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Journal Article
Science, ISSN 0036-8075, 11/2010, Volume 330, Issue 6005, pp. 831 - 835
The dose-limiting side effect of the common colon cancer chemotherapeutic CPT-11 is severe diarrhea caused by symbiotic bacterial β-glucuronidases that... 
Enzymes | Anaerobic bacteria | Toxicity | REPORTS | Colorectal cancer | Diarrhea | Anaerobic conditions | Bacteria | Mice | Monomers | Crystal structure | IRINOTECAN CPT-11 | DIARRHEA | METABOLISM | COLITIS | MULTIDISCIPLINARY SCIENCES | BETA-GLUCURONIDASE | CAMPTOTHECINS | TOPOISOMERASE-I | PHARMACOGENETICS | GUT FLORA | CARCINOMA | Camptothecin - toxicity | Humans | Colon - drug effects | Glucuronidase - metabolism | Crystallography, X-Ray | Diarrhea - prevention & control | Intestinal Mucosa - drug effects | Prodrugs - metabolism | Enzyme Inhibitors - chemistry | Female | Glucuronidase - antagonists & inhibitors | Antineoplastic Agents, Phytogenic - metabolism | Escherichia coli Proteins - antagonists & inhibitors | Bacteria, Anaerobic - drug effects | Drug Evaluation, Preclinical | Camptothecin - analogs & derivatives | Camptothecin - metabolism | Escherichia coli - enzymology | Enzyme Inhibitors - metabolism | Colon - pathology | Glucuronidase - isolation & purification | Enzyme Inhibitors - pharmacology | Models, Molecular | Escherichia coli Proteins - metabolism | Glucuronidase - chemistry | Intestinal Mucosa - microbiology | Escherichia coli Proteins - isolation & purification | Antineoplastic Agents, Phytogenic - toxicity | Animals | Prodrugs - toxicity | Cell Line, Tumor | Protein Conformation | Colon - microbiology | Mice, Inbred BALB C | Glucuronidase - pharmacology | Escherichia coli Proteins - chemistry | Intestinal Mucosa - pathology | Antimitotic agents | Drugs | Prevention | Complications and side effects | Care and treatment | Dosage and administration | Antineoplastic agents | Health aspects | Cancer | Chemotherapy | Side effects | Index Medicus | Microorganisms | Inhibitors | LARGE INTESTINE | BACTERIA | NEOPLASMS | BASIC BIOLOGICAL SCIENCES | CRYSTAL STRUCTURE | TOXICITY | 60 APPLIED LIFE SCIENCES | ENZYMES | ORAL ADMINISTRATION | TARGETS | MICE | SIDE EFFECTS
Journal Article
Nature Communications, ISSN 2041-1723, 06/2017, Volume 8, Issue 1, p. 15790
We recently developed base editing, a genome-editing approach that enables the programmable conversion of one base pair into another without double-stranded... 
MULTIDISCIPLINARY SCIENCES
Journal Article
Modern Pathology, ISSN 0893-3952, 06/2018, Volume 31, Issue 6, pp. 965 - 973
Journal Article
by Patrick S. Schnable and Doreen Ware and Robert S. Fulton and Joshua C. Stein and Fusheng Wei and Shiran Pasternak and Chengzhi Liang and Jianwei Zhang and Lucinda Fulton and Tina A. Graves and Patrick Minx and Amy Denise Reily and Laura Courtney and Scott S. Kruchowski and Chad Tomlinson and Cindy Strong and Kim Delehaunty and Catrina Fronick and Bill Courtney and Susan M. Rock and Eddie Belter and Feiyu Du and Kyung Kim and Rachel M. Abbott and Marc Cotton and Andy Levy and Pamela Marchetto and Kerri Ochoa and Stephanie M. Jackson and Barbara Gillam and Weizu Chen and Le Yan and Jamey Higginbotham and Marco Cardenas and Jason Waligorski and Elizabeth Applebaum and Lindsey Phelps and Jason Falcone and Krishna Kanchi and Thynn Thane and Adam Scimone and Nay Thane and Jessica Henke and Tom Wang and Jessica Ruppert and Neha Shah and Kelsi Rotter and Jennifer Hodges and Elizabeth Ingenthron and Matt Cordes and Sara Kohlberg and Jennifer Sgro and Brandon Delgado and Kelly Mead and Asif Chinwalla and Shawn Leonard and Kevin Crouse and Kristi Collura and Dave Kudrna and Jennifer Currie and Ruifeng He and Angelina Angelova and Shanmugam Rajasekar and Teri Mueller and Rene Lomeli and Gabriel Scara and Ara Ko and Krista Delaney and Marina Wissotski and Georgina Lopez and David Campos and Michele Braidotti and Elizabeth Ashley and Wolfgang Golser and HyeRan Kim and Seunghee Lee and Jinke Lin and Zeljko Dujmic and Woojin Kim and Jayson Talag and Andrea Zuccolo and Chuanzhu Fan and Aswathy Sebastian and Melissa Kramer and Lori Spiegel and Lidia Nascimento and Theresa Zutavern and Beth Miller and Claude Ambroise and Stephanie Muller and Will Spooner and Apurva Narechania and Liya Ren and Sharon Wei and Sunita Kumari and Ben Faga and Michael J. Levy and Linda McMahan and Peter Van Buren and Matthew W. Vaughn and ...
Science, ISSN 0036-8075, 11/2009, Volume 326, Issue 5956, pp. 1112 - 1115
Journal Article
by Lozano, Rafael, Prof and Naghavi, Mohsen, PhD and Foreman, Kyle, MPH and Lim, Stephen, PhD and Shibuya, Kenji, Prof and Aboyans, Victor, Prof and Abraham, Jerry, MPH and Adair, Timothy, PhD and Aggarwal, Rakesh, Prof and Ahn, Stephanie Y, MPH and AlMazroa, Mohammad A, MD and Alvarado, Miriam, BA and Anderson, H Ross, Prof and Anderson, Laurie M, PhD and Andrews, Kathryn G, MPH and Atkinson, Charles, BS and Baddour, Larry M, Prof and Barker-Collo, Suzanne, PhD and Bartels, David H, BA and Bell, Michelle L, Prof and Benjamin, Emelia J, Prof and Bennett, Derrick, PhD and Bhalla, Kavi, PhD and Bikbov, Boris, MD and Abdulhak, Aref Bin, MD and Birbeck, Gretchen, Prof and Blyth, Fiona, PhD and Bolliger, Ian, AB and Boufous, Soufiane, PhD and Bucello, Chiara, BPsych and Burch, Michael, MD and Burney, Peter, Prof and Carapetis, Jonathan, Prof and Chen, Honglei, PhD and Chou, David, BA and Chugh, Sumeet S, Prof and Coffeng, Luc E, MD and Colan, Steven D, Prof and Colquhoun, Samantha, MPH and Colson, K Ellicott, BA and Condon, John, PhD and Connor, Myles D, PhD and Cooper, Leslie T, Prof and Corriere, Matthew, MD and Cortinovis, Monica, BiotechD and de Vaccaro, Karen Courville, MD and Couser, William, Prof and Cowie, Benjamin C, MBBS and Criqui, Michael H, Prof and Cross, Marita, PhD and Dabhadkar, Kaustubh C, MBBS and Dahodwala, Nabila, MD and De Leo, Diego, Prof and Degenhardt, Louisa, Prof and Delossantos, Allyne, BS and Denenberg, Julie, MA and Des Jarlais, Don C, PhD and Dharmaratne, Samath D, Prof and Dorsey, E Ray, MD and Driscoll, Tim, PhD and Duber, Herbert, MD and Ebel, Beth, MD and Erwin, Patricia J, MLS and Espindola, Patricia, MD and Ezzati, Majid, Prof and Feigin, Valery, Prof and Flaxman, Abraham D, PhD and Forouzanfar, Mohammad H, MD and Fowkes, Francis Gerry R, Prof and Franklin, Richard, PhD and Fransen, Marlene, PhD and Freeman, Michael K, BA and Gabriel, Sherine E, Prof and Gakidou, Emmanuela, PhD and Gaspari, Flavio, ChemD and Gillum, Richard F, Prof and Gonzalez-Medina, Diego, BA and Halasa, Yara A, DDS and Haring, Diana, BS and Harrison, James E, Prof and Havmoeller, Rasmus, MD and Hay, Roderick J, Prof and Hoen, Bruno, Prof and Hotez, Peter J, Prof and Hoy, Damian, PhD and Jacobsen, Kathryn H, PhD and James, Spencer L, MPH and Jasrasaria, Rashmi, BA and Jayaraman, Sudha, MD and Johns, Nicole, BA and Karthikeyan, Ganesan, MD and Kassebaum, Nicholas, MD and Keren, Andre, Prof and Khoo, Jon-Paul, MBBS and Knowlton, Lisa Marie, MD and Kobusingye, Olive, MMed and Koranteng, Adofo, MSc and Krishnamurthi, Rita, PhD and Lipnick, Michael, MD and Lipshultz, Steven E, Prof and ...
Lancet, The, ISSN 0140-6736, 2012, Volume 380, Issue 9859, pp. 2095 - 2128
Journal Article