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humans (19) 19
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1. Full Text Regulation of Mammalian Autophagy in Physiology and Pathophysiology
by Brinda Ravikumar and Sovan Sarkar and Janet E. Davies and Marie Futter and Moises Garcia-Arencibia and Zeyn W. Green-Thompson and Maria Jimenez-Sanchez and Viktor I. Korolchuk and Maike Lichtenberg and Shouqing Luo and Dunecan C. O. Massey and Fiona M. Menzies and Kevin Moreau and Usha Narayanan and Maurizio Renna and Farah H. Siddiqi and Benjamin R. Underwood and Ashley R. Winslow and David C. Rubinsztein
Physiological Reviews, ISSN 0031-9333, 10/2010, Volume 90, Issue 4, pp. 1383 - 1435
(Macro)autophagy is a bulk degradation process that mediates the clearance of long-lived proteins and organelles. Autophagy is initiated by double-membraned... 
SKELETAL-MUSCLE ATROPHY | CLASS-II PRESENTATION | MALIGNANT GLIOMA-CELLS | HERPES-SIMPLEX-VIRUS | PHYSIOLOGY | UNFOLDED PROTEIN RESPONSE | CHAPERONE-MEDIATED AUTOPHAGY | AGGREGATE-PRONE PROTEINS | ENDOPLASMIC-RETICULUM STRESS | STARVATION-INDUCED AUTOPHAGY | NF-KAPPA-B | Animals | Signal Transduction | Humans | Phagosomes - metabolism | Mammals - physiology | Stress, Physiological | Eukaryotic Cells - metabolism | Autophagy - physiology | Eukaryotic Cells - pathology | Erythropoiesis | Autophagy (Cytology) | Analysis | Aging | Research | Chemical properties | Structure | Protein kinases | Proteins | Pathology | Signal transduction | Membranes | Disease | Anatomy & physiology | Mammals | Autophagy | Cells | Cytoplasm
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2. Full Text Genome-wide Association Scanning Highlights Two Autophagy Genes, ATG16L1 and IRGM, as Being Significantly Associated with Crohn's Disease
by Massey, Dunecan C.O and Parkes, Miles
Autophagy, ISSN 1554-8627, 11/2007, Volume 3, Issue 6, pp. 649 - 651
The era of genome-wide association (GWA) scanning has shed new light on the genetic basis of common disease and nowhere is this better illustrated than Crohn's... 
Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | genome-wide association scan | autophagy | VARIANTS | ATG16L1 | ROLES | SUSCEPTIBILITY | Crohn's disease | INFECTION | LOCI | LRG-47 | IRGM | CELL BIOLOGY | Carrier Proteins - genetics | Crohn Disease - genetics | Autophagy-Related Proteins | Crohn Disease - pathology | Humans | Autophagy - physiology | Autophagy - genetics | Genome, Human | GTP-Binding Proteins - genetics
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3. Full Text Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls
by Craddock, Nick and Hurles, Matthew E and Cardin, Niall and Pearson, Richard D and Plagnol, Vincent and Robson, Samuel and Vukcevic, Damjan and Barnes, Chris and Conrad, Donald F and Giannoulatou, Eleni and Holmes, Chris and Marchini, Jonathan L and Stirrups, Kathy and Tobin, Martin D and Wain, Louise V and Yau, Chris and Aerts, Jan and Ahmad, Tariq and Andrews, T. Daniel and Arbury, Hazel and Attwood, Anthony and Auton, Adam and Ball, Stephen G and Balmforth, Anthony J and Barrett, Jeffrey C and Barroso, Inês and Barton, Anne and Bennett, Amanda J and Bhaskar, Sanjeev and Blaszczyk, Katarzyna and Bowes, John and Brand, Oliver J and Braund, Peter S and Bredin, Francesca and Breen, Gerome and Brown, Morris J and Bruce, Ian N and Bull, Jaswinder and Burren, Oliver S and Burton, John and Byrnes, Jake and Caesar, Sian and Clee, Chris M and Coffey, Alison J and Connell, John M. C and Cooper, Jason D and Dominiczak, Anna F and Downes, Kate and Drummond, Hazel E and Dudakia, Darshna and Dunham, Andrew and Ebbs, Bernadette and Eccles, Diana and Edkins, Sarah and Edwards, Cathryn and Elliot, Anna and Emery, Paul and Evans, David M and Evans, Gareth and Eyre, Steve and Farmer, Anne and Ferrier, I. Nicol and Feuk, Lars and Fitzgerald, Tomas and Flynn, Edward and Forbes, Alistair and Forty, Liz and Franklyn, Jayne A and Freathy, Rachel M and Gibbs, Polly and Gilbert, Paul and Gokumen, Omer and Gordon-Smith, Katherine and Gray, Emma and Green, Elaine and Groves, Chris J and Grozeva, Detelina and Gwilliam, Rhian and Hall, Anita and Hammond, Naomi and Hardy, Matt and Harrison, Pile and Hassanali, Neelam and Hebaishi, Husam and Hines, Sarah and Hinks, Anne and Hitman, Graham A and Hocking, Lynne and Howard, Eleanor and Howard, Philip and Howson, Joanna M. M and Hughes, Debbie and Hunt, Sarah and Isaacs, John D and Jain, Mahim and Jewell, Derek P and Johnson, Toby and Jolley, Jennifer D and Jones, Ian R and Jones, Lisa A and ... and Wellcome Trust Case Control and Wellcome Trust Case Control Consortium and The Wellcome Trust Case Control Consortium and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Institutionen för genetik och patologi and Uppsala universitet
Nature, ISSN 0028-0836, 04/2010, Volume 464, Issue 7289, pp. 713 - 720
Copy number variants (CNVs) account for a major proportion of human genetic polymorphism and have been predicted to have an important role in genetic... 
DUPLICATIONS | POLYMORPHISMS | CCL3L1 | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY | SCHIZOPHRENIA | LARGE-SCALE | HERITABILITY | PSORIASIS | COPY-NUMBER VARIATION | DELETION | Crohn Disease - genetics | Gene Frequency - genetics | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Nucleic Acid Hybridization | Disease | Oligonucleotide Array Sequence Analysis | Diabetes Mellitus - genetics | Humans | DNA Copy Number Variations - genetics | Case-Control Studies | Arthritis, Rheumatoid - genetics | Pilot Projects | Polymorphism, Single Nucleotide - genetics | Quality Control | Genetic variation | Chronic diseases | Genetic aspects | Research | Single nucleotide polymorphisms | Health aspects | Risk factors | Studies | Design | Rheumatoid arthritis | Genetics | Cardiovascular disease | Principal components analysis | Statistical methods | Diabetes | Cancer | Human | Crohn's Disease | Reproduction | Arrays | Loci | Polymorphism | Diseases | Life Sciences | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
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4. Full Text Erratum: Genome-wide association scanning highlights two autophagy genes, ATG16L1 and IRGM, as being significantly associated with Crohn's disease (Autophagy)
by Massey, Dunecan C.O and Parkes, Miles
Autophagy, ISSN 1554-8627, 2007, Volume 3, Issue 6, pp. 649 - 651
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5. Full Text Mammalian macroautophagy at a glance
by Ravikumar, Brinda and Futter, Marie and Jahreiss, Luca and Korolchuk, Viktor I and Lichtenberg, Maike and Luo, Shouqing and Massey, Dunecan C.O and Menzies, Fiona M and Narayanan, Usha and Renna, Maurizio and Jimenez-Sanchez, Maria and Sarkar, Sovan and Underwood, Benjamin and Winslow, Ashley and Rubinsztein, David C
Journal of Cell Science, ISSN 0021-9533, 06/2009, Volume 122, Issue 11, pp. 1707 - 1711
CONJUGATION | APOPTOSIS | CELLS | PROTEIN | BIOGENESIS | DISEASE | AUTOPHAGOSOME FORMATION | ENDOPLASMIC-RETICULUM | HOMOLOG | ASSOCIATION | CELL BIOLOGY | Immunity - physiology | Animals | Humans | Signal Transduction - physiology | Autophagy - physiology | Lysosomal-Associated Membrane Protein 2 - metabolism | HSP70 Heat-Shock Proteins - metabolism | Cell Science at a Glance
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6. Full Text Tu1933 Expression Association Analysis of the ATG5, ATG12 and ATG16L1 Genes in Crohn's Disease (CD)
by Zhang, Hu and Massey, Dunecan C and Parkes, Miles
Gastroenterology, ISSN 0016-5085, 2014, Volume 146, Issue 5, pp. S-876 - S-876
Gastroenterology and Hepatology
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7. Full Text Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
by Jostins, Luke and Ripke, Stephan and Weersma, Rinse K and Duerr, Richard H and McGovern, Dermot P and Hui, Ken Y and Lee, James C and Schumm, L. Philip and Sharma, Yashoda and Anderson, Carl A and Essers, Jonah and Mitrovic, Mitja and Ning, Kaida and Cleynen, Isabelle and Theatre, Emilie and Spain, Sarah L and Raychaudhuri, Soumya and Goyette, Philippe and Wei, Zhi and Abraham, Clara and Achkar, Jean-Paul and Ahmad, Tariq and Amininejad, Leila and Ananthakrishnan, Ashwin N and Andersen, Vibeke and Anews, Jane M and Baidoo, Leonard and Balschun, Tobias and Bampton, Peter A and Bitton, Alain and Boucher, Gabrielle and Brand, Stephan and Büning, Carsten and Cohain, Ariella and Cichon, Sven and D'Amato, Mauro and de Jong, Dirk and Devaney, Kathy L and Dubinsky, Marla and Edwards, Cathryn and Ellinghaus, David and Ferguson, Lynnette R and Franchimont, Denis and Fransen, Karin and Gearry, Richard and Georges, Michel and Gieger, Christian and Glas, Jürgen and Haritunians, Talin and Hart, Ailsa and Hawkey, Chris and Hedl, Matija and Hu, Xinli and Karlsen, Tom H and Kupcinskas, Limas and Kugathasan, Subra and Latiano, Anna and Laukens, Debby and Lawrance, Ian C and Lees, Charlie W and Louis, Edouard and Mahy, Gillian and Mansfield, John and Morgan, Angharad R and Mowat, Craig and Newman, William and Palmieri, Orazio and Ponsioen, Cyriel Y and Potocnik, Uros and Prescott, Natalie J and Regueiro, Miguel and Rotter, Jerome I and Russell, Richard K and Sanderson, Jeremy D and Sans, Miquel and Satsangi, Jack and Schreiber, Stefan and Simms, Lisa A and Sventoraityte, Jurgita and Targan, Stephan R and Taylor, Kent D and Tremelling, Mark and Verspaget, Hein W and de Vos, Martine and Wijmenga, Cisca and Wilson, David C and Winkelmann, Juliane and Xavier, Ramnik J and Zeissig, Sebastian and Zhang, Bin and Zhang, Clarence K and Zhao, Hongyu and Silverberg, Mark S and Annese, Vito and Hakonarson, Hakon and Brant, Steven R and Radford-Smith, Graham and Mathew, Christopher G and Rioux, John D and Schadt, Eric E and ... and Int IBD Genetics Consortium IIBDGC and International IBD Genetics Consortium (IIBDGC) and The International IBD Genetics Consortium (IIBDGC) and Region Örebro län and Örebro universitet and Institutionen för medicinska vetenskaper
Nature, ISSN 0028-0836, 2012, Volume 491, Issue 7422, pp. 119 - 124
Crohn's disease and ulcerative colitis, the two common forms of inflammatory bowel disease (IBD), affect over 2.5 million people of European ancestry, with... 
HYPER-IGE SYNDROME | RISK LOCI | NETWORK | NUMBER | METAANALYSIS | TUBERCULOSIS | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY | MUTATIONS | EXPRESSION | Crohn Disease - genetics | Humans | Inflammatory Bowel Diseases - immunology | Colitis, Ulcerative - genetics | Mycobacterium tuberculosis - immunology | Inflammatory Bowel Diseases - physiopathology | Colitis, Ulcerative - immunology | Host-Pathogen Interactions - immunology | Mycobacterium tuberculosis - pathogenicity | Haplotypes - genetics | Mycobacterium - pathogenicity | Mycobacterium Infections - genetics | Inflammatory Bowel Diseases - genetics | Crohn Disease - microbiology | Mycobacterium Infections - microbiology | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Reproducibility of Results | Mycobacterium - immunology | Crohn Disease - immunology | Genome, Human - genetics | Phenotype | Colitis, Ulcerative - microbiology | Host-Pathogen Interactions - genetics | Polymorphism, Single Nucleotide - genetics | Inflammatory Bowel Diseases - microbiology | Crohn Disease - physiopathology | Colitis, Ulcerative - physiopathology | Inflammatory bowel disease | Candidates | Tuberculosis | Architecture | Genetics | Genomes | Diabetes | Gene expression | Health risk assessment | Immune system | Rheumatology and Autoimmunity | Basic Medicine | Medical Genetics | Medicinsk genetik | Clinical Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Reumatologi och inflammation | Medicinska och farmaceutiska grundvetenskaper | Klinisk medicin
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8. Full Text Investigation of Crohn's Disease Risk Loci in Ulcerative Colitis Further Defines Their Molecular Relationship
by Anderson, Carl A and Massey, Dunecan C.O and Barrett, Jeffrey C and Prescott, Natalie J and Tremelling, Mark and Fisher, Sheila A and Gwilliam, Rhian and Jacob, Jemima and Nimmo, Elaine R and Drummond, Hazel and Lees, Charlie W and Onnie, Clive M and Hanson, Catherine and Blaszczyk, Katarzyna and Ravindrarajah, Radhi and Hunt, Sarah and Varma, Dhiraj and Hammond, Naomi and Lewis, Gregory and Attlesey, Heather and Watkins, Nick and Ouwehand, Willem and Strachan, David and McArdle, Wendy and Lewis, Cathryn M and Lobo, Alan and Sanderson, Jeremy and Jewell, Derek P and Deloukas, Panos and Mansfield, John C and Mathew, Christopher G and Satsangi, Jack and Parkes, Miles and Wellcome Trust Case Control and Wellcome Trust Case Control Consortium
Gastroenterology, ISSN 0016-5085, 2009, Volume 136, Issue 2, pp. 523 - 529.e3
Background & Aims Identifying shared and disease-specific susceptibility loci for Crohn's disease (CD) and ulcerative colitis (UC) would help define the... 
Gastroenterology and Hepatology | POPULATION | INFLAMMATORY-BOWEL-DISEASE | REPLICATION | VARIANTS | SEQUENCE | SUSCEPTIBILITY LOCI | AUTOPHAGY | GASTROENTEROLOGY & HEPATOLOGY | MDR1 GENE POLYMORPHISM | MULTIPLE | GENOME-WIDE ASSOCIATION | Crohn Disease - genetics | Genetic Predisposition to Disease - genetics | Extracellular Matrix Proteins - genetics | Humans | Risk Factors | Colitis, Ulcerative - genetics | Janus Kinase 2 - genetics | Genotype | Male | Case-Control Studies | Cyclin-Dependent Kinase 5 - genetics | tRNA Methyltransferases | Polymorphism, Single Nucleotide - genetics | Adult | Female | STAT3 Transcription Factor - genetics | Medical colleges | Genomics | Crohn's disease | Colitis | Risk factors | Investigations | Public health
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9. Full Text Splenic rupture due to metastatic disease: A rare complication
by Smith, Rachel and Massey, Dunecan
BMJ Case Reports, ISSN 1757-790X, 2017, Volume 2017, p. bcr-2017-221336
We report a case of splenic rupture in an 83-year-old woman presenting with symptoms concerning for upper gastrointestinal malignancy. CT imaging revealed... 
stomach and duodenum | endoscopy | gastric cancer | gastrointestinal surgery | Splenic Neoplasms - complications | Splenic Rupture - etiology | Humans | Fatal Outcome | Aged, 80 and over | Esophagogastric Junction - pathology | Female | Stomach Neoplasms - pathology | Splenic Neoplasms - secondary | Adenocarcinoma - complications | Adenocarcinoma - secondary | Ostomy | Biopsy | Lung cancer | Blood tests | Melanoma | Dysphagia | Metastasis | Abdomen | Skin cancer
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10. Full Text Mucosal genome‐wide methylation changes in inflammatory bowel disease
by Cooke, James and Zhang, Hu and Greger, Liliana and Silva, Ana‐Luisa and Massey, Dunecan and Dawson, Claire and Metz, Andrew and Ibrahim, Ashraf and Parkes, Miles
Inflammatory Bowel Diseases, ISSN 1078-0998, 11/2012, Volume 18, Issue 11, pp. 2128 - 2137
Background: DNA methylation constitutes a key epigenetic mechanism by which cells regulate gene transcription. Among its roles are the dynamic regulation of... 
microarray | Crohn's disease | ulcerative colitis | epigenetic | mucosa | methylation | NUMBER | CROHNS-DISEASE | SUSCEPTIBILITY LOCI | E-CADHERIN | AUTOPHAGY | MULTIPLE | COMMON DISEASES | GENE-EXPRESSION | GASTROENTEROLOGY & HEPATOLOGY | ASSOCIATION | Biomarkers - metabolism | Crohn Disease - genetics | Genome-Wide Association Study | Oligonucleotide Array Sequence Analysis | Humans | RNA, Messenger - genetics | Colitis, Ulcerative - genetics | Gene Expression Profiling | Colitis, Ulcerative - blood | Reverse Transcriptase Polymerase Chain Reaction | Case-Control Studies | DNA Methylation | Crohn Disease - blood | Genome, Human | Real-Time Polymerase Chain Reaction | Methylation | Gastrointestinal diseases | Genomics | Inflammatory bowel disease | DNA methylation | Genomes | Deoxyribonucleic acid--DNA
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11. Full Text Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
by Fisher, Sheila A and Tremelling, Mark and Anderson, Carl A and Gwilliam, Rhian and