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Journal Article
by Okada, Yukinori and Wu, Di and Trynka, Gosia and Raj, Towfique and Terao, Chikashi and Ikari, Katsunori and Kochi, Yuta and Ohmura, Koichiro and Suzuki, Akari and Yoshida, Shinji and Graham, Robert R and Manoharan, Arun and Ortmann, Ward and Bhangale, Tushar and Denny, Joshua C and Carroll, Robert J and Eyler, Anne E and Greenberg, Jeffrey D and Kremer, Joel M and Pappas, Dimitrios A and Jiang, Lei and Yin, Jian and Ye, Lingying and Su, Ding-Feng and Yang, Jian and Xie, Gang and Keystone, Ed and Westra, Harm-Jan and Esko, Tõnu and Metspalu, Anes and Zhou, Xuezhong and Gupta, Namrata and Mirel, Daniel and Stahl, Eli A and Diogo, Dorothée and Cui, Jing and Liao, Katherine and Guo, Michael H and Myouzen, Keiko and Kawaguchi, Takahisa and Coenen, Marieke J. H and van Riel, Piet L. C. M and van de Laar, Mart A. F. J and Guchelaar, Henk-Jan and Huizinga, Tom W. J and Dieudé, Philippe and Mariette, Xavier and Bridges, S. Louis and Zhernakova, Alexana and Toes, Rene E. M and Tak, Paul P and Miceli-Richard, Corinne and Bang, So-Young and Lee, Hye-Soon and Martin, Javier and Gonzalez-Gay, Miguel A and Roiguez-Roiguez, Luis and Rantapää-Dahlqvist, Solbritt and Arlestig, Lisbeth and Choi, Hyon K and Kamatani, Yoichiro and Galan, Pilar and Lathrop, Mark and Eyre, Steve and Bowes, John and Barton, Anne and de Vries, Niek and Moreland, Larry W and Criswell, Lindsey A and Karlson, Elizabeth W and Taniguchi, Atsuo and Yamada, Ryo and Kubo, Michiaki and Liu, Jun S and Bae, Sang-Cheol and Worthington, Jane and Padyukov, Leonid and Klareskog, Lars and Gregersen, Peter K and Raychaudhuri, Soumya and Stranger, Barbara E and de Jager, Philip L and Franke, Lude and Visscher, Peter M and Brown, Matthew A and Yamanaka, Hisashi and Mimori, Tsuneyo and Takahashi, Atsushi and Xu, Huji and Behrens, Timothy W and Siminovitch, Katherine A and Momohara, Shigeki and Matsuda, Fumihiko and Yamamoto, Kazuhiko and Plenge, Robert M and Lee, Annette and Martin, Paul and Stahl, Eli and Viatte, Sebastien and McAllister, Kate and ... and RACI Consortium and GARNET Consortium and RACI consortium and GARNET consortium and the RACI consortium and the GARNET consortium and Medicinska fakulteten and Institutionen för folkhälsa och klinisk medicin and Umeå universitet and Reumatologi
Nature, ISSN 0028-0836, 2014, Volume 506, Issue 7488, pp. 376 - +
A major challenge in human genetics is to devise a systematic strategy to integrate disease-associated variants with diverse genomic and biological data sets... 
RECEPTOR INHIBITION | VARIANTS | MULTIDISCIPLINARY SCIENCES | DISEASE | SUSCEPTIBILITY | RISK | LOCI | IDENTIFICATION | TRAITS | GENOME-WIDE ASSOCIATION | RESOURCE | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Humans | Asian Continental Ancestry Group - genetics | Computational Biology | Male | Drug Repositioning | Molecular Targeted Therapy | Drug Discovery | Case-Control Studies | Arthritis, Rheumatoid - pathology | Mice, Knockout | Arthritis, Rheumatoid - metabolism | Arthritis, Rheumatoid - genetics | Animals | Arthritis, Rheumatoid - drug therapy | Alleles | Polymorphism, Single Nucleotide - genetics | Female | Hematologic Neoplasms - genetics | Mice | Hematologic Neoplasms - metabolism | Quantitative trait loci | Genome-wide association studies | Rheumatoid arthritis | Genetic research | Genetic aspects | Research | Human genetics | Disease | Hematology | Cytokines | Genes | Genomics | Genomes | Meta-analysis | Proteins | Confidence intervals | Hypotheses | Quality control | Epigenetics | Population | Genetics | Health risk assessment | Asians | Cancer | Index Medicus | Rheumatology and Autoimmunity | Clinical Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Reumatologi och inflammation | Virtual screening | Klinisk medicin
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 01/2017, Volume 114, Issue 5, pp. E761 - E770
Although immunotherapy by PD-1 blockade has dramatically improved the survival rate of cancer patients, further improvement in efficacy is required to reduce... 
Mitochondria | PGC-1α | Immune metabolism | Cancer immunotherapy | PD-1 | PGC-1 alpha | mitochondria | MULTIDISCIPLINARY SCIENCES | CANCER-IMMUNOTHERAPY | DILATED CARDIOMYOPATHY | PROTEIN-SYNTHESIS | EFFECTOR | RESPONSES | MEMORY | IMMUNE CHECKPOINT BLOCKADE | ENERGY HOMEOSTASIS | cancer immunotherapy | immune metabolism | TUMOR MICROENVIRONMENT | PD-1-DEFICIENT MICE | Neoplasms - metabolism | Thiophenes - therapeutic use | AMP-Activated Protein Kinases - metabolism | Reactive Oxygen Species - metabolism | TOR Serine-Threonine Kinases - metabolism | Triazines - therapeutic use | Antibodies, Monoclonal - therapeutic use | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Pyrones - pharmacology | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism | Morpholines - therapeutic use | Cytokines - immunology | T-Lymphocytes, Cytotoxic - immunology | Triazines - pharmacology | Antibodies, Monoclonal - pharmacology | Mice, Inbred C57BL | Oxygen Consumption | Morpholines - pharmacology | Programmed Cell Death 1 Receptor - metabolism | Thiophenes - pharmacology | Mitochondria - metabolism | Lymph Nodes - immunology | Mitochondria - drug effects | Mice, Knockout | Neoplasms - drug therapy | Animals | T-Lymphocytes, Cytotoxic - metabolism | Neoplasms - immunology | Cell Line, Tumor | Pyrones - therapeutic use | Mice, Inbred BALB C | Programmed Cell Death 1 Receptor - immunology | Programmed Cell Death 1 Receptor - genetics | Care and treatment | T cells | Health aspects | Immunotherapy | Methods | Cancer | Oxygen | Adipocytes | Kinases | Chemicals | Tumors | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
CIRP Journal of Manufacturing Science and Technology, ISSN 1755-5817, 05/2015, Volume 9, pp. 97 - 106
This paper proposes sustainable manufacturing using a digital eco-factory. When a digital eco-factory is used, green performance is examined in addition to... 
Software agent | Green performance simulation | Virtual factory
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2014, Volume 9, Issue 6, pp. e100924 - e100924
Profiles of sequence variants that influence gene transcription are very important for understanding mechanisms that affect phenotypic variation and disease... 
IMPACT | POLYMORPHISMS | LONG NONCODING RNAS | ANNOTATION | MULTIDISCIPLINARY SCIENCES | POPULATIONS | LOCI | WIDE ASSOCIATION | IDENTIFICATION | CROHNS-DISEASE SUSCEPTIBILITY | EXPRESSION | Crohn Disease - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Reproducibility of Results | Genetic Association Studies | Humans | Middle Aged | Linkage Disequilibrium - genetics | Male | Chromosome Mapping | Gene Expression Profiling | DNA, Intergenic - genetics | Genome, Human - genetics | Base Sequence | Polymorphism, Single Nucleotide - genetics | Adult | Female | Transcription, Genetic | Aged | Far East | Quantitative Trait Loci - genetics | Quantitative genetics | Epigenetic inheritance | Analysis | Genes | Genomics | Genetic aspects | Genomes | Genetic transcription | Single nucleotide polymorphisms | Inflammatory bowel diseases | Parkinson's disease | Transcription | Mapping | Single-nucleotide polymorphism | Experiments | Proteins | Maps | Intestine | Peripheral blood | Population | Genetics | Chromosomes | Bioinformatics | Genotypes | Movement disorders | Deoxyribonucleic acid--DNA | University graduates | Hematology | Neurodegenerative diseases | Blood cells | Phenotypic variations | Gene expression | Quantitative trait loci | Medicine | Studies | Hypotheses | Gene mapping | Ulcerative colitis | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Gastroenterology, ISSN 0016-5085, 2016, Volume 150, Issue 7, pp. 1633 - 1645
Journal Article
Nature Genetics, ISSN 1061-4036, 11/2015, Volume 47, Issue 11, pp. 1304 - 1315
Journal Article