Nature Neuroscience, ISSN 1097-6256, 05/2018, Volume 21, Issue 5, pp. 744 - 756
Behaviorally and pathologically relevant cortico-thalamo-cortical oscillations are driven by diverse interacting cell-intrinsic and synaptic processes....
CELLS | SLEEP | RECORDINGS | SPIKE-WAVE DISCHARGES | NEURONS | NETWORK MECHANISMS | BURST | MODEL | EPILEPSY | NEUROSCIENCES | RETICULARIS | Rats, Wistar | Rats | Male | Calcium Channels, T-Type | Electroencephalography | Recruitment, Neurophysiological | Cerebral Cortex - physiopathology | Action Potentials - physiology | Seizures - physiopathology | Feedback, Physiological | Animals | Thalamus - physiopathology | Computer Simulation | Neurons - physiology | Neural Pathways - physiopathology | Neurons | Epilepsy | Research | Seizing | Calcium | Cortex | Oscillations | Thalamus | Inhibition | Feedforward | Calcium channels (T-type) | Calcium ions | Seizures | Life Sciences | Neurons and Cognition | Neurobiology | microdialysis | thalamic ventrobasal nucleus | T-type Ca2+ channels | feed-forward GABA-A inhibition | thalamic reticular nucleus | ensemble recordings | neocortex
CELLS | SLEEP | RECORDINGS | SPIKE-WAVE DISCHARGES | NEURONS | NETWORK MECHANISMS | BURST | MODEL | EPILEPSY | NEUROSCIENCES | RETICULARIS | Rats, Wistar | Rats | Male | Calcium Channels, T-Type | Electroencephalography | Recruitment, Neurophysiological | Cerebral Cortex - physiopathology | Action Potentials - physiology | Seizures - physiopathology | Feedback, Physiological | Animals | Thalamus - physiopathology | Computer Simulation | Neurons - physiology | Neural Pathways - physiopathology | Neurons | Epilepsy | Research | Seizing | Calcium | Cortex | Oscillations | Thalamus | Inhibition | Feedforward | Calcium channels (T-type) | Calcium ions | Seizures | Life Sciences | Neurons and Cognition | Neurobiology | microdialysis | thalamic ventrobasal nucleus | T-type Ca2+ channels | feed-forward GABA-A inhibition | thalamic reticular nucleus | ensemble recordings | neocortex
Journal Article
Psychopharmacology, ISSN 0033-3158, 1/2019, Volume 236, Issue 1, pp. 265 - 272
Post-traumatic stress disorder (PTSD) is a devastating anxiety-related disorder which develops subsequent to a severe psychologically traumatic event. Only ~...
mGlu 7 receptor expression | Neurosciences | Biomedicine | Post-traumatic stress disorder | Pharmacology/Toxicology | Psychiatry | Trauma | mGlu | receptor expression | mGlu receptor expression | POSTTRAUMATIC-STRESS-DISORDER | ANTIDEPRESSANT | ACTIVATION | ANXIETY | PSYCHIATRY | MGLU | ACQUISITION | NEUROSCIENCES | ANIMAL-MODELS | PHARMACOLOGY & PHARMACY | MICE | HEART-RATE DYNAMICS | WORKING-MEMORY | Extinction (Psychology) | Fear | Messenger RNA | Physiological aspects | Genetic aspects | Research | Neurological research | Brain | Cortex (prefrontal) | Subdivisions | Amygdala | Mental disorders | Cognitive ability | Posttraumatic stress disorder | Glutamic acid receptors | mRNA | Fear conditioning | Strain | Dentate gyrus | Post traumatic stress disorder | Rodents | Genetics | Inbreeding | Mice | Anxiety | Glutamic acid receptors (metabotropic) | Hippocampus | mGlu7 receptor expression
mGlu 7 receptor expression | Neurosciences | Biomedicine | Post-traumatic stress disorder | Pharmacology/Toxicology | Psychiatry | Trauma | mGlu | receptor expression | mGlu receptor expression | POSTTRAUMATIC-STRESS-DISORDER | ANTIDEPRESSANT | ACTIVATION | ANXIETY | PSYCHIATRY | MGLU | ACQUISITION | NEUROSCIENCES | ANIMAL-MODELS | PHARMACOLOGY & PHARMACY | MICE | HEART-RATE DYNAMICS | WORKING-MEMORY | Extinction (Psychology) | Fear | Messenger RNA | Physiological aspects | Genetic aspects | Research | Neurological research | Brain | Cortex (prefrontal) | Subdivisions | Amygdala | Mental disorders | Cognitive ability | Posttraumatic stress disorder | Glutamic acid receptors | mRNA | Fear conditioning | Strain | Dentate gyrus | Post traumatic stress disorder | Rodents | Genetics | Inbreeding | Mice | Anxiety | Glutamic acid receptors (metabotropic) | Hippocampus | mGlu7 receptor expression
Journal Article
Epilepsia, ISSN 0013-9580, 12/2015, Volume 56, Issue 12, pp. e198 - e202
Summary Focal temporal lobe seizures often cause impaired cortical function and loss of consciousness. Recent work suggests that the mechanism for depressed...
Neurostimulation | Optogenetics | Acetylcholine | Consciousness | Sudden unexpected death in epilepsy (SUDEP) | Epilepsy | SLEEP | AROUSAL | BEHAVIOR | IMPAIRED CONSCIOUSNESS | MODULATION | CLINICAL NEUROLOGY | Optogenetics - methods | Pedunculopontine Tegmental Nucleus - physiopathology | Rats, Long-Evans | Channelrhodopsins | Rats | Male | Limbic Lobe - physiopathology | Cerebral Cortex - physiopathology | Cholinergic Neurons - physiology | Seizures - physiopathology | Animals | Female | Brain Stem - physiopathology | Photic Stimulation | Disease Models, Animal | Physiological aspects | Seizures (Medicine) | Neurons | Rodents | Brainstem
Neurostimulation | Optogenetics | Acetylcholine | Consciousness | Sudden unexpected death in epilepsy (SUDEP) | Epilepsy | SLEEP | AROUSAL | BEHAVIOR | IMPAIRED CONSCIOUSNESS | MODULATION | CLINICAL NEUROLOGY | Optogenetics - methods | Pedunculopontine Tegmental Nucleus - physiopathology | Rats, Long-Evans | Channelrhodopsins | Rats | Male | Limbic Lobe - physiopathology | Cerebral Cortex - physiopathology | Cholinergic Neurons - physiology | Seizures - physiopathology | Animals | Female | Brain Stem - physiopathology | Photic Stimulation | Disease Models, Animal | Physiological aspects | Seizures (Medicine) | Neurons | Rodents | Brainstem
Journal Article
CNS Neuroscience & Therapeutics, ISSN 1755-5930, 08/2018, Volume 24, Issue 8, pp. 745 - 758
PHARMACOLOGY & PHARMACY | INHIBITION | EPILEPSY | NEUROSCIENCES | Seizures - genetics | Calcium Channels - metabolism | Humans | Mice, Transgenic | Electroencephalography | Mutation - genetics | Seizures - therapy | Animals | Receptors, GABA-A - genetics | Mice | Receptors, GABA-A - metabolism | RNA Interference - physiology | Calcium Channels - genetics | Disease Models, Animal | Genetic Therapy - methods | Seizures
Journal Article
Nature Neuroscience, ISSN 1097-6256, 2018, Volume 21, pp. 744 - 756
Behaviorally and pathologically relevant cortico-thalamo-cortical oscillations are driven by diverse interacting cell-intrinsic and synaptic processes....
Life Sciences | Neurons and Cognition | Neurobiology
Life Sciences | Neurons and Cognition | Neurobiology
Journal Article
The Journal of Neuroscience, ISSN 0270-6474, 11/2017, Volume 37, Issue 47, p. 11441
The thalamus plays diverse roles in cortical-subcortical brain activity patterns. Recent work suggests that focal temporal lobe seizures depress subcortical...
Seizing | Brain | Temporal lobe | Firing pattern | Propagation | Epilepsy | Cortex | Switching theory | Cognition | Nuclei | Activity patterns | Quality of life | Thalamic nuclei | Sleep | Information flow | Arousal | Slow waves | Thalamus | Spindles | Cortex (temporal) | Seizures
Seizing | Brain | Temporal lobe | Firing pattern | Propagation | Epilepsy | Cortex | Switching theory | Cognition | Nuclei | Activity patterns | Quality of life | Thalamic nuclei | Sleep | Information flow | Arousal | Slow waves | Thalamus | Spindles | Cortex (temporal) | Seizures
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 02/2013, Volume 33, Issue 9, pp. 3780 - 3785
Tonic inhibitory GABA(A) receptor-mediated currents are observed in numerous cell types in the CNS, including thalamocortical neurons of the ventrobasal...
Electric Stimulation | Cyclic AMP-Dependent Protein Kinases - pharmacology | Rats, Wistar | Receptors, GABA-B - deficiency | Male | Receptors, GABA-A - deficiency | Drug Interactions | Neurons - physiology | Female | Tetrodotoxin - pharmacology | Neurons - drug effects | Guanosine Diphosphate - pharmacology | Cyclic AMP-Dependent Protein Kinases - metabolism | Membrane Potentials - drug effects | Neural Inhibition - genetics | Synapses - drug effects | Brain - cytology | Adenine - analogs & derivatives | Synapses - physiology | Enzyme Inhibitors - pharmacology | Rats | Receptors, GABA-B - physiology | Sodium Channel Blockers - pharmacology | Adenine - pharmacology | Signal Transduction - genetics | Biophysics | Thionucleotides - pharmacology | Membrane Potentials - physiology | Mice, Knockout | GABA Agents - pharmacology | Patch-Clamp Techniques | Animals | Guanosine Diphosphate - analogs & derivatives | Signal Transduction - drug effects | Mice | Mice, Inbred BALB C | Receptors, GABA-A - metabolism | In Vitro Techniques | Neural Inhibition - drug effects
Electric Stimulation | Cyclic AMP-Dependent Protein Kinases - pharmacology | Rats, Wistar | Receptors, GABA-B - deficiency | Male | Receptors, GABA-A - deficiency | Drug Interactions | Neurons - physiology | Female | Tetrodotoxin - pharmacology | Neurons - drug effects | Guanosine Diphosphate - pharmacology | Cyclic AMP-Dependent Protein Kinases - metabolism | Membrane Potentials - drug effects | Neural Inhibition - genetics | Synapses - drug effects | Brain - cytology | Adenine - analogs & derivatives | Synapses - physiology | Enzyme Inhibitors - pharmacology | Rats | Receptors, GABA-B - physiology | Sodium Channel Blockers - pharmacology | Adenine - pharmacology | Signal Transduction - genetics | Biophysics | Thionucleotides - pharmacology | Membrane Potentials - physiology | Mice, Knockout | GABA Agents - pharmacology | Patch-Clamp Techniques | Animals | Guanosine Diphosphate - analogs & derivatives | Signal Transduction - drug effects | Mice | Mice, Inbred BALB C | Receptors, GABA-A - metabolism | In Vitro Techniques | Neural Inhibition - drug effects
Journal Article
Cerebral cortex (New York, N.Y. : 1991), ISSN 1047-3211, 03/2017, Volume 27, Issue 3, pp. 1964 - 1975
Impaired consciousness occurs suddenly and unpredictably in people with epilepsy, markedly worsening quality of life and increasing risk of mortality. Focal...
epilepsy | consciousness | intralaminar thalamus | pontine reticular formation | neurostimulation | PONTINE RETICULAR-FORMATION | TEMPORAL-LOBE EPILEPSY | NEUROSCIENCES | PEDUNCULOPONTINE NUCLEUS | CHOLINERGIC AROUSAL | THALAMIC-STIMULATION | ELECTRICAL-STIMULATION | EYE-MOVEMENT SLEEP | QUALITY-OF-LIFE | IMPAIRED CONSCIOUSNESS | PARKINSONS-DISEASE | Pons - physiopathology | Consciousness - physiology | Intralaminar Thalamic Nuclei - physiopathology | Seizures - complications | Seizures - therapy | Rats, Sprague-Dawley | Consciousness Disorders - therapy | Deep Brain Stimulation - methods | Epilepsies, Partial - physiopathology | Consciousness Disorders - etiology | Exploratory Behavior - physiology | Neural Inhibition - physiology | Seizures - physiopathology | Arousal - physiology | Animals | Female | Epilepsies, Partial - therapy | Consciousness Disorders - physiopathology | Disease Models, Animal | Epilepsies, Partial - complications | Original
epilepsy | consciousness | intralaminar thalamus | pontine reticular formation | neurostimulation | PONTINE RETICULAR-FORMATION | TEMPORAL-LOBE EPILEPSY | NEUROSCIENCES | PEDUNCULOPONTINE NUCLEUS | CHOLINERGIC AROUSAL | THALAMIC-STIMULATION | ELECTRICAL-STIMULATION | EYE-MOVEMENT SLEEP | QUALITY-OF-LIFE | IMPAIRED CONSCIOUSNESS | PARKINSONS-DISEASE | Pons - physiopathology | Consciousness - physiology | Intralaminar Thalamic Nuclei - physiopathology | Seizures - complications | Seizures - therapy | Rats, Sprague-Dawley | Consciousness Disorders - therapy | Deep Brain Stimulation - methods | Epilepsies, Partial - physiopathology | Consciousness Disorders - etiology | Exploratory Behavior - physiology | Neural Inhibition - physiology | Seizures - physiopathology | Arousal - physiology | Animals | Female | Epilepsies, Partial - therapy | Consciousness Disorders - physiopathology | Disease Models, Animal | Epilepsies, Partial - complications | Original
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 11/2017, Volume 37, Issue 47, pp. 11441 - 11454
The thalamus plays diverse roles in cortical-subcortical brain activity patterns. Recent work suggests that focal temporal lobe seizures depress subcortical...
Temporal lobe epilepsy | Thalamus | Juxtacellular recording | Sleep | Consciousness | Burst firing | TONIC-CLONIC SEIZURES | temporal lobe epilepsy | RELAY CELLS | consciousness | TEMPORAL-LOBE EPILEPSY | SUBCORTICAL STRUCTURES | burst firing | NEUROSCIENCES | juxtacellular recording | sleep | ANTERIOR NUCLEUS | FUNCTIONAL-ANATOMY | ELECTRICAL-STIMULATION | IMPROVE LEVEL | CELLULAR MECHANISMS | IMPAIRED CONSCIOUSNESS | thalamus | Brain Waves | Rats | Epilepsy, Temporal Lobe - physiopathology | Rats, Sprague-Dawley | Thalamic Nuclei - physiology | Seizures - physiopathology | Thalamic Nuclei - physiopathology | Temporal Lobe - physiopathology | Animals | Limbic System - physiology | Limbic System - physiopathology | Female | Temporal Lobe - physiology | Sleep - physiology
Temporal lobe epilepsy | Thalamus | Juxtacellular recording | Sleep | Consciousness | Burst firing | TONIC-CLONIC SEIZURES | temporal lobe epilepsy | RELAY CELLS | consciousness | TEMPORAL-LOBE EPILEPSY | SUBCORTICAL STRUCTURES | burst firing | NEUROSCIENCES | juxtacellular recording | sleep | ANTERIOR NUCLEUS | FUNCTIONAL-ANATOMY | ELECTRICAL-STIMULATION | IMPROVE LEVEL | CELLULAR MECHANISMS | IMPAIRED CONSCIOUSNESS | thalamus | Brain Waves | Rats | Epilepsy, Temporal Lobe - physiopathology | Rats, Sprague-Dawley | Thalamic Nuclei - physiology | Seizures - physiopathology | Thalamic Nuclei - physiopathology | Temporal Lobe - physiopathology | Animals | Limbic System - physiology | Limbic System - physiopathology | Female | Temporal Lobe - physiology | Sleep - physiology
Journal Article
2014
Absence seizures (ASs) are the predominant form of seizure featuring in the idiopathic generalised epilepsies, and are the only seizure type of childhood...
RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Dissertation
The Sun, ISSN 0307-2681, 01/2008
[Pippa] reveals: "I don't know why but I never get chatted up. Maybe I'm giving out the wrong signals. "I'm not used to being single but I'm feeling good about...
Newspaper Article
The Sun, ISSN 0307-2681, 05/2007
SEXY Pippa O'Connor may be pals with ex-Miss World Rosanna Davison and dating a millionaire -but she insists: "I'll make it on my own". "But that is where the...
Newspaper Article
Daily Mail, ISSN 0307-7578, 07/2007
There will be no squinting windows. Everybody gets champagne, one thousand bottles of Dom Perignon for the toast, and 'his and hers' themed menus courtesy of...
Newspaper Article
11/1946, Volume 25, Issue 3
THE cement man came in to use the phone. He stopped in the middle of the kitchen and burst out laughing. "So that's how you know to the inch how you want...
Magazine Article
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