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JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2008, Volume 52, Issue 25, pp. 2190 - 2197
Objectives The aim of this substudy was to ascertain whether long-term treatment with fenofibrate reduces surrogate measures of atherosclerosis, biomarkers of... 
Cardiovascular | Internal Medicine | intima-media thickness | fenofibrate | type 2 diabetes | inflammation | augmentation index | C-REACTIVE PROTEIN | OXIDATIVE STRESS | CARDIAC & CARDIOVASCULAR SYSTEMS | ENDOTHELIAL DYSFUNCTION | ATORVASTATIN | ARTERIAL STIFFNESS | DENSITY-LIPOPROTEIN | CARDIOVASCULAR-DISEASE | CELL-ADHESION MOLECULES | CORONARY-HEART-DISEASE | Carotid Arteries - drug effects | Tunica Media - pathology | Tunica Media - drug effects | Humans | Middle Aged | Carotid Artery Diseases - physiopathology | Male | Fenofibrate - therapeutic use | Inflammation - blood | Fenofibrate - pharmacology | Time Factors | Carotid Artery Diseases - pathology | Treatment Failure | Female | C-Reactive Protein - drug effects | Diabetes Complications - pathology | Diabetes Mellitus, Type 2 - complications | Carotid Artery Diseases - drug therapy | Severity of Illness Index | Double-Blind Method | Acute-Phase Proteins - drug effects | Diabetes Complications - drug therapy | Biomarkers - blood | Hypolipidemic Agents - pharmacology | Tunica Intima - drug effects | Diabetes Mellitus, Type 2 - physiopathology | Tunica Intima - pathology | Aged | Carotid Arteries - pathology | Hypolipidemic Agents - therapeutic use | Diabetes Mellitus, Type 2 - pathology | Type 2 diabetes | Proteolipids | Lipoproteins | C-reactive protein | Atherosclerosis | Phospholipases | Universities and colleges | Blood lipoproteins | Public health | Fibric acids | Endothelium | Research institutes | Cardiovascular disease | Drug therapy | Cholesterol | Statins | Veins & arteries | MEDICIN OCH HÄLSOVETENSKAP | MEDICAL AND HEALTH SCIENCES
Journal Article
by Tabassum, R and Ramo, JT and Ripatti, P and Koskela, JT and Kurki, M and Karjalainen, J and Palta, P and Hassan, S and Nunez-Fontarnau, J and Kiiskinen, TTJ and Soderlund, S and Matikainen, N and Gerl, MJ and Surma, MA and Klose, C and Stitziel, NO and Laivuori, H and Havulinna, AS and Service, SK and Salomaa, V and Pirinen, M and Jauhiainen, M and Daly, MJ and Freimer, NB and Palotie, A and Taskinen, MR and Simons, K and Ripatti, S and Jalanko, A and Kaprio, J and Donner, K and Kaunisto, M and Mars, N and Dada, A and Shcherban, A and Ganna, A and Lehisto, A and Kilpelainen, E and Brein, G and Awaisa, G and Harju, J and Parr, K and Parolo, PD and Kajanne, R and Lemmela, S and Sipila, TP and Sipila, T and Lyhs, U and Llorens, V and Niiranen, T and Kristiansson, K and Mannikko, L and Jimenez, MG and Perola, M and Wong, R and Kilpi, T and Hiekkalinna, T and Jarvensivu, E and Kaiharju, E and Mattsson, H and Laukkanen, M and Laiho, P and Lahteenmaki, S and Sistonen, T and Soini, S and Ziemann, A and Lehtonen, A and Lertratanakul, A and Georgantas, B and Riley-Gillis, B and Quarless, D and Rahimov, F and Heap, G and Jacob, H and Waring, J and Davis, JW and Smaoui, N and Popovic, R and Esmaeeli, S and Matakidou, A and Challis, B and Close, D and Petrovski, S and Karlsson, A and Schleutker, J and Pulkki, K and Virolainen, P and Kallio, L and Mannermaa, A and Heikkinen, S and Kosma, VM and Chen, CY and Runz, H and Liu, J and Bronson, P and John, S and Landenpera, S and Eaton, S and Zhou, W and Hendolin, M and ... and FinnGen Project
NATURE COMMUNICATIONS, ISSN 2041-1723, 09/2019, Volume 10, Issue 1, pp. 1 - 14
Understanding genetic architecture of plasma lipidome could provide better insights into lipid metabolism and its link to cardiovascular diseases (CVDs). Here,... 
INSULIN | PREDIMED TRIAL | HOSPITAL DISCHARGE REGISTER | RISK-FACTORS | RARE VARIANTS | GENOTYPE IMPUTATION | CERAMIDES | MULTIDISCIPLINARY SCIENCES | DEATH | VALIDITY | GENOME-WIDE ASSOCIATION | Phenotypes | Architecture | Lipids | Genomes | Lipoprotein lipase | Triglycerides | Lipase | Gene expression | Metabolism | Fatty acids | Loci | Blood plasma | Genetic variance | Heritability | Lipid metabolism | Cardiovascular diseases | Species
Journal Article
Nature, ISSN 0028-0836, 07/2015, Volume 523, Issue 7561, pp. 459 - U176
Homozygosity has long been associated with rare, often devastating, Mendelian disorders(1), and Darwin was one of the first to recognize that inbreeding... 
INTELLIGENCE | HOMOZYGOSITY | PATHWAYS | ASSOCIATION ANALYSIS | QUANTITATIVE TRAITS | INBREEDING DEPRESSION | DISEASE | ARCHITECTURE | GENETIC-VARIANTS | BLOOD-PRESSURE | MULTIDISCIPLINARY SCIENCES | TRAITS | ASSOCIATION | Studies | Cognition & reasoning | Disease | Genomics | Cognitive ability | Genomes | Educational attainment
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 4285 - 13
Journal Article
by Mace, Aurelien and Tuke, M.A and Deelen, Patrick and Kristiansson, Kati and Mattsson, Hannele and Nõukas, M and Sapkota, Y and Schick, Ursula and Porcu, Eleonora and Rüeger, S and McDaid, A.F and Porteous, David J and Winkler, Thomas W and Salvi, E and Shrine, Nick and Liu, X and Ang, Wei and Zhang, Weihua and Feitosa, M.F and Venturini, Cristina and Most, Peter and Rosengren, A and Wood, Anew and Beaumont, R.N and Jones, Samuel E and Ruth, Katherine S and Yaghootkar, H and Tyrrell, A.W.R and Havulinna, Aki and Boers, H and Mägi, R and Kriebel, Jennifer and Müller-Nurasyid, M and Perola, M and Nieminen, Markku and Lokki, M.L and Kähönen, Mika and Viikari, Jorma and Geller, Frank and Lahti, J and Palotie, A and Koponen, P and Lundqvist, Annamari and Rissanen, Harri and Bottinger, Erwin and Afaq, S and Wojczynski, Mary and Lenzini, P and Nolte, Ilja and Sparsø, Thomas and Schupf, N and Christensen, Kaare and Perls, Thomas T and Newman, A.B and Werge, Thomas and Snieder, Harold and Spector, Timothy and Chambers, J.C and Koskinen, Seppo and Melbye, Mads and Raitakari, O.T and Lehtimäki, Terho and Tobin, Martin and Wain, L.V and Sinisalo, J and Peters, Annette and Meitinger, T and Martin, Nicholas and Wray, Naomi and Montgomery, G.W and Medland, Sarah Elizabeth and Swertz, M.A and Vartiainen, Erkki and Borodulin, Katja and Männistö, Satu and Murray, A and Bochud, Murielle and Jacquemont, Sébastien and Rivadeneira, F and Hansen, Thomas and Oldehinkel, Albertine and Mangino, Massimo and Province, Mike and Deloukas, P and Kooner, Jaspal S and Freathy, Rachel and Pennell, Craig and Feenstra, Bjarke and Strachan, David and Lettre, Guillaume and Hirschhorn, Joel and Cusi, Daniele and Heid, Iris and Hayward, Caroline and Männik, K and Beckmann, Jacques and Loos, Ruth and Nyholt, Dale and Metspalu, A and Hagen, Knut and ...
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 744 - 11
Journal Article
by Joshi, Peter and Esko, Tõnu and Mattsson, Hannele and Eklund, Niina and Gandin, Ilaria and Nutile, T and Jackson, Anne and Schurmann, Claudia and Smith, Davey and Zhang, Weihua and Okada, Yukinori and Stancáková, Alena and Faul, Jessica D and Zhao, Wei and Bartz, Traci M and Concas, Maria Pina and Franceschini, Nora and Enroth, Stefan and Vitart, Veronique and Trompet, Stella and Guo, Xiuqing and Chasman, Daniel and O'Connel, Jeffrey R and Corre, Tanguy and Nongmaithem, Suraj S and Chen, Yuning and Mangino, Massimo and Ruggiero, D and Traglia, Michela and Farmaki, Aliki-Eleni and Kacprowski, Tim and Bjonnes, Anew and Spek, Ashley and Wu, Ying and Giri, Anil K and Yanek, Lisa and Wang, Lihua and Hofer, Edith and Rietveld, Niels and McLeod, Olga and Cornelis, Marilyn and Pattaro, Cristian and Verweij, Niek and Baumbach, Clemens and Abdellaoui, Abdel and Warren, Helen and Vuckovic, gana and Mei, Hao and Bouchard, Claude and Perry, John and Cappellani, Stefania and Mirza, Saira and Benton, Miles C and Broeckel, Ulrich and Medland, Sarah Elizabeth and Lind, Penelope and Malerba, Giovanni and ng, Alexander and Yengo, Loic and Bielak, Lawrence F and Zhi, Degui and Most, Peter and Shriner, Daniel and Mägi, Reedik and Hemani, G and Karaderi, Tugce and Wang, Zhaoming and Liu, Tian and Demuth, Ilja and Zhao, Jing Hua and Meng, Weihua and Lataniotis, Lazaros and Van Der Laan, Sander W and Bradfield, Jonathan and Wood, Anew and Bonnefond, Amélie and Ahluwalia, Tarunveer Singh and Hall, Leanne M and Salvi, Erika and Yazar, Seyhan and Carstensen, Lisbeth and Haan, Hugoline and Abney, Mark and Afzal, Uzma and Allison, Matthew and Amin, Najaf and Asselbergs, Folkert W and Bakker, Stephan and Barr, Graham and Baumeister, Sebastian and Benjamin, Daniel J and Bergmann, Sven and Boerwinkle, Eric and Bottinger, Erwin P and Campbell, Archie and Chakravarti, Aravinda and Chan, Yingleong and Chanock, Stephen and Chen, Constance and Chen, Y.-D. Ida and ... and Science for Life Laboratory, SciLifeLab and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Institutionen för immunologi, genetik och patologi and Medicinsk genetik och genomik and Kardiovaskulär epidemiologi and Uppsala universitet and Institutionen för medicinska vetenskaper and Molekylär epidemiologi
Nature: international weekly journal of science, ISSN 0028-0836, 07/2015, Volume 523, Issue 7561, pp. 459 - 462
textabstractHomozygosity has long been associated with rare, often devastating, Mendelian disorders, and Darwin was one of the first to recognize that... 
Forced Expiratory Volume - genetics | Blood Pressure - genetics | Humans | Male | Cognition | Educational Status | Body Height - genetics | Genome, Human - genetics | Lung Volume Measurements | Biological Evolution | Cholesterol, LDL - genetics | Homozygote | Phenotype | Female | Cohort Studies | Medical and Health Sciences | Medicin och hälsovetenskap
Journal Article
by Clark, David W and Okada, Yukinori and Moore, Kristjan H S and Mason, Dan and Pirastu, Nicola and Gandin, Ilaria and Mattsson, Hannele and Barnes, Catriona L K and Lin, Kuang and Zhao, Jing Hua and Deelen, Patrick and Rohde, Rebecca and Schurmann, Claudia and Guo, Xiuqing and Giulianini, Franco and Zhang, Weihua and Medina-Gomez, Carolina and Karlsson, Robert and Bao, Yanchun and Bartz, Traci M and Baumbach, Clemens and Biino, Ginevra and Bixley, Matthew J and Brumat, Marco and Chai, Jin-Fang and Corre, Tanguy and Cousminer, Diana L and Dekker, Annelot M and Eccles, David A and van Eijk, Kristel R and Fuchsberger, Christian and Gao, He and Germain, Marine and Gordon, Scott D and de Haan, Hugoline G and Harris, Sarah E and Hofer, Edith and Huerta-Chagoya, Alicia and Igartua, Catherine and Jansen, Iris E and Jia, Yucheng and Kacprowski, Tim and Karlsson, Torgny and Kleber, Marcus E and Li, Shengchao Alfred and Li-Gao, Ruifang and Mahajan, Anubha and Matsuda, Koichi and Meidtner, Karina and Meng, Weihua and Montasser, May E and van der Most, Peter J and Munz, Matthias and Nutile, Teresa and Palviainen, Teemu and Prasad, Gauri and Prasad, Rashmi B and Priyanka, Tallapragada Divya Sri and Rizzi, Federica and Salvi, Erika and Sapkota, Bishwa R and Shriner, Daniel and Skotte, Line and Smart, Melissa C and Smith, Albert Vernon and van der Spek, Ashley and Spracklen, Cassana N and Strawbridge, Rona J and Tajuddin, Salman M and Trompet, Stella and Turman, Constance and Verweij, Niek and Viberti, Clara and Wang, Lihua and Warren, Helen R and Wootton, Robyn E and Yanek, Lisa R and Yao, Jie and Yousri, Noha A and Zhao, Wei and Adeyemo, Adebowale A and Afaq, Saima and Aguilar-Salinas, Carlos Alberto and Akiyama, Masato and Albert, Matthew L and Allison, Matthew A and Alver, Maris and Aung, Tin and Azizi, Fereidoun and Bentley, Amy R and Boeing, Heiner and Boerwinkle, Eric and Borja, Judith B and de Borst, Gert J and Bottinger, Erwin P and Broer, Linda and Campbell, Harry and Chanock, Stephen and Chee, Miao-Li and Chen, Guanjie and ... and Genomik, diabetes och endokrinologi and Lund University and Genomics, Diabetes and Endocrinology and Lunds universitet and EXODIAB: Excellence in Diabetes Research in Sweden and et al
Nature Communications, ISSN 2041-1723, 10/2019, Volume 10, Issue 1
In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance... 
Medicinsk genetik | Basic Medicine | Medical Genetics | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper
Journal Article
by Clark, David W and Okada, Yukinori and Moore, Kristjan H. S and Mason, Dan and Pirastu, Nicola and Gandin, Ilaria and Mattsson, Hannele and Barnes, Catriona L. K and Lin, Kuang and Zhao, Jing Hua and Deelen, Patrick and Rohde, Rebecca and Schurmann, Claudia and Guo, Xiuqing and Giulianini, Franco and Zhang, Weihua and Medina-Gomez, Carolina and Karlsson, Robert and Bao, Yanchun and Bartz, Traci M and Baumbach, Clemens and Biino, Ginevra and Bixley, Matthew J and Brumat, Marco and Chai, Jin-Fang and Corre, Tanguy and Cousminer, Diana L and Dekker, Annelot M and Eccles, David A and Van Eijk, Kristel R and Fuchsberger, Christian and Gao, He and Germain, Marine and Gordon, Scott D and de Haan, Hugoline G and Harris, Sarah E and Hofer, Edith and Huerta-Chagoya, Alicia and Igartua, Catherine and Jansen, Iris E and Jia, Yucheng and Kacprowski, Tim and Karlsson, Torgny and Kleber, Marcus E and Li, Shengchao Alfred and Li-Gao, Ruifang and Mahajan, Anubha and Matsuda, Koichi and Meidtner, Karina and Meng, Weihua and Montasser, May E and van der Most, Peter J and Munz, Matthias and Nutile, Teresa and Palviainen, Teemu and Prasad, Gauri and Prasad, Rashmi B and Priyanka, Tallapragada Divya Sri and Rizzi, Federica and Salvi, Erika and Sapkota, Bishwa R and Shriner, Daniel and Skotte, Line and Smart, Melissa C and Smith, Albert Vernon and van der Spek, Ashley and Spracklen, Cassana N and Strawbridge, Rona J and Tajuddin, Salman M and Trompet, Stella and Turman, Constance and Verweij, Niek and Viberti, Clara and Wang, Lihua and Warren, Helen R and Wootton, Robyn E and Yanek, Lisa R and Yao, Jie and Yousri, Noha A and Zhao, Wei and Adeyemo, Adebowale A and Afaq, Saima and Alberto Aguilar-Salinas, Carlos and Akiyama, Masato and Albert, Matthew L and Allison, Matthew A and Alver, Maris and Aung, Tin and Azizi, Fereidoun and Bentley, Amy R and Boeing, Heiner and Boerwinkle, Eric and Borja, Judith B and de Borst, Gert J and Bottinger, Erwin P and Broer, Linda and Campbell, Harry and Chanock, Stephen and Chee, Miao-Li and Chen, Guanjie and ...
Nature Communications, ISSN 2041-1723, 10/2019, Volume 10
In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance... 
HOMOZYGOSITY | QUANTIFICATION | INBREEDING DEPRESSION | LOCI | RUNS | FERTILITY
Journal Article
by Clark, David W and Okada, Yukinori and Moore, Kristjan H. S and Mason, Dan and Pirastu, Nicola and Gandin, Ilaria and Mattsson, Hannele and Barnes, Catriona L. K and Lin, Kuang and Zhao, Jing Hua and Deelen, Patrick and Rohde, Rebecca and Schurmann, Claudia and Guo, Xiuqing and Giulianini, Franco and Zhang, Weihua and Medina-Gomez, Carolina and Karlsson, Robert and Bao, Yanchun and Bartz, Traci M and Baumbach, Clemens and Biino, Ginevra and Bixley, Matthew J and Brumat, Marco and Chai, Jin-Fang and Corre, Tanguy and Cousminer, Diana L and Dekker, Annelot M and Eccles, David A and van Eijk, Kristel R and Fuchsberger, Christian and Gao, He and Germain, Marine and Gordon, Scott D and de Haan, Hugoline G and Harris, Sarah E and Hofer, Edith and Huerta-Chagoya, Alicia and Igartua, Catherine and Jansen, Iris E and Jia, Yucheng and Kacprowski, Tim and Karlsson, Torgny and Kleber, Marcus E and Li, Shengchao Alfred and Li-Gao, Ruifang and Mahajan, Anubha and Matsuda, Koichi and Meidtner, Karina and Meng, Weihua and Montasser, May E and van der Most, Peter J and Munz, Matthias and Nutile, Teresa and Palviainen, Teemu and Prasad, Gauri and Prasad, Rashmi B and Priyanka, Tallapragada Divya Sri and Rizzi, Federica and Salvi, Erika and Sapkota, Bishwa R and Shriner, Daniel and Skotte, Line and Smart, Melissa C and Smith, Albert Vernon and van der Spek, Ashley and Spracklen, Cassana N and Strawbridge, Rona J and Tajuddin, Salman M and Trompet, Stella and Turman, Constance and Verweij, Niek and Viberti, Clara and Wang, Lihua and Warren, Helen R and Wootton, Robyn E and Yanek, Lisa R and Yao, Jie and Yousri, Noha A and Zhao, Wei and Adeyemo, Adebowale A and Afaq, Saima and Aguilar-Salinas, Carlos Alberto and Akiyama, Masato and Albert, Matthew L and Allison, Matthew A and Alver, Maris and Aung, Tin and Azizi, Fereidoun and Bentley, Amy R and Boeing, Heiner and Boerwinkle, Eric and Borja, Judith B and de Borst, Gert J and Bottinger, Erwin P and Broer, Linda and Campbell, Harry and Chanock, Stephen and Chee, Miao-Li and Chen, Guanjie and ...
Nature Communications, ISSN 2041-1723, 2019, Volume 10, Issue 1
In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance... 
Journal Article
by Macé, Aurélien and Tuke, Marcus A and Deelen, Patrick and Kristiansson, Kati and Mattsson, Hannele and Nõukas, Margit and Sapkota, Yadav and Schick, Ursula and Porcu, Eleonora and Rüeger, Sina and McDaid, Aaron F and Porteous, David and Winkler, Thomas W and Salvi, Erika and Shrine, Nick and Liu, Xueping and Ang, Wei Q and Zhang, Weihua and Feitosa, Mary F and Venturini, Cristina and van der Most, Peter J and Rosengren, Anders and Wood, Anew R and Beaumont, Robin N and Jones, Samuel E and Ruth, Katherine S and Yaghootkar, Hanieh and Tyrrell, Jessica and Havulinna, Aki S and Boers, Harmen and Mägi, Reedik and Kriebel, Jennifer and Müller-Nurasyid, Martina and Perola, Markus and Nieminen, Markku and Lokki, Marja-Liisa and Kähönen, Mika and Viikari, Jorma S and Geller, Frank and Lahti, Jari and Palotie, Aarno and Koponen, Päivikki and Lundqvist, Annamari and Rissanen, Harri and Bottinger, Erwin P and Afaq, Saima and Wojczynski, Mary K and Lenzini, Petra and Nolte, Ilja M and Sparsø, Thomas and Schupf, Nicole and Christensen, Kaare and Perls, Thomas T and Newman, Anne B and Werge, Thomas and Snieder, Harold and Spector, Timothy D and Chambers, John C and Koskinen, Seppo and Melbye, Mads and Raitakari, Olli T and Lehtimäki, Terho and Tobin, Martin D and Wain, Louise V and Sinisalo, Juha and Peters, Annette and Meitinger, Thomas and Martin, Nicholas G and Wray, Naomi R and Montgomery, Grant W and Medland, Sarah E and Swertz, Morris A and Vartiainen, Erkki and Borodulin, Katja and Männistö, Satu and Murray, Anna and Bochud, Murielle and Jacquemont, Sébastien and Rivadeneira, Fernando and Hansen, Thomas F and Oldehinkel, Albertine J and Mangino, Massimo and Province, Michael A and Deloukas, Panos and Kooner, Jaspal S and Freathy, Rachel M and Pennell, Craig and Feenstra, Bjarke and Strachan, David P and Lettre, Guillaume and Hirschhorn, Joel and Cusi, Daniele and Heid, Iris M and Hayward, Caroline and Männik, Katrin and Beckmann, Jacques S and Loos, Ruth J F and Nyholt, Dale R and Metspalu, Anes and Eriksson, Johan G and ...
Nature Communications, ISSN 2041-1723, 09/2017, Volume 8, Issue 1
There are few examples of robust associations between rare copy number variants (CNVs) and complex continuous human traits. Here we present a large-scale CNV... 
HUMAN HEIGHT | MICRODUPLICATION | OBESITY | VARIANTS | SNP | BODY-MASS INDEX | WILLIAMS-BEUREN-SYNDROME | DEVELOPMENTAL DELAY | DELETION SYNDROME | GENOME-WIDE ASSOCIATION
Journal Article
Journal Article
Diabetes, ISSN 0012-1797, 09/2009, Volume 58, Issue 9, pp. 2018 - 2026
ApoCIII-Enriched LDL in Type 2 Diabetes Displays Altered Lipid Composition, Increased Susceptibility for Sphingo