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Rheumatology, ISSN 1462-0332, 04/2016
Journal Article
Rheumatology, ISSN 1462-0324, 04/2016, Volume 55, Issue suppl_1, pp. i11 - i11
Journal Article
Drugs, ISSN 0012-6667, 4/2017, Volume 77, Issue 5, pp. 521 - 546
The Janus kinase/signal transduction and activator of transcription (JAK–STAT) signaling pathway is implicated in the pathogenesis of inflammatory and... 
Pharmacotherapy | Internal Medicine | Medicine & Public Health | Pharmacology/Toxicology | PHASE 2B TRIAL | VX-509 DECERNOTINIB | ALOPECIA-AREATA | MODIFYING ANTIRHEUMATIC DRUG | JANUS KINASE INHIBITOR | ACTIVE RHEUMATOID-ARTHRITIS | INADEQUATE RESPONSE | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | TOXICOLOGY | TOFACITINIB CP-690,550 | DRUG-DRUG INTERACTIONS | Janus Kinases - genetics | Humans | STAT Transcription Factors - metabolism | Janus Kinases - metabolism | Janus Kinases - antagonists & inhibitors | Protein Kinase Inhibitors - administration & dosage | Inflammation - metabolism | STAT Transcription Factors - genetics | Signal Transduction - drug effects | Inflammation - drug therapy | Protein Kinase Inhibitors - therapeutic use | Protein Kinase Inhibitors - pharmacology | STAT Transcription Factors - antagonists & inhibitors | Autoimmune Diseases - metabolism | Autoimmune Diseases - drug therapy | Dosage and administration | Tofacitinib | Autoimmune diseases | Drug therapy | Regulatory agencies | Inflammatory bowel diseases | Phosphorylation | Transcription factors | Disease | Transcription | Pathogenesis | Genes | Disorders | Clinical trials | Intracellular signalling | Arthritis | Kinases | Inflammatory diseases | Signal transduction | Intestine | Rodents | Janus kinase | Tumor necrosis factor-TNF | Medical research | Cytokines | Psoriasis | Baldness | Immunodeficiency | Patients | Diseases | Reviews | Rheumatoid arthritis | Transduction | Intracellular | Mutation
Journal Article
Nature Reviews Rheumatology, ISSN 1759-4790, 01/2016, Volume 12, Issue 1, pp. 25 - 36
Journal Article
Nature Reviews Rheumatology, ISSN 1759-4790, 02/2019, Volume 15, Issue 2, pp. 74 - 75
Janus kinase (JAK) inhibitors (jakinibs) that target downstream signalling by a large range of cytokines are effective in treating autoimmune and rheumatic... 
RHEUMATOLOGY
Journal Article
Nature, ISSN 0028-0836, 04/2015, Volume 520, Issue 7548, pp. 558 - 562
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 08/2014, Volume 371, Issue 6, pp. 507 - 518
The stimulator of interferon genes (STING) protein bridges sensors of cytosolic DNA and the inflammatory pathway mediated by interferon-β. Activating mutations... 
MEDICINE, GENERAL & INTERNAL | FAMILIAL CHILBLAIN LUPUS | CYCLIC GMP-AMP | DNA | PROTEASOME SUBUNIT | LIPODYSTROPHY | SENSOR | MONOGENIC AUTOINFLAMMATORY DISEASES | EXPRESSION | I INTERFERON | INBORN-ERRORS | Up-Regulation | Phosphorylation | Humans | Infant | Male | Interferon-gamma - metabolism | Inflammation - metabolism | STAT1 Transcription Factor - metabolism | Skin Diseases, Vascular - genetics | Genes, Dominant | Female | Transcription, Genetic | Interferon-gamma - genetics | Cytokines - genetics | Infant, Newborn | Fibroblasts - metabolism | Skin Diseases, Vascular - metabolism | Cytokines - metabolism | Membrane Proteins - genetics | Sequence Analysis, DNA | Syndrome | Janus Kinases - antagonists & inhibitors | Lung Diseases - genetics | Pedigree | Age of Onset | Inflammation - genetics | Mutation | Pulmonary manifestations of general diseases | Blood circulation disorders | Genetic aspects | Research | Gene mutations | Risk factors | Transcription | Genes | Guanosine | Leukocytes (mononuclear) | Arthritis | Interleukin 6 | Cell activation | Vascular diseases | Lymphocytes | Cyclic GMP | Interleukin 1 | Peripheral blood | Fingers & toes | Fibroblasts | Janus kinase | Skin diseases | Children | Stat1 protein | Age | Deoxyribonucleic acid--DNA | Phenotypes | AMP | Patients | Endothelial cells | Studies | Biopsy | Ligands | Interferon | Autoimmune diseases | Apoptosis
Journal Article