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index medicus (14) 14
humans (10) 10
gastroenterology & hepatology (6) 6
insulin resistance (6) 6
obesity (6) 6
type 2 diabetes (6) 6
diabetes (5) 5
female (5) 5
male (5) 5
medicine & public health (5) 5
diabetes mellitus (4) 4
diet (4) 4
endocrinology & metabolism (4) 4
gastroenterology and hepatology (4) 4
hepatology (4) 4
hypoglycemic agents - therapeutic use (4) 4
insulin (4) 4
internal medicine (4) 4
middle aged (4) 4
adult (3) 3
aged (3) 3
body mass index (3) 3
diabetes mellitus, type 2 - complications (3) 3
disease (3) 3
fatty liver (3) 3
fatty liver-disease (3) 3
follow-up (3) 3
further section (3) 3
health aspects (3) 3
insulin-resistance (3) 3
lifestyles (3) 3
metabolic diseases (3) 3
metformin - therapeutic use (3) 3
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risk (3) 3
risk factors (3) 3
surveys (3) 3
thiazolidinediones - therapeutic use (3) 3
vitamin-e (3) 3
weight control (3) 3
weight loss (3) 3
cardiovascular diseases - etiology (2) 2
cardiovascular outcomes (2) 2
conformational analysis (2) 2
diabetes mellitus, type 2 - drug therapy (2) 2
drug treatment (2) 2
enzymes (2) 2
exercise (2) 2
fibrosis (2) 2
gastroenterology (2) 2
general-population (2) 2
glucose-lowering drugs (2) 2
health surveys (2) 2
hepatitis b (2) 2
hepatitis c virus (2) 2
in-vivo (2) 2
insulin sensitizers (2) 2
integrins - antagonists & inhibitors (2) 2
kidney-disease (2) 2
life style (2) 2
lifestyle (2) 2
liver - pathology (2) 2
liver enzymes (2) 2
metaanalysis (2) 2
metabolism (2) 2
molecular docking (2) 2
non-alcoholic fatty liver disease (2) 2
non-alcoholic fatty liver disease - epidemiology (2) 2
nonalcoholic fatty liver (2) 2
nonalcoholic steatohepatitis (2) 2
nutrition & dietetics (2) 2
nutritional and metabolic diseases (2) 2
patients (2) 2
peptidomimetics (2) 2
physical activity (2) 2
physical-activity (2) 2
pioglitazone (2) 2
randomized controlled-trial (2) 2
surgery (2) 2
surveys and questionnaires (2) 2
treatment outcome (2) 2
vegetables (2) 2
abridged index medicus (1) 1
abstracts (1) 1
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adipose tissue - metabolism (1) 1
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1. Full Text NAFLD incidence and remission: Only a matter of weight gain and weight loss?
by Marchesini, Giulio and Mazzotti, Arianna
Journal of Hepatology, ISSN 0168-8278, 2014, Volume 62, Issue 1, pp. 15 - 17
Gastroenterology and Hepatology | FOLLOW-UP | GENERAL-POPULATION | RISK-FACTORS | GASTROENTEROLOGY & HEPATOLOGY | FATTY LIVER-DISEASE | INSULIN-RESISTANCE | Female | Male | Magnetic Resonance Spectroscopy - methods | Non-alcoholic Fatty Liver Disease - epidemiology | Population Surveillance | Humans | Weight loss
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2. The role of medications for the management of patients with NAFLD
by Mazzella, Natalia and Ricciardi, Laura M and Mazzotti, Arianna and Marchesini, Giulio
Clinics in Liver Disease, ISSN 1089-3261, 02/2014, Volume 18, Issue 1, pp. 73 - 89
The article is intended to provide an overview of the strengths and limits of controlled trials of pharmacologic treatment of nonalcoholic fatty liver disease.... 
Antioxidants | Nonalcoholic fatty liver disease | Insuin-sensitizers | PPAR agonists | Drug treatment | Anti-fibrotic agents | VITAMIN-E | OBESE SUBJECTS | FATTY LIVER-DISEASE | NONALCOHOLIC STEATOHEPATITIS | DELTA AGONIST | URSODEOXYCHOLIC ACID | PLACEBO-CONTROLLED TRIAL | INSULIN SENSITIZERS | RECEPTOR AGONIST | GASTROENTEROLOGY & HEPATOLOGY | AMELIORATES HEPATIC STEATOSIS | Hypoglycemic Agents - therapeutic use | Peroxisome Proliferator-Activated Receptors - agonists | Antioxidants - therapeutic use | Thiazolidinediones - therapeutic use | Metformin - therapeutic use | Humans | Insulin Resistance | Non-alcoholic Fatty Liver Disease | Hypolipidemic Agents - therapeutic use | Fatty Liver - drug therapy | Randomized Controlled Trials as Topic
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3. Heterocyclic scaffolds in the design of peptidomimetic integrin ligands: Synthetic strategies, structural aspects, and biological activity
by de Marco, Rossella and Mazzotti, Giacomo and Greco, Arianna and Gentilucci, Luca
Current Topics in Medicinal Chemistry, ISSN 1568-0266, 01/2016, Volume 16, Issue 3, pp. 343 - 359
The integrin receptors represent valuable targets for therapeutic interventions; being overexpressed in many pathological states, their inhibition can be... 
Peptidomimetic | Conformational analysis | Dipeptide scaffold | Antagonist | Heterocycle | Molecular docking | Cancer | BIFUNCTIONAL DIKETOPIPERAZINE SCAFFOLDS | CHEMISTRY, MEDICINAL | ANTITHROMBOTIC COMPOUNDS | NONPEPTIDE ALPHA(V)BETA ANTAGONISTS | CYCLIC RGD-PEPTIDOMIMETICS | BETA-PEPTIDES | FIBRINOGEN RECEPTOR ANTAGONISTS | AMINO-ACIDS | IN-VIVO | CONSTRAINED PEPTIDOMIMETICS | PHENYLALANINE DERIVATIVES | Humans | Heterocyclic Compounds - pharmacology | Heterocyclic Compounds - chemical synthesis | Heterocyclic Compounds - metabolism | Structure-Activity Relationship | Integrins - metabolism | Animals | Heterocyclic Compounds - chemistry | Peptidomimetics | Drug Design | Ligands | Molecular Structure | Integrins - antagonists & inhibitors
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4. Full Text Effects on the incidence of cardiovascular events of the addition of pioglitazone versus sulfonylureas in patients with type 2 diabetes inadequately controlled with metformin (TOSCA.IT): a randomised, multicentre trial
by Vaccaro, Olga and Masulli, Maria and Nicolucci, Antonio and Bonora, Enzo and Del Prato, Stefano and Maggioni, Aldo Pietro and Maggioni, Aldo P and Rivellese, Angela A and Rivellese, Angela Albarosa and Squatrito, Sebastiano and Giorda, Carlo B and Sesti, Giorgio and Mocarelli, Paolo and Lucisano, Giuseppe and Sacco, Michele and Signorini, Stefano and Cappellini, Fabrizio and Perriello, Gabriele and Babini, Massimiliano and Babini, Anna Carla and Lapolla, Annunziata and Gregori, Giovanna and Giordano, Carla and Corsi, Simona and Corsi, Laura and Corsi, Anna and Buzzetti, Raffaella and Clemente, Gennaro and Di Cianni, Graziano and Iannarelli, Rossella and Cordera, Renzo and La Macchia, Olga and Zamboni, Chiara and Scaranna, Cristiana and Boemi, Massimo and Iovine, Ciro and Lauro, Davide and Leotta, Sergio and Dall'Aglio, Elisabetta and Cannarsa, Emanuela and Tonutti, Laura and Pugliese, Giuseppe and Bossi, Antonio C and Bossi, Antonio Carlo and Anichini, Roberto and Dotta, Francesco and Di Benedetto, Antonino and Citro, Giuseppe and Antenucci, Daniela and Ricci, Lucia and Giorgino, Francesco and Santini, Costanza and Gnasso, Agostino and De Cosmo, Salvatore and Zavaroni, Donatella and Vedovato, Monica and Consoli, Agostino and Calabrese, Maria and di Bartolo, Paolo and Fornengo, Paolo and Riccardi, Gabriele and D'Angelo, Federica and D'Angelo, Paola and Giansanti, Roberto and Tanase, Laura and Lanari, Luigi and Testa, Ivano and Pancani, Francesca and Ranchelli, Anna and Vagheggi, Paolo and Scatona, Alessia and Fontana, Lucia and Laviola, Luigi and Tarantino, Lucia and Ippolito, Claudia and Ippolito, Giulio and Gigantelli, Vittoria and Manicone, Mariangela and Conte, Eleonora and Trevisan, Roberto and Rota, Giuseppe and Rota, Rossella and Dodesini, Alessandro R and Reggiani, Giulio Marchesini and Montesi, Luca and Mazzella, Natalia and Forlani, Gabriele and Caselli, Chiara and Di Luzio, Raffaella and Mazzotti, Arianna and Aiello, Antimo and Barrea, Angelina and Musto, Antonio and D'Amico, Fiorentina and Sinagra, Tiziana and Longhitano, Sara and Trowpea, Vanessa and Sparti, Maria and Italia, Salvatore and Lisi, Enrico and ... and Thizolidinediones Sulfonylureas Ca and Italian Diabetes Society and Thiazolidinediones Or Sulfonylureas Cardiovascular Accidents Intervention Trial (TOSCA.IT) study group
The Lancet Diabetes & Endocrinology, ISSN 2213-8587, 11/2017, Volume 5, Issue 11, pp. 887 - 897
The best treatment option for patients with type 2 diabetes in whom treatment with metformin alone fails to achieve adequate glycaemic control is debated. We... 
MORTALITY | INSULIN | GLYCEMIC CONTROL | IMPACT | METAANALYSIS | GLUCOSE-LOWERING DRUGS | ENDOCRINOLOGY & METABOLISM | FOLLOW-UP | RISK | GLIMEPIRIDE | Hypoglycemic Agents - therapeutic use | Cardiovascular Diseases - etiology | Metformin - therapeutic use | Cardiovascular Diseases - drug therapy | Humans | Middle Aged | Pioglitazone | Sulfonylurea Compounds - therapeutic use | Male | Treatment Outcome | Diabetes Mellitus, Type 2 - epidemiology | Incidence | Thiazolidinediones - therapeutic use | Cardiovascular Diseases - epidemiology | Female | Aged | Drug Therapy, Combination | Diabetes Mellitus, Type 2 - complications
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5. An internet-based approach for lifestyle changes in patients with NAFLD: Two-year effects on weight loss and surrogate markers
by Arianna Mazzotti and Maria Turchese Caletti and Lucia Brodosi and Silvia Di Domizio and Maria Luisa Forchielli and Salvatore Petta and Elisabetta Bugianesi and Giampaolo Bianchi and Giulio Marchesini
Journal of Hepatology, ISSN 0168-8278, 11/2018, Volume 69, Issue 5, p. 1155
Background & Aims: Interventions aimed at lifestyle changes are pivotal for the treatment of non-alcoholic fatty liver disease (NAFLD), and web-based programs... 
Enzymes | Alanine | Liver diseases | Physical activity | Medical treatment | Diabetes mellitus | Body weight loss | Patients | Steatosis | Body mass index | Weight control | Fatty liver | Education | Fibrosis | Alanine transaminase | Lifestyles | Diabetes mellitus (non-insulin dependent)
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6. Full Text Which treatment for type 2 diabetes associated with non-alcoholic fatty liver disease?
by Mazzotti, Arianna and Caletti, Maria Turchese and Marchignoli, Francesca and Forlani, Giulia and Marchesini, Giulio
Digestive and Liver Disease, ISSN 1590-8658, 2017, Volume 49, Issue 3, pp. 235 - 240
Abstract Type 2 diabetes (T2DM) and nonalcoholic fatty liver disease (NAFLD) are highly prevalent in the community, and share common pathogenic mechanisms.... 
Gastroenterology and Hepatology | Incretins | Glucose-lowering drugs | Metformin | Insulin | Thiazolidinediones | Na-glucose cotransport 2 | KIDNEY-DISEASE | METFORMIN | VITAMIN-E | PLACEBO | CARDIOVASCULAR OUTCOMES | RECEPTOR AGONISTS | SITAGLIPTIN | WEIGHT-LOSS | RISK | RANDOMIZED CONTROLLED-TRIAL | Metformin Na-glucose cotransport 2 | GASTROENTEROLOGY & HEPATOLOGY | Hypoglycemic Agents - therapeutic use | Non-alcoholic Fatty Liver Disease - pathology | Liver - pathology | Thiazolidinediones - therapeutic use | Metformin - therapeutic use | Humans | Insulin Resistance | Triglycerides - blood | Diabetes Mellitus, Type 2 - drug therapy | Non-alcoholic Fatty Liver Disease - epidemiology | Diabetes Mellitus, Type 2 - complications | Type 2 diabetes | Fatty liver | Development and progression | Drug therapy | Risk factors | Diabetes therapy | Glucose | Dextrose
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7. Full Text Pharmacotherapy of type 2 diabetes in patients with chronic liver disease: focus on nonalcoholic fatty liver disease
by Raschi, Emanuel and Mazzotti, Arianna and Poluzzi, Elisabetta and De Ponti, Fabrizio and Marchesini, Giulio
Expert Opinion on Pharmacotherapy, ISSN 1465-6566, 11/2018, Volume 19, Issue 17, pp. 1903 - 1914
Introduction: Pharmacotherapy used to treat type 2 diabetes mellitus (T2DM) is facing a paradigm shift in clinical practice with recent cardiovascular (CV)... 
treatment | chronic liver disease | Nonalcoholic fatty liver disease | type 2 diabetes | drug-induce liver injury | KIDNEY-DISEASE | CONTROLLED-TRIAL | VITAMIN-E | CARDIOVASCULAR OUTCOMES | AMERICAN ASSOCIATION | INTRAHEPATIC LIPID-CONTENT | PIOGLITAZONE | METFORMIN USE | PHARMACOLOGY & PHARMACY | COTRANSPORTER 2 INHIBITOR | STEATOHEPATITIS | Hypoglycemic Agents - therapeutic use | Insulin - metabolism | Humans | Insulin Resistance | Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Pioglitazone - therapeutic use | Non-alcoholic Fatty Liver Disease - drug therapy
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8. Full Text Dietary intake and major food sources of polyphenols in people with type 2 diabetes: The TOSCA.IT Study
by Vitale, M and Vitale, M and Masulli, M and Masulli, M and Rivellese, A A and Rivellese, A A and Bonora, E and Bonora, E and Cappellini, F and Cappellini, F and Nicolucci, A and Nicolucci, A and Squatrito, S and Squatrito, S and Antenucci, D and Antenucci, D and Barrea, A and Barrea, A and Bianchi, C and Bianchi, C and Bianchini, F and Bianchini, F and Fontana, L and Fontana, L and Fornengo, P and Fornengo, P and Giorgino, F and Giorgino, F and Gnasso, A and Gnasso, A and Mannucci, E and Mannucci, E and Mazzotti, A and Mazzotti, A and Nappo, R and Nappo, R and Palena, A P and Palena, A P and Pata, P and Pata, P and Perriello, G and Perriello, G and Potenziani, S and Potenziani, S and Radin, R and Radin, R and Ricci, L and Ricci, L and Romeo, F and Romeo, F and Santini, C and Santini, C and Scarponi, M and Scarponi, M and Serra, R and Serra, R and Timi, A and Timi, A and Turco, A A and Turco, A A and Vedovato, M and Vedovato, M and Zavaroni, D and Zavaroni, D and Grioni, S and Grioni, S and Riccardi, G and Riccardi, G and Vaccaro, O and Vaccaro, O and TOSCAIT Study Grp and on behalf of the TOSCA.IT Study Group
European Journal of Nutrition, ISSN 1436-6207, 3/2018, Volume 57, Issue 2, pp. 679 - 688
Proper evaluation of polyphenols intake at the population level is a necessary step in order to establish possible associations with health outcomes. Available... 
Nutrition | TOSCA.IT study | Phenolic acids | Food groups | Chemistry | Flavonoids | Diet | Polyphenols | Geographical area | Intake | Diabetes | Age | BMI | METAANALYSIS | PREVENTION | RISK | TRIAL | NUTRITION & DIETETICS | LIPID PROFILE | DISEASE | LOW-GRADE INFLAMMATION | COHORT | HEALTH | Type 2 diabetes | Diet therapy | Legumes | Vegetables | Food sources | Oils | Cakes | Anthropometry | Diabetes mellitus | Chocolate | Dietary intake | Tubers | Databases | Food intake | Phenols | Alcoholic beverages | Beverages | Diabetes mellitus (non-insulin dependent) | Food
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9. Full Text 5-aminomethyloxazolidine-2,4-dione hybrid α/β-dipeptide scaffolds as inductors of constrained conformations: Applications to the synthesis of integrin antagonists
: Amo Scaffolds as Inductors of Constrained Conformations
by De Marco, Rossella and Mazzotti, Giacomo and Dattoli, Samantha D and Baiula, Monica and Spampinato, Santi and Greco, Arianna and Gentilucci, Luca
Biopolymers, ISSN 0006-3525, 09/2015, Volume 104, Issue 5, pp. 636 - 649
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10. Full Text An internet-based approach for lifestyle changes in patients with NAFLD: Two-year effects on weight loss and surrogate markers
by Mazzotti, Arianna and Caletti, Maria Turchese and Brodosi, Lucia and Di Domizio, Silvia and Forchielli, Maria Luisa and Petta, Salvatore and Bugianesi, Elisabetta and Bianchi, Giampaolo and Marchesini, Giulio
Journal of Hepatology, ISSN 0168-8278, 11/2018, Volume 69, Issue 5, pp. 1155 - 1163
Interventions aimed at lifestyle changes are pivotal for the treatment of non-alcoholic fatty liver disease (NAFLD), and web-based programs might help remove... 
NAFLD progression | Liver enzymes | Diet | Physical activity | COGNITIVE-BEHAVIORAL TREATMENT | MANAGEMENT | SCORE | RANDOMIZED CONTROLLED-TRIAL | NONALCOHOLIC FATTY LIVER | OBESITY | DISEASE | OVERWEIGHT | PHYSICAL-ACTIVITY | GASTROENTEROLOGY & HEPATOLOGY | INTERVENTION
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11. Full Text 5‐aminomethyloxazolidine‐2,4‐dione hybrid α/β‐dipeptide scaffolds as inductors of constrained conformations: Applications to the synthesis of integrin antagonists
by De Marco, Rossella and Mazzotti, Giacomo and Dattoli, Samantha D and Baiula, Monica and Spampinato, Santi and Greco, Arianna and Gentilucci, Luca
Peptide Science, ISSN 0006-3525, 09/2015, Volume 104, Issue 5, pp. 636 - 649
ABSTRACT Peptidomimetics represent an attractive starting point for drug discovery programs; in particular, peptidomimetics that result from the incorporation... 
freidinger lactam | β2‐amino acid | conformational analysis | jurkat cells | integrin inhibitor | β2-amino acid | beta 2-amino acid | ENDOMORPHIN-1 ANALOGS | ALPHABETA INTEGRIN | SIDE-CHAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENZYMATIC-HYDROLYSIS | VLA-4 ANTAGONISTS | MOLECULAR DOCKING | BETA-AMINO ACIDS | BIOPHYSICS | RING-CLOSING METATHESIS | IN-VIVO | MONOCLONAL-ANTIBODIES | Small Molecule Libraries - chemical synthesis | Small Molecule Libraries - chemistry | Peptidomimetics | Molecular Conformation | Integrins - antagonists & inhibitors | Oxazolidinones - chemistry | Correlation | Stability | Parents | Affinity | Serums | Scaffolds | Biopolymers | Inductors | Adhesion
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12. Full Text Trend over time in hepatic fibrosis score in a cohort of type 2 diabetes patients
by Giorda, Carlo Bruno and Forlani, Gabriele and Manti, Roberta and Mazzotti, Arianna and De Cosmo, Salvatore and Rossi, Maria Chiara and Nicolucci, Antonio and Di Bartolo, Paolo and Ceriello, Antonio and Guida, Pietro and Tartaglino, Barbara and Russo, Giuseppina and AMD-Annals Study Grp
Diabetes Research and Clinical Practice, ISSN 0168-8227, 01/2018, Volume 135, pp. 65 - 72
The prevalence and progression of hepatic fibrosis and its correlated factors in type 2 diabetes (T2DM) are poorly known. We aimed to define the percentage of... 
Nonalcoholic steatohepatitis | Risk of cirrhosis | Diabetes mellitus | Fibrosis 4 score | NONALCOHOLIC FATTY LIVER | MRI | DISEASE | ENDOCRINOLOGY & METABOLISM | CARE
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13. Full Text Pathophysiology of Nonalcoholic Fatty Liver Disease: Lifestyle-Gut-Gene Interaction
by Mazzotti, Arianna and Caletti, Maria Turchese and Sasdelli, Anna Simona and Brodosi, Lucia and Marchesini, Giulio
Digestive Diseases, ISSN 0257-2753, 08/2016, Volume 34, Issue 1, pp. 3 - 10
Background: The accumulation of fat droplets in the hepatic parenchyma is driven by several factors, synergistically acting to increase triglyceride flow to... 
Nonalcoholic Fatty Liver Disease | Obesity | Microbiota | Nonalcoholic fatty liver disease | Diet | Genes | FIBROSIS | VARIANTS | MICROBIOME | HUMANS | NASH | METABOLISM | INSULIN-RESISTANCE | PNPLA3 | GASTROENTEROLOGY & HEPATOLOGY | HEPATIC STEATOSIS | SEVERITY | Cardiovascular Diseases - etiology | Life Style | Liver - pathology | Non-alcoholic Fatty Liver Disease - genetics | Diet - adverse effects | Obesity - complications | Humans | Liver - metabolism | Adipose Tissue - pathology | Gastrointestinal Microbiome | Insulin Resistance | Non-alcoholic Fatty Liver Disease - etiology | Non-alcoholic Fatty Liver Disease - physiopathology | Lipolysis | Obesity - metabolism | Polymorphism, Genetic | Triglycerides - metabolism | Adipose Tissue - metabolism | Liver Diseases - etiology | Lipogenesis | Index Medicus
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14. Full Text Insulin resistance: mechanism and implications for carcinogenesis and hepatocellular carcinoma in NASH
by Montesi, Luca and Montesi, Luca and Mazzotti, Arianna and Mazzotti, Arianna and Moscatiello, Simona and Moscatiello, Simona and Forlani, Gabriele and Forlani, Gabriele and Marchesini, Giulio and Marchesini, Giulio
Hepatology International, ISSN 1936-0533, 12/2013, Volume 7, Issue S2, pp. 814 - 822
The effects of insulin resistance in human diseases are of paramount importance. Since the original proposal by the WHO indicating insulin resistance as the... 
Insulin sensitizers | Medicine & Public Health | Colorectal Surgery | Hepatology | Surgery | Drug treatment | Insulin secretagogs | Insulin | Glucagon-like peptide 1 | GASTROENTEROLOGY & HEPATOLOGY | Complications and side effects | Insulin resistance | Fatty liver | Hepatoma | Research | Risk factors
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