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Cell Reports, ISSN 2211-1247, 10/2018, Volume 25, Issue 4, pp. 1018 - 1026.e4
Neomorphic mutations in NADP-dependent isocitrate dehydrogenases ( and ) contribute to tumorigenesis in several cancers. Although significant research has... 
NADPH | metabolic flux analysis | deuterium | IDH1 | IDH2 | redox metabolism | 2-hydroxyglutrate (2HG) | metabolism | cancer
Journal Article
Cancer Research, ISSN 0008-5472, 04/2011, Volume 71, Issue 8 Supplement, pp. 1268 - 1268
Journal Article
Journal Article
Science, ISSN 0036-8075, 2019, Volume 363, Issue 6432, pp. 1217 - 1222
Journal Article
Blood, ISSN 0006-4971, 05/2012, Volume 119, Issue 20, pp. 4686 - 4697
Journal Article
Cell, ISSN 0092-8674, 09/2018, Volume 175, Issue 1, pp. 101 - 116.e25
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 04/2018, Volume 115, Issue 16, pp. E3741 - E3748
Journal Article
Cell Reports, ISSN 2211-1247, 10/2018, Volume 25, Issue 4, pp. 1018 - 1026.e4
Neomorphic mutations in NADP-dependent isocitrate dehydrogenases (IDH1 and IDH2) contribute to tumorigenesis in several cancers. Although significant research... 
NADPH | metabolic flux analysis | deuterium | IDH1 | IDH2 | redox metabolism | 2-hydroxyglutrate (2HG) | cancer | metabolism | SUPPORT | STEM-CELLS | PENTOSE-PHOSPHATE PATHWAY | ACID | METABOLISM | MUTANT IDH1 | ALPHA-KETOGLUTARATE | INHIBITOR | TUMOR-GROWTH | CANCER | CELL BIOLOGY
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2012, Volume 7, Issue 7, p. e41455
The nucleoside analogues 8-amino-adenosine and 8-chloro-adenosine have been investigated in the context of B-lineage lymphoid malignancies by our laboratories... 
OXIDATIVE STRESS | IN-VITRO | ILLUMINA MICROARRAY | MULTIDISCIPLINARY SCIENCES | 8-CHLORO-ADENOSINE | LEUKEMIA-CELLS | LYMPHOMA | CLASSIFICATION | DEPLETION | MULTIPLE-MYELOMA CELLS | GLUCOSE-6-PHOSPHATE-DEHYDROGENASE G6PD | Gene Expression Regulation, Enzymologic - drug effects | Pentose Phosphate Pathway - drug effects | Glucosephosphate Dehydrogenase - biosynthesis | 2-Chloroadenosine - pharmacology | Humans | Lymphoma, Mantle-Cell - pathology | 2-Chloroadenosine - analogs & derivatives | Gene Expression Profiling | Hematologic Neoplasms - enzymology | Hematologic Neoplasms - pathology | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Neoplasm Proteins - metabolism | RNA, Neoplasm - metabolism | Multiple Myeloma - drug therapy | RNA, Neoplasm - antagonists & inhibitors | Gene Expression Regulation, Neoplastic - drug effects | Multiple Myeloma - enzymology | Neoplasm Proteins - genetics | Lymphoma, Mantle-Cell - genetics | Gene Expression Regulation, Neoplastic - genetics | Drug Screening Assays, Antitumor - methods | Lymphoma, Mantle-Cell - drug therapy | Adenosine - pharmacology | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Drug Resistance, Neoplasm - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - enzymology | Multiple Myeloma - pathology | Gene Expression Regulation, Enzymologic - genetics | Lymphoma, Mantle-Cell - enzymology | Adenosine - analogs & derivatives | Cell Line, Tumor | Hematologic Neoplasms - drug therapy | RNA, Neoplasm - genetics | Hematologic Neoplasms - genetics | Pentose Phosphate Pathway - genetics | Glucosephosphate Dehydrogenase - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Clinical Trials, Phase I as Topic | Multiple Myeloma - genetics | Drug Resistance, Neoplasm - drug effects | Phosphates | Enzymes | RNA | Genes | Nucleosides | B cells | Non-Hodgkin's lymphomas | Gene expression | Drugs | Biotechnology | Dehydrogenases | Transcription | Toxicity | Leukemia | Multiple myeloma | Cytotoxicity | Glucose | Kinases | Neoplasms | Anticancer properties | Glucose 6 phosphate dehydrogenase | Glucose dehydrogenase | Antitumor agents | Rodents | Pentose | Cell cycle | Glucosephosphate dehydrogenase | Bioinformatics | Pentose phosphate | Adenosine | Chronic lymphatic leukemia | Hematology | Pharmacology | Lymphatic leukemia | Tumor cell lines | Ribonucleic acid--RNA | Lymphoma | Lymphocytes B | Medical prognosis | Cell lines | Mantle cell lymphoma | Pentose phosphate pathway | Lymphomas | Nucleoside analogs | Tumors | Cancer | Apoptosis | Ribonucleic acid
Journal Article