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Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2018, Volume 61, Issue 5, pp. 1969 - 1989
A group III metabotropic glutamate (mGlu) receptor agonist (PCEP) was identified by virtual HTS. This orthosteric ligand is composed by an l-AP4-derived... 
Life Sciences | Neurons and Cognition
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 1 - 13
Metabotropic glutamate receptors (mGluRs) are dimeric G-protein-coupled receptors that operate at synapses. Macroscopic and single molecule FRET to monitor... 
OPTICAL CONTROL | METABOTROPIC GLUTAMATE-RECEPTOR | ACTIVATION | ALLOSTERIC MODULATORS | MECHANISM | STRUCTURAL BASIS | PHARMACOLOGY | MULTIDISCIPLINARY SCIENCES | DYNAMICS | GROUP-II | BINDING | Life Sciences | Organic chemistry | Neurons and Cognition | Chemical Sciences | Neurobiology
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 2009, Volume 7, Issue 4, pp. 706 - 716
Stable, water-soluble aminosugar staurosporine, K-252a and rebeccamycin analogs have been prepared by nucleophilic opening of C(2)-symmetric N-activated... 
Drug Stability | Piperidines | Aza Compounds | Solubility | Pyrrolidines | Staurosporine - analogs & derivatives | Aziridines - chemistry | Staurosporine - chemical synthesis
Journal Article
Neurobiology of Disease, ISSN 0969-9961, 09/2019, Volume 129, pp. 13 - 28
Finding new targets to control or reduce seizure activity is essential to improve the management of epileptic patients. We hypothesized that activation of the... 
Life Sciences | Medicinal Chemistry | Organic chemistry | Chemical Sciences
Journal Article
Synlett, ISSN 0936-5214, 03/2012, Volume 23, Issue 5, pp. 791 - 795
Abstract Regioselective Michael addition of N -9 adenine to ethyl acrylate under microwave activation in solid-liquid solvent-free phase-transfer catalysis... 
letter
Journal Article
Synlett, ISSN 0936-5214, 2012, Volume 23, Issue 5, pp. 791 - 795
Regioselective Michael addition of N-9 adenine to ethyl acrylate under microwave activation in solid-liquid solvent-free phase-transfer catalysis using TBAB as... 
Michael addition | azaheterocycles | microwave irradiation | phase-transfer catalysis | green chemistry | ANALOGS | ALKYLATION | CHEMISTRY, ORGANIC | PURINE NUCLEOBASES | CATALYST | GREEN | HIGHLY EFFICIENT | INDOLES | IRRADIATION | PYRIMIDINE | DERIVATIVES
Journal Article
Neurobiology of Disease, ISSN 0969-9961, 09/2019, Volume 129, Issue 1, pp. 13 - 28
Finding new targets to control or reduce seizure activity is essential to improve the management of epileptic patients. We hypothesized that activation of the... 
Animal models | Neuropharmacology | Epilepsy | Metabotropic glutamate receptor | Seizures | ACTIVATION | TEMPORAL-LOBE EPILEPSY | RAT | METABOTROPIC GLUTAMATE RECEPTORS | ALLOSTERIC MODULATION | NEUROSCIENCES | MICE LACKING | KAINATE MOUSE MODEL | ABSENCE | ANTIEPILEPTIC DRUGS | STRESS | Amino acids | Seizures (Medicine) | Glutamate | Analysis | Life Sciences
Journal Article
Journal Article
ChemInform, ISSN 0931-7597, 07/2012, Volume 43, Issue 27, pp. no - no
Michael addition of N‐9 adenine (I) to tert‐butylacrylate or acrylic acid proceeds under phase‐transfer catalysis in the presence of DABCO to give N‐alkylated... 
indole derivatives, isoindole derivatives | microwave chemistry, sonochemistry, mechanochemistry | purine derivatives | amination, N‐alkylation, N‐arylation
Journal Article
ChemInform, ISSN 0931-7597, 06/2010, Volume 41, Issue 24, pp. no - no
ChemInform is a weekly ing Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform of an... 
organocatalysis | organic chemistry, review
Journal Article
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