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Nature Genetics, ISSN 1061-4036, 04/2015, Volume 47, Issue 4, pp. 367 - 372
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 505, Issue 7482, pp. 212 - 217
Non-small-cell lung cancer (NSCLC) is the most prevalent histological cancer subtype worldwide(1). As the majority of patients present with invasive,... 
TRANSFORMATION | MESSENGER-RNAS | OVEREXPRESSION | TGF-BETA | GENE | ADENOCARCINOMA | MULTIDISCIPLINARY SCIENCES | LET-7 | INHIBITOR | BINDING | EXPRESSION DATA | Receptors, Transforming Growth Factor beta - genetics | Cell Proliferation | Humans | Lung Neoplasms - pathology | MicroRNAs - metabolism | Proteoglycans - deficiency | RNA Isoforms - metabolism | HMGA2 Protein - genetics | Gene Expression Regulation, Neoplastic - genetics | Disease Models, Animal | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Argonaute Proteins - metabolism | RNA Isoforms - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Proteoglycans - biosynthesis | Disease Progression | Neoplasm Metastasis - genetics | Receptors, Transforming Growth Factor beta - biosynthesis | Animals | Cell Line, Tumor | Binding, Competitive - genetics | Mice | MicroRNAs - genetics | Transcription, Genetic - genetics | Neoplasm Invasiveness - genetics | Transforming Growth Factor beta - metabolism | Proteoglycans - genetics | Receptors, Transforming Growth Factor beta - deficiency | RNA sequencing | Gene targeting | Development and progression | Genetic aspects | Genetic transcription | Lung cancer, Non-small cell | Identification and classification | Methods | Proteins | Hypothesis testing | Survival analysis | Hypotheses | Transplants & implants | Lung cancer | Genomes | Tumorigenesis | Mutation | Gene expression | Tumors | Index Medicus
Journal Article
by Behjati, Sam and Gundem, Gunes and Wedge, David C and Roberts, Nicola D and Tarpey, Patrick S and Cooke, Susanna L and Van Loo, Peter and Alexandrov, Ludmil B and Ramakrishna, Manasa and Davies, Helen and Nik-Zainal, Serena and Hardy, Claire and Latimer, Calli and Raine, Keiran M and Stebbings, Lucy and Menzies, Andy and Jones, David and Shepherd, Rebecca and Butler, Adam P and Teague, Jon W and Jorgensen, Mette and Khatri, Bhavisha and Pillay, Nischalan and Shlien, Adam and Futreal, P. Andrew and Badie, Christophe and McDermott, Ultan and Bova, G. Steven and Richardson, Andrea L and Flanagan, Adrienne M and Stratton, Michael R and Campbell, Peter J and Cooper, Colin S and Eeles, Rosalind A and Easton, Douglas and Foster, Christopher and Neal, David E and Brewer, Daniel S and Hamdy, Freddie and Lu, Yong-Jie and Lynch, Andrew G and Massi, Charlie E and Ng, Anthony and Whitaker, Hayley C and Yu, Yongwei and Zhang, Hongwei and Bancroft, Elizabeth and Berney, Dan and Camacho, Niedzica and Corbishley, Cathy and Dadaev, Tokhir and Dennis, Nening and Dudderidge, Tim and Edwards, Sandra and Fisher, Cyril and Ghori, Jilur and Gnanapragasam, Vincent J and Greenman, Christopher and Hawkins, Steve and Hazell, Steven and Howat, Will and Karaszi, Katalin and Kay, Jonathan and Kote-Jarai, Zsofia and Kremeyer, Barbara and Kumar, Pardeep and Lambert, Adam and Leongamornlert, Daniel and Livni, Naomi and Luxton, Hayley and Matthews, Lucy and Mayer, Erik and Merson, Susan and Nicol, David and Ogden, Christopher and O'Meara, Sarah and Pelvender, Gill and Shah, Nimish C and Tavare, Simon and Thomas, Sarah and Thompson, Alan and Verrill, Claire and Warren, Anne and Zamora, Jorge and ICGC Prostate Grp and ICGC Prostate Group
Nature Communications, ISSN 2041-1723, 09/2016, Volume 7, Issue 1, pp. 12605 - 12605
Ionizing radiation is a potent carcinogen, inducing cancer through DNA damage. The signatures of mutations arising in human tissues following in vivo exposure... 
21 BREAST CANCERS | MUTAGENESIS | PAST EXPOSURE | MULTIDISCIPLINARY SCIENCES | PROSTATE-CANCER | GENOME-WIDE ANALYSIS | INDUCED SARCOMAS | RADIOTHERAPY | ANGIOSARCOMA | LYMPHOCYTES | INVERSIONS | Index Medicus
Journal Article
Journal Article
by Jamal-Hanjani, Mariam and Wilson, Gareth A and McGranahan, Nicholas and Birkbak, Nicolai J and Watkins, Thomas B.K and Veeriah, Selvaraju and Shafi, Seema and Johnson, Diana H and Mitter, Richard and Rosenthal, Rachel and Salm, Max and Horswell, Stuart and Escudero, Mickael and Matthews, Nik and Rowan, Andrew and Chambers, Tim and Moore, David A and Turajlic, Samra and Xu, Hang and Lee, Siow-Ming and Forster, Martin D and Ahmad, Tanya and Hiley, Crispin T and Abbosh, Christopher and Falzon, Mary and Borg, Elaine and Marafioti, Teresa and Lawrence, David and Hayward, Martin and Kolvekar, Shyam and Panagiotopoulos, Nikolaos and Janes, Sam M and Thakrar, Ricky and Ahmed, Asia and Blackhall, Fiona and Summers, Yvonne and Shah, Rajesh and Joseph, Leena and Quinn, Anne M and Crosbie, Phil A and Naidu, Babu and Middleton, Gary and Langman, Gerald and Trotter, Simon and Nicolson, Marianne and Remmen, Hardy and Kerr, Keith and Chetty, Mahendran and Gomersall, Lesley and Fennell, Dean A and Nakas, Apostolos and Rathinam, Sridhar and Anand, Girija and Khan, Sajid and Russell, Peter and Ezhil, Veni and Ismail, Babikir and Irvin-Sellers, Melanie and Prakash, Vineet and Lester, Jason F and Kornaszewska, Malgorzata and Attanoos, Richard and Adams, Haydn and Davies, Helen and Dentro, Stefan and Taniere, Philippe and O’Sullivan, Brendan and Lowe, Helen L and Hartley, John A and Iles, Natasha and Bell, Harriet and Ngai, Yenting and Shaw, Jacqui A and Herrero, Javier and Szallasi, Zoltan and Schwarz, Roland F and Stewart, Aengus and Quezada, Sergio A and Le Quesne, John and Van Loo, Peter and Dive, Caroline and Hackshaw, Allan and Swanton, Charles and TRACERx Consortium
The New England Journal of Medicine, ISSN 0028-4793, 06/2017, Volume 376, Issue 22, pp. 2109 - 2121
Journal Article
by Arce Vargas, Frederick and Furness, Andrew J.S and Solomon, Isabelle and Joshi, Kroopa and Mekkaoui, Leila and Lesko, Marta H and Miranda Rota, Enrique and Dahan, Rony and Georgiou, Andrew and Sledzinska, Anna and Ben Aissa, Assma and Franz, Dafne and Werner Sunderland, Mariana and Wong, Yien Ning Sophia and Henry, Jake Y and O’Brien, Tim and Nicol, David and Challacombe, Ben and Beers, Stephen A and Spain, Lavinia and Wotherspoon, Andrew and Francis, Nicholas and Smith, Amy and Smith, Sean and Smith, Myles and Smith, Elaine and Strauss, Dirk and Hayes, Andrew and Soultati, Aspasia and Stares, Mark and Lynch, Joanna and Fotiadis, Nicos and Fernando, Archana and Hazell, Steve and Chandra, Ashish and Pickering, Lisa and Rudman, Sarah and Chowdhury, Simon and Swanton, Charles and Jamal-Hanjani, Mariam and Veeriah, Selvaraju and Shafi, Seema and Czyzewska-Khan, Justyna and Johnson, Benjamin and Johnson, Diana and Laycock, Joanne and Bosshard-Carter, Leticia and Goh, Gerald and Rosenthal, Rachel and Gorman, Pat and Murugaesu, Nirupa and Hynds, Robert E and Wilson, Gareth and Birkbak, Nicolai J and Watkins, Thomas B.K and McGranahan, Nicholas and Horswell, Stuart and Mitter, Richard and Escudero, Mickael and Stewart, Aengus and Van Loo, Peter and Rowan, Andrew and Xu, Hang and Turajlic, Samra and Hiley, Crispin and Abbosh, Christopher and Goldman, Jacki and Stone, Richard Kevin and Denner, Tamara and Matthews, Nik and Matthews, Sue and Elgar, Greg and Ward, Sophia and Biggs, Jennifer and Costa, Marta and Begum, Sharmin and Phillimore, Ben and Chambers, Tim and Nye, Emma and Graca, Sofia and Al Bakir, Maise and Hartley, John A and Lowe, Helen L and Herrero, Javier and Lawrence, David and Hayward, Martin and Panagiotopoulos, Nikolaos and Kolvekar, Shyam and Falzon, Mary and Borg, Elaine and Simeon, Celia and Hector, Gemma and Aranda, Marie and Novelli, Marco and Oukrif, Dahmane and Janes, Sam M and Thakrar, Ricky and Forster, Martin and Ahmad, Tanya and Lee, Siow Ming and ... and Melanoma TRACERx Consortium and Renal TRACERx Consortium and Lung TRACERx Consortium
Immunity, ISSN 1074-7613, 04/2017, Volume 46, Issue 4, pp. 577 - 586
CD25 is expressed at high levels on regulatory T (Treg) cells and was initially proposed as a target for cancer immunotherapy. However, anti-CD25 antibodies... 
regulatory T cells | tumor immunotherapy | anti-CD25 | Treg depletion | inhibitory Fc receptor | CD25 | tumor microenvironment | Fc gamma receptors | anti-PD-1 | EFFECTOR | RESPONSES | LYMPHOCYTE-ASSOCIATED ANTIGEN-4 | CANCER-PATIENTS | MELANOMA | MONOCLONAL-ANTIBODY | ANTI-CTLA-4 ANTIBODIES | IMMUNOLOGY | ANTITUMOR-ACTIVITY | COMBINATION | GAMMA-RS | T-Lymphocytes, Regulatory - metabolism | Immunotherapy - methods | Humans | Antibodies, Monoclonal - therapeutic use | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Lymphocyte Depletion | Receptors, IgG - metabolism | T-Lymphocytes, Regulatory - immunology | Neoplasms - therapy | Flow Cytometry | Immunoglobulin Fc Fragments - immunology | Antibodies, Monoclonal - immunology | Interleukin-2 Receptor alpha Subunit - immunology | Kaplan-Meier Estimate | Programmed Cell Death 1 Receptor - metabolism | Receptors, IgG - immunology | Protein Binding - immunology | Animals | Neoplasms - immunology | K562 Cells | Cell Line, Tumor | Mice | Antibodies, Monoclonal - metabolism | Programmed Cell Death 1 Receptor - immunology | Neoplasms - pathology | Viral antibodies | Cell death | Analysis | Immunotherapy | Antibodies | T cells | Cancer | Fc receptors | Beer | Immunoglobulins | Lymphatic system | Immune response | Cytokines | Melanoma | Light emitting diodes | Lymphocytes T | Anticancer properties | Depletion | Lymphocytes | Tumors | Immune system | Report
Journal Article
PLoS Biology, ISSN 1544-9173, 2014, Volume 12, Issue 7, pp. 1 - 7
Journal Article