Journal of Virology, ISSN 0022-538X, 08/2008, Volume 82, Issue 16, pp. 7964 - 7976
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VIROLOGY | NS5A PROTEIN | LIPID DROPLET | REPRESSION | RNA REPLICATION | PHOSPHORYLATION | PKR | KINASE | BINDING DOMAIN | INTERFERON RESISTANCE | MOLECULAR-MECHANISMS | Protein Structure, Tertiary | Amino Acid Sequence | Phosphorylation | Humans | Molecular Sequence Data | Alanine - chemistry | Serine - chemistry | Virion - metabolism | Viral Nonstructural Proteins - physiology | Sequence Homology, Amino Acid | Virus Replication | Capsid Proteins - chemistry | Viral Nonstructural Proteins - metabolism | Mutation | Subcellular Fractions | Fluorescent Antibody Technique, Indirect | Genome and Regulation of Viral Gene Expression
VIROLOGY | NS5A PROTEIN | LIPID DROPLET | REPRESSION | RNA REPLICATION | PHOSPHORYLATION | PKR | KINASE | BINDING DOMAIN | INTERFERON RESISTANCE | MOLECULAR-MECHANISMS | Protein Structure, Tertiary | Amino Acid Sequence | Phosphorylation | Humans | Molecular Sequence Data | Alanine - chemistry | Serine - chemistry | Virion - metabolism | Viral Nonstructural Proteins - physiology | Sequence Homology, Amino Acid | Virus Replication | Capsid Proteins - chemistry | Viral Nonstructural Proteins - metabolism | Mutation | Subcellular Fractions | Fluorescent Antibody Technique, Indirect | Genome and Regulation of Viral Gene Expression
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Light-induced structural changes and the site of O=O bond formation in PSII caught by XFEL
Nature, ISSN 0028-0836, 03/2017, Volume 543, Issue 7643, pp. 131 - 135
Photosystem II (PSII) is a huge membrane-protein complex consisting of 20 different subunits with a total molecular mass of 350 kDa for a monomer. It catalyses...
OXYGEN-EVOLVING COMPLEX | PROTON RELEASE | MECHANISM | MULTIDISCIPLINARY SCIENCES | PHOTOSYSTEM-II | X-RAY-DIFFRACTION | PHOTOSYNTHETIC WATER OXIDATION | STATE | INFRARED DETECTION | OXIDIZING COMPLEX | BINDING | Protons | Temperature | Nonheme Iron Proteins - metabolism | Electron Transport - radiation effects | Cyanobacteria - chemistry | Crystallography - methods | Oxygen - metabolism | Fourier Analysis | Time Factors | Lasers | Light | Oxygen - chemistry | Water - chemistry | Nonheme Iron Proteins - chemistry | Biocatalysis - radiation effects | Water - metabolism | Models, Molecular | Nonheme Iron Proteins - radiation effects | Manganese - chemistry | Photosystem II Protein Complex - metabolism | Manganese - metabolism | Photosystem II Protein Complex - radiation effects | Photosystem II Protein Complex - chemistry | Oxygen - radiation effects | Electrons | Chemical bonds | Physiological aspects | Photosystem II | Structure | Photosynthesis research | Membrane proteins | Datasets | Ligands | Fourier transforms | Binding sites
OXYGEN-EVOLVING COMPLEX | PROTON RELEASE | MECHANISM | MULTIDISCIPLINARY SCIENCES | PHOTOSYSTEM-II | X-RAY-DIFFRACTION | PHOTOSYNTHETIC WATER OXIDATION | STATE | INFRARED DETECTION | OXIDIZING COMPLEX | BINDING | Protons | Temperature | Nonheme Iron Proteins - metabolism | Electron Transport - radiation effects | Cyanobacteria - chemistry | Crystallography - methods | Oxygen - metabolism | Fourier Analysis | Time Factors | Lasers | Light | Oxygen - chemistry | Water - chemistry | Nonheme Iron Proteins - chemistry | Biocatalysis - radiation effects | Water - metabolism | Models, Molecular | Nonheme Iron Proteins - radiation effects | Manganese - chemistry | Photosystem II Protein Complex - metabolism | Manganese - metabolism | Photosystem II Protein Complex - radiation effects | Photosystem II Protein Complex - chemistry | Oxygen - radiation effects | Electrons | Chemical bonds | Physiological aspects | Photosystem II | Structure | Photosynthesis research | Membrane proteins | Datasets | Ligands | Fourier transforms | Binding sites
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Nature Genetics, ISSN 1061-4036, 10/2009, Volume 41, Issue 10, pp. 1105 - 1109
The recommended treatment for patients with chronic hepatitis C, pegylated interferon-alpha (PEG-IFN-alpha) plus ribavirin (RBV), does not provide sustained...
PLUS RIBAVIRIN | VIROLOGICAL RESPONSE | COMBINATION THERAPY | GENETICS & HEREDITY | Haplotypes | Genome-Wide Association Study | Antiviral Agents - therapeutic use | Humans | Ribavirin - therapeutic use | Asian Continental Ancestry Group - genetics | Interferon-alpha - therapeutic use | Hepatitis C, Chronic - virology | Male | Treatment Outcome | Hepatitis C, Chronic - drug therapy | Interleukins - genetics | Chromosomes, Human, Pair 19 | Alleles | Female | Polymorphism, Single Nucleotide | Genome, Human | Hepatitis C, Chronic - genetics | Drug Combinations
PLUS RIBAVIRIN | VIROLOGICAL RESPONSE | COMBINATION THERAPY | GENETICS & HEREDITY | Haplotypes | Genome-Wide Association Study | Antiviral Agents - therapeutic use | Humans | Ribavirin - therapeutic use | Asian Continental Ancestry Group - genetics | Interferon-alpha - therapeutic use | Hepatitis C, Chronic - virology | Male | Treatment Outcome | Hepatitis C, Chronic - drug therapy | Interleukins - genetics | Chromosomes, Human, Pair 19 | Alleles | Female | Polymorphism, Single Nucleotide | Genome, Human | Hepatitis C, Chronic - genetics | Drug Combinations
Journal Article
Nature, ISSN 0028-0836, 05/2010, Volume 465, Issue 7295, pp. 223 - 226
Amyotrophic lateral sclerosis (ALS) has its onset in middle age and is a progressive disorder characterized by degeneration of motor neurons of the primary...
OPEN-ANGLE GLAUCOMA | COMPLEX | PROTEIN | GENE | MULTIDISCIPLINARY SCIENCES | EXPRESSION | NEMO | MYOSIN-VI | Amyotrophic Lateral Sclerosis - physiopathology | Humans | Middle Aged | Transcription Factor TFIIIA - genetics | Cytoplasm - metabolism | Male | NF-kappa B - metabolism | Cytoplasm - pathology | Transcription Factor TFIIIA - metabolism | Mutation, Missense - genetics | DNA-Binding Proteins - metabolism | Young Adult | Base Sequence | Aged, 80 and over | Adult | Female | Child | Superoxide Dismutase - metabolism | NF-kappa B - agonists | Amino Acid Sequence | NF-kappa B - antagonists & inhibitors | Amyotrophic Lateral Sclerosis - genetics | Japan | Mutant Proteins - genetics | Transcription Factor TFIIIA - chemistry | Exons - genetics | Mutant Proteins - metabolism | Mutation - genetics | Transcription Factor TFIIIA - analysis | Protein Transport | Amyotrophic Lateral Sclerosis - pathology | Asian Continental Ancestry Group | Pedigree | Mutant Proteins - chemistry | Adolescent | Amyotrophic Lateral Sclerosis - metabolism | Polymorphism, Single Nucleotide - genetics | Aged | Consanguinity | Superoxide Dismutase-1 | Mutant Proteins - analysis | Codon, Nonsense - genetics | Sequence Deletion - genetics | Cellular proteins | Gene mutations | Physiological aspects | Amyotrophic lateral sclerosis | Genetic aspects | Research | Health aspects | Risk factors | Haplotypes | Studies | Genes | Genetics | Amino acids | Mutation | Family medical history | Chromosomes | Apoptosis
OPEN-ANGLE GLAUCOMA | COMPLEX | PROTEIN | GENE | MULTIDISCIPLINARY SCIENCES | EXPRESSION | NEMO | MYOSIN-VI | Amyotrophic Lateral Sclerosis - physiopathology | Humans | Middle Aged | Transcription Factor TFIIIA - genetics | Cytoplasm - metabolism | Male | NF-kappa B - metabolism | Cytoplasm - pathology | Transcription Factor TFIIIA - metabolism | Mutation, Missense - genetics | DNA-Binding Proteins - metabolism | Young Adult | Base Sequence | Aged, 80 and over | Adult | Female | Child | Superoxide Dismutase - metabolism | NF-kappa B - agonists | Amino Acid Sequence | NF-kappa B - antagonists & inhibitors | Amyotrophic Lateral Sclerosis - genetics | Japan | Mutant Proteins - genetics | Transcription Factor TFIIIA - chemistry | Exons - genetics | Mutant Proteins - metabolism | Mutation - genetics | Transcription Factor TFIIIA - analysis | Protein Transport | Amyotrophic Lateral Sclerosis - pathology | Asian Continental Ancestry Group | Pedigree | Mutant Proteins - chemistry | Adolescent | Amyotrophic Lateral Sclerosis - metabolism | Polymorphism, Single Nucleotide - genetics | Aged | Consanguinity | Superoxide Dismutase-1 | Mutant Proteins - analysis | Codon, Nonsense - genetics | Sequence Deletion - genetics | Cellular proteins | Gene mutations | Physiological aspects | Amyotrophic lateral sclerosis | Genetic aspects | Research | Health aspects | Risk factors | Haplotypes | Studies | Genes | Genetics | Amino acids | Mutation | Family medical history | Chromosomes | Apoptosis
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2017, Volume 12, Issue 12, p. e0189346
Background and aims We developed a bio-artificial liver (BAL) using a radial-flow bioreactor and rescued mini-pig models with lethal acute liver failure (ALF)....
ACUTE LIVER-FAILURE | HEPATOCELLULAR-CARCINOMA | PORTACAVAL ANASTOMOSIS | TRAUMATIC BRAIN-INJURY | AMMONIA | ALZHEIMERS-DISEASE | EDEMA | MULTIDISCIPLINARY SCIENCES | AQUAPORIN-4 EXPRESSION | CULTURED ASTROCYTES | ALPHA-1-ANTICHYMOTRYPSIN | Astrocytes - drug effects | Cell Line | Acute Disease | alpha 1-Antichymotrypsin - pharmacology | Hepatic Encephalopathy - metabolism | Liver, Artificial | Humans | Male | Ammonium Chloride - pharmacology | Hepatic Encephalopathy - pathology | Animals | Arginine Vasopressin - metabolism | Swine | Swine, Miniature | Astrocytes - metabolism | Astrocytes | Development and progression | Genetic aspects | Research | Injuries | Hepatic encephalopathy | Vasopressin
ACUTE LIVER-FAILURE | HEPATOCELLULAR-CARCINOMA | PORTACAVAL ANASTOMOSIS | TRAUMATIC BRAIN-INJURY | AMMONIA | ALZHEIMERS-DISEASE | EDEMA | MULTIDISCIPLINARY SCIENCES | AQUAPORIN-4 EXPRESSION | CULTURED ASTROCYTES | ALPHA-1-ANTICHYMOTRYPSIN | Astrocytes - drug effects | Cell Line | Acute Disease | alpha 1-Antichymotrypsin - pharmacology | Hepatic Encephalopathy - metabolism | Liver, Artificial | Humans | Male | Ammonium Chloride - pharmacology | Hepatic Encephalopathy - pathology | Animals | Arginine Vasopressin - metabolism | Swine | Swine, Miniature | Astrocytes - metabolism | Astrocytes | Development and progression | Genetic aspects | Research | Injuries | Hepatic encephalopathy | Vasopressin
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Forest Ecology and Management, ISSN 0378-1127, 07/2019, Volume 444, pp. 393 - 404
Plantations are expanding globally and dominate landscapes in many parts of the world. Biodiversity conservation within plantations is becoming an important...
Mapping | Plantation species | Planted tree density | Native broad-leaved tree | Indicator | Naturalness index | BIODIVERSITY | HARDWOOD RECRUITMENT | DISTURBANCE REGIME | ENVIRONMENTAL-FACTORS | SITE INDEX | BROADLEAVED TREES | LARCH PLANTATIONS | LAND-USE | DIVERSITY | FORESTRY | DECIDUOUS FORESTS | Forest management | Sustainable forestry | Biological diversity conservation | Forest reserves | Analysis | Plantations
Mapping | Plantation species | Planted tree density | Native broad-leaved tree | Indicator | Naturalness index | BIODIVERSITY | HARDWOOD RECRUITMENT | DISTURBANCE REGIME | ENVIRONMENTAL-FACTORS | SITE INDEX | BROADLEAVED TREES | LARCH PLANTATIONS | LAND-USE | DIVERSITY | FORESTRY | DECIDUOUS FORESTS | Forest management | Sustainable forestry | Biological diversity conservation | Forest reserves | Analysis | Plantations
Journal Article
Nature, ISSN 0028-0836, 06/2006, Volume 441, Issue 7096, pp. 1007 - 1010
There is a debate over how protein trafficking is performed through the Golgi apparatus(1-4). In the secretory pathway, secretory proteins that are synthesized...
SEC7 | TRANSPORT | COMPLEX | CONTINUITIES | MULTIDISCIPLINARY SCIENCES | PICHIA-PASTORIS | ENDOPLASMIC-RETICULUM | MEMBRANE-PROTEINS | MICROSCOPY | SACCHAROMYCES-CEREVISIAE | APPARATUS | Saccharomyces cerevisiae - physiology | Saccharomyces cerevisiae - genetics | Qb-SNARE Proteins - metabolism | COP-Coated Vesicles - metabolism | Golgi Apparatus - physiology | Saccharomyces cerevisiae Proteins - genetics | Coatomer Protein - genetics | Saccharomyces cerevisiae - metabolism | Microscopy, Confocal | Coatomer Protein - metabolism | Models, Biological | Saccharomyces cerevisiae Proteins - metabolism | Golgi Apparatus - metabolism | Membrane Proteins - metabolism | Mutation | SNARE Proteins | Intracellular Membranes - metabolism | Microscopy, Fluorescence | Fungal Proteins - metabolism | Vesicular Transport Proteins | Proteins | Models | Scientific imaging | Cellular biology | Microscopy
SEC7 | TRANSPORT | COMPLEX | CONTINUITIES | MULTIDISCIPLINARY SCIENCES | PICHIA-PASTORIS | ENDOPLASMIC-RETICULUM | MEMBRANE-PROTEINS | MICROSCOPY | SACCHAROMYCES-CEREVISIAE | APPARATUS | Saccharomyces cerevisiae - physiology | Saccharomyces cerevisiae - genetics | Qb-SNARE Proteins - metabolism | COP-Coated Vesicles - metabolism | Golgi Apparatus - physiology | Saccharomyces cerevisiae Proteins - genetics | Coatomer Protein - genetics | Saccharomyces cerevisiae - metabolism | Microscopy, Confocal | Coatomer Protein - metabolism | Models, Biological | Saccharomyces cerevisiae Proteins - metabolism | Golgi Apparatus - metabolism | Membrane Proteins - metabolism | Mutation | SNARE Proteins | Intracellular Membranes - metabolism | Microscopy, Fluorescence | Fungal Proteins - metabolism | Vesicular Transport Proteins | Proteins | Models | Scientific imaging | Cellular biology | Microscopy
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Gastric Cancer, ISSN 1436-3291, 10/2015, Volume 18, Issue 4, pp. 691 - 697
Although some small-scale studies have suggested that human epidermal growth factor receptor 2 (HER2)-positive status in gastric cancer is associated with poor...
Heterogeneity | Medicine & Public Health | Human epidermal growth factor receptor 2 | Gastroenterology | Epidermal growth factor receptor 2 | ERBB2 | Abdominal Surgery | Oncology | Cancer Research | Surgical Oncology | Trastuzumab | ONCOLOGY | TRASTUZUMAB TREATMENT | GROWTH-FACTOR RECEPTORS | GASTROENTEROLOGY & HEPATOLOGY | CLINICAL-SIGNIFICANCE | Immunohistochemistry | Stomach Neoplasms - genetics | Receptor, ErbB-2 - biosynthesis | Adenocarcinoma - pathology | Prognosis | Biomarkers, Tumor - analysis | Humans | Middle Aged | Kaplan-Meier Estimate | Proportional Hazards Models | In Situ Hybridization, Fluorescence | Male | Stomach Neoplasms - pathology | Aged, 80 and over | Adult | Female | Adenocarcinoma - genetics | Aged | Stomach Neoplasms - mortality | Adenocarcinoma - mortality | Care and treatment | Cancer patients | Analysis | Oncology, Experimental | Fluorescence | Research | Stomach cancer | Cancer
Heterogeneity | Medicine & Public Health | Human epidermal growth factor receptor 2 | Gastroenterology | Epidermal growth factor receptor 2 | ERBB2 | Abdominal Surgery | Oncology | Cancer Research | Surgical Oncology | Trastuzumab | ONCOLOGY | TRASTUZUMAB TREATMENT | GROWTH-FACTOR RECEPTORS | GASTROENTEROLOGY & HEPATOLOGY | CLINICAL-SIGNIFICANCE | Immunohistochemistry | Stomach Neoplasms - genetics | Receptor, ErbB-2 - biosynthesis | Adenocarcinoma - pathology | Prognosis | Biomarkers, Tumor - analysis | Humans | Middle Aged | Kaplan-Meier Estimate | Proportional Hazards Models | In Situ Hybridization, Fluorescence | Male | Stomach Neoplasms - pathology | Aged, 80 and over | Adult | Female | Adenocarcinoma - genetics | Aged | Stomach Neoplasms - mortality | Adenocarcinoma - mortality | Care and treatment | Cancer patients | Analysis | Oncology, Experimental | Fluorescence | Research | Stomach cancer | Cancer
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Autophagy, ISSN 1554-8627, 01/2016, Volume 12, Issue 1, pp. 1 - 222
stress | chaperone-mediated autophagy | vacuole | autolysosome | macroautophagy | flux | autophagosome | LC3 | lysosome | phagophore | Phagophore | Lysosome | Autolysosome | Flux | Autophagosome | Vacuole | Chaperonemediated autophagy | Macroautophagy | Stress | ACTIVATED PROTEIN-KINASE | ENDOPLASMIC-RETICULUM STRESS | STARVATION-INDUCED AUTOPHAGY | GLUCAGON-INDUCED AUTOPHAGY | CELL BIOLOGY | PROGRAMMED CELL-DEATH | LIFE-SPAN EXTENSION | BETAINE HOMOCYSTEINE METHYLTRANSFERASE | VACUOLAR MEMBRANE DYNAMICS | NF-KAPPA-B | Autophagy - physiology | Biological Assay - methods | Animals | Biological Assay - standards | Computer Simulation | Humans | Life Sciences | Medical and Health Sciences | Medicin och hälsovetenskap
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