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1. Full Text Harnessing Genetic Complexity to Enhance Translatability of Alzheimer's Disease Mouse Models: A Path toward Precision Medicine
by Neuner, Sarah M and Heuer, Sarah E and Huentelman, Matthew J and O'Connell, Kristen M.S and Kaczorowski, Catherine C
Neuron, ISSN 0896-6273, 02/2019, Volume 101, Issue 3, pp. 399 - 411.e5
Neuner et al. describe the generation and validation of the AD-BXDs, the first reproducible set of AD mouse models incorporating genetic diversity. These... 
mouse models | genetic diversity | amyloid | susceptibility | translational | 5XFAD | genetic risk score | resilience | Alzheimer's | BXD | SET | SIGNATURES | EXCITABILITY | CONTEXTUAL FEAR | RISK | MICE | PATHOLOGY | EXPRESSION | STRAIN | NEUROSCIENCES | ONSET | Neurosciences | Analysis | Genomics | Disease susceptibility | Models | Alzheimer's disease | Biological diversity
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2. Full Text Harnessing Genetic Complexity to Enhance Translatability of Alzheimer’s Disease Mouse Models: A Path toward Precision Medicine
by Neuner, Sarah M and Heuer, Sarah E and Huentelman, Matthew J and O’Connell, Kristen M.S and Kaczorowski, Catherine C
Neuron, ISSN 0896-6273, 02/2019, Volume 101, Issue 3, pp. 399 - 411.e5
An individual’s genetic makeup plays a large role in determining susceptibility to Alzheimer’s disease (AD) but has largely been ignored in preclinical... 
mouse models | genetic diversity | susceptibility | amyloid | translational | 5XFAD | genetic risk score | resilience | Alzheimer’s | BXD | Studies | Animal models | Phenotypes | Risk groups | Precision medicine | Genes | Cognitive ability | Genomes | Genetic diversity | Mutation | Alzheimer's disease | Age
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3. Transcriptome response of human skeletal muscle to divergent exercise stimuli
by Jared M Dickinson and Andrew C D’Lugos and Marcus A Naymik and Ashley L Siniard and Amanda J Wolfe and Donald R Curtis and Matthew J Huentelman and Chad C Carroll
Journal of Applied Physiology, ISSN 8750-7587, 06/2018, Volume 124, Issue 6, p. 1529
Aerobic (AE) and resistance exercise (RE) elicit unique adaptations in skeletal muscle that have distinct implications for health and performance. The purpose... 
Adaptations | Transcription factors | Target recognition | Transcription | Genes | Gene regulation | AKT protein | Gene sequencing | Angiogenesis | Ubiquitination | Cell adhesion | Uniqueness | Muscles | Data processing | Aerobics | Gene expression | Clustering | Ribonucleic acid--RNA | Molecular chains | Skeletal muscle | Zinc | 1-Phosphatidylinositol 3-kinase | Musculoskeletal system | Exercise physiology | Muscle function | Human behavior
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4. Full Text APOE and BCHE as modulators of cerebral amyloid deposition: A florbetapir PET genome-wide association study
by Ramanan, V.K and Risacher, S.L and Nho, K and Kim, S and Swaminathan, S and Shen, L and Foroud, T.M and Hakonarson, H and Huentelman, M.J and Aisen, P.S and Petersen, R.C and Green, R.C and Jack, C.R and Koeppe, R.A and Jagust, W.J and Weiner, M.W and Saykin, A.J and Alzheimer's Dis Neuroimaging Initi and Alzheimer’s Disease Neuroimaging Initiative and for the Alzheimer’s Disease Neuroimaging Initiative
Molecular Psychiatry, ISSN 1359-4184, 03/2014, Volume 19, Issue 3, pp. 351 - 357
Deposition of amyloid-beta (A beta) in the cerebral cortex is thought to be a pivotal event in Alzheimer's disease (AD) pathogenesis with a significant genetic... 
Alzheimer's disease (AD) | Apolipoprotein E (APOE) | Amyloid | Butyrylcholinesterase (BCHE) | Florbetapir (AV-45) | Genomewide association study (GWAS) | APOLIPOPROTEIN-E EPSILON-4 | COMMON VARIANTS | florbetapir (AV-45) | butyrylcholinesterase (BCHE) | PSYCHIATRY | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PLAQUES | MILD COGNITIVE IMPAIRMENT | IDENTIFICATION | NEUROSCIENCES | BETA | amyloid | apolipoprotein E (APOE) | PROGRESS | genome-wide association study (GWAS) | NEUROPATHOLOGY | BUTYRYLCHOLINESTERASE-K-VARIANT | European Continental Ancestry Group - genetics | Genome-Wide Association Study | Butyrylcholinesterase - genetics | Aniline Compounds | Humans | Middle Aged | Male | Positron-Emission Tomography | Cerebral Cortex - diagnostic imaging | Cerebral Cortex - metabolism | Plaque, Amyloid - diagnostic imaging | Functional Neuroimaging | Ethylene Glycols | Apolipoproteins E - genetics | Aged, 80 and over | Cognitive Dysfunction - genetics | Female | Plaque, Amyloid - metabolism | Aged | Alzheimer Disease - genetics | Physiological aspects | Research | Alzheimer's disease | Psychiatric research | Amyloid beta-protein | Alzheimer’s disease (AD)
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5. Full Text Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
by Lambert, Jean-Charles and Ibrahim-Verbaas, Carla A and Harold, Denise and Naj, Adam C and Sims, Rebecca and Bellenguez, Céline and Jun, Gyungah and DeStefano, Anita L and Bis, Joshua C and Beecham, Gary W and Grenier-Boley, Benjamin and Russo, Giancarlo and Thornton-Wells, Tricia A and Jones, Nicola and Smith, Albert V and Chouraki, Vincent and Thomas, Charlene and Ikram, M. Arfan and Zelenika, Diana and Vardarajan, Badri N and Kamatani, Yoichiro and Lin, Chiao-Feng and Gerrish, Amy and Schmidt, Helena and Kunkle, Brian and Fiévet, Nathalie and Amouyel, Philippe and Pasquier, Florence and Deramecourt, Vincent and De Bruijn, Renee F.A.G and Amin, Najaf and Hofman, Albert and Van Duijn, Cornelia M and Dunstan, Melanie L and Hollingworth, Paul and Owen, Michael J and O'Donovan, Michael C and Jones, Lesley and Holmans, Peter A and Moskvina, Valentina and Williams, Julie and Baldwin, Clinton and Farrer, Lindsay A and Choi, Seung-Hoan and Lunetta, Kathryn L and Fitzpatrick, Annette L and Harris, Tamara B and Psaty, Bruce M and Gilbert, John R and Hamilton-Nelson, Kara L and Martin, Eden R and Kunkle, Brian and Haines, Jonathan L and Gudnason, Vilmundur and Jonsson, Palmi V and Eiriksdottir, Gudny and Bihoreau, Marie-Thérèse and Lathrop, Mark and Valladares, Otto and Cantwell, Laura B and Wang, Li-San and Schellenberg, Gerard D and Ruiz, Agustin and Boada, Mercè and Reitz, Christiane and Mayeux, Richard and Ramirez, Alfredo and Maier, Wolfgang and Hanon, Olivier and Kukull, Walter A and Buxbaum, Joseph D and Campion, Dominique and Wallon, David and Hannequin, Didier and Crane, Paul K and Larson, Eric B and Becker, Tim and Cruchaga, Carlos and Goate, Alison M and Craig, David and Johnston, Janet A and Mc-Guinness, Bernadette and Todd, Stephen and Passmore, Peter and Berr, Claudine and Ritchie, Karen and Lopez, Oscar L and De Jager, Philip L and Evans, Denis and Lovestone, Simon and Proitsi, Petroula and Powell, John F and Letenneur, Luc and Barberger-Gateau, Pascale and Dufouil, Carole and Dartigues, Jean-François and Morón, Francisco J and Rubinsztein, David C and St. George-Hyslop, Peter and Sleegers, Kristel and ... and EADI and CHARGE and ADGC and GERAD and Cohorts for Heart and Aging Research in Genomic Epidemiology and Genetic and Environmental Risk in Alzheimer's Disease and Alzheimer's Disease Genetic Consortium and European Alzheimer's Disease Initiative (EADI) and Alzheimer's Disease Genetic Consortium (ADGC) and Genetic and Environmental Risk in Alzheimer's Disease (GERAD) and Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) and Stockholms universitet and Centrum för forskning om äldre och åldrande (ARC), (tills m KI) and Samhällsvetenskapliga fakulteten
Nature Genetics, ISSN 1061-4036, 12/2013, Volume 45, Issue 12, pp. 1452 - 1458
Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous studies; however, a large portion of the genetic risk for this... 
GENOTYPES | COMMON VARIANTS | IMPUTATION | GENETIC RISK | SEQUENCE | GENETICS & HEREDITY | NEURONS | RECEPTOR | MUTATIONS | CD33 | GENOME-WIDE ASSOCIATION | Genetic Predisposition to Disease | Humans | Middle Aged | Male | Genetic Loci | Genome-Wide Association Study - statistics & numerical data | Case-Control Studies | Age of Onset | Aged, 80 and over | Alzheimer Disease - epidemiology | Female | Aged | Polymorphism, Single Nucleotide | Alzheimer Disease - genetics | Cohort Studies | Quantitative trait loci | Genetic aspects | Research | Genetic susceptibility | Alzheimer's disease | Identification and classification | Genealogy | Genomics | Genes | Quality control | Aging | Genomes | Alzheimers disease | Health risk assessment | Meta-analysis | Genetik | Biological Sciences | Genetics | Naturvetenskap | Natural Sciences | Biologiska vetenskaper
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6. Full Text Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer's disease in the presenilin 1 E280A kindred: a case-control study
by Reiman, Eric M, Prof Dr and Quiroz, Yakeel T, MA and Fleisher, Adam S, MD and Chen, Kewei, PhD and Velez-Pardo, Carlos, PhD and Jimenez-Del-Rio, Marlene, PhD and Fagan, Anne M, PhD and Shah, Aarti R, MSc and Alvarez, Sergio, MD and Arbelaez, Andrés, MD and Giraldo, Margarita, MD and Acosta-Baena, Natalia, MD and Sperling, Reisa A, MD and Dickerson, Brad, MD and Stern, Chantal E, DPhil and Tirado, Victoria, MSc and Munoz, Claudia, BA and Reiman, Rebecca A, BA and Huentelman, Matthew J, PhD and Alexander, Gene E, Prof and Langbaum, Jessica BS, PhD and Kosik, Kenneth S, Prof and Tariot, Pierre N, MD and Lopera, Francisco, Prof
Lancet Neurology, The, ISSN 1474-4422, 2012, Volume 11, Issue 12, pp. 1048 - 1056
Summary Background We have previously characterised functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's disease. To gain... 
Neurology | MILD | DEMENTIA | MEMORY | AMYLOID-BETA | DEPOSITION | IN-VIVO | EPSILON-4 ALLELE | GAMMA-SECRETASE | CARRIERS | CLINICAL NEUROLOGY | APOLIPOPROTEIN-E | Humans | Magnetic Resonance Imaging - methods | Male | Amyloid beta-Peptides - blood | Case-Control Studies | Alzheimer Disease - diagnosis | Young Adult | Genes, Dominant | Peptide Fragments - blood | Amyloid beta-Peptides - cerebrospinal fluid | Adult | Female | Presenilin-1 - blood | Genetic Predisposition to Disease - genetics | Presenilin-1 - cerebrospinal fluid | Peptide Fragments - cerebrospinal fluid | Cross-Sectional Studies | Risk Factors | Presenilin-1 - genetics | Biomarkers - blood | Mutation - genetics | Adolescent | Alzheimer Disease - metabolism | Brain - pathology | Biomarkers - cerebrospinal fluid | Alzheimer Disease - genetics | Brain | Medical research | Neurosciences | Genetic research | Medicine, Experimental | Youth | Teenagers | Diagnostic imaging | Alzheimer's disease | Risk factors
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7. Full Text Genome-wide association between DNA methylation and alternative splicing in an invertebrate
by Flores, Kevin and Wolschin, Florian and Corneveaux, Jason J and Allen, April N and Huentelman, Matthew J and Amdam, Gro V
BMC Genomics, ISSN 1471-2164, 09/2012, Volume 13, Issue 1, pp. 480 - 480
Background: Gene bodies are the most evolutionarily conserved targets of DNA methylation in eukaryotes. However, the regulatory functions of gene body DNA... 
METHYLOME | CONSERVATION | RNA-SEQ | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | RESOLUTION | HONEYBEE | TRANSCRIPTION | GENETICS & HEREDITY | PATTERNS | ARABIDOPSIS | DIVERGENCE | EXPRESSION | Genes, Insect | Genome-Wide Association Study | Alternative Splicing | Transcriptome | Molecular Sequence Data | Exons - genetics | Gene Expression Profiling | Wasps - genetics | DNA Methylation | Animals | Sequence Analysis, RNA | Base Sequence | Conserved Sequence | CpG Islands | Bees - genetics | Evolution, Molecular | Messenger RNA | Analysis | Physiological aspects | Genetic transcription | Research | Methylation | RNA splicing | Honeybee | Wildlife conservation | Genes | Genomics | Genomes | Bees | DNA | Genetic research | Genetic aspects | Wasps | Alternative splicing | Statistical analysis | Transcription | Exons | Conservation | DNA methylation | Data processing | Evolution | Evolutionary genetics | Homology | Gene expression
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8. Full Text Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort
by Shen, Li and Kim, Sungeun and Risacher, Shannon L and Nho, Kwangsik and Swaminathan, Shanker and West, John D and Foroud, Tatiana and Pankratz, Nathan and Moore, Jason H and Sloan, Chantel D and Huentelman, Matthew J and Craig, David W and DeChairo, Bryan M and Potkin, Steven G and Jack, Clifford R and Weiner, Michael W and Saykin, Andrew J and Alzheimers Dis Neuroimaging Initia and Alzheimer's Disease Neuroimaging Initiative
NeuroImage, ISSN 1053-8119, 11/2010, Volume 53, Issue 3, pp. 1051 - 1063
A genome-wide, whole brain approach to investigate genetic effects on neuroimaging phenotypes for identifying quantitative trait loci is described. The... 
SURFACE-BASED ANALYSIS | ALZHEIMER-DISEASE | MRI | ATROPHY | SUSCEPTIBILITY | EPSILON-4 | NEUROSCIENCES | NEUROIMAGING | GENETIC ASSOCIATIONS | SEGMENTATION | CANDIDATE GENE | EXPRESSION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Genetic Predisposition to Disease | Genome-Wide Association Study | Humans | Genotype | Male | Cognition Disorders - genetics | Magnetic Resonance Imaging | Phenotype | Apolipoproteins E - genetics | Female | Aged | Polymorphism, Single Nucleotide | Alzheimer Disease - genetics | Quantitative Trait Loci | Cluster Analysis | Databases, Factual | Studies | Genotype & phenotype | Automation | Medical imaging | Genomics | Genetics | Genomes | Public private partnerships | Alzheimer's disease
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9. Full Text Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease
by Naj, Adam C and Jun, Gyungah and Beecham, Gary W and Wang, Li-San and Vardarajan, Badri Narayan and Buros, Jacqueline and Gallins, Paul J and Buxbaum, Joseph D and Jarvik, Gail P and Crane, Paul K and Larson, Eric B and Bird, Thomas D and Boeve, Bradley F and Graff-Radford, Neill R and De Jager, Philip L and Evans, Denis and Schneider, Julie A and Carrasquillo, Minerva M and Ertekin-Taner, Nilufer and Younkin, Steven G and Cruchaga, Carlos and Kauwe, John S. K and Nowotny, Petra and Kramer, Patricia and Hardy, John and Huentelman, Matthew J and Myers, Amanda J and Barmada, Michael M and Demirci, F Yesim and Baldwin, Clinton T and Green, Robert C and Rogaeva, Ekaterina and George-Hyslop, Peter St and Arnold, Steven E and Barber, Robert and Beach, Thomas and Bigio, Eileen H and Bowen, James D and Boxer, Adam and Burke, James R and Cairns, Nigel J and Carlson, Chris S and Carney, Regina M and Carroll, Steven L and Chui, Helena C and Clark, David G and Corneveaux, Jason and Cotman, Carl W and Cummings, Jeffrey L and Decarli, Charles and Dekosky, Steven T and Diaz-Arrastia, Ramon and Dick, Malcolm and Dickson, Dennis W and Ellis, William G and Faber, Kelley M and Fallon, Kenneth B and Farlow, Martin R and Ferris, Steven and Frosch, Matthew P and Galasko, Douglas R and Ganguli, Mary and Gearing, Marla and Geschwind, Daniel H and Ghetti, Bernardino and Gilbert, John R and Gilman, Sid and Giordani, Bruno and Glass, Jonathan D and Growdon, John H and Hamilton, Ronald L and Harrell, Lindy E and Head, Elizabeth and Honig, Lawrence S and Hulette, Christine M and Hyman, Bradley T and Jicha, Gregory A and Jin, Lee-Way and Johnson, Nancy and Karlawish, Jason and Karydas, Anna and Kaye, Jeffrey A and Kim, Ronald and Koo, Edward H and Kowall, Neil W and Lah, James J and Levey, Allan I and Lieberman, Andrew P and Lopez, Oscar L and MacK, Wendy J and Marson, Daniel C and Martiniuk, Frank and Mash, Deborah C and Masliah, Eliezer and McCormick, Wayne C and McCurry, Susan M and McDavid, Andrew N and McKee, Ann C and Mesulam, Marsel and Miller, Bruce L and ...
Nature Genetics, ISSN 1061-4036, 05/2011, Volume 43, Issue 5, pp. 436 - 443
The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association study of late-onset Alzheimer disease using a three-stage design... 
POPULATION | IDENTIFIES VARIANTS | METAANALYSIS | GENE | GENETICS & HEREDITY | RISK | LOCI | APOE | MISSENSE MUTATIONS | GENOME-WIDE ASSOCIATION | APOLIPOPROTEIN-E | Genetic Predisposition to Disease | Genome-Wide Association Study | Multigene Family | Cytoskeletal Proteins - genetics | Membrane Proteins - genetics | Humans | Databases, Genetic | Male | Antigens, CD - genetics | Antigens, Differentiation, Myelomonocytic - genetics | Genetic Variation | Receptor, EphA1 - genetics | Adaptor Proteins, Signal Transducing - genetics | Age of Onset | Aged, 80 and over | Female | Aged | Polymorphism, Single Nucleotide | Sialic Acid Binding Ig-like Lectin 3 | Alzheimer Disease - genetics | Cohort Studies | Conferences, meetings and seminars | Alzheimer's disease | Medical societies | Studies | Medical research | Genomes | Statistical methods | Alzheimers disease | Independent sample | Meta-analysis
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