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The FEBS Journal, ISSN 1742-464X, 09/2018, Volume 285, Issue 17, pp. 3168 - 3174
How did the nucleosome, the fundamental building block of all eukaryotic chromatin, evolve? This central question has been impossible to address because the... 
nucleosome | DNA organization | histones | chromatin structure | archaea | HMFB | PROTEIN | CHROMATIN | STABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | METHANOTHERMUS-FERVIDUS | BINDING | Histones | Epigenetic inheritance | DNA binding proteins | DNA | Proteins | Coils | Chromatin | Eukaryotes | Superhelix | Archaea | Topology | Polymers | Deoxyribonucleic acid--DNA | Core making
Journal Article
Nature communications, ISSN 2041-1723, 2014, Volume 5, Issue 1, p. 3291
During DNA damage response, the RING E3 ligase RNF168 ubiquitinates nucleosomal H2A at K13-15. Here we show that the ubiquitination reaction is regulated by... 
RNF168 | CORE PARTICLES | PROTEIN | CHROMATIN | H3 METHYLATION | DNA-DAMAGE RESPONSE | MULTIDISCIPLINARY SCIENCES | UBIQUITYLATION | RING FINGER | RECOMBINANT HISTONES | LIGASE COMPLEX | Nucleosomes - metabolism | Ubiquitination | Histones - metabolism | Humans | HEK293 Cells | Ubiquitin-Protein Ligases - metabolism
Journal Article
Scientific Reports, ISSN 2045-2322, 04/2017, Volume 7, Issue 1, pp. 46274 - 46274
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 05/2012, Volume 122, Issue 5, pp. 1920 - 1932
Prostate cancer (PCa) is a major lethal malignancy in men, but the molecular events and their interplay underlying prostate carcinogenesis remain poorly... 
MEDICINE, RESEARCH & EXPERIMENTAL | GROUP PROTEIN BMI1 | CHROMATIN-ASSOCIATION | STRAND BREAK REPAIR | EPITHELIAL-CELLS | CELL SELF-RENEWAL | IN-VIVO | TUMOR-SUPPRESSOR GENE | C-MYC | PHOSPHOPROTEOME ANALYSIS | TRANSGENIC MICE | Genomic Instability | Neoplasm Transplantation | Prostatic Neoplasms - metabolism | Phosphorylation | Prostatic Intraepithelial Neoplasia - pathology | Adenocarcinoma - pathology | Humans | Male | DNA Breaks, Double-Stranded | Prostate - metabolism | Prostate - pathology | Ubiquitination | Adenocarcinoma - metabolism | Neoplasm Grading | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Prostatic Intraepithelial Neoplasia - metabolism | Repressor Proteins - metabolism | Proto-Oncogene Proteins - metabolism | PTEN Phosphohydrolase - genetics | Prostatic Neoplasms - pathology | Signal Transduction | Adenocarcinoma - enzymology | Ubiquitin-Protein Ligases - metabolism | PTEN Phosphohydrolase - metabolism | Repressor Proteins - genetics | Mice, Transgenic | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Haploinsufficiency | Animals | Polycomb Repressive Complex 1 | Cell Transformation, Neoplastic | Mice, Nude | Prostatic Intraepithelial Neoplasia - enzymology | DNA Repair | Cell Line, Tumor | Prostatic Neoplasms - enzymology | Mice | Mice, Inbred BALB C | Protein Processing, Post-Translational | Enzyme Activation | Histones - metabolism | Ligases | DNA damage | Development and progression | Genetic aspects | Research | Prostate cancer | Oncogenes | Index Medicus | Abridged Index Medicus
Journal Article
Bio-protocol, ISSN 2331-8325, 02/2018, Volume 8, Issue 3
Nucleosomes organize the eukaryotic genome into chromatin. In cells, nucleosome assembly relies on the activity of histone chaperones, proteins with high... 
Journal Article
Bio-protocol, ISSN 2331-8325, 02/2018, Volume 7, Issue 3
For a complete understanding of biochemical reactions, information on complex stoichiometry is essential. However, measuring stoichiometry is experimentally... 
Journal Article