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by Medema, Marnix H and Kottmann, Renzo and Yilmaz, Pelin and Cummings, Matthew and Biggins, John B and Blin, Kai and de Bruijn, Irene and Chooi, Yit Heng and Claesen, Jan and Coates, R Cameron and Cruz-Morales, Pablo and Duddela, Srikanth and Düsterhus, Stephanie and Edwards, Daniel J and Fewer, David P and Garg, Neha and Geiger, Christoph and Gomez-Escribano, Juan Pablo and Greule, Anja and Hadjithomas, Michalis and Haines, Anthony S and Helfrich, Eric J N and Hillwig, Matthew L and Ishida, Keishi and Jones, Adam C and Jones, Carla S and Jungmann, Katrin and Kegler, Carsten and Kim, Hyun Uk and Kötter, Peter and Krug, Daniel and Masschelein, Joleen and Melnik, Alexey V and Mantovani, Simone M and Monroe, Emily A and Moore, Marcus and Moss, Nathan and Nützmann, Hans-Wilhelm and Pan, Guohui and Pati, Amrita and Petras, Daniel and Reen, F Jerry and Rosconi, Federico and Rui, Zhe and Tian, Zhenhua and Tobias, Nicholas J and Tsunematsu, Yuta and Wiemann, Philipp and Wyckoff, Elizabeth and Yan, Xiaohui and Yim, Grace and Yu, Fengan and Xie, Yunchang and Aigle, Bertrand and Apel, Alexander K and Balibar, Carl J and Balskus, Emily P and Barona-Gómez, Francisco and Bechthold, Aneas and Bode, Helge B and Borriss, Rainer and Brady, Sean F and Brakhage, Axel A and Caffrey, Patrick and Cheng, Yi-Qiang and Clardy, Jon and Cox, Russell J and De Mot, René and Donadio, Stefano and Donia, Mohamed S and van der Donk, Wilfred A and Dorrestein, Pieter C and Doyle, Sean and essen, Arnold J M and Ehling-Schulz, Monika and Entian, Karl-Dieter and Fischbach, Michael A and Gerwick, Lena and Gerwick, William H and Gross, Harald and Gust, Bertolt and Hertweck, Christian and Höfte, Monica and Jensen, Susan E and Ju, Jianhua and Katz, Leonard and Kaysser, Leonard and Klassen, Jonathan L and Keller, Nancy P and Kormanec, Jan and Kuipers, Oscar P and Kuzuyama, Tomohisa and Kyrpides, Nikos C and Kwon, Hyung-Jin and Lautru, Sylvie and Lavigne, Rob and Lee, Chia Y and Linquan, Bai and Liu, Xinyu and Liu, Wen and ...
Nature Chemical Biology, ISSN 1552-4469, 08/2015, Volume 11, Issue 9, pp. 625 - 631
Journal Article
NATURE CHEMISTRY, ISSN 1755-4330, 10/2019, Volume 11, Issue 10, pp. 906 - 912
Polyketide synthases assemble diverse natural products with numerous important applications. The thioester intermediates in polyketide assembly are covalently... 
IIA | BOND FORMATION | ELONGATION-FACTOR TU | KETOSYNTHASE | LOGIC | CHEMISTRY, MULTIDISCIPLINARY | Chains | Biosynthesis | Carboxylic acids | Condensation | Intermediates | Proteins | Polyketide synthase | Domains | Antibiotics | Natural products | Condensates | Acyl carrier protein | Elongation
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2013, Volume 8, Issue 1, p. e54143
Serratia plymuthica strain RVH1, initially isolated from an industrial food processing environment, displays potent antimicrobial activity towards a broad... 
MODULAR POLYKETIDE SYNTHASES | PULSED-FIELD GRADIENTS | GRAM-NEGATIVE BACTERIA | COMPLETE GENOME SEQUENCE | NONRIBOSOMAL PEPTIDE SYNTHETASES | MULTIDISCIPLINARY SCIENCES | PHOSPHOPANTETHEINYL TRANSFERASE GENE | ESCHERICHIA-COLI | MARINA STRAIN MP-1 | POLYUNSATURATED FATTY-ACIDS | EICOSAPENTAENOIC ACID | Multigene Family | Fatty Acid Synthases - metabolism | Molecular Sequence Data | Peptide Synthases - genetics | Polyketide Synthases - metabolism | Macrolides - chemistry | Anti-Bacterial Agents - chemistry | Cloning, Molecular | DNA Transposable Elements - genetics | Macrolides - pharmacology | Molecular Structure | Serratia - genetics | Fatty Acid Synthases - genetics | Gene Order | Amino Acid Sequence | Magnetic Resonance Spectroscopy | Polyamines - chemistry | Bacterial Proteins - genetics | Gene Fusion | Macrolides - metabolism | Sequence Analysis, DNA | Peptide Synthases - metabolism | Polyamines - metabolism | Sequence Homology, Amino Acid | Polyamines - pharmacology | Serratia - metabolism | Bacterial Proteins - metabolism | Anti-Bacterial Agents - biosynthesis | Anti-Bacterial Agents - pharmacology | Mutagenesis, Insertional | Polyketide Synthases - genetics | Staphylococcus aureus - drug effects | Staphylococcus aureus - growth & development | Mass Spectrometry - methods | Enzymes | Unsaturated fatty acids | Metabolites | Antibiotics | Physiological aspects | Amino acids | Biosynthesis | Drugs | Antimicrobial activity | Peptides | Molecular structure | Laboratories | Polyunsaturated fatty acids | Genes | Homology | Biochemistry | Experiments | Food industry | Clusters | Bacteria | Gram-negative bacteria | Pharmaceutical sciences | Food | Assembly lines | Prodrugs | Architecture | Antimicrobial agents | Artificial chromosomes | Food processing | Fermentation | Fatty acids | Chemical compounds | Serratia | Chemistry | Biofilms | Genetic engineering | Food processing industry
Journal Article
NATURE CHEMISTRY, ISSN 1755-4330, 10/2019, Volume 11, Issue 10, pp. 913 - 923
Modular polyketide synthases and non-ribosomal peptide synthetases are molecular assembly lines that consist of several multienzyme subunits that undergo... 
DOMAIN | SOLID-STATE NMR | CRYSTAL-STRUCTURE | BIOSYNTHESIS | DYNAMICS | PROTEIN-PROTEIN INTERACTIONS | LIGAND | CHEMISTRY, MULTIDISCIPLINARY | WEB SERVER | PEPTIDE | PREDICTION | Self assembly | Peptides | Chains | Polyketide synthase | Domains | Interfaces | Self-assembly | Antibiotics | Assembling | Docking | Catalysis | Bioinformatics | Assembly lines
Journal Article
Journal Article
Chemical Science, ISSN 2041-6520, 2017, Volume 8, Issue 9, pp. 6196 - 6201
Kalimantacin A and batumin exhibit potent and selective antibiotic activity against Staphylococcus species including MRSA. Both compounds are formed via a... 
Journal Article
Chemical Science, ISSN 2041-6520, 2015, Volume 6, Issue 2, pp. 923 - 929
The zeamines are a unique group of antibiotics produced by Serratia plymuthica RVH1 that contain variable hybrid peptide–polyketide moieties connected to a... 
Journal Article
Chemical Science, ISSN 2041-6520, 2019, Volume 10, Issue 21, pp. 5489 - 5494
is a multi-talented genus of Gram-negative bacteria, which in recent years has become increasingly recognised as a promising source of bioactive natural... 
Journal Article
ISSN 2041-6520, 5/2019, Volume 1, Issue 21, pp. 5489 - 5494
Burkholderia is a multi-talented genus of Gram-negative bacteria, which in recent years has become increasingly recognised as a promising source of bioactive... 
Journal Article
Applied and Environmental Microbiology, ISSN 0099-2240, 02/2015, Volume 81, Issue 3, p. 1139
  The zeamines (zeamine, zeamine I, and zeamine II) constitute an unusual class of cationic polyamine-polyketide-nonribosomal peptide antibiotics produced by... 
Pathogens | Membranes | Antibiotics | Lipids | Gram-negative bacteria | Binding sites
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 06/2017, Volume 139, Issue 23, pp. 7974 - 7981
An antimicrobial activity screen of Burkholderia gladioli BCC0238, a clinical isolate from a cystic fibrosis patient, led to the discovery of gladiolin, a... 
ACYLTRANSFERASE POLYKETIDE SYNTHASES | ETNANGIEN | SORANGIUM-CELLULOSUM | DRUGS | THAILANDENSIS | ACYL CARRIER PROTEINS | DIVERSITY | CEPACIA COMPLEX | CHEMISTRY, MULTIDISCIPLINARY | RNA-POLYMERASE | REVEALS | Macrolide antibiotics | Biosynthesis | Gladiolus | Research | Mycobacterium tuberculosis
Journal Article
MicrobiologyOpen, ISSN 2045-8827, 04/2016, Volume 5, Issue 2, pp. 279 - 286
Journal Article
Chemical Science, ISSN 2041-6520, 02/2015, Volume 6, Issue 2, pp. 923 - 929
The zeamines are a unique group of antibiotics produced by Serratia plymuthica RVH1 that contain variable hybrid peptide-polyketide moieties connected to a... 
SYNTHASE | COMPONENT PRODUCTION | DOMAIN | ENZYME | GENE-CLUSTER | ESCHERICHIA-COLI | SACCHAROPOLYSPORA-ERYTHRAEA | MECHANISMS | SERRATIA-PLYMUTHICA | LOGIC | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Chemical Science, ISSN 2041-6520, 2017, Volume 8, Issue 9, pp. 6196 - 6201
Kalimantacin A and batumin exhibit potent and selective antibiotic activity against Staphylococcus species including MRSA. Both compounds are formed via a... 
ALCOHOLS | KETONES | REDUCTION | BIOSYNTHESIS | RESISTANCE | POLYKETIDES | CONFIGURATIONAL ASSIGNMENT | ALDEHYDES | CHEMISTRY, MULTIDISCIPLINARY | ALCALIGENES SP YL-02632S | BATUMIN
Journal Article
ACS Chemical Biology, ISSN 1554-8929, 06/2019, Volume 14, Issue 6, pp. 1305 - 1309
Pentamycin is a polyene antibiotic, registered in Switzerland for the treatment of vaginal candidiasis, trichomoniasis, and mixed infections. Chemical... 
AVERMITILIS | CHEMISTRY | ANTIFUNGAL POLYENE | FILIPIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENOME
Journal Article
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