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Cancer Microenvironment, ISSN 1875-2292, 12/2011, Volume 4, Issue 3, pp. 237 - 246
Bone serves one of the most congenial metastatic microenvironments for multiple types of solid tumors, but its role in this process remains under-explored.... 
Biochemistry, general | Myeloid-derived suppressor cells | Oncology | Metastasis | Macrophages | Biomedicine general | Hematopoietic stem cells | Cell Biology | Biomedicine | Immunology | Bone marrow | Cancer Research | Megakaryocytes | Stem cell research
Journal Article
Bone Research, ISSN 2095-4700, 06/2015, Volume 3, p. 15014
The bone marrow contains a heterogeneous milieu of cells, including macrophages, which are key cellular mediators for resolving infection and inflammation.... 
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 01/2013, Volume 114, Issue 1, pp. 67 - 78
Hematopoietic stem cells (HSC) are maintained in a tightly regulated bone microenvironment constituted by a rich milieu of cells. Bone cells such as... 
ZOLEDRONIC ACID | NICHE | BONE VASCULATURE | HEMATOPOIETIC STEM CELLS | BISPHOSPHONATE | BLOOD VESSELS | PROGENITOR CELLS | MARROW | OSTEOCLASTS | ANGIOGENESIS | BMI-1 | MOBILIZATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | CELL BIOLOGY | MAINTENANCE | BISPHOSPHONATES | MICE | Neovascularization, Physiologic - drug effects | Age Factors | Gene Expression - drug effects | Polycomb Repressive Complex 1 - metabolism | Male | Bone Remodeling - drug effects | Bone and Bones - drug effects | Polycomb Repressive Complex 1 - genetics | Bone Morphogenetic Protein 6 - genetics | Bone Morphogenetic Protein 2 - metabolism | Bone and Bones - metabolism | Osteoblasts - cytology | Hematopoietic Stem Cells - drug effects | Proto-Oncogene Proteins - metabolism | Bone Morphogenetic Protein 2 - genetics | Osteoblasts - drug effects | Bone and Bones - blood supply | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Proto-Oncogene Proteins - genetics | Hematopoietic Stem Cells - metabolism | Imidazoles - pharmacology | Bone Density Conservation Agents - pharmacology | Cell Movement - drug effects | Bone Density - drug effects | Animals | Bone Morphogenetic Protein 6 - metabolism | Signal Transduction - drug effects | Cell Differentiation - drug effects | Hematopoietic Stem Cells - cytology | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Stem Cell Niche - physiology | Mice | Stem Cell Niche - drug effects | Osteoblasts - metabolism | Diphosphonates - pharmacology | Anopheles | Orthopedic surgery | Analysis | Genes | Bone morphogenetic proteins | Bones | Gene expression | Density | Hematopoietic stem cells
Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 01/2012, Volume 27, Issue 1, pp. 11 - 25
Proteoglycan 4 (Prg4), known for its lubricating and protective actions in joints, is a strong candidate regulator of skeletal homeostasis and parathyroid... 
FGF‐2 | Prg4 | bone | PTH | liver | FGF-2 | GROWING RATS | RESTORES CANCELLOUS BONE | IGF-I | TISSUE IGF-1 | RECEPTOR MESSENGER-RNA | FIBROBLAST-GROWTH-FACTOR | I GENE-EXPRESSION | OVARIECTOMIZED RATS | OSTEOBLASTIC CELLS | HUMAN BONE-MARROW | ENDOCRINOLOGY & METABOLISM | Humans | Tibia - anatomy & histology | Parathyroid Hormone - pharmacology | Femur - diagnostic imaging | RNA, Messenger - metabolism | X-Ray Microtomography | Bone Remodeling - drug effects | Range of Motion, Articular - drug effects | Bone and Bones - drug effects | Bone and Bones - anatomy & histology | Proteoglycans - deficiency | Liver - drug effects | Bone and Bones - diagnostic imaging | Bone and Bones - metabolism | Growth Plate - drug effects | Fibroblast Growth Factor 2 - metabolism | Tibia - growth & development | Tibia - metabolism | Osteogenesis - genetics | Biomarkers - metabolism | Femur - anatomy & histology | Mesenchymal Stromal Cells - drug effects | Femur - metabolism | Joints - drug effects | Liver - metabolism | Mice, Inbred C57BL | Osteogenesis - drug effects | RNA, Messenger - genetics | Mesenchymal Stromal Cells - metabolism | Proteoglycans - metabolism | Femur - drug effects | Joints - physiology | Fibroblast Growth Factor 2 - blood | Growth Plate - metabolism | Tibia - drug effects | Gene Expression Regulation - drug effects | Organ Size - drug effects | Animals | Fibroblast Growth Factor 2 - genetics | Mice | Insulin-Like Growth Factor I - metabolism | Proteoglycans - genetics | Messenger RNA | Parathyroid hormone | Genes | Physiological aspects | Bones | Fibroblast growth factors | Density | PRG4 | BONE | LIVER
Journal Article
Journal Article
BoneKEy reports, ISSN 2047-6396, 2015, Volume 4, p. 706
On the road to metastasis a cancer cell has to overcome two major obstacles: the physical escape from the primary tumor to a distant tissue and the adaptation... 
Journal Article
Nature, ISSN 0028-0836, 02/1997, Volume 385, Issue 6618, pp. 733 - 736
Journal Article
Journal Article