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Journal Article
PLoS Biology, ISSN 1544-9173, 04/2010, Volume 8, Issue 4, p. e1000355
Current antidepressant treatments are inadequate for many individuals, and when they are effective, they require several weeks of administration before a... 
NERVOUS-SYSTEM | DOMAIN | PROTEIN | MESSENGER-RNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOLOGY | BACKGROUND K+ CHANNEL | MAJOR DEPRESSION | RECEPTORS | HIPPOCAMPAL NEUROGENESIS | EXPRESSION | POTASSIUM CHANNEL | Humans | Adaptor Proteins, Vesicular Transport - genetics | Peptides - genetics | Cercopithecus aethiops | Motor Activity - drug effects | Depressive Disorder - drug therapy | Male | Adaptor Proteins, Vesicular Transport - metabolism | Antidepressive Agents - metabolism | Potassium Channel Blockers - metabolism | Peptides - metabolism | Adaptor Proteins, Vesicular Transport - pharmacology | Antidepressive Agents - chemistry | Drug Design | Synaptic Transmission - drug effects | Adaptor Proteins, Vesicular Transport - chemistry | Potassium Channels, Tandem Pore Domain - metabolism | Peptides - chemistry | Mice, Inbred C57BL | Potassium Channels, Tandem Pore Domain - genetics | Peptides - pharmacology | Antidepressive Agents - therapeutic use | Patch-Clamp Techniques | Animals | Raphe Nuclei - drug effects | Serotonin - metabolism | Cyclic AMP Response Element-Binding Protein - metabolism | Potassium Channels, Tandem Pore Domain - antagonists & inhibitors | Mice | COS Cells | Peptides - therapeutic use | Antidepressants | Depression, Mental | Neuropeptides | Models | Genetic aspects | Product development | Health aspects | Life Sciences | Neurons and Cognition | Proteins | Neurons | Rodents
Journal Article
Canadian Journal of Experimental Psychology, ISSN 1196-1961, 03/2018, Volume 72, Issue 1, pp. 48 - 57
Journal Article
Journal Article
FRONTIERS IN PHARMACOLOGY, ISSN 1663-9812, 01/2019, Volume 9, p. 1541
The molecular identification of sortilin, also called neurotensin receptor-3, from three different biochemical approaches already predicted the involvement of... 
DOMAIN | PROTEIN | NEUROTROPHIC FACTOR | TRAFFICKING | SERUM | protein complex | SORTILIN/NEUROTENSIN RECEPTOR-3 | spadin | sortilin | TREK-1 channel | PHARMACOLOGY & PHARMACY | CHANNELS | depression | ELECTROCONVULSIVE-THERAPY ECT | 100-KDA NEUROTENSIN RECEPTOR | BRAIN | Genetic aspects | Diagnosis | Research | Neurotensin | Gene expression | Depression, Mental | Life Sciences | Biochemistry, Molecular Biology
Journal Article
by Alexander, Stephen PH and Christopoulos, Arthur and Davenport, Anthony P and Kelly, Eamonn and Mathie, Alistair and Peters, John A and Veale, Emma L and Armstrong, Jane F and Faccenda, Elena and Harding, Simon D and Pawson, Adam J and Sharman, Joanna L and Southan, Christopher and Davies, Jamie A and Abbracchio, Maria P and Alexander, Wayne and Al-hosaini, Khaled and Bäck, Magnus and Beaulieu, Jean‐Martin and Bernstein, Kenneth E and Bettler, Bernhard and Birdsall, Nigel JM and Blaho, Victoria and Bousquet, Corinne and Bräuner-Osborne, Hans and Burnstock, Geoffrey and Caló, Girolamo and Castaño, Justo P and Catt, Kevin J and Ceruti, Stefania and Chazot, Paul and Chiang, Nan and Chun, Jerold and Cianciulli, Antonia and Clapp, Lucie H and Couture, Réjean and Csaba, Zsolt and Dent, Gordon and Singh, Khuraijam Dhanachandra and Douglas, Steven D and Dournaud, Pascal and Eguchi, Satoru and Escher, Emanuel and Filardo, Edward and Fong, Tung M and Fumagalli, Marta and Gainetdinov, Raul R and Gasparo, Marc de and Gershengorn, Marvin and Gobeil, Fernand and Goodfriend, Theodore L and Goudet, Cyril and Gregory, Karen J and Gundlach, Andrew L and Hamann, Jörg and Hanson, Julien and Hauger, Richard L and Hay, Debbie and Heinemann, Akos and Hollenberg, Morley D and Holliday, Nicholas D and Horiuchi, Mastgugu and Hoyer, Daniel and Hunyady, László and Husain, Ahsan and Ijzerman, Adriaan P and Inagami, Tadashi and Jacobson, Kenneth A and Jensen, Robert T and Jockers, Ralf and Jonnalagadda, Deepa and Karnik, Sadashiva and Kaupmann, Klemens and Kemp, Jacqueline and Kennedy, Charles and Kihara, Yasuyuki and Kozielewicz, Paweł and Kreienkamp, Hans‐Jürgen and Kukkonen, Jyrki P and Langenhan, Tobias and Leach, Katie and Lecca, Davide and Lee, John D and Leeman, Susan E and Leprince, Jérôme and Lolait, Stephen J and Lupp, Amelie and Macrae, Robyn and Maguire, Janet and Mazella, Jean and McArdle, Craig A and Melmed, Shlomo and Michel, Martin C and Miller, Laurence and Mitolo, Vincenzo and Mouillac, Bernard and Murphy, Philip M and Nahon, Jean‐Louis and Norel, Xavier and Nyimanu, Duuamene and ... and CGTP Collaborators
British Journal of Pharmacology, ISSN 0007-1188, 12/2019, Volume 176, Issue S1, pp. S21 - S141
The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key... 
PHARMACOLOGY & PHARMACY | POTENT | Proteins | Receptors | Websites | Nomenclature | Classification | Ligands | Pharmacology | Ion channels | Knowledge base | Nuclear receptors | Life Sciences | Neurons and Cognition
Journal Article
FRONTIERS IN PHARMACOLOGY, ISSN 1663-9812, 04/2019, Volume 10, p. 379
TREK-1 is the most studied background K-2P channel. Its main role is to control cell excitability and maintain the membrane potential below the threshold of... 
RILUZOLE | K-2P | potassium | K-2P CHANNELS | DOMAIN POTASSIUM CHANNEL | INSULIN-SECRETION | ARACHIDONIC-ACID | TREK-1 | ion channel | arrhythmia | FUNCTIONAL EXPRESSION | neurological disorders | PHARMACOLOGY & PHARMACY | ION CHANNELS | modulators | K+ CHANNEL | INDUCED INHIBITION | BRAIN | Life Sciences | Neurons and Cognition | Neurobiology | K2P
Journal Article
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 15311 - 10
Journal Article