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SCIENTIFIC REPORTS, ISSN 2045-2322, 09/2019, Volume 9, Issue 1, pp. 13567 - 13
Shigella spp., the bacteria responsible for shigellosis, are one of the leading causes of diarrheal morbidity and mortality amongst children. There is a... 
PATHOGENESIS | CELLS | RESISTANT | INVASION | TRANSMISSION | DIARRHEA | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | DISSEMINATION | CIPROFLOXACIN | GENTAMICIN | Cell culture | Animal models | Antibiotics | Ampicillin | Epithelial cells | Diarrhea | Ciprofloxacin | Drug development | Shigellosis | Morbidity
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 09/2012, Volume 56, Issue 9, pp. 4914 - 4921
Journal Article
The Journal of Infectious Diseases, ISSN 0022-1899, 1/2014, Volume 209, Issue 2, pp. 275 - 284
Journal Article
PLoS Neglected Tropical Diseases, ISSN 1935-2727, 08/2018, Volume 12, Issue 8, p. e0006673
Journal Article
by Baragaña, Beatriz and Forte, Barbara and Choi, Ryan and Hewitt, Stephen Nakazawa and Bueren-Calabuig, Juan A and Pisco, João Pedro and Peet, Caroline and Dranow, David M and Robinson, David A and Jansen, Chimed and Norcross, Neil R and Vinayak, Sumiti and Anderson, Mark and Brooks, Carrie F and Cooper, Caitlin A and Damerow, Sebastian and Delves, Michael and Dowers, Karen and Duffy, James and Edwards, Thomas E and Hallyburton, Irene and Horst, Benjamin G and Hulverson, Matthew A and Ferguson, Liam and Jiménez-Díaz, María Belén and Jumani, Rajiv S and Lorimer, Donald D and Love, Melissa S and Maher, Steven and Matthews, Holly and McNamara, Case W and Miller, Peter and O’Neill, Sandra and Ojo, Kayode K and Osuna-Cabello, Maria and Pinto, Erika and Post, John and Riley, Jennifer and Rottmann, Matthias and Sanz, Laura M and Scullion, Paul and Sharma, Arvind and Shepherd, Sharon M and Shishikura, Yoko and Simeons, Frederick R.C and Stebbins, Erin E and Stojanovski, Laste and Straschil, Ursula and Tamaki, Fabio K and Tamjar, Jevgenia and Torrie, Leah S and Vantaux, Amélie and Witkowski, Benoît and Wittlin, Sergio and Yogavel, Manickam and Zuccotto, Fabio and Angulo-Barturen, Iñigo and Sinden, Robert and Baum, Jake and Gamo, Francisco-Javier and Mäser, Pascal and Kyle, Dennis E and Winzeler, Elizabeth A and Myler, Peter J and Wyatt, Paul G and Floyd, David and Matthews, David and Sharma, Amit and Striepen, Boris and Huston, Christopher D and Gray, David W and Fairlamb, Alan H and Pisliakov, Andrei V and Walpole, Chris and Read, Kevin D and Van Voorhis, Wesley C and Gilbert, Ian H and Argonne National Lab. (ANL), Argonne, IL (United States)
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 04/2019, Volume 116, Issue 14, pp. 7015 - 7020
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 07/2018, Volume 62, Issue 7
Recent reports highlighting the global significance of cryptosporidiosis among children have renewed efforts to develop control measures. We evaluated the... 
Cryptosporidium hominis | BKI 1369 | Bumped kinase inhibitor | Gnotobiotic pigs | SYSTEM | gnotobiotic pigs | CDPK1 | C. PARVUM | MICROBIOLOGY | bumped kinase inhibitor | CHILDREN | POTENT | T. GONDII | COMMUNITY | SELECTIVE INHIBITORS | PHARMACOLOGY & PHARMACY | BURDEN | DEVELOPING-COUNTRIES
Journal Article
The Journal of Infectious Diseases, ISSN 0022-1899, 08/2019, Volume 220, Issue 7, pp. 1188 - 1198
Abstract Recent studies have illustrated the burden Cryptosporidium infection places on the lives of malnourished children and immunocompromised individuals.... 
Cryptosporidium | INFECTIOUS DISEASES | P-gp | DIARRHEA | PROTEIN | drug development | MICROBIOLOGY | DRUG-RESISTANCE | IMMUNOLOGY | BINDING CASSETTE TRANSPORTERS | enteric | CHILDREN | gastrointestinal | drug efflux | PARVUM | BUMPED-KINASE INHIBITORS | ABC TRANSPORTERS | MULTIDRUG-RESISTANCE | EXPRESSION | Index Medicus | Abridged Index Medicus | Major and Brief Reports
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2014, Volume 57, Issue 3, pp. 828 - 835
Journal Article
Journal Article
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, ISSN 0066-4804, 07/2019, Volume 63, Issue 7
Previous studies on drug efficacy showed low protection against abortion and vertical transmission of Toxoplasma gondii in pregnant sheep. Bumped kinase... 
TARGET | treatment | HOST-CELLS | abortion | EFFICACY | VACCINATION | MICROBIOLOGY | BKI-1294 | MODEL | EXPERIMENTAL OVINE TOXOPLASMOSIS | CHALLENGE | MONENSIN | POTENT | Toxoplasma gondii | safety | vertical transmission | SELECTIVE INHIBITORS | protein kinase inhibitor | PHARMACOLOGY & PHARMACY | sheep
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 06/2018, Volume 62, Issue 6, pp. e00051 - e00118
In Toxoplasma gondii, calcium-dependent protein kinase 1 (CDPK1) is an essential protein kinase required for invasion of host cells. We have developed several... 
Inhibitor | Cellular thermal shift assay | Toxoplasma gondii | Bumped kinase inhibitor | Protein kinase | TARGET | CELLS | PARASITES | ACTIVATION | CDPK1 | C. PARVUM | MICROBIOLOGY | bumped kinase inhibitor | protein kinase | POTENT | T. GONDII | inhibitor | SELECTIVE INHIBITORS | PHARMACOLOGY & PHARMACY | INFECTION | cellular thermal shift assay
Journal Article