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Nature, ISSN 0028-0836, 11/2014, Volume 515, Issue 7528, pp. 568 - 571
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 1, pp. 118 - 122
Treatment of BRAF(V600E) mutant melanoma by small molecule drugs that target the BRAF or MEK kinases can be effective, but resistance develops invariably(1,2).... 
GROWTH-FACTOR RECEPTOR | BRAF INHIBITOR | RAF INHIBITION | CELLS | MULTIDISCIPLINARY SCIENCES | IMPROVED SURVIVAL | DIFFERENTIATION | C-JUN | CANCER | EXPRESSION | EGFR | Receptor, Epidermal Growth Factor - genetics | Humans | Receptor Protein-Tyrosine Kinases - biosynthesis | Cellular Senescence - drug effects | Melanoma - enzymology | Antineoplastic Agents - administration & dosage | Receptor, Platelet-Derived Growth Factor beta - genetics | Indoles - administration & dosage | Mitogen-Activated Protein Kinase Kinases - metabolism | Receptor, Epidermal Growth Factor - metabolism | Flow Cytometry | Melanoma - genetics | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | SOXE Transcription Factors - deficiency | Proto-Oncogene Proteins B-raf - metabolism | Receptor, Platelet-Derived Growth Factor beta - metabolism | Receptor, Epidermal Growth Factor - biosynthesis | Gene Library | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Melanoma - pathology | Receptor Protein-Tyrosine Kinases - metabolism | Sulfonamides - pharmacology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Protein Kinase Inhibitors - administration & dosage | Transforming Growth Factor beta - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Receptor Protein-Tyrosine Kinases - genetics | Signal Transduction - drug effects | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | RNA, Small Interfering | Transforming Growth Factor beta - metabolism | Receptor, Platelet-Derived Growth Factor beta - biosynthesis | Sulfonamides - administration & dosage | Drug Resistance, Neoplasm - drug effects | SOXE Transcription Factors - genetics | Proteins | Biopsy | Rodents | Genes | Melanoma | Mutation | Kinases | Drug resistance | Patients | Tumors | Index Medicus
Journal Article
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 513, Issue 7516, pp. 105 - 109
In BRAF(V600)-mutant tumours, most mechanisms of resistance to drugs that target the BRAF and/or MEK kinases rely on reactivation of the RAS-RAF-MEK-ERK... 
MESSENGER-RNA TRANSLATION | SILVESTROL | MELANOMA | INITIATION | RAF | MULTIDISCIPLINARY SCIENCES | ACQUIRED-RESISTANCE | LEUKEMIA-CELLS | MODEL | FEEDBACK INHIBITION | Triterpenes - pharmacology | Humans | Eukaryotic Initiation Factor-4E - metabolism | Eukaryotic Initiation Factor-4G - metabolism | Eukaryotic Initiation Factor-4F - metabolism | Melanoma - genetics | Protein Binding - drug effects | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Cell Death - drug effects | Phosphorylation - drug effects | Eukaryotic Initiation Factor-4F - antagonists & inhibitors | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Melanoma - pathology | Sulfonamides - pharmacology | Eukaryotic Initiation Factor-4A - antagonists & inhibitors | Drug Synergism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | MAP Kinase Signaling System - drug effects | Eukaryotic Initiation Factor-4F - chemistry | Signal Transduction - drug effects | Proto-Oncogene Proteins B-raf - genetics | Colonic Neoplasms - pathology | Melanoma - drug therapy | Cell Line, Tumor | Mice | Protein Kinase Inhibitors - pharmacology | Eukaryotic Initiation Factor-4A - metabolism | Drug Resistance, Neoplasm - drug effects | Thyroid Neoplasms - pathology | Antimitotic agents | Pharmaceutical research | Vemurafenib | Protein research | Research | Antineoplastic agents | Drug resistance | Phosphorylation | Biopsy | Melanoma | Mutation | Metastasis | Cancer therapies | Tumors | Cancer | Index Medicus | Cell and Molecular Biology | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Cell- och molekylärbiologi | Medicinska och farmaceutiska grundvetenskaper
Journal Article
Revue du Praticien, ISSN 0035-2640, 01/2014, Volume 64, Issue 1, pp. 45 - 52
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2013, Volume 8, Issue 1, pp. e53745 - e53745
Background: Ipilimumab, a cytotoxic T-lymphocyte antigen-4 (CTLA-4) blocking antibody, has been approved for the treatment of metastatic melanoma and induces... 
TRIAL | CTLA-4 BLOCKADE | INDUCED SARCOIDOSIS | LYMPHOCYTE-ASSOCIATED ANTIGEN-4 | AUTOIMMUNE-DISEASES | PHASE-I/II | MULTIDISCIPLINARY SCIENCES | TREMELIMUMAB CP-675,206 | MONOCLONAL-ANTIBODY | PATIENT | CANCER | Skin Neoplasms - drug therapy | Humans | Ipilimumab | Middle Aged | Antibodies, Monoclonal - adverse effects | Antibodies, Monoclonal - therapeutic use | Male | Antineoplastic Agents - therapeutic use | Neoplasm Metastasis | Liver - drug effects | Antineoplastic Agents - adverse effects | Aged, 80 and over | Endocrine System - drug effects | Adult | Female | Retrospective Studies | Antibodies, Monoclonal - immunology | Kidney - drug effects | Antineoplastic Agents - immunology | Pancreas - drug effects | Gastrointestinal Tract - drug effects | Melanoma - pathology | CTLA-4 Antigen - immunology | Nervous System - drug effects | Melanoma - drug therapy | Respiratory System - drug effects | Aged | Skin - drug effects | Antimitotic agents | Antigens | Care and treatment | Algorithms | Lymphocytes | Melanoma | Skin | Metastasis | Antineoplastic agents | Skin cancer | Cancer | Aseptic meningitis | Guillain-Barre syndrome | Exanthema | Central nervous system | Blocking antibodies | Cytotoxicity | Oncology | Lymphocytes T | Metastases | CTLA-4 protein | Intestine | Gastroenterology | Meningitis | Internal medicine | Hematology | Sarcoidosis | Dermatology | Management | Regression analysis | Patients | Eosinophilia | Morbidity | Inflammatory bowel disease | Pathology | Side effects | Hospitals | Perforations | Medical prognosis | Antitumor activity | Autoimmune diseases | Endocrinology | Index Medicus
Journal Article
Cellular Physiology and Biochemistry, ISSN 1015-8987, 06/2017, Volume 41, Issue 5, pp. 1736 - 1752
Journal Article
by Ramos, Flavio Nunes and Mortara, Sara Ribeiro and Monalisa‐Francisco, Nathalia and Elias, João Pedro Costa and Neto, Luiz Menini and Freitas, Leandro and Kersten, Rodrigo and Amorim, André Márcio and Matos, Fernando Bittencourt and Nunes‐Freitas, André Felippe and Alcantara, Suzana and Alexandre, Marcia Helena Nagahama and Almeida‐Scabbia, Renata Jimenez and Almeida, Odair José Garcia and Alves, Fernanda Eliane and Oliveira Alves, Rogério Marcos and Alvim, Francine Seehaber and Andrade, Antônio Carlos Silva and Andrade, Simone and Aona, Lidyanne Yuriko Saleme and Araujo, Andréa Cardoso and Araújo, Kelianne Carolina Targino and Ariati, Vanessa and Assis, Julia Camara and Azevedo, Cecília Oliveira and Barbosa, Bruno Ferreira and Barbosa, Daniel Elias Ferreira and Barbosa, Fernando dos Reis and Barros, Fabio and Basilio, Geicilaine Alves and Bataghin, Fernando Antonio and Bered, Fernanda and Bianchi, Juliana Santos and Blum, Christopher Thomas and Boelter, Carlos Renato and Bonnet, Annete and Brancalion, Pedro Henrique Santin and Breier, Tiago Bӧer and Brion, Caio de Toledo and Buzatto, Cristiano Roberto and Cabral, Andressa and Cadorin, Tiago João and Caglioni, Eder and Canêz, Luciana and Cardoso, Pedro Henrique and Carvalho, Fábia Silva and Carvalho, Renan Gonçalves and Catharino, Eduardo Luis Martins and Ceballos, Sergio Javier and Cerezini, Monise Terra and César, Ricardo Gomes and Cestari, Cesar and Chaves, Cleber Juliano Neves and Citadini‐Zanette, Vanilde and Coelho, Luiz Francisco Mello and Coffani‐Nunes, João Vicente and Colares, Renato and Colletta, Gabriel Dalla and Corrêa, Nadjara de Medeiros and Costa, Andrea Ferreira and Costa, Grênivel Mota and Costa, Laís Mara Santana and Costa, Natália Gabriela Souza and Couto, Dayvid Rodrigues and Cristofolini, Caroline and Cruz, Ana Carolina Rodrigues and Del Neri, Leopoldo Angelo and Pasquo, Mercedes and Santos Dias, Aline and Dias, Letícia do Carmo Dutra and Dislich, Ricardo and Duarte, Marília Cristina and Fabricante, Juliano Ricardo and Farache, Fernando Henrique Antoniolli and Faria, Ana Paula Gelli and Faxina, Claudenice and Ferreira, Mariana Terrola Martins and Fischer, Erich and Fonseca, Carlos Roberto and Fontoura, Talita and Francisco, Talitha Mayumi and Furtado, Samyra Gomes and Galetti, Mauro and Garbin, Mário Luís and Gasper, André Luís and Goetze, Márcia and Gomes‐da‐Silva, Janaína and Gonçalves, Mateus Felipe Araujo and Gonzaga, Diego Rafael and Silva, Ana Carolina Granero e and Guaraldo, André de Camargo and Guarino, Ernestino de Souza Gomes and Guislon, Aline Votri and Hudson, Luigy Bitencourt and Jardim, Jomar Gomes and Jungbluth, Patricia and Kaeser, Selma dos Santos and Kessous, Igor Musauer and Koch, Natália Mossmann and Kuniyoshi, Yoshiko Saito and ...
Ecology, ISSN 0012-9658, 02/2019, Volume 100, Issue 2, pp. e02541 - n/a
Epiphytes are hyper‐diverse and one of the frequently undervalued life forms in plant surveys and biodiversity inventories. Epiphytes of the Atlantic Forest,... 
phorophyte | abundance | biodiversity data set | tropical forest | Atlantic Forest | biodiversity hotspot | epiphyte | presence/absence | Lichens | Forests | Endemism | Abundance | Ecology | Epiphytes | Forest ecosystems | Plants | Biodiversity | Pliocene | Biological diversity | Datasets | Ferns | Qualitative analysis | Flowers & plants | Sampling | Books | Species | Angiosperms
Journal Article
Bulletin de l'Académie nationale de médecine, ISSN 0001-4079, 02/2014, Volume 198, Issue 2, pp. 297 - 308
Journal Article
Science, ISSN 0036-8075, 11/2015, Volume 350, Issue 6264, pp. 1079 - 1084
Journal Article
Applied Mechanics and Materials, ISSN 1662-7482, 04/2019, Volume 890, pp. 113 - 145
Additive manufacturing (AM) is a well-known technology for making real three dimensional objects, based on metal, ceramic and plastic material used for various... 
Nanoparticles | State of the art | Selective laser sintering | Fused deposition modeling | Nanocomposites | Lithography | Rapid prototyping | Additive manufacturing | Polymers
Journal Article
Journal of Physics: Conference Series, ISSN 1742-6588, 10/2015, Volume 646, Issue 1, p. 12034
Conference Proceeding