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1. Full Text DExSI: A new tool for the rapid quantitation of 13 C-labelled metabolites detected by GC-MS
by Dagley, Michael J and McConville, Malcolm J
Bioinformatics, ISSN 1367-4803, 06/2018, Volume 34, Issue 11, pp. 1957 - 1958
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2. Full Text DExSI: a new tool for the rapid quantitation of 13C-labelled metabolites detected by GC-MS
by Dagley, Michael J and McConville, Malcolm J
Bioinformatics, ISSN 1367-4803, 06/2018, Volume 34, Issue 11, pp. 1957 - 1958
Abstract Summary Stable isotope directed metabolomics is increasingly being used to measure metabolic fluxes in microbial, plant and animal cells.... 
Applications Notes
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3. Full Text Using Fat to Turbo-Charge Intracellular Parasite Growth
by McConville, Malcolm J
Cell Host & Microbe, ISSN 1931-3128, 12/2014, Volume 16, Issue 6, pp. 705 - 707
Early during infection, the malaria parasite invades liver cells and undergoes robust replication, generating thousands of new parasites within days. In this... 
MICROBIOLOGY | VIROLOGY | PARASITOLOGY | PLASMODIUM LIVER STAGE | Plasmodium berghei - metabolism | Animals | Humans | Phosphatidylcholines - biosynthesis | Female | Plasmodium falciparum - metabolism | Liver - parasitology | Malaria - metabolism
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4. Full Text Metabolomic profiling of the excretory–secretory products of hookworm and whipworm
by Wangchuk, Phurpa and Kouremenos, Konstantinos and Eichenberger, Ramon M and Pearson, Mark and Susianto, Atik and Wishart, David S and McConville, Malcolm J and Loukas, Alex
Metabolomics, ISSN 1573-3882, 7/2019, Volume 15, Issue 7, pp. 1 - 15
Soil-transmitted helminths infect billions of people, livestock and companion animals worldwide, and chronic infections with these nematodes represent a major... 
Life Sciences | Biochemistry, general | Biomedicine, general | Small molecule metabolites | Metabolomics | Excretory–secretory products | Molecular Medicine | Trichuris muris | Developmental Biology | Nippostrongylus brasiliensis | Gas chromatography–mass spectrometry | Cell Biology | METABOLITES | ACTIVATION | Gas chromatography-mass spectrometry | URIDINE | HELMINTH-PARASITES | DOG HOOKWORM | ANTIINFLAMMATORY PROPERTIES | ASCARIS-LUMBRICOIDES | CHAIN FATTY-ACIDS | BIOCHEMISTRY | ENDOCRINOLOGY & METABOLISM | Excretory-secretory products | ANIMAL-MODEL | Disease transmission | Metabolites | Developing countries | Liquid chromatography | Livestock | Mass spectrometry | Nematoda | Fatty acids
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5. Full Text Characterization of Metabolically Quiescent Leishmania Parasites in Murine Lesions Using Heavy Water Labeling
: e1004683
by Joachim Kloehn and Eleanor C Saunders and Sean O'Callaghan and Michael J Dagley and Malcolm J McConville
PLoS Pathogens, ISSN 1553-7366, 02/2015, Volume 11, Issue 2
  Information on the growth rate and metabolism of microbial pathogens that cause long-term chronic infections is limited, reflecting the absence of suitable... 
Proteins | Lymphatic system | Growth rate | Lipids | Physiology | Infections | Parasites | Labeling | Fatty acids | Deoxyribonucleic acid--DNA
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6. Full Text Metabolic Crosstalk between Leishmania and the Macrophage Host
by McConville, Malcolm J
Trends in Parasitology, ISSN 1471-4922, 2016, Volume 32, Issue 9, pp. 666 - 668
Goldman-Pinkovich et al. have shown that intracellular stages of Leishmania actively sense arginine levels within the phagolysosome of the host macrophage and... 
Infectious Disease | Gastroenterology and Hepatology | ARGINASE | PATHWAY | PARASITOLOGY | Macrophages - parasitology | Macrophages - metabolism | Animals | Host-Parasite Interactions - physiology | Humans | Host-Parasite Interactions - immunology | Leishmania - physiology | Macrophages | Molecular biology
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7. Full Text Determining the Mode of Action of Antimalarial Drugs Using Time-Resolved LC-MS-Based Metabolite Profiling
by Cobbold, Simon A and Cobbold, Simon A and McConville, Malcolm J and McConville, Malcolm J
Methods in molecular biology (Clifton, N.J.), ISSN 1064-3745, 2019, Volume 1859, pp. 225 - 239
Methods for assessing the mode of action of new antimalarial compounds identified in high throughput phenotypic screens are needed to triage and facilitate... 
Antimalarial | Metabolomics | Plasmodium | LC-MS | Malaria | Metabolism
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8. Full Text Metabolic Pathways Required for the Intracellular Survival ofLeishmania
by McConville, Malcolm J and Naderer, Thomas
Annual Review of Microbiology, ISSN 0066-4227, 10/2011, Volume 65, Issue 1, pp. 543 - 561
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9. Full Text MR1 presents microbial vitamin B metabolites to MAIT cells
by Kjer-Nielsen, Lars and Patel, Onisha and Corbett, Alexandra J and Le Nours, Jérôme and Meehan, Bronwyn and Liu, Ligong and Bhati, Mugdha and Chen, Zhenjun and Kostenko, Lyudmila and Reantragoon, Rangsima and Williamson, Nicholas A and Purcell, Anthony W and Dudek, Nadine L and McConville, Malcolm J and O'Hair, Richard A. J and Khairallah, George N and Godfrey, Dale I and Fairlie, David P and Rossjohn, Jamie and McCluskey, James
Nature, ISSN 0028-0836, 11/2012, Volume 491, Issue 7426, pp. 717 - 723
Antigen-presenting molecules, encoded by the major histocompatibility complex (MHC) and CD1 family, bind peptide- and lipid-based antigens, respectively, for... 
INVARIANT T-CELLS | RECOGNITION | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | CLASS-I MOLECULE | RECEPTOR | ANTIGEN PRESENTATION | SELECTION | PROTEINS | PEPTIDE | Pterins - metabolism | Folic Acid - immunology | Minor Histocompatibility Antigens | Humans | Histocompatibility Antigens - chemistry | Salmonella Infections - immunology | Crystallography, X-Ray | beta 2-Microglobulin - immunology | Histocompatibility Antigens Class I - metabolism | Pterins - immunology | Antigen Presentation | Bacterial Infections - immunology | beta 2-Microglobulin - metabolism | Pterins - chemistry | Binding Sites | Bacterial Infections - microbiology | Salmonella - metabolism | Cell Line | Histocompatibility Antigens - immunology | Jurkat Cells | Lymphocyte Activation | Folic Acid - chemistry | Histocompatibility Antigens Class I - immunology | Models, Molecular | Protein Refolding - drug effects | Histocompatibility Antigens Class I - chemistry | Static Electricity | Immunologic Surveillance - immunology | Salmonella - immunology | Pterins - pharmacology | Folic Acid - metabolism | Ligands | Salmonella Infections - microbiology | T-Lymphocytes - immunology | Vitamin B complex | Metabolites | Vitamin B | Physiological aspects | Virulence (Microbiology) | Research | T cells | Health aspects | Photodegradation | Cell culture | Bacterial infections | Lipids | T cell receptors | Infections | Chromatography | Immunology | Acids | Mass spectrometry | Methods
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10. Full Text Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites
by Thorburn, Alison N and McKenzie, Craig I and Shen, Sj and Stanley, Dragana and MacIa, Laurence and Mason, Linda J and Roberts, Laura K and Wong, Connie H. Y and Shim, Raymond and Robert, Remy and Chevalier, Nina and Tan, Jian K and Marinõ, Eliana and Moore, Rob J and Wong, Lee and McConville, Malcolm J and Tull, Dedreia L and Wood, Lisa G and Murphy, Vanessa E and Mattes, Joerg and Gibson, Peter G and MacKay, Charles R
Nature Communications, ISSN 2041-1723, 06/2015, Volume 6, Issue 1, p. 7320
Asthma is prevalent in Western countries, and recent explanations have evoked the actions of the gut microbiota. Here we show that feeding mice a high-fibre... 
LIFE-STYLE | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | REGULATORY T-CELLS | ALLERGIC AIRWAYS DISEASE | PREGNANT-WOMEN | RECEPTOR | GUT MICROBIOTA | RESPIRATORY SYMPTOMS | FAST FOODS | EXPRESSION | Fatty Acids, Volatile - pharmacology | Asthma - metabolism | Forkhead Transcription Factors - drug effects | Fatty Acids, Volatile - metabolism | T-Lymphocytes, Regulatory - immunology | Asthma - immunology | T-Lymphocytes, Regulatory - cytology | Female | Epigenesis, Genetic - drug effects | Repressor Proteins - metabolism | Disease Models, Animal | Promoter Regions, Genetic | Acetates - metabolism | Gastrointestinal Microbiome | Dietary Fiber - metabolism | Histone Deacetylases - metabolism | Forkhead Transcription Factors - genetics | Prenatal Exposure Delayed Effects - metabolism | Pregnancy | Acetylation - drug effects | T-Lymphocytes, Regulatory - drug effects | Animals | Prenatal Exposure Delayed Effects - immunology | Diet | Histone Deacetylases - drug effects | Repressor Proteins - drug effects | Acetates - pharmacology | Mice
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11. Metabolic Pathways Required for the Intracellular Survival of Leishmania
by Malcolm J McConville and Thomas Naderer
Annual Review of Microbiology, ISSN 0066-4227, 01/2011, Volume 65, p. 543
Leishmania spp. are sandfly-transmitted parasitic protozoa that cause a spectrum of important diseases and lifelong chronic infections in humans. In the... 
Survival analysis | Parasitic diseases | Parasitic protozoa | Metabolism | Cells
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12. Full Text The Leishmania-macrophage interaction: A metabolic perspective
by Naderer, Thomas and McConville, Malcolm J
Cellular Microbiology, ISSN 1462-5814, 02/2008, Volume 10, Issue 2, pp. 301 - 308
Protozoan parasites belonging to the genus Leishmania exhibit a pronounced tropism for macrophages although they have the capacity to infect a variety of other... 
MAMMALIAN HOSTS | AMAZONENSIS AMASTIGOTES | GENETIC-ANALYSIS | MEXICANA AMASTIGOTES | MAJOR INFECTION | MURINE MACROPHAGES | APOPTOTIC CELLS | L-ARGININE | MICROBIOLOGY | PARASITOPHOROUS VACUOLES | VIRULENCE | CELL BIOLOGY | Macrophages - parasitology | Glycocalyx - physiology | Macrophages - metabolism | Animals | Leishmania - metabolism | Leishmania - physiology | Host-Parasite Interactions | Leishmania - growth & development | Phagosomes - parasitology | Glycocalyx - metabolism
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13. Full Text Induction of a Stringent Metabolic Response in Intracellular Stages of Leishmania mexicana Leads to Increased Dependence on Mitochondrial Metabolism
: e1003888
by Eleanor C Saunders and William W Ng and Joachim Kloehn and Jennifer M Chambers and Milica Ng and Malcolm J McConville
PLoS Pathogens, ISSN 1553-7366, 01/2014, Volume 10, Issue 1
  Leishmania parasites alternate between extracellular promastigote stages in the insect vector and an obligate intracellular amastigote stage that... 
Studies | Enzymes | Metabolites | Parasitic diseases | Dependence | Infections | Parasites | Glucose | Metabolism | Labeling | Carbon | Experiments
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14. Full Text High-Content Assay for Measuring Intracellular Growth ofLeishmaniain Human Macrophages
by Dagley, Michael J and Saunders, Eleanor C and Simpson, Kaylene J and McConville, Malcolm J
ASSAY and Drug Development Technologies, ISSN 1540-658X, 09/2015, Volume 13, Issue 7, pp. 389 - 401
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15. Full Text Metabolic Pathways Required for the Intracellular Survival of Leishmania
by McConville, Malcolm J and Naderer, Thomas
Annual Review of Microbiology, ISSN 0066-4227, 10/2011, Volume 6, pp. 543 - 561
Leishmania spp. are sandfly-transmitted parasitic protozoa that cause a spectrum of important diseases and lifelong chronic infections in humans. In the... 
phagolysosome | macrophage | protozoan parasites | virulence | leishmaniasis | intracellular pathogens | Intracellular pathogens | Phagolysosome | Leishmaniasis | Virulence | Protozoan parasites | Macrophage | AMAZONENSIS AMASTIGOTES | LIPID-METABOLISM | TRYPANOTHIONE REDUCTASE | STRESS-RESPONSE | VIRULENCE FACTOR | MICROBIOLOGY | CARBON METABOLISM | MUTANTS LACKING | CYTOCHROME-C-OXIDASE | MAJOR INFECTION | ENDOPLASMIC-RETICULUM | Animals | Metabolic Networks and Pathways | Cell Survival | Leishmaniasis - metabolism | Humans | Leishmania - metabolism | Leishmaniasis - parasitology | Leishmania - pathogenicity | Leishmania - growth & development | Leishmania - genetics | Gene mutations | Physiological aspects | Genetic aspects | Research | Macrophages | Risk factors
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16. Full Text Characterization of Metabolically Quiescent Leishmania Parasites in Murine Lesions Using Heavy Water Labeling
by Kloehn, Joachim and Saunders, Eleanor C and O’Callaghan, Sean and Dagley, Michael J and McConville, Malcolm J
PLoS Pathogens, ISSN 1553-7366, 2015, Volume 11, Issue 2, p. e1004683
Information on the growth rate and metabolism of microbial pathogens that cause long-term chronic infections is limited, reflecting the absence of suitable... 
MICROBIOLOGY | PROLIFERATION | LUCIFERASE | GRANULOMA | (H2O)-H-2 | AMASTIGOTES | VIROLOGY | IN-VIVO | COMPLEXITY | INFANTUM | EXPRESSION | PARASITOLOGY | REVEALS | Staining and Labeling - methods | Leishmaniasis, Cutaneous - diagnosis | Macrophages - pathology | Cells, Cultured | Leishmania mexicana - metabolism | Leishmaniasis, Cutaneous - pathology | Leishmania mexicana - physiology | Macrophages - parasitology | Deuterium Oxide | Animals | Leishmania mexicana - isolation & purification | Leishmaniasis, Cutaneous - parasitology | Mice | Mice, Inbred BALB C |