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Human Mutation, ISSN 1059-7794, 10/2019, Volume 40, Issue 10, pp. 1886 - 1898
Transforming growth factor β‐activated kinase 1 (TAK1) mediates multiple biological processes through the nuclear factor κ‐light‐chain‐enhancer of activated B... 
collagen | TAK1‐TAB complex | haploinsufficiency | extracellular matrix | MAPK signaling pathways | Phenotypes | TAK1 protein | Pathogenesis | Transforming growth factor | Homeostasis | MAP kinase | mRNA | Kinases | Haploinsufficiency | Polymerase chain reaction | Signal transduction | Lymphocytes B | Protein kinase | Collagen | Fibroblasts | Extracellular matrix | Immunofluorescence
Journal Article
Marine Drugs, ISSN 1660-3397, 2018, Volume 16, Issue 12, p. 467
The ubiquitin-proteasome pathway (UPP) is the central protein degradation system in eukaryotic cells, playing a key role in homeostasis maintenance, through... 
Ubiquitin | Secondary metabolites | Marine | Natural products | Salinosporamide | High-throughput screening | Lead compounds | Cancer | Proteasome | MULTIPLE-MYELOMA | proteasome | CHEMISTRY, MEDICINAL | LIGASE ACTIVITY | SALINOSPORAMIDE-A NPI-0052 | ANTIMYELOMA ACTIVITY | high-throughput screening | lead compounds | ubiquitin | marine | salinosporamide | UBC13-UEV1A INTERACTION | natural products | BORTEZOMIB RESISTANCE | secondary metabolites | MECHANISTIC INSIGHTS | THERAPEUTIC TARGET | cancer | NF-KAPPA-B | ACTIVATING ENZYME | Drug Development - methods | Proteasome Inhibitors - pharmacology | Humans | Drug Development - trends | Proteasome Inhibitors - chemistry | Antineoplastic Agents - therapeutic use | Biological Products - pharmacology | Invertebrates - metabolism | Antineoplastic Agents - chemistry | Biological Products - isolation & purification | Proteasome Inhibitors - therapeutic use | Neoplasms - drug therapy | Proteolysis - drug effects | Biological Products - chemistry | Animals | Ubiquitin-Protein Ligase Complexes - metabolism | Signal Transduction - drug effects | Antineoplastic Agents - isolation & purification | Antineoplastic Agents - pharmacology | Proteasome Endopeptidase Complex - metabolism | Aquatic Organisms - metabolism | Proteasome Inhibitors - isolation & purification | Biological Products - therapeutic use
Journal Article
The Journal of Pathology, ISSN 0022-3417, 09/2017, Volume 243, Issue 1, pp. 123 - 134
Regulation of tumour cell proliferation by molecular chaperones is still a complex issue. Here, the role of the HSP90 molecular chaperone TRAP1 in cell cycle... 
CDK1 | TRAP1 | MAD2 | cell cycle | mitotic entry | PROTEIN | CLASSIFICATION | HEAT-SHOCK | PROLIFERATION | COLORECTAL-CARCINOMA | PATHOLOGY | MITOCHONDRIAL CHAPERONE TRAP1 | CANCER | TUMORS | MITOSIS | ONCOLOGY | DEPENDENT KINASES | CDC2 Protein Kinase | Cell Proliferation | Cyclin-Dependent Kinases - metabolism | Mad2 Proteins - metabolism | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Ki-67 Antigen - metabolism | Male | Cyclin B1 - metabolism | Ubiquitination | Transfection | Neoplasms - genetics | RNA Interference | Time Factors | Aged, 80 and over | Adult | Female | Transcription, Genetic | HSP90 Heat-Shock Proteins - genetics | Cyclin-Dependent Kinases - genetics | ATPases Associated with Diverse Cellular Activities | Signal Transduction | Neoplasms - enzymology | G2 Phase Cell Cycle Checkpoints | Mad2 Proteins - genetics | Cell Line, Tumor | HSP90 Heat-Shock Proteins - metabolism | Aged | Proteasome Endopeptidase Complex - metabolism | Neoplasms - pathology | Analysis | Cell cycle | Cell proliferation | Post-transcription | Regulations | Biotechnology | Hsp90 protein | Regulators | Deregulation | Profiling | Transcription | Gene regulation | Colorectal carcinoma | Chaperones | Machinery | Cyclin B1 | Machinery and equipment | Degradation | Proteins | Breast carcinoma | Eukaryotes | Translocation | Lung carcinoma | Tumor cell lines | Gene expression | Transit | Nuclear transport | Quality control | Breast | Biomarkers | Tumors
Journal Article
Journal Article
BBA - Bioenergetics, ISSN 0005-2728, 09/2018, Volume 1859, pp. e64 - e64
Journal Article
American Journal of Hematology, ISSN 0361-8609, 01/2013, Volume 88, Issue 1, pp. 16 - 23
Journal Article
Autoimmunity Highlights, ISSN 2038-0305, 12/2019, Volume 10, Issue 1
Journal Article
CELLS, ISSN 2073-4409, 05/2019, Volume 8, Issue 5, p. 478
Targeting metabolism represents a possible successful approach to treat cancer. Dichloroacetate (DCA) is a drug known to divert metabolism from anaerobic... 
DRUG | ONCOGENE | THERAPY | mitochondria | LIN28 | RESISTANCE | metabolism | MITOPHAGY | AGENTS | cancer stem cells | CELL BIOLOGY
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2014, Volume 57, Issue 15, pp. 6531 - 6552
Journal Article
Journal Article
British Journal of Haematology, ISSN 0007-1048, 07/2015, Volume 170, Issue 2, pp. 236 - 246
Journal Article