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Genes and Development, ISSN 0890-9369, 01/2003, Volume 17, Issue 1, pp. 101 - 114
We show that the Xenopus homologs of Ndc8o/Tid3/HEC1 (xNdc80) and Nuf2/MPP1/Him-10 (xNuf2) proteins physically interact in a 190-kD complex that associates... 
Spindle checkpoint | Kinetochore | Centromere | Mitosis | Chromosome segregation | Cell cycle | ANAPHASE | centromere | PROTEIN | cell cycle | BUDDING YEAST | DEVELOPMENTAL BIOLOGY | mitosis | SACCHAROMYCES-CEREVISIAE | COILED COILS | chromosome segregation | INTEGRITY | GENETICS & HEREDITY | kinetochore | MITOTIC EXIT | CELL-CYCLE | spindle checkpoint | Protein Kinases - metabolism | Microtubule-Associated Proteins - metabolism | Saccharomyces cerevisiae - genetics | Protein-Serine-Threonine Kinases | Recombinant Fusion Proteins - physiology | Phosphoproteins - metabolism | Mad2 Proteins | Nuclear Proteins - genetics | Spindle Apparatus - physiology | Spindle Apparatus - ultrastructure | Insect Proteins - metabolism | Repressor Proteins - metabolism | Carrier Proteins | Calcium-Binding Proteins - metabolism | Drosophila Proteins | Kinetochores - metabolism | Antibodies, Monoclonal - pharmacology | Xenopus laevis | Cell Cycle Proteins - metabolism | Dynactin Complex | Fungal Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Macromolecular Substances | Protein Interaction Mapping | Saccharomyces cerevisiae - cytology | Leupeptins - pharmacology | Fungal Proteins - physiology | Kinetochores - ultrastructure | Animals | Signal Transduction - physiology | Xenopus Proteins - metabolism | Nuclear Proteins - physiology | Saccharomyces cerevisiae Proteins - physiology | Spindle Apparatus - drug effects | Anaphase | Genes, cdc | Fungal Proteins - metabolism | Analysis | Genetic research | Physiological aspects | Genetic aspects | Research | Chromosomes | Ndc80 protein | kinetochores | Nuf2 protein | Research Paper
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 03/2016, Volume 7, Issue 3, pp. 223 - 228
Beginning with promiscuous COT inhibitors, which were found to inhibit CDK8, a series of 6-aza-benzothiophene containing compounds were developed into potent,... 
CDK8 | kinase inhibitor | cyclin C | CHEMISTRY, MEDICINAL | STAT1 | TRANSCRIPTION | GENES | BETA-CATENIN | EXPRESSION | MEDIATOR COMPLEX | DELETION | FAMILY
Journal Article
Molecular Therapy, ISSN 1525-0016, 03/2000, Volume 1, Issue 3, pp. 225 - 235
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 10/2009, Volume 187, Issue 1, pp. 7 - 14
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 10/2009, Volume 187, Issue 1, p. 7
  We examined the contribution of S phase in timing cell cycle progression during Drosophila embryogenesis using an approach that deletes S phase rather than... 
Embryology | Insects | Cell cycle | Embryos | Chromosomes | Deoxyribonucleic acid--DNA
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 06/2016, Volume 7, Issue 6, pp. 595 - 600
Using Sorafenib as a starting point, a series of potent and selective inhibitors of CDK8 was developed. When cocrystallized with CDK8 and cyclin C, these... 
CDK8 | DMG-out | inhibitor | Sorafenib | CELLS | CHEMISTRY, MEDICINAL | TRANSCRIPTION | KINASE INHIBITOR | BETA-CATENIN | MEDIATOR COMPLEX
Journal Article
Current Biology, ISSN 0960-9822, 01/2004, Volume 14, Issue 2, pp. 131 - 137
How kinetochores bind to microtubules and move on the mitotic spindle remain unanswered questions. Multiple systems have implicated the Ndc80/Hec1 (Ndc80)... 
CELLS | PROTEIN | BUDDING YEAST | SPINDLE POLE | BIOCHEMISTRY & MOLECULAR BIOLOGY | NUF2 | CHROMOSOME SEGREGATION | CENTROMERE
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 10/2005, Volume 16, Issue 10, pp. 4882 - 4892
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 03/2009, Volume 184, Issue 5, p. 639
  Cyclins are key cell cycle regulators, yet few analyses test their role in timing the events that they regulate. We used RNA interference and real-time... 
Genotype & phenotype | Insects | Cell cycle | Cell division | Ribonucleic acid--RNA | Embryos
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 03/2009, Volume 184, Issue 5, pp. 639 - 646
Journal Article
Cancer Research, ISSN 0008-5472, 04/2013, Volume 73, Issue 8 Supplement, pp. 3203 - 3203
Journal Article
Cancer Research, ISSN 0008-5472, 04/2012, Volume 72, Issue 8, pp. 2129 - 2139
CDK8 is a cyclin-dependent kinase that mediates transcriptional control of pathways linked to both cancer and stem cells. In this study, we show that CDK8 is... 
Cyclin-dependent kinase | Colon cancer | Transcription | Tumor cells | Embryo cells | Stem cells | Myc protein | Differentiation | Tumors
Journal Article
Journal Article
Methods in molecular biology (Clifton, N.J.), ISSN 1064-3745, 2005, Volume 296, pp. 383 - 391
The identification of protein binding partners often facilitates understanding of protein complex function. However, identifying binding partners has proven... 
Chromatography, Agarose | Chromatography, Ion Exchange | Immunoprecipitation | Nuclear Proteins - isolation & purification | Mitosis | Coloring Agents | Xenopus laevis | Ovum - cytology | Animals | Ovum - chemistry | Female | Anion Exchange Resins | Heparin | Kinetochores - chemistry | Resins, Synthetic | Xenopus Proteins - isolation & purification
Journal Article
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