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Cancer Cell, ISSN 1535-6108, 2011, Volume 19, Issue 6, pp. 740 - 753
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 05/2014, Volume 111, Issue 21, pp. E2219 - E2228
The unfolded protein response (UPR) pathway, a stress-induced signaling cascade emanating from the endoplasmic reticulum (ER), regulates the expression and... 
MULTIPLE-MYELOMA | BLIMP-1 | GENE | ER STRESS | MULTIDISCIPLINARY SCIENCES | IRE1-ALPHA | DISTINCT | MOUSE | ENDOPLASMIC-RETICULUM STRESS | PLASMA-CELL DIFFERENTIATION | EXPRESSION | Endoribonucleases - genetics | Humans | beta-Galactosidase | Molecular Sequence Data | X-Box Binding Protein 1 | DNA-Binding Proteins - metabolism | Heat-Shock Proteins - genetics | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Flow Cytometry | Heterografts | Chromatin Immunoprecipitation | Microarray Analysis | Base Sequence | Gene Deletion | Adult | Cell Differentiation - physiology | Child | Real-Time Polymerase Chain Reaction | B-Lymphocytes - metabolism | Protein-Serine-Threonine Kinases - metabolism | Repressor Proteins - metabolism | DNA-Binding Proteins - pharmacology | Unfolded Protein Response - drug effects | Endoplasmic Reticulum Stress - drug effects | Endoribonucleases - metabolism | Heat-Shock Proteins - metabolism | Kaplan-Meier Estimate | Protein-Serine-Threonine Kinases - genetics | B-Lymphocytes - physiology | Repressor Proteins - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Regulatory Factor X Transcription Factors | Blotting, Western | Gene Expression Regulation - drug effects | Transcription Factors - metabolism | Animals | Sequence Analysis, RNA | Basic-Leucine Zipper Transcription Factors - pharmacology | Mice | Unfolded Protein Response - physiology | Endoplasmic Reticulum Stress - physiology | Positive Regulatory Domain I-Binding Factor 1 | Proto-Oncogene Proteins c-bcl-6 | PNAS Plus | Biological Sciences
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2015, Volume 10, Issue 5, p. e0125783
The adapter protein metastasis suppressor 1 (MTSS1) is implicated as a tumor suppressor or tumor promoter, depending on the type of solid cancer. Here, we... 
MIM | HEPATOCELLULAR-CARCINOMA | METASTASIS | GENE | COLORECTAL-CANCER | MULTIDISCIPLINARY SCIENCES | MUTATIONS | EXPRESSION | CONTRIBUTES | REMISSION | MIM/MTSS1 | Gene Expression | Tumor Suppressor Proteins - metabolism | Prognosis | Humans | Leukemia, Myeloid, Acute - metabolism | Gene Expression Regulation, Leukemic - drug effects | Gene Expression Profiling | Neoplasm Proteins - metabolism | Leukemia, Myeloid, Acute - mortality | RUNX1 Translocation Partner 1 Protein | fms-Like Tyrosine Kinase 3 - genetics | Oncogene Proteins, Fusion - genetics | Tumor Suppressor Proteins - genetics | Chromosome Aberrations | Cell Line, Tumor | Microfilament Proteins - metabolism | Protein Kinase Inhibitors - pharmacology | Neoplasm Proteins - genetics | Core Binding Factor Alpha 2 Subunit - genetics | Microfilament Proteins - genetics | Karyotype | Cluster Analysis | Leukemia, Myeloid, Acute - genetics | Physiological aspects | Tumor suppressor genes | Research | Gene mutations | Protein kinase C | Pathogenesis | Leukemia | Colorectal cancer | Oncology | mRNA | Metastasis | Metastases | Ovarian cancer | Liver cancer | Fusion protein | Tretinoin | Hematology | Myeloid leukemia | Adapters | Pharmacology | Gene expression | Patients | Medicine | Signaling | AML1 protein | Derepression | MicroRNAs | Medical prognosis | Stem cells | Mutation | Prostate cancer | Acute myeloid leukemia | Retinoic acid | Health informatics | Cancer
Journal Article
Archives of Toxicology, ISSN 0340-5761, 1/2017, Volume 91, Issue 1, pp. 289 - 300
Polychlorinated biphenyls (PCBs) are organochlorine pollutants with a worldwide dissemination. We examined telomere length (TL) in peripheral blood cells of... 
Biomedicine, general | Biomedicine | Environmental Health | Occupational Medicine/Industrial Medicine | Lymphocytes | Polychlorinated biphenyls | Pharmacology/Toxicology | Occupational exposure | Telomere | SURROUNDING COMPANIES | LENGTH DYNAMICS | FAMILY-MEMBERS | SKIN KERATINOCYTES HACAT | POLYBROMINATED BIPHENYLS | RECYCLING COMPANY | TOXICOLOGY | FLOW-CYTOMETRY | T-CELLS | STEM-CELL TURNOVER | ORGANOCHLORINE PESTICIDES | Gene Expression Regulation, Enzymologic - drug effects | Humans | Carcinogens, Environmental - analysis | Polychlorinated Biphenyls - blood | Male | Carcinogens, Environmental - toxicity | Telomerase - blood | Biotransformation | Female | Telomerase - metabolism | Recycling | Telomere Shortening - drug effects | Lymphocytes - metabolism | Occupational Exposure - adverse effects | Cells, Cultured | Lymphocytes - cytology | Immunologic Surveillance - drug effects | Polychlorinated Biphenyls - metabolism | Drug Residues - analysis | Toxicokinetics | Lymphocytes - pathology | Polychlorinated Biphenyls - toxicity | Lymphocytes - drug effects | Cell Proliferation - drug effects | Kinetics | Telomerase - antagonists & inhibitors | Population Surveillance | Germany | Cohort Studies | Antigens | Enzymes | Communicable diseases | Genes | Disease susceptibility | Transplantation | T cells | Gene expression | Risk factors | Occupational health and safety | Telomeres | Metabolites | Stem cells | Recycling industry | Pollutants | Telomerase | Polychlorinated biphenyls--PCB | Occupational hazards | Index Medicus | Molecular Toxicology
Journal Article
Experimental Hematology and Oncology, ISSN 2162-3619, 02/2016, Volume 5, Issue 1, p. 5
Proteostasis is defined by the orchestrated control of anabolic and catabolic protein pathways. Disruption of proteostasis results in cell stress and... 
DNAJ | Acute lymphoblastic leukemia | Auxilin-2 | Auxilin-1 | Chronic myeloid leukemia | HSP40 | Unfolded protein response | Medicine, Experimental | Heat shock proteins | Medical research | B cells | Ribonuclease | Proteins | Hematology | Leukemia | Nervous system | Kinases | Multivariate analysis | Gene expression | Experiments | Patients | Molecular weight | Cancer | Adaptation | Life Sciences
Journal Article
Cell, ISSN 0092-8674, 2010, Volume 141, Issue 1, pp. 178 - 190
Our findings that PlGF is a cancer target and anti-PlGF is useful for anticancer treatment have been challenged by Bais et al. Here we take advantage of... 
CELLIMUNNO | HUMDISEASE | CELLCYLCE | Cellimunno | Cellcylce | Humdisease | LUNG | HEPATOCELLULAR-CARCINOMA | METASTASIS | ANGIOGENESIS | PATHOLOGICAL CONDITIONS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE MODEL | PLACENTA GROWTH-FACTOR | MICE | HYPOXIA | PROGRESSION | CELL BIOLOGY | Neovascularization, Physiologic - drug effects | Pregnancy Proteins - antagonists & inhibitors | Papilloma - prevention & control | Carcinoma, Hepatocellular - prevention & control | Humans | Antibodies, Monoclonal - therapeutic use | Pregnancy Proteins - metabolism | Liver Neoplasms, Experimental - prevention & control | Skin Neoplasms - prevention & control | Angiogenesis Inhibitors - therapeutic use | Carcinoma, Hepatocellular - blood supply | Skin Neoplasms - blood supply | Eye Diseases - pathology | Papilloma - blood supply | Papilloma - chemically induced | Disease Models, Animal | Mice, Inbred C57BL | Choroid - blood supply | Mice, Transgenic | Liver Neoplasms, Experimental - blood supply | Skin Neoplasms - chemically induced | Animals | Placenta Growth Factor | Mice | Mice, Inbred BALB C | Basic Medicine | Medical and Health Sciences | Internal medicine | Medicin och hälsovetenskap | Molekylär medicin (genetik och patologi) | Molecular medicine (genetics and pathology) | MEDICINE | Dermatology and venerology,clinical genetics, internal medicine | Medical Genetics | Medicinsk genetik | MEDICIN | Medicinska och farmaceutiska grundvetenskaper | Invärtesmedicin | Dermatologi och venerologi, klinisk genetik, invärtesmedicin
Journal Article
Journal Article
Journal of Hematology and Oncology, ISSN 1756-8722, 09/2016, Volume 9, Issue 1, pp. 1 - 10
Background: Risk stratification based on cytogenetics of acute myeloid leukemia (AML) remains imprecise. The introduction of novel genetic and epigenetic... 
SURVIVAL | CAP1 | MIGRATION | CANCER CELLS | ONCOLOGY | CYCLASE-ASSOCIATED PROTEIN-1 | CYTOSCAPE | PROLIFERATION | ACUTE MYELOID-LEUKEMIA | INDUCTION | HEMATOLOGY | SIGNATURE | Cytogenetics | Physiological aspects | Research
Journal Article
Blood, ISSN 0006-4971, 11/2012, Volume 120, Issue 21, pp. 872 - 872
Abstract Abstract 872 Background: The unfolded protein response (UPR) is a cellular machinery required to salvage of ER stress and to promote cell survival.... 
Journal Article