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Cancer Research, ISSN 0008-5472, 03/2011, Volume 71, Issue 5, pp. 1849 - 1857
Journal Article
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2005, Volume 48, Issue 22, pp. 6772 - 6775
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 09/2016, Volume 7, Issue 9, pp. 857 - 861
In an effort to develop a novel therapeutic agent aimed at addressing the unmet need of patients with osteoarthritis pain, we set out to develop an inhibitor... 
tool molecule | LPA | Autotaxin | osteoarthritis | SITE | CHEMISTRY, MEDICINAL | ARTHRITIS | LYSOPHOSPHATIDIC ACID PRODUCTION | MOTILITY
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2008, Volume 51, Issue 7, pp. 2302 - 2306
Journal Article
Investigational New Drugs, ISSN 0167-6997, 6/2012, Volume 30, Issue 3, pp. 936 - 949
LY2457546 is a potent and orally bioavailable inhibitor of multiple receptor tyrosine kinases involved in angiogenic and tumorigenic signalling. In biochemical... 
AML | Sunitinib | Medicine & Public Health | LY2457546 | Xenograft efficacy | Oncology | Multikinase inhibitor | Pharmacology/Toxicology | In vivo target inhibition | ACTIVATION | HAIR | TYROSINE KINASE | ACUTE MYELOID-LEUKEMIA | ANTITUMOR-ACTIVITY | GENE | ONCOLOGY | PATHWAY | PHARMACOLOGY & PHARMACY | ENDOTHELIAL GROWTH-FACTOR | Human Umbilical Vein Endothelial Cells | Acetanilides - chemical synthesis | Cricetulus | Humans | Leukemia, Myeloid, Acute - metabolism | Neovascularization, Pathologic - pathology | Neoplasms, Experimental - pathology | fms-Like Tyrosine Kinase 3 - genetics | Acetanilides - therapeutic use | Angiogenesis Inhibitors - therapeutic use | Leukemia, Myeloid, Acute - drug therapy | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Female | Angiogenesis Inhibitors - chemical synthesis | CHO Cells | Pyridines - therapeutic use | Protein Kinase Inhibitors - chemical synthesis | Acetanilides - pharmacology | Cricetinae | Leukemia, Myeloid, Acute - pathology | Pyridines - chemical synthesis | Angiogenesis Inhibitors - pharmacology | Rats | Rats, Sprague-Dawley | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Neovascularization, Pathologic - drug therapy | Protein Kinase Inhibitors - therapeutic use | Dogs | Cell Line, Tumor | Mice | Neovascularization, Pathologic - metabolism | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Neoplasms, Experimental - metabolism | Neoplasms, Experimental - drug therapy | Discovery and exploration | Enzyme inhibitors | Chemical properties | Studies | Pharmacology | Inhibitor drugs | Vascular endothelial growth factor | Leukemia | Index Medicus
Journal Article
Endocrinology, ISSN 0013-7227, 10/2005, Volume 146, Issue 10, pp. 4524 - 4535
The use of selective estrogen receptor modulators for the treatment of estrogen-dependent diseases in premenopausal women has been hindered by undesirable... 
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2005, Volume 48, Issue 7, pp. 2270 - 2273
We report the design and discovery of a 2-amino-benzimidazole-based series of potent and highly selective p38 alpha inhibitors. The lead compound 1 had... 
RHEUMATOID-ARTHRITIS | PYRIMIDINYLIMIDAZOLE INHIBITORS | CYTOKINES | CHEMISTRY, MEDICINAL | ACTIVATED PROTEIN-KINASE | SPECIFICITY | MODELS | STRUCTURAL BASIS | IMIDAZOLE | P38 KINASE
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 10/2004, Volume 47, Issue 22, pp. 5367 - 5380
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2007, Volume 17, Issue 13, pp. 3544 - 3549
Journal Article
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