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1. Full Text Gibbs Free Energy of Hydrolytic Water Molecule in Acyl-Enzyme Intermediates of a Serine Protease: A Potential Application for Computer-Aided Discovery of Mechanism-Based Reversible Covalent Inhibitors
by Masuda, Yosuke and Yamaotsu, Noriyuki and Hirono, Shuichi and School of Pharmaceutical Sciences and Kitasato University
Chemical & pharmaceutical bulletin, ISSN 0009-2363, 2017, Volume 65, Issue 10, pp. 889 - 892
Gibbs free energy | hydrolytic water molecule | catalytic rate constant | WaterMap | mechanism-based reversible covalent inhibitor | hydration thermodynamics analysis | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Chemistry, Multidisciplinary | Science & Technology | Serine Proteases - metabolism | Serine Proteinase Inhibitors - metabolism | Molecular Dynamics Simulation | Guanidines - chemistry | Hydrolysis | Thermodynamics | Serine Proteinase Inhibitors - chemistry | Gabexate - chemistry | Water - chemistry | Gabexate - metabolism | Serine Proteases - chemistry | Binding Sites | Guanidines - metabolism | Dynamic structural analysis | Rate constants | Computer simulation | Serine | Energy measurement | Molecular dynamics | Free energy | Intermediates | Covalence | Trypsin | Inhibitors | Hydrogen bonds | Serine proteinase | Logarithms | Catalysis | Index Medicus
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2. Full Text Linear Discriminant Analysis for the in Silico Discovery of Mechanism-Based Reversible Covalent Inhibitors of a Serine Protease: Application of Hydration Thermodynamics Analysis and Semi-empirical Molecular Orbital Calculation
by Masuda, Yosuke and Yoshida, Tomoki and Yamaotsu, Noriyuki and Hirono, Shuichi and School of Pharmaceutical Sciences and Kitasato University
Chemical & pharmaceutical bulletin, ISSN 0009-2363, 2018, Volume 66, Issue 4, pp. 399 - 409
Gibbs free energy | hydrolytic water molecule | semi-empirical molecular orbital calculation | linear discriminant analysis | covalent inhibitor | hydration thermodynamics analysis | Covalent inhibitor | Linear discriminant analysis | Semi-empirical molecular orbital calculation | Hydrolytic water molecule | Hydration thermodynamics analysis | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Chemistry, Multidisciplinary | Science & Technology | Serine Proteases - metabolism | Thermodynamics | Quantum Theory | Serine Proteinase Inhibitors - chemistry | Water - chemistry | Molecular Dynamics Simulation | Serine Proteinase Inhibitors - pharmacology | Discriminant Analysis | Rate constants | Serine | Optimization | Training | Catalysis | Crystal structure | Carbonyls | Discriminant analysis | Water chemistry | Hydration | Estimation | Molecular orbitals | Substrate inhibition | Proteinase inhibitors | Empirical analysis | Superposition (mathematics) | Free energy | Intermediates | Covalence | Trypsin | Inhibitors | Protease inhibitors | Ligands | Serine proteinase | Index Medicus
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3. Full Text Safety and effectiveness of alectinib in a real‐world surveillance study in patients with ALK‐positive non–small‐cell lung cancer in Japan
by Masuda, Noriyuki and Ohe, Yuichiro and Gemma, Akihiko and Kusumoto, Masahiko and Yamada, Ikuyo and Ishii, Tadashi and Yamamoto, Nobuyuki
Cancer science, ISSN 1347-9032, 04/2019, Volume 110, Issue 4, pp. 1401 - 1407
real‐world study | ALK‐positive | NSCLC | Japan | alectinib | Life Sciences & Biomedicine | Oncology | Science & Technology | Lung Neoplasms - drug therapy | Lung Neoplasms - mortality | Humans | Middle Aged | Carbazoles - administration & dosage | Lung Neoplasms - pathology | Male | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Protein Kinase Inhibitors - adverse effects | Anaplastic Lymphoma Kinase - genetics | Young Adult | Antineoplastic Agents - adverse effects | Aged, 80 and over | Adult | Anaplastic Lymphoma Kinase - metabolism | Female | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Carbazoles - adverse effects | Piperidines - administration & dosage | Carcinoma, Non-Small-Cell Lung - genetics | Treatment Outcome | Carcinoma, Non-Small-Cell Lung - mortality | Protein Kinase Inhibitors - administration & dosage | Oncogene Proteins, Fusion - genetics | Piperidines - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Piperidines - adverse effects | Survival Analysis | Aged | Carbazoles - therapeutic use | Carcinoma, Non-Small-Cell Lung - drug therapy | Crizotinib | Care and treatment | Safety and security measures | Oncology, Experimental | Respiratory tract diseases | Metastasis | Research | Lung cancer, Non-small cell | Blood cell count | Cancer | Research funding | Lung cancer | Lung diseases | Neutrophils | Non-small cell lung carcinoma | Family medical history | FDA approval | Patients | Metastases | Polymerase chain reaction | Studies | Brain research | Surveillance | Population | Safety | Age | Pharmaceuticals | Index Medicus | Original
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4. Full Text Phase III Study, V-15-32, of Gefitinib Versus Docetaxel in Previously Treated Japanese Patients With Non–Small-Cell Lung Cancer
by Riichiroh Maruyama and Yutaka Nishiwaki and Tomohide Tamura and Nobuyuki Yamamoto and Masahiro Tsuboi and Kazuhiko Nakagawa and Tetsu Shinkai and Shunichi Negoro and Fumio Imamura and Kenji Eguchi and Koji Takeda and Akira Inoue and Keisuke Tomii and Masao Harada and Noriyuki Masuda and Haiyi Jiang and Yohji Itoh and Yukito Ichinose and Nagahiro Saijo and Masahiro Fukuoka
Journal of clinical oncology, ISSN 0732-183X, 09/2008, Volume 26, Issue 26, pp. 4244 - 4252
Life Sciences & Biomedicine | Oncology | Science & Technology | Tumors of the respiratory system and mediastinum | Biological and medical sciences | Medical sciences | Tumors | Pneumology | Lung Neoplasms - drug therapy | Lung Neoplasms - mortality | Humans | Middle Aged | Proportional Hazards Models | Male | Antineoplastic Agents - therapeutic use | Carcinoma, Non-Small-Cell Lung - mortality | Taxoids - therapeutic use | Quinazolines - therapeutic use | Survival Analysis | Female | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Index Medicus
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5. Full Text Dopamine stimulation of the septum enhances exercise efficiency during complicated treadmill running in mice
by Shiuchi, Tetsuya and Masuda, Takuya and Shimizu, Noriyuki and Chikahisa, Sachiko and Sei, Hiroyoshi
The journal of physiological sciences, ISSN 1880-6546, 11/2019, Volume 69, Issue 6, pp. 1019 - 1028
Life Sciences & Biomedicine | Physiology | Science & Technology | Receptors, Dopamine D1 - antagonists & inhibitors | Genes, fos - physiology | Sulpiride - pharmacology | Mice, Inbred C57BL | Dopamine - pharmacology | Male | Septum of Brain - drug effects | Benzazepines - pharmacology | Physical Conditioning, Animal - physiology | Oxygen Consumption - physiology | Gene Expression Regulation - drug effects | Animals | Dopamine Antagonists - pharmacology | Serotonin - metabolism | Biomarkers | Running | Mice | Physiological aspects | Phenols | Dopamine | College teachers | Neurotransmitters | Physical training | Efficiency | Fitness equipment | Septum | c-Fos protein | Fitness training programs | Dopamine receptors | Index Medicus
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6. Full Text Prototheca miyajii sp. nov., isolated from a patient with systemic protothecosis
by Masuda, Michiaki and Hirose, Noriyuki and Ishikawa, Tomohiro and Ikawa, Yoshiya and Nishimura, Kazuko
International journal of systematic and evolutionary microbiology, ISSN 1466-5026, 03/2016, Volume 66, Issue 3, pp. 1510 - 1520
Life Sciences & Biomedicine | Microbiology | Science & Technology | Prototheca - isolation & purification | Exons | Introns | Humans | Japan | Prototheca - classification | Phylogeny | Prototheca - genetics | Sequence Analysis, DNA | Infection | Base Sequence | Genes, rRNA | Nucleic Acid Conformation | DNA, Ribosomal - genetics | Index Medicus
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7. Full Text Effect of ASP2205 fumarate, a novel 5-HT2C receptor agonist, on urethral closure function in rats
by Ishigami, Takao and Ueshima, Koji and Ukai, Masashi and Asai, Norio and Takamatsu, Hajime and Yokono, Masanori and Takeda, Masahiro and Masuda, Noriyuki
Journal of pharmacological sciences, ISSN 1347-8613, 04/2019, Volume 139, Issue 4, pp. 333 - 339
Leak point pressure | Urethral closure response | 5-HT2C receptor | ASP2205 | Urethral pressure | receptor | 5-HT | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Index Medicus
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8. Full Text Direct Asymmetric Mannich‐Type Reaction of α‐Isocyanoacetates with Ketimines using Cinchona Alkaloid/Copper(II) Catalysts
by Hayashi, Masashi and Iwanaga, Masaru and Shiomi, Noriyuki and Nakane, Daisuke and Masuda, Hideki and Nakamura, Shuichi
Angewandte Chemie (International ed.), ISSN 1433-7851, 08/2014, Volume 53, Issue 32, pp. 8411 - 8415
Lewis acid | organocatalysis | copper | asymmetric synthesis | alkaloids | Stereoisomerism | Imines - chemistry | Nitriles - chemistry | Acetates - chemistry | Molecular Structure | Catalysis | Cinchona Alkaloids - chemistry | Index Medicus | Alkaloids | Synthesis | Asymmetry | Catalysts | Enantiomers
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9. Full Text Successful Desensitization with Crizotinib after Crizotinib-induced Liver Injury in ROS1-rearranged Lung Adenocarcinoma
by Ota, Takayo and Masuda, Noriyuki and Matsui, Kaoru and Yamada, Takao and Tanaka, Noriko and Fujimoto, Shunsuke and Fukuoka, Masahiro
Internal medicine (Tokyo, 1992), ISSN 0918-2918, 01/2019, Volume 58, Issue 18, pp. 2651 - 2655
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Lung Neoplasms - drug therapy | Antineoplastic Agents - adverse effects | Humans | Middle Aged | Adenocarcinoma of Lung - drug therapy | Male | Chemical and Drug Induced Liver Injury, Chronic - etiology | Protein Kinase Inhibitors - adverse effects | Crizotinib - adverse effects | Adenocarcinoma | C-reactive protein | Desensitization | Lungs | Toxicity | Liver | Transaminases | Kinases | Lymphoma | Protein-tyrosine kinase | Injuries | Bile | Index Medicus | crizotinib | liver injury | c-ROS oncogene 1 | desensitization | Case Report
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10. Full Text Case report of cutaneous protothecosis caused by Prototheca wickerhamii designated as genotype 2 and current status of human protothecosis in Japan
by Inoue, Maki and Miyashita, Azusa and Noguchi, Hiromitsu and Hirose, Noriyuki and Nishimura, Kazuko and Masuda, Michiaki and Ihn, Hironobu
Journal of dermatology, ISSN 0385-2407, 01/2018, Volume 45, Issue 1, pp. 67 - 71
algae | phycology | antifungals | protothecosis | Prototheca wickerhamii | Life Sciences & Biomedicine | Dermatology | Science & Technology | Skin Diseases, Infectious - microbiology | Prototheca - isolation & purification | Humans | Japan | Aged, 80 and over | Female | Prototheca - genetics | Microorganisms | Protothecosis | Forearm | Genetic analysis | Dermis | Sporangia | Erythema | Genotypes | Itraconazole | Index Medicus
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11. Full Text A Case of Brunner Gland Adenoma, Which Exhibited Dramatic Macroscopic Metamorphosis in 2 Years Without Canceration
: 2436
by Sasaki, Kenji and Takano, Nobuo and Iwama, Noriyuki and Masuda, Takayuki
The American journal of gastroenterology, ISSN 0002-9270, 10/2017, Volume 112, p. S1326
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12. Full Text The role of prophylactic cranial irradiation for patients with small-cell lung cancer
by Nakahara, Yoshiro and Sasaki, Jiichiro and Fukui, Tomoya and Otani, Sakiko and Igawa, Satoshi and Hayakawa, Kazushige and Masuda, Noriyuki
Japanese journal of clinical oncology, ISSN 0368-2811, 01/2018, Volume 48, Issue 1, pp. 26 - 30
Lung medicine | CNS-RadOncol | Radiation therapy | Life Sciences & Biomedicine | Oncology | Science & Technology | Neurotoxicity Syndromes - etiology | Small Cell Lung Carcinoma - prevention & control | Small Cell Lung Carcinoma - pathology | Small Cell Lung Carcinoma - radiotherapy | Lung Neoplasms - prevention & control | Time Factors | Humans | Lung Neoplasms - radiotherapy | Lung Neoplasms - pathology | Cranial Irradiation - adverse effects | Dose-Response Relationship, Radiation | Index Medicus
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13. Full Text Tandem PCR-RFLP analysis helps distinguish among three Japanese gnomefish (Teleostei: Scombropidae: Scombrops)
by Itoi, Shiro and Tanaka, Minori and Mochizuki, Yukako and Oyama, Hikaru and Togawa, Shu and Yamada, Riko and Ito, Takeshi and Shishido, Hirotoshi and Masuda, Yasuji and Abe, Koko and Nakai, Shizuko and Takai, Noriyuki and Sugita, Haruo
Ichthyological research, ISSN 1341-8998, 01/2020, Volume 67, Issue 1, pp. 197 - 202
Fisheries | Life Sciences & Biomedicine | Marine & Freshwater Biology | Zoology | Science & Technology | Cytochrome b | RNA | Agricultural policy | Analysis | Polymerase chain reaction | Cytochrome | rRNA 16S | Restriction fragment length polymorphism | Nucleotide sequence | DNA | Archipelagoes | Cytochromes | Biology | Species
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