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Nature Biotechnology, ISSN 1087-0156, 03/2002, Volume 20, Issue 3, pp. 301 - 305
Protein kinases are coded by more than 2,000 genes and thus constitute the largest single enzyme family in the human genome. Most cellular processes are in... 
BIOTECHNOLOGY & APPLIED MICROBIOLOGY | Biotechnology - methods | Phosphorylation | Algorithms | Time Factors | Saccharomyces cerevisiae - genetics | Chromatography, High Pressure Liquid | Proteins - chemistry | Binding Sites | Mass Spectrometry - methods | Chromatography | Saccharomyces cerevisiae - chemistry | Databases as Topic
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 02/2016, Volume 126, Issue 2, pp. 639 - 652
Journal Article
Nature, ISSN 0028-0836, 10/2017, Volume 550, Issue 7677, pp. 534 - 538
The ubiquitin system regulates essential cellular processes in eukaryotes. Ubiquitin is ligated to substrate proteins as monomers or chains and the topology of... 
DEUBIQUITINATING ENZYME | MULTIDISCIPLINARY SCIENCES | LINKED UBIQUITIN | Pyridines - chemistry | Ubiquitin-Specific Peptidase 7 - chemistry | Humans | Ubiquitin - metabolism | Substrate Specificity | Tumor Suppressor Protein p53 - genetics | Aminopyridines - chemistry | Ubiquitin-Specific Peptidase 7 - deficiency | Proto-Oncogene Proteins c-pim-1 - antagonists & inhibitors | Female | Proto-Oncogene Proteins c-mdm2 - metabolism | Phenols - pharmacology | Binding, Competitive | Indazoles - chemistry | Tumor Suppressor Protein p53 - metabolism | Ubiquitin - chemistry | Models, Molecular | Neoplasms - enzymology | Ubiquitin-Specific Peptidase 7 - antagonists & inhibitors | Ubiquitin-Specific Peptidase 7 - metabolism | Mice, SCID | Tumor Suppressor Protein p53 - deficiency | Neoplasms - drug therapy | Drug Synergism | Indazoles - pharmacology | Animals | Aminopyridines - pharmacology | Cell Line, Tumor | Protein Binding | Phenols - chemistry | Mice | Pyridines - pharmacology | Neoplasms - pathology | Biological research | Physiological aspects | Chemical inhibitors | Research | Ubiquitin-proteasome system | Biology, Experimental | Ubiquitin | Nuclear magnetic resonance--NMR | Toxicity | Hydrogen | p53 Protein | Cytotoxicity | Chains | Kinases | Monomers | Proteins | Depolymerization | Eukaryotes | Ubiquitination | Cell cycle | Reaction kinetics | Catalysis | Crystal structure | Binding | Enzymes | Magnetic resonance | Topology | Substrates | Chemotherapy | Inhibitors | Cell death | Proteasomes | Resonance | Mutation | Kinetics | Cancer | Tumors
Journal Article
Journal Article
The Journal of Pathology, ISSN 0022-3417, 12/2015, Volume 237, Issue 4, pp. 508 - 519
CDK8 is a dissociable kinase module of the Mediator complex and has been shown to play an important role in transcriptional regulation in organisms as diverse... 
Cdk8 | ApcMin | colon cancer | cyclin C | Apc | Colon cancer | RNA | Analysis | Melanoma | Tumors
Journal Article
Cancer Research, ISSN 0008-5472, 07/2016, Volume 76, Issue 14 Supplement, pp. 406 - 406
Colon tumors arise in a stepwise fashion from either discrete genetic perturbations or epigenetic dysregulation. To uncover the key epigenetic regulators that... 
Journal Article
Journal Article
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 04/2011, Volume 71, Issue 8 Supplement, pp. 5191 - 5191
Journal Article
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 02/2018, Volume 217, Issue 2, p. 763
Epithelial-to-mesenchymal transition is implicated in metastasis, where carcinoma cells lose sessile epithelial traits and acquire mesenchymal migratory... 
Sensitivity analysis | Mesenchyme | Invasiveness | Tumor cell lines | Cells | Metastases | Molecules | Chemotherapy | Biopsy | Correlation analysis | Pancreatic cancer | Stem cells | Cell lines | Epigenetics | Histone methyltransferase | Cancer
Journal Article