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Psychopharmacology, ISSN 0033-3158, 07/2012, Volume 222, Issue 1, pp. 81 - 87
Preclinical evidence indicates that D-1 dopamine receptor full agonists have potential as therapeutic agents for a variety of neurological conditions.... 
Contralateral rotation | Doxanthrine | Dihydrexidine | receptor | Parkinson's disease | Rat | 6-Hydroxydopamine | Dopamine D | STIMULATION | PSYCHIATRY | NEUROSCIENCES | LESIONS | A-77636 | POTENT | NIGROSTRIATAL PATHWAY | PHARMACOLOGY & PHARMACY | THERAPIES | Dopamine D-1 receptor | RECEPTOR AGONIST | MONKEYS
Journal Article
Nature, ISSN 0028-0836, 08/2016, Volume 537, Issue 7619, pp. 185 - 190
Journal Article
Pharmacology and Therapeutics, ISSN 0163-7258, 06/2015, Volume 150, pp. 129 - 142
Journal Article
Psychopharmacology, ISSN 0033-3158, 07/2012, Volume 222, Issue 1, p. 81
  Preclinical evidence indicates that D^sub 1^ dopamine receptor full agonists have potential as therapeutic agents for a variety of neurological conditions.... 
Dopamine | Psychopharmacology | Parkinsons disease | Drug therapy
Journal Article
Psychopharmacology, ISSN 0033-3158, 07/2012, Volume 222, Issue 1, pp. 81 - 87
Rationale: Preclinical evidence indicates that D sub(1) dopamine receptor full agonists have potential as therapeutic agents for a variety of neurological... 
Animal models | Oxygen | Dopamine D1 receptors | Parkinson's disease | Neurodegenerative diseases | Oral administration | Catechol | Movement disorders
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 05/2017, Volume 114, Issue 22, p. 5595
Recently, an alternative theory concerning the method by which olfactory proteins are activated has garnered attention. This theory proposes that the... 
Vibration | G protein-coupled receptors | Calcium | Serotonin | Central nervous system | Activation | Serotonin S2 receptors | Experiments | Proteins | Receptors | Serotonin receptors | Tunneling | Electron tunneling | Affinity | Deuteration | Receptor mechanisms | Viability | Electrons
Journal Article
Bioorganic and Medicinal Chemistry, ISSN 0968-0896, 09/2011, Volume 19, Issue 18, pp. 5420 - 5431
To assess the effect of conformational mobility on receptor activity, the β-phenyl substituent of dopamine D agonist ligands of the phenylbenzazepine class,... 
Agonist | Dopamine D | Conformation | CHEMISTRY, MEDICINAL | COGNITIVE PERFORMANCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | Dopamine D-1
Journal Article
Science, ISSN 0036-8075, 5/2013, Volume 340, Issue 6132, pp. 615 - 619
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 02/2018, Volume 14, Issue 2, p. 126
Development of biased ligands targeting G protein-coupled receptors (GPCRs) is a promising approach for current drug discovery. Although structure-based drug... 
Design | Residues | Signaling | Receptors | G protein-coupled receptors | Amino acids | Ligands | Arrestin | Drug discovery | Drug development | Crystal structure
Journal Article
Bioorganic and Medicinal Chemistry, ISSN 0968-0896, 09/2011, Volume 19, Issue 18, pp. 5420 - 5431
To assess the effect of conformational mobility on receptor activity, the [beta]-phenyl substituent of dopamine D sub(1 agonist ligands of the... 
Journal Article
Science, ISSN 0036-8075, 5/2013, Volume 340, Issue 6132, pp. 610 - 614
Serotonin or 5-hydroxytryptamine (5-HT) regulates a wide spectrum of human physiology through the 5-HT receptor family. We report the crystal structures of the... 
Receptors | Sand sheets | Hydrogen bonds | Serotonin receptors | REPORTS | Ligands | Agonists | Indoles | Grants | LSD | Binding sites | LIGANDS | PROTEIN-COUPLED RECEPTOR | PHARMACOLOGY | MULTIDISCIPLINARY SCIENCES | MUTATION | CARDIAC VALVULOPATHY | VALVULAR HEART-DISEASE | SCHIZOPHRENIA | DISORDERS | FENFLURAMINE | AGONIST | Pindolol - chemistry | Humans | Lysergic Acid Diethylamide - metabolism | Molecular Sequence Data | Crystallography, X-Ray | Propranolol - metabolism | Serotonin 5-HT1 Receptor Agonists - chemistry | Ergotamine - chemistry | Ergotamine - metabolism | Receptor, Serotonin, 5-HT1B - genetics | Receptor, Serotonin, 5-HT1B - metabolism | Binding Sites | Amino Acid Sequence | Tryptamines - chemistry | Norfenfluramine - metabolism | Dihydroergotamine - chemistry | Protein Structure, Secondary | Models, Molecular | Dihydroergotamine - metabolism | Lysergic Acid Diethylamide - chemistry | Propranolol - chemistry | Serotonin 5-HT1 Receptor Agonists - metabolism | Pindolol - analogs & derivatives | Protein Folding | Norfenfluramine - chemistry | Hydrogen Bonding | Mutagenesis | Tryptamines - metabolism | Receptor, Serotonin, 5-HT1B - chemistry | Hydrophobic and Hydrophilic Interactions | Protein Conformation | Molecular Docking Simulation | Pindolol - metabolism | Physiological aspects | Research | G proteins | Serotonin | Molecular biology | Ligands (Biochemistry) | Neurons | Index Medicus
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 05/2019, Volume 62, Issue 9, pp. 4755 - 4771
Functionally selective G protein-coupled receptor ligands are valuable tools for deciphering the roles of downstream signaling pathways that potentially... 
DESIGN | CHEMISTRY, MEDICINAL | LIGANDS | ILLUMINATE | FUNCTIONAL SELECTIVITY | SEROTONIN | MODEL | DISCOVERY
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 04/2019, Volume 62, Issue 7, pp. 3753 - 3772
G protein-coupled receptors (GPCRs) are capable of downstream signaling through distinct noncanonical pathways such as beta-arrestins in addition to the... 
ACTIVATION | DESIGN | CHEMISTRY, MEDICINAL | BIASED AGONISM | LIGANDS | OPIOID RECEPTOR | BETA-ARRESTIN-2 | TRANSDUCTION | BETA-ARRESTIN | DISCOVERY | MOLECULAR-MECHANISMS
Journal Article
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 1910 - 7
Schistosomiasis is a debilitating tropical disease caused by infection with parasitic blood flukes. Approximately 260 million people are infected worldwide,... 
MUSCLE | FIELDS | SCHISTOSOMA-MANSONI | DOCKING | MULTIDISCIPLINARY SCIENCES | G protein-coupled receptors | Target recognition | Serotonin | Praziquantel | Socio-economic aspects | Blood vessels | Chronic infection | Infections | Parasites | Blood | Tropical diseases | Coupling (molecular) | Schistosomiasis | Signaling | Parasitic diseases | Ligands
Journal Article