 - metabolism | Plasmids - genetics | Oligodendrocyte Transcription Factor 2 - genetics | Disease Models, Animal | Astrocytes - cytology | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Cells, Cultured | Brain Neoplasms - drug therapy | Down-Regulation - drug effects | Mice, SCID | Plicamycin - pharmacology | Plasmids - metabolism | Animals | Quinazolines - therapeutic use | Receptor, Platelet-Derived Growth Factor alpha - genetics | Glioblastoma - pathology | Brain - pathology | Mice, Inbred NOD | Cell Proliferation - drug effects | Mice | Glioblastoma - drug therapy | Astrocytes - metabolism | Index Medicus
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9. Full Text Gliomas Interact with Non-glioma Brain Cells via Extracellular Vesicles
by Gao, Xiaofei and Zhang, Zhaohuan and Mashimo, Tomoyuki and Shen, Bo and Nyagilo, James and Wang, Hao and Wang, Yihui and Liu, Zhida and Mulgaonkar, Aditi and Hu, Xiao-Ling and Piccirillo, Sara G. M and Eskiocak, Ugur and Dave, Digant P and Qin, Song and Yang, Yongjie and Sun, Xiankai and Fu, Yang-Xin and Zong, Hui and Sun, Wenzhi and Bachoo, Robert M and Ge, Woo-Ping
Cell reports (Cambridge), ISSN 2211-1247, 02/2020, Volume 30, Issue 8, pp. 2489 - 2500.e5
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Index Medicus
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10. Full Text Interaction of KAI1 on tumor cells with DARC on vascular endothelium leads to metastasis suppression
by Pai, Sudha K and Watabe, Kounosuke and Hayashi, Sunao and Zhan, Rui and Mashimo, Tomoyuki and Tsukada, Taisei and Furuta, Eiji and Iiizumi, Megumi and Chaudhuri, Asok and Pauza, Mary E and Bandyopadhyay, Sucharita and Wang, Ying and Saito, Ken and Hirota, Shigeru and Takano, Yukio and Watabe, Misako and Mohinta, Sonia and Hosobe, Sadahiro and Miura, Kunio
Nature medicine, ISSN 1078-8956, 08/2006, Volume 12, Issue 8, pp. 933 - 938
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Prostatic Neoplasms - metabolism | Membrane Glycoproteins - metabolism | Humans | Membrane Glycoproteins - chemistry | Molecular Sequence Data | Lung Neoplasms - pathology | Male | Breast Neoplasms - metabolism | Kangai-1 Protein - chemistry | Protein Isoforms - metabolism | Kangai-1 Protein - metabolism | Neoplasm Metastasis - prevention & control | Base Sequence | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Female | Receptors, Cell Surface - chemistry | Protein Structure, Tertiary | Amino Acid Sequence | Prostatic Neoplasms - pathology | Cellular Senescence - physiology | Rats | Receptors, Cell Surface - metabolism | T-Box Domain Proteins - metabolism | Membrane Glycoproteins - genetics | Mice, Knockout | Animals | Breast Neoplasms - pathology | Endothelium, Vascular - metabolism | Alleles | Cell Line, Tumor | Duffy Blood-Group System - metabolism | Heterozygote | Mice | Duffy Blood-Group System - chemistry | Protein Isoforms - genetics | Proteins | Cellular biology | Gene expression | Prostate cancer | Rodents | Index Medicus
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11. Full Text Isotope Tracing of Human Clear Cell Renal Cell Carcinomas Demonstrates Suppressed Glucose Oxidation In Vivo
by Courtney, Kevin D and Bezwada, Divya and Mashimo, Tomoyuki and Pichumani, Kumar and Vemireddy, Vamsidhara and Funk, Alexander M and Wimberly, Jennifer and McNeil, Sarah S and Kapur, Payal and Lotan, Yair and Margulis, Vitaly and Cadeddu, Jeffrey A and Pedrosa, Ivan and DeBerardinis, Ralph J and Malloy, Craig R and Bachoo, Robert M and Maher, Elizabeth A
Cell metabolism, ISSN 1550-4131, 11/2018, Volume 28, Issue 5, pp. 793 - 800.e2
kidney cancer | cancer metabolism | clear cell renal cell carcinoma | human cancer | mass spectrometry | stable isotope tracing | nuclear magnetic resonance spectroscopy (NMR) | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Glucose metabolism | Analysis | Lung cancer | Brain tumors | Nuclear magnetic resonance spectroscopy | Oxidation-reduction reaction | Glucose | Mass spectrometry | Dextrose | Cancer | Index Medicus
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