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RNA, ISSN 1355-8382, 05/2016, Volume 22, Issue 5, pp. 793 - 809
Pre-mRNA splicing must occur with high fidelity and efficiency for proper gene expression. The spliceosome uses DExD/H box helicases to promote on-pathway... 
Retinitis pigmentosa | Splicing fidelity | Splicing mechanism | Retinitis Pigmentosa - genetics | RNA-Binding Proteins - genetics | RNA Splicing | Catalysis | Mutation | Humans | retinitis pigmentosa | splicing fidelity | splicing mechanism
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 03/2016, Volume 23, Issue 3, pp. 189 - 190
Journal Article
Methods, ISSN 1046-2023, 08/2017, Volume 125, pp. 3 - 9
The spliceosome is not a single macromolecular machine. Rather it is a collection of dynamic heterogeneous subcomplexes that rapidly interconvert throughout... 
U1 SNRNA | U4/U6.U5 TRI-SNRNP | IN-VITRO | SPLICING FACTOR PRP8 | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | YEAST PREMESSENGER RNA | SACCHAROMYCES-CEREVISIAE | SMALL NUCLEAR RNAS | U6 SNRNA | CATALYTIC STEPS | PRE-MESSENGER-RNA | Analysis | Biochemistry | RNA
Journal Article
Biophysical Journal, ISSN 0006-3495, 02/2018, Volume 114, Issue 3, pp. 253a - 253a
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2019, Volume 116, Issue 6, pp. 2193 - 2199
Journal Article
Biophysical Journal, ISSN 0006-3495, 01/2014, Volume 106, Issue 2, pp. 496a - 496a
Journal Article
ISSN 1355-8382, 06/2018, Volume 24, Issue 6, p. 769
Prp8 is an essential protein that regulates spliceosome assembly and conformation during pre-mRNA splicing. Recent cryo-EM structures of the spliceosome model... 
Site fidelity | Splicing | Mutagenesis | Amino acids | mRNA | snRNA | Guanosinetriphosphatase
Journal Article
Circulation Research, ISSN 0009-7330, 05/2019, Volume 124, Issue 10, pp. 1420 - 1424
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 05/2017, Volume 114, Issue 18, p. 4739
Pre-mRNA splicing is an essential step of eukaryotic gene expression that requires both high efficiency and high fidelity. Prp8 has long been considered the... 
Fidelity | Errors | Eukaryotes | Splicing | Efficiency | Alleles | Crosslinking | In vitro testing | Catalysis | Ribonucleic acid--RNA | Gene expression
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 05/2017, Volume 114, Issue 18, pp. 4739 - 4744
Journal Article
Circulation research, 05/2019, Volume 124, Issue 10, pp. 1420 - 1424
Journal Article
Journal Article
Biophysical Journal, ISSN 0006-3495, 01/2012, Volume 102, Issue 3, pp. 645a - 645a
Journal Article
01/2012, ISBN 9781267913531
The assembly of bacterial 30S ribosomal subunits requires precise structural rearrangements to both its 16S rRNA and ribosomal protein components. Primary... 
Biology | Biochemistry | Biophysics
Dissertation
01/2012, ISBN 9781267913531, Volume 74, Issue 6
The assembly of bacterial 30S ribosomal subunits requires precise structural rearrangements to both its 16S rRNA and ribosomal protein components. Primary... 
Book Chapter
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