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Nature Reviews Immunology, ISSN 1474-1733, 03/2017, Volume 17, Issue 3, pp. 208 - 214
Journal Article
Clinical Immunology, ISSN 1521-6616, 2012, Volume 147, Issue 3, pp. 223 - 228
Abstract Blocking the cytokines Interleukin-1beta (IL-1β) and Interleukin-18 (IL-18) benefits a diverse range of inflammatory pathologies. In each of these... 
Allergy and Immunology | NLRP3 | Interleukin-1 | Inflammasome | Autoinflammation | JUVENILE IDIOPATHIC ARTHRITIS | CONTACT HYPERSENSITIVITY | THIOREDOXIN-INTERACTING PROTEIN | NLRP3 INFLAMMASOME | BEHCETS-DISEASE | IMMUNOLOGY | NALP3 INFLAMMASOME | INTESTINAL INFLAMMATION | RECEPTOR ANTAGONIST GENE | INTERLEUKIN-1-BETA INHIBITION | AUTOIMMUNE ADDISONS-DISEASE | Neoplasms - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Obesity - immunology | Atherosclerosis - genetics | Humans | Inflammatory Bowel Diseases - immunology | Intracellular Signaling Peptides and Proteins - immunology | Intracellular Signaling Peptides and Proteins - metabolism | Diabetes Mellitus, Type 2 - metabolism | Inflammatory Bowel Diseases - metabolism | Obesity - genetics | Neoplasms - genetics | Interleukin-1beta - metabolism | Diabetes Mellitus, Type 2 - immunology | Inflammatory Bowel Diseases - genetics | Alzheimer Disease - immunology | Nuclear Proteins - genetics | Gout - immunology | DNA-Binding Proteins | Atherosclerosis - immunology | Nuclear Proteins - immunology | Atherosclerosis - metabolism | Apoptosis Regulatory Proteins - metabolism | Obesity - metabolism | Gout - metabolism | Animals | Carrier Proteins - metabolism | Neoplasms - immunology | Inflammasomes - immunology | Alzheimer Disease - metabolism | Gout - genetics | Adaptor Proteins, Signal Transducing - metabolism | Alzheimer Disease - genetics | Interleukin-18 - metabolism | Autoimmunity
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2018, Volume 1714, pp. 41 - 55
CRISPR/Cas9-based gene targeting allows deletion of a gene of interest from cultured cell lines. Due to difficulty in transiently transfecting hematopoetic... 
CRISPR validation | CRISPR | THP-1 | Immortalized BMDM | Myeloid | Lentivirus | Myeloid Cells - cytology | Animals | Humans | CRISPR-Cas Systems | Cells, Cultured | Myeloid Cells - metabolism | Lentivirus - genetics | Mice | Genetic Vectors | Gene Knockout Techniques - methods
Journal Article
Annual Review of Immunology, ISSN 0732-0582, 2009, Volume 27, Issue 1, pp. 621 - 668
The autoinflammatory diseases are characterized by seemingly unprovoked episodes of inflammation, without high-titer autoantibodies or antigen-specific T... 
Pulmonary fibrosis | Atherosclerosis | Innate immunity | Crohn's disease | Inflammasome | Type 2 diabetes mellitus | IL-1β | Ankylosing spondylitis | atherosclerosis | HEMOLYTIC-UREMIC SYNDROME | INTERLEUKIN-1 RECEPTOR ANTAGONIST | ankylosing spondylitis | JUVENILE IDIOPATHIC ARTHRITIS | IL-1 beta | INNATE IMMUNE-SYSTEM | ENDOPLASMIC-RETICULUM STRESS | IMMUNOLOGY | ENCODING MEVALONATE KINASE | UNFOLDED PROTEIN RESPONSE | innate immunity | FAMILIAL MEDITERRANEAN FEVER | inflammasome | MACROPHAGE ACTIVATION SYNDROME | pulmonary fibrosis | type 2 diabetes mellitus | NF-KAPPA-B | Tumor Necrosis Factor-alpha - metabolism | Phosphotransferases (Alcohol Group Acceptor) - immunology | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Tumor Necrosis Factor-alpha - genetics | NF-kappa B - immunology | NF-kappa B - metabolism | Interleukin-1beta - genetics | Autoimmune Diseases - genetics | Interleukin-1beta - metabolism | Tumor Necrosis Factor-alpha - immunology | Cytokines - genetics | Carrier Proteins - immunology | Cytokines - immunology | Autoimmune Diseases - classification | Cytokines - metabolism | Autoimmune Diseases - immunology | Interleukin-1beta - immunology | Phosphotransferases (Alcohol Group Acceptor) - genetics | Inflammation - immunology | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | NF-kappa B - genetics | Inflammation - classification | Inflammation - genetics | Crohn’s disease
Journal Article
Journal of Immunology, ISSN 0022-1767, 10/2012, Volume 189, Issue 8, pp. 3795 - 3799
Journal Article
Clinical Science, ISSN 0143-5221, 09/2018, Volume 132, Issue 17, pp. 1901 - 1924
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 18, pp. 7068 - 7069
Inflammatory cell death can be mediated by the murine caspase-1 and -11. Genetic and cell biological data point to conflicting conclusions whether these... 
GSDMD | COMBINATORIAL APPROACH | SPECIFICITIES | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEASE | Animals | Peptides | Cell Death | Substrate Specificity | Caspase 1 | Mice | Caspases | Editors' Picks Highlights
Journal Article
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 10/2012, Volume 189, Issue 8, pp. 3795 - 3799
Journal Article
Nature Medicine, ISSN 1078-8956, 2015, Volume 21, Issue 3, pp. 248 - 257
Journal Article
Journal Article
Seminars in Immunopathology, ISSN 1863-2297, 7/2015, Volume 37, Issue 4, pp. 311 - 312
Initially, the concept of autoinflammation posited that there be no involvement of autoreactive B or T cells, and no evidence of infection. These criteria... 
Internal Medicine | Biomedicine | Immunology | IMMUNOLOGY | PATHOLOGY | Humans | Autoimmune Diseases - diagnosis | Hereditary Autoinflammatory Diseases - diagnosis | Hereditary Autoinflammatory Diseases - etiology | Inflammation - diagnosis | Autoimmune Diseases - etiology | Inflammation - etiology | Autoimmunity | T cells
Journal Article