Journal of Antimicrobial Chemotherapy, ISSN 0305-7453, 12/2015, Volume 70, Issue 7, pp. 2084 - 2089
Background: Our study describes the prevalence of transmitted drug resistance (TDR) among 1318 French patients diagnosed at the time of primary HIV-1 infection...
HIV-1 | Resistance-associated mutations | Primary HIV infection | INFECTIOUS DISEASES | primary HIV infection | SURVEILLANCE | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | DRUG-RESISTANCE | MUTATIONS | RILPIVIRINE | PREVALENCE | resistance-associated mutations | SPAIN | Anti-HIV Agents - pharmacology | France - epidemiology | Prevalence | HIV-1 - drug effects | HIV Infections - epidemiology | Humans | Drug Resistance, Viral | Genotype | Male | Mutation, Missense | Genotyping Techniques | HIV-1 - genetics | HIV-1 - classification | Homosexuality, Male | HIV-1 - isolation & purification | Female | HIV Infections - transmission | Disease Transmission, Infectious | Life Sciences | Microbiology and Parasitology | Immunology
HIV-1 | Resistance-associated mutations | Primary HIV infection | INFECTIOUS DISEASES | primary HIV infection | SURVEILLANCE | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | DRUG-RESISTANCE | MUTATIONS | RILPIVIRINE | PREVALENCE | resistance-associated mutations | SPAIN | Anti-HIV Agents - pharmacology | France - epidemiology | Prevalence | HIV-1 - drug effects | HIV Infections - epidemiology | Humans | Drug Resistance, Viral | Genotype | Male | Mutation, Missense | Genotyping Techniques | HIV-1 - genetics | HIV-1 - classification | Homosexuality, Male | HIV-1 - isolation & purification | Female | HIV Infections - transmission | Disease Transmission, Infectious | Life Sciences | Microbiology and Parasitology | Immunology
Journal Article
Journal of Antimicrobial Chemotherapy, ISSN 0305-7453, 06/2013, Volume 68, Issue 6, pp. 1237 - 1242
The prevalence of rilpivirine, emtricitabine and tenofovir resistance-associated mutations (RAMs), described in vitro and in vivo, was determined in...
Primary resistance | Non-nucleoside reverse transcriptase inhibitors | NNRTIs | INFECTIOUS DISEASES | EFFICACY | ECHO | REVERSE-TRANSCRIPTASE | SUSCEPTIBILITY | primary resistance | MICROBIOLOGY | FAILURE | TRIAL | THERAPY | non-nucleoside reverse transcriptase inhibitors | EFAVIRENZ | PHARMACOLOGY & PHARMACY | TMC278 | ETRAVIRINE | Emtricitabine | Adenine - analogs & derivatives | Prevalence | Nitriles - pharmacology | HIV-1 - drug effects | Rilpivirine | HIV Infections - epidemiology | HIV Infections - virology | Humans | Reverse Transcriptase Inhibitors - pharmacology | Deoxycytidine - pharmacology | Genotype | Adenine - pharmacology | Pyrimidines - pharmacology | HIV-1 - genetics | Mutation - genetics | Antiretroviral Therapy, Highly Active | Tenofovir | Mutation - physiology | Drug Resistance, Viral - genetics | Organophosphonates - pharmacology | HIV Infections - drug therapy | Deoxycytidine - analogs & derivatives
Primary resistance | Non-nucleoside reverse transcriptase inhibitors | NNRTIs | INFECTIOUS DISEASES | EFFICACY | ECHO | REVERSE-TRANSCRIPTASE | SUSCEPTIBILITY | primary resistance | MICROBIOLOGY | FAILURE | TRIAL | THERAPY | non-nucleoside reverse transcriptase inhibitors | EFAVIRENZ | PHARMACOLOGY & PHARMACY | TMC278 | ETRAVIRINE | Emtricitabine | Adenine - analogs & derivatives | Prevalence | Nitriles - pharmacology | HIV-1 - drug effects | Rilpivirine | HIV Infections - epidemiology | HIV Infections - virology | Humans | Reverse Transcriptase Inhibitors - pharmacology | Deoxycytidine - pharmacology | Genotype | Adenine - pharmacology | Pyrimidines - pharmacology | HIV-1 - genetics | Mutation - genetics | Antiretroviral Therapy, Highly Active | Tenofovir | Mutation - physiology | Drug Resistance, Viral - genetics | Organophosphonates - pharmacology | HIV Infections - drug therapy | Deoxycytidine - analogs & derivatives
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 02/2010, Volume 54, Issue 2, pp. 728 - 733
Susceptibility to etravirine (ETR), an expanded-spectrum nonnucleoside reverse transcriptase inhibitor (NNRTI), is dependent on the type and number of NNRTI...
GENETIC DIVERSITY | CLINICAL-SAMPLES | EFFICACY | EXPERIENCED HIV-1-INFECTED PATIENTS | TMC125 ETRAVIRINE | REVERSE-TRANSCRIPTASE | DOUBLE-BLIND | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | PLACEBO-CONTROLLED TRIAL | DRUG-RESISTANCE | UNTREATED PATIENTS | Anti-HIV Agents - pharmacology | HIV-1 - drug effects | HIV Infections - virology | Humans | Genotype | Phylogeny | Pyridazines - pharmacology | HIV-1 - genetics | HIV-1 - classification | Drug Resistance, Viral - genetics | HIV-1 - physiology | Anti-HIV Agents - therapeutic use | HIV Infections - drug therapy | Mutation | Pyridazines - therapeutic use | Antiviral Agents
GENETIC DIVERSITY | CLINICAL-SAMPLES | EFFICACY | EXPERIENCED HIV-1-INFECTED PATIENTS | TMC125 ETRAVIRINE | REVERSE-TRANSCRIPTASE | DOUBLE-BLIND | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | PLACEBO-CONTROLLED TRIAL | DRUG-RESISTANCE | UNTREATED PATIENTS | Anti-HIV Agents - pharmacology | HIV-1 - drug effects | HIV Infections - virology | Humans | Genotype | Phylogeny | Pyridazines - pharmacology | HIV-1 - genetics | HIV-1 - classification | Drug Resistance, Viral - genetics | HIV-1 - physiology | Anti-HIV Agents - therapeutic use | HIV Infections - drug therapy | Mutation | Pyridazines - therapeutic use | Antiviral Agents
Journal Article
Journal of Antimicrobial Chemotherapy, ISSN 0305-7453, 2010, Volume 65, Issue 12, pp. 2620 - 2627
To estimate the prevalence of transmitted drug resistance mutations and non-B subtype circulation in antiretroviral-naive chronically HIV-1-infected patients...
HIV-1 | France | Resistance surveillance | INFECTIOUS DISEASES | VIRUS | SEROCONVERTERS | VARIANTS | PERFORMANCE | MICROBIOLOGY | TRANSMISSION | THERAPY | FREQUENCY | SURVEILLANCE | PHARMACOLOGY & PHARMACY | IMMUNOASSAY | resistance surveillance | TYPE-1 | Anti-HIV Agents - pharmacology | Prevalence | HIV Infections - epidemiology | Humans | HIV Protease - genetics | Reverse Transcriptase Inhibitors - pharmacology | HIV Reverse Transcriptase - genetics | HIV Seropositivity - drug therapy | Male | HIV Seropositivity - transmission | Anti-HIV Agents - therapeutic use | Female | HIV Infections - transmission | Reverse Transcriptase Inhibitors - therapeutic use | France - epidemiology | HIV-1 - drug effects | HIV Infections - virology | HIV-1 - genetics | HIV-1 - classification | Drug Resistance, Viral - genetics | HIV Seropositivity - epidemiology | HIV Infections - drug therapy | HIV-1 - enzymology | Mutation | Chronic Disease | HIV Seropositivity - virology
HIV-1 | France | Resistance surveillance | INFECTIOUS DISEASES | VIRUS | SEROCONVERTERS | VARIANTS | PERFORMANCE | MICROBIOLOGY | TRANSMISSION | THERAPY | FREQUENCY | SURVEILLANCE | PHARMACOLOGY & PHARMACY | IMMUNOASSAY | resistance surveillance | TYPE-1 | Anti-HIV Agents - pharmacology | Prevalence | HIV Infections - epidemiology | Humans | HIV Protease - genetics | Reverse Transcriptase Inhibitors - pharmacology | HIV Reverse Transcriptase - genetics | HIV Seropositivity - drug therapy | Male | HIV Seropositivity - transmission | Anti-HIV Agents - therapeutic use | Female | HIV Infections - transmission | Reverse Transcriptase Inhibitors - therapeutic use | France - epidemiology | HIV-1 - drug effects | HIV Infections - virology | HIV-1 - genetics | HIV-1 - classification | Drug Resistance, Viral - genetics | HIV Seropositivity - epidemiology | HIV Infections - drug therapy | HIV-1 - enzymology | Mutation | Chronic Disease | HIV Seropositivity - virology
Journal Article
The Journal of Antimicrobial Chemotherapy, ISSN 0305-7453, 06/2013, Volume 68, Issue 6, p. 1237
The prevalence of rilpivirine, emtricitabine and tenofovir resistance-associated mutations (RAMs), described in vitro and in vivo, was determined in...
Antiretroviral drugs | Human immunodeficiency virus--HIV | Mutation | Drug resistance | Polymorphism
Antiretroviral drugs | Human immunodeficiency virus--HIV | Mutation | Drug resistance | Polymorphism
Journal Article
Journal of Antimicrobial Chemotherapy, ISSN 0305-7453, 7/2011, Volume 66, Issue 7, pp. 1481 - 1483
Objectives To compare the frequency of previously in vitro-selected integrase mutations (T124A, T124A/S153F, S153Y, T124A/S153Y and L101I/T124A/S153Y)...
Failure | Prevalence | Polymorphism | prevalence | INFECTIOUS DISEASES | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | polymorphism | failure | Anti-HIV Agents - pharmacology | Heterocyclic Compounds, 3-Ring | HIV-1 - drug effects | HIV Infections - virology | Humans | Drug Resistance, Viral | Viral Proteins - genetics | Genotype | Mutation, Missense | HIV-1 - genetics | Sequence Analysis, DNA | Anthracenes - pharmacology | HIV-1 - classification | Anti-HIV Agents - administration & dosage | Pyrrolidinones - administration & dosage | HIV Integrase - genetics | HIV-1 - isolation & purification | Amino Acid Substitution - genetics | HIV Infections - drug therapy | Raltegravir Potassium
Failure | Prevalence | Polymorphism | prevalence | INFECTIOUS DISEASES | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | polymorphism | failure | Anti-HIV Agents - pharmacology | Heterocyclic Compounds, 3-Ring | HIV-1 - drug effects | HIV Infections - virology | Humans | Drug Resistance, Viral | Viral Proteins - genetics | Genotype | Mutation, Missense | HIV-1 - genetics | Sequence Analysis, DNA | Anthracenes - pharmacology | HIV-1 - classification | Anti-HIV Agents - administration & dosage | Pyrrolidinones - administration & dosage | HIV Integrase - genetics | HIV-1 - isolation & purification | Amino Acid Substitution - genetics | HIV Infections - drug therapy | Raltegravir Potassium
Journal Article
AIDS, ISSN 0269-9370, 12/2003, Volume 17, Issue 18, pp. 2635 - 2643
Objective: To evaluate the frequency of drug-resistant HIV-1 viral strains from patients presenting with primary infection in 1999-2000 and to survey the...
HIV-1 primary infection | Drug resistance | France | Epidemiology | Subtype | INFECTIOUS DISEASES | FITNESS | IMMUNOLOGY | INDIVIDUALS | epidemiology | TRANSMISSION | MUTANTS | IMPACT | POLYMORPHISMS | VIROLOGY | subtype | ACTIVE ANTIRETROVIRAL THERAPY | FREQUENCY | drug resistance | TYPE-1 | PROTEASE | France - epidemiology | Prevalence | HIV Infections - epidemiology | HIV Infections - genetics | Humans | Genotype | Male | RNA, Viral - blood | Phylogeny | HIV-1 - genetics | Mutation - genetics | HIV Protease Inhibitors - therapeutic use | Polymorphism, Genetic | Drug Resistance, Viral - genetics | Female | HIV Infections - drug therapy | Reverse Transcriptase Inhibitors - therapeutic use | Drug Therapy, Combination
HIV-1 primary infection | Drug resistance | France | Epidemiology | Subtype | INFECTIOUS DISEASES | FITNESS | IMMUNOLOGY | INDIVIDUALS | epidemiology | TRANSMISSION | MUTANTS | IMPACT | POLYMORPHISMS | VIROLOGY | subtype | ACTIVE ANTIRETROVIRAL THERAPY | FREQUENCY | drug resistance | TYPE-1 | PROTEASE | France - epidemiology | Prevalence | HIV Infections - epidemiology | HIV Infections - genetics | Humans | Genotype | Male | RNA, Viral - blood | Phylogeny | HIV-1 - genetics | Mutation - genetics | HIV Protease Inhibitors - therapeutic use | Polymorphism, Genetic | Drug Resistance, Viral - genetics | Female | HIV Infections - drug therapy | Reverse Transcriptase Inhibitors - therapeutic use | Drug Therapy, Combination
Journal Article
AIDS Research and Human Retroviruses, ISSN 0889-2229, 09/2012, Volume 28, Issue 9, pp. 1124 - 1130
The molecular characterization of non-B HIV type 1 subtypes and the sociodemographic baseline characteristics have been studied for 114 non-B HIV-1-infected...
Sequence Notes | GENETIC DIVERSITY | INFECTIOUS DISEASES | TRANSMITTED DRUG-RESISTANCE | IMPACT | VIRUS | VIROLOGY | SUBTYPES | SURVEILLANCE | PREVALENCE | MUTATIONS | IMMUNOLOGY | Amino Acid Sequence | France - epidemiology | Pregnancy Complications, Infectious - epidemiology | Humans | Middle Aged | Molecular Sequence Data | Genotype | Male | Phylogeny | HIV-1 - genetics | Sequence Analysis, DNA | Genetic Variation | Pregnancy | Young Adult | env Gene Products, Human Immunodeficiency Virus - genetics | RNA, Viral - genetics | HIV-1 - isolation & purification | Recombination, Genetic | HIV Seropositivity - epidemiology | Adult | Female | pol Gene Products, Human Immunodeficiency Virus - genetics | Life Sciences | Microbiology and Parasitology
Sequence Notes | GENETIC DIVERSITY | INFECTIOUS DISEASES | TRANSMITTED DRUG-RESISTANCE | IMPACT | VIRUS | VIROLOGY | SUBTYPES | SURVEILLANCE | PREVALENCE | MUTATIONS | IMMUNOLOGY | Amino Acid Sequence | France - epidemiology | Pregnancy Complications, Infectious - epidemiology | Humans | Middle Aged | Molecular Sequence Data | Genotype | Male | Phylogeny | HIV-1 - genetics | Sequence Analysis, DNA | Genetic Variation | Pregnancy | Young Adult | env Gene Products, Human Immunodeficiency Virus - genetics | RNA, Viral - genetics | HIV-1 - isolation & purification | Recombination, Genetic | HIV Seropositivity - epidemiology | Adult | Female | pol Gene Products, Human Immunodeficiency Virus - genetics | Life Sciences | Microbiology and Parasitology
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 11/2003, Volume 349, Issue 21, pp. 1993 - 2003
This prospective, observational study assessed the risk of myocardial infarction among 23,468 HIV-1–infected patients in relation to treatment with combination...
MONICA PROJECT | HEART-DISEASE | ADULTS | LIPODYSTROPHY | HIV-1-INFECTED PATIENTS | EVENT RATES | ASSOCIATION | UMCG Approved | CORONARY-ARTERY-DISEASE | PROTEASE INHIBITORS | HIV-INFECTED PATIENTS | MEDICINE, GENERAL & INTERNAL | HIV-1 | Myocardial Infarction - chemically induced | Anti-Retroviral Agents - therapeutic use | Myocardial Infarction - epidemiology | Prospective Studies | Follow-Up Studies | Humans | Middle Aged | Risk Factors | Anti-Retroviral Agents - adverse effects | Male | CD4 Lymphocyte Count | Incidence | Regression Analysis | HIV Infections - complications | Adult | Female | HIV Infections - drug therapy | Poisson Distribution | Drug Therapy, Combination | Adverse and side effects | Antiviral agents | Anti-HIV agents | Heart attack | Risk factors | Clinical trials | Therapy | Heart attacks | Metabolism | Human immunodeficiency virus--HIV | Older people
MONICA PROJECT | HEART-DISEASE | ADULTS | LIPODYSTROPHY | HIV-1-INFECTED PATIENTS | EVENT RATES | ASSOCIATION | UMCG Approved | CORONARY-ARTERY-DISEASE | PROTEASE INHIBITORS | HIV-INFECTED PATIENTS | MEDICINE, GENERAL & INTERNAL | HIV-1 | Myocardial Infarction - chemically induced | Anti-Retroviral Agents - therapeutic use | Myocardial Infarction - epidemiology | Prospective Studies | Follow-Up Studies | Humans | Middle Aged | Risk Factors | Anti-Retroviral Agents - adverse effects | Male | CD4 Lymphocyte Count | Incidence | Regression Analysis | HIV Infections - complications | Adult | Female | HIV Infections - drug therapy | Poisson Distribution | Drug Therapy, Combination | Adverse and side effects | Antiviral agents | Anti-HIV agents | Heart attack | Risk factors | Clinical trials | Therapy | Heart attacks | Metabolism | Human immunodeficiency virus--HIV | Older people
Journal Article
New England Journal of Medicine, ISSN 0028-4793, 11/2003, Volume 349, Issue 21, pp. 1993 - 2003
Journal Article
The Journal of Antimicrobial Chemotherapy, ISSN 0305-7453, 07/2011, Volume 66, Issue 7, p. 1481
To compare the frequency of previously in vitro-selected integrase mutations (T124A, T124A/S153F, S153Y, T124A/S153Y and L101I/T124A/S153Y) conferring...
Antiretroviral drugs | Human immunodeficiency virus--HIV | Mutation | Drug resistance | Virology
Antiretroviral drugs | Human immunodeficiency virus--HIV | Mutation | Drug resistance | Virology
Journal Article
Clinical Infectious Diseases, ISSN 1058-4838, 4/2009, Volume 48, Issue 8, pp. 1138 - 1151
Background. The extent to which mortality differs following individual acquired immunodeficiency syndrome (AIDS)-defining events (ADEs) has not been assessed...
HIV/AIDS | Antiretrovirals | HIV | Physicians | Mortality | Pulmonary tuberculosis | AIDS | Death | Epidemiology | Viral load | Carts | Prognosis | Humans | Proportional Hazards Models | AIDS-Related Opportunistic Infections - diagnosis | Male | Acquired Immunodeficiency Syndrome - drug therapy | Lymphoma, AIDS-Related - diagnosis | Lymphoma, AIDS-Related - mortality | AIDS-Related Opportunistic Infections - mortality | Acquired Immunodeficiency Syndrome - mortality | Acquired Immunodeficiency Syndrome - diagnosis | Adult | Anti-HIV Agents - therapeutic use | Female | Acquired Immunodeficiency Syndrome - complications | Drug Therapy, Combination | Cohort Studies | Research | Demographic aspects | United States | Patient outcomes | AIDS (Disease)
HIV/AIDS | Antiretrovirals | HIV | Physicians | Mortality | Pulmonary tuberculosis | AIDS | Death | Epidemiology | Viral load | Carts | Prognosis | Humans | Proportional Hazards Models | AIDS-Related Opportunistic Infections - diagnosis | Male | Acquired Immunodeficiency Syndrome - drug therapy | Lymphoma, AIDS-Related - diagnosis | Lymphoma, AIDS-Related - mortality | AIDS-Related Opportunistic Infections - mortality | Acquired Immunodeficiency Syndrome - mortality | Acquired Immunodeficiency Syndrome - diagnosis | Adult | Anti-HIV Agents - therapeutic use | Female | Acquired Immunodeficiency Syndrome - complications | Drug Therapy, Combination | Cohort Studies | Research | Demographic aspects | United States | Patient outcomes | AIDS (Disease)
Journal Article