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1. Full Text High-throughput discovery of novel developmental phenotypes
by Dickinson, Mary E and Flenniken, Ann M and Ji, Xiao and Teboul, Lydia and Wong, Michael D and White, Jacqueline K and Meehan, Terrence F and Weninger, Wolfgang J and Westerberg, Henrik and Adissu, Hibret and Baker, Candice N and Bower, Lynette and Brown, James M and Brianna Caddle, L and Chiani, Francesco and Clary, Dave and Cleak, James and Daly, Mark J and Denegre, James M and Doe, Brendan and Dolan, Mary E and Edie, Sarah M and Fuchs, Helmut and Gailus-Durner, Valerie and Galli, Antonella and Gambadoro, Alessia and Gallegos, Juan and Guo, Shiying and Horner, Neil R and Hsu, Chih-wei and Johnson, Sara J and Kalaga, Sowmya and Keith, Lance C and Lanoue, Louise and Lawson, Thomas N and Lek, Monkol and Mark, Manuel and Marschall, Susan and Mason, Jeremy and McElwee, Melissa L and Newbigging, Susan and Nutter, Lauryl M.J and Peterson, Kevin A and Ramirez-Solis, Ramiro and Rowland, Douglas J and Ryder, Edward and Samocha, Kaitlin E and Seavitt, John R and Selloum, Mohammed and Szoke-Kovacs, Zsombor and Tamura, Masaru and Trainor, Amanda G and Tudose, Ilinca and Wakana, Shigeharu and Warren, Jonathan and Wendling, Olivia and West, David B and Wong, Leeyean and Yoshiki, Atsushi and MacArthur, Daniel G and Tocchini-Valentini, Glauco P and Gao, Xiang and Flicek, Paul and Bradley, Allan and Skarnes, William C and Justice, Monica J and Parkinson, Helen E and Moore, Mark and Wells, Sara and Braun, Robert E and Svenson, Karen L and Hrabe de Angelis, Martin and Herault, Yann and Mohun, Tim and Mallon, Ann-Marie and Mark Henkelman, R and Brown, Steve D.M and Adams, David J and Kent Lloyd, K.C and McKerlie, Colin and Beaudet, Arthur L and Bucan, Maja and Murray, Stephen A and McKay, Matthew and Urban, Barbara and Lund, Caroline and Froeter, Erin and LaCasse, Taylor and Mehalow, Adrienne and Gordon, Emily and Donahue, Leah Rae and Taft, Robert and Kutney, Peter and Dion, Stephanie and Goodwin, Leslie and Kales, Susan and Urban, Rachel and Palmer, Kristina and Pertuy, Fabien and Bitz, Deborah and ... and Int Mouse Phenotyping Consortium and The International Mouse Phenotyping Consortium
Nature, ISSN 0028-0836, 09/2016, Volume 537, Issue 7621, pp. 508 - 514
Approximately one-third of all mammalian genes are essential for life. Phenotypes resulting from knockouts of these genes in mice have provided tremendous... 
MICRO-CT | MULTIDISCIPLINARY SCIENCES | DISEASE | GENOME-WIDE | MAMMALIAN GENE-FUNCTION | SCREENS | GLYCOGENIN-1 DEFICIENCY | IDENTIFICATION | EXPRESSION | MOUSE EMBRYO | RESOURCE | Genetic research | Phenotype | Research | High-throughput screening (Biochemical assaying) | Methods | Genotype & phenotype | Disease | Developmental biology | Genes | Genomes | Mutation | Embryos | knockout | embryonic lethal | mouse | KOMP | IMPC | EUCOMM
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2. Full Text Three-dimensional microCT imaging of mouse development from early post-implantation to early postnatal stages
by Hsu, Chih-Wei and Wong, Leeyean and Rasmussen, Tara L and Kalaga, Sowmya and McElwee, Melissa L and Keith, Lance C and Bohat, Ritu and Seavitt, John R and Beaudet, Arthur L and Dickinson, Mary E
Developmental Biology, ISSN 0012-1606, 11/2016, Volume 419, Issue 2, pp. 229 - 236
In this work, we report the use of iodine-contrast microCT to perform high-throughput 3D morphological analysis of mouse embryos and neonates between embryonic... 
MicroCT | IMPC | Embryonic lethal screening | ATLAS | EMBRYO | DNA-DAMAGE | DEVELOPMENTAL BIOLOGY | MICROSCOPY | MORPHOLOGY | TOOL | Animals, Newborn | Staining and Labeling - methods | Yolk Sac - ultrastructure | Genetic Association Studies | Hydrogels | Imaging, Three-Dimensional - methods | Embryonic Development | X-Ray Microtomography - methods | Gestational Age | Mice - embryology | Genes, Lethal | Phenotype | Animals | Contrast Media | Decidua - ultrastructure | Female | Iodine | Physiological aspects | Medical colleges | Infants (Newborn)
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3. Full Text Macrophages engulf endothelial cell membrane particles preceding pupillary membrane capillary regression
by Poché, Ross A and Hsu, Chih-Wei and McElwee, Melissa L and Burns, Alan R and Dickinson, Mary E
Developmental Biology, ISSN 0012-1606, 07/2015, Volume 403, Issue 1, pp. 30 - 42
Programmed capillary regression and remodeling are essential developmental processes. However, the cellular and molecular mechanisms that regulate vessel... 
Eye | Macrophages | Pupillary membrane | Endothelial cells | SYSTEM | APOPTOSIS | MOUSE | RECEPTOR | DEATH | DEVELOPMENTAL BIOLOGY | MICROPARTICLES | VASCULAR MORPHOGENESIS | REPORTER | FILOPODIA | MICE | Pupil - physiology | Eye - blood supply | Cell Surface Extensions - metabolism | Mice, Inbred C57BL | Phagocytosis - immunology | Cell Membrane - physiology | Wnt Proteins - metabolism | beta Catenin - metabolism | Mice, Inbred ICR | Mice, Knockout | Animals | Cell-Derived Microparticles - immunology | Endothelial Cells - cytology | Mice | Capillaries | Macrophages - immunology | Embryonic development | Developmental biology | Cell membranes | Genetic engineering | Electron microscopy | Endothelium | eye | pupillary membrane | endothelial cells | macrophages
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4. Full Text Corrigendum: High-throughput discovery of novel developmental phenotypes
by Dickinson, Mary E and Flenniken, Ann M and Ji, Xiao and Teboul, Lydia and Wong, Michael D and White, Jacqueline K and Meehan, Terrence F and Weninger, Wolfgang J and Westerberg, Henrik and Adissu, Hibret and Baker, Candice N and Bower, Lynette and Brown, James M and Caddle, L Brianna and Chiani, Francesco and Clary, Dave and Cleak, James and Daly, Mark J and Denegre, James M and Doe, Brendan and Dolan, Mary E and Edie Helmut Fuchs, Sarah M and Gailus-Durner, Valerie and Galli, Antonella and Gambadoro, Alessia and Gallegos, Juan and Guo, Shiying and Horner, Neil R and Hsu, Chih-Wei and Johnson, Sara J and Kalaga, Sowmya and Keith, Lance C and Lanoue, Louise and Lawson, Thomas N and Lek, Monkol and Mark, Manuel and Marschall, Susan and Mason, Jeremy and McElwee, Melissa L and Nutter, Susan Newbigging Lauryl M J and Peterson, Kevin A and Ramirez-Solis, Ramiro and Rowland, Douglas J and Ryder, Edward and Samocha, Kaitlin E and Seavitt, John R and Selloum, Mohammed and Szoke-Kovacs, Zsombor and Tamura, Masaru and Trainor, Amanda G and Tudose, Ilinca and Wakana, Shigeharu and Warren, Jonathan and Wendling, Olivia and West, David B and Wong, Leeyean and Yoshiki, Atsushi and Wurst, Wolfgang and MacArthur, Daniel G and Tocchini-Valentini, Glauco P and Gao, Xiang and Flicek, Paul and Bradley, Allan and Skarnes, William C and Justice, Monica J and Parkinson, Helen E and Moore, Mark and Wells, Sara and Braun, Robert E and Svenson, Karen L and de Angelis, Martin Hrabe and Herault, Yann and Mohun, Tim and Mallon, Ann-Marie and Henkelman, R Mark and Brown, Steve D M and Adams, David J and Lloyd, K C Kent and McKerlie, Colin and Beaudet, Arthur L and Murray, Maja Bućan Stephen A and International Mouse Phenotyping Consortium
Nature, ISSN 0028-0836, 11/2017, Volume 551, Issue 7680, pp. 398 - 398
This corrects the article DOI: 10.1038/nature19356. 
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5. Full Text Erratum: Corrigendum: High-throughput discovery of novel developmental phenotypes
by Dickinson, Mary E and Flenniken, Ann M and Ji, Xiao and Teboul, Lydia and Wong, Michael D and White, Jacqueline K and Meehan, Terrence F and Weninger, Wolfgang J and Westerberg, Henrik and Adissu, Hibret and Baker, Candice N and Bower, Lynette and Brown, James M and Caddle, L. Brianna and Chiani, Francesco and Clary, Dave and Cleak, James and Daly, Mark J and Denegre, James M and Doe, Brendan and Dolan, Mary E and Edie Helmut Fuchs, Sarah M and Gailus-Durner, Valerie and Galli, Antonella and Gambadoro, Alessia and Gallegos, Juan and Guo, Shiying and Horner, Neil R and Hsu, Chih-Wei and Johnson, Sara J and Kalaga, Sowmya and Keith, Lance C and Lanoue, Louise and Lawson, Thomas N and Lek, Monkol and Mark, Manuel and Marschall, Susan and Mason, Jeremy and McElwee, Melissa L and Nutter, Susan Newbigging Lauryl M. J and Peterson, Kevin A and Ramirez-Solis, Ramiro and Rowland, Douglas J and Ryder, Edward and Samocha, Kaitlin E and Seavitt, John R and Selloum, Mohammed and Szoke-Kovacs, Zsombor and Tamura, Masaru and Trainor, Amanda G and Tudose, Ilinca and Wakana, Shigeharu and Warren, Jonathan and Wendling, Olivia and West, David B and Wong, Leeyean and Yoshiki, Atsushi and Wurst, Wolfgang and MacArthur, Daniel G and Tocchini-Valentini, Glauco P and Gao, Xiang and Flicek, Paul and Bradley, Allan and Skarnes, William C and Justice, Monica J and Parkinson, Helen E and Moore, Mark and Wells, Sara and Braun, Robert E and Svenson, Karen L and de Angelis, Martin Hrabe and Herault, Yann and Mohun, Tim and Mallon, Ann-Marie and Henkelman, R. Mark and Brown, Steve D. M and Adams, David J and Lloyd, K. C. Kent and McKerlie, Colin and Beaudet, Arthur L and Murray, Maja Bućan Stephen A and The International Mouse Phenotyping Consortium
Nature, ISSN 0028-0836, 11/2017, Volume 551, Issue 7680, pp. 398 - 398
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6. Full Text RONIN Is an Essential Transcriptional Regulator of Genes Required for Mitochondrial Function in the Developing Retina
by Poché, Ross A and Zhang, Min and Rueda, Elda M and Tong, Xuefei and McElwee, Melissa L and Wong, Leeyean and Hsu, Chih-Wei and Dejosez, Marion and Burns, Alan R and Fox, Donald A and Martin, James F and Zwaka, Thomas P and Dickinson, Mary E
Cell Reports, ISSN 2211-1247, 02/2016, Volume 14, Issue 7, pp. 1684 - 1697
A fundamental principle governing organ size and function is the fine balance between cell proliferation and cell differentiation. Here, we identify RONIN... 
PROGENITORS | APOPTOSIS | SUPERCOMPLEXES | BIOGENESIS | RESPIRATION | EMBRYONIC STEM-CELLS | MOUSE | CELL-CYCLE PROGRESSION | DROSOPHILA | CELL BIOLOGY | Cell Proliferation | Oxidative Stress | Signal Transduction | Embryo, Mammalian | Repressor Proteins - genetics | Mice, Transgenic | Photoreceptor Cells, Vertebrate - cytology | Electron Transport Chain Complex Proteins - genetics | Mitochondria - metabolism | Stem Cells - cytology | Adenosine Triphosphate - biosynthesis | Stem Cells - metabolism | G1 Phase Cell Cycle Checkpoints - genetics | Animals | Gene Expression Regulation, Developmental | Electron Transport Chain Complex Proteins - metabolism | Transcription, Genetic | Cell Differentiation | Mice | Photoreceptor Cells, Vertebrate - metabolism | Repressor Proteins - metabolism
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7. Full Text High-throughput discovery of novel developmental phenotypes
by Dickinson, Mary E and Flenniken, Ann M and Ji, Xiao and Teboul, Lydia and Wong, Michael D and White, Jacqueline K and Meehan, Terrence F and Weninger, Wolfgang J and Westerberg, Henrik and Adissu, Hibret and Baker, Candice N and Bower, Lynette and Brown, James M and Caddle, L Brianna and Chiani, Francesco and Clary, Dave and Cleak, James and Daly, Mark J and Denegre, James M and Doe, Brendan and Dolan, Mary E and Edie, Sarah M and Fuchs, Helmut and Gailus-Durner, Valerie and Galli, Antonella and Gambadoro, Alessia and Gallegos, Juan and Guo, Shiying and Horner, Neil R and Hsu, Chih-Wei and Johnson, Sara J and Kalaga, Sowmya and Keith, Lance C and Lanoue, Louise and Lawson, Thomas N and Lek, Monkol and Mark, Manuel and Marschall, Susan and Mason, Jeremy and McElwee, Melissa L and Newbigging, Susan and Nutter, Lauryl M J and Peterson, Kevin A and Ramirez-Solis, Ramiro and Rowland, Douglas J and Ryder, Edward and Samocha, Kaitlin E and Seavitt, John R and Selloum, Mohammed and Szoke-Kovacs, Zsombor and Tamura, Masaru and Trainor, Amanda G and Tudose, Ilinca and Wakana, Shigeharu and Warren, Jonathan and Wendling, Olivia and West, David B and Wong, Leeyean and Yoshiki, Atsushi and MacArthur, Daniel G and Tocchini-Valentini, Glauco P and Gao, Xiang and Flicek, Paul and Bradley, Allan and Skarnes, William C and Justice, Monica J and Parkinson, Helen E and Moore, Mark and Wells, Sara and Braun, Robert E and Svenson, Karen L and de Angelis, Martin Hrabe and Herault, Yann and Mohun, Tim and Mallon, Ann-Marie and Henkelman, R Mark and Brown, Steve D M and Adams, David J and Lloyd, K C Kent and McKerlie, Colin and Beaudet, Arthur L and Bućan, Maja and Murray, Stephen A and Charles River Laboratories and RIKEN BioResource Center and International Mouse Phenotyping Consortium and Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris (ICS) and Jackson Laboratory and MRC Harwell and Wellcome Trust Sanger Institute and Toronto Centre for Phenogenomics
Nature, 09/2016, Volume 537, Issue 7621, p. 508
Approximately one-third of all mammalian genes are essential for life. Phenotypes resulting from knockouts of these genes in mice have provided tremendous... 
Conserved Sequence - genetics | Genome-Wide Association Study | Disease | Humans | Mice, Inbred C57BL | Penetrance | Mutation - genetics | Embryo, Mammalian - metabolism | Mice, Knockout | Sequence Homology | Phenotype | Animals | High-Throughput Screening Assays | Embryo, Mammalian - embryology | Genes, Lethal - genetics | Polymorphism, Single Nucleotide - genetics | Mice | Imaging, Three-Dimensional | Genes, Essential - genetics
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8. Full Text Muc5b is required for airway defence
by Roy, Michelle G and Livraghi-Butrico, Alessandra and Fletcher, Ashley A and McElwee, Melissa M and Evans, Scott E and Boerner, Ryan M and Alexander, Samantha N and Bellinghausen, Lindsey K and Song, Alfred S and Petrova, Youlia M and Tuvim, Michael J and Adachi, Roberto and Romo, Irlanda and Bordt, Andrea S and Bowden, M. Gabriela and Sisson, Joseph H and Woodruff, Prescott G and Thornton, David J and Rousseau, Karine and De La Garza, Maria M and Moghaddam, Seyed J and Karmouty-Quintana, Harry and Blackburn, Michael R and Drouin, Scott M and Davis, C. William and Terrell, Kristy A and Grubb, Barbara R and O'Neal, Wanda K and Flores, Sonia C and Cota-Gomez, Adela and Lozupone, Catherine A and Donnelly, Jody M and Watson, Alan M and Hennessy, Corinne E and Keith, Rebecca C and Yang, Ivana V and Barthel, Lea and Henson, Peter M and Janssen, William J and Schwartz, David A and Boucher, Richard C and Dickey, Burton F and Evans, Christopher M
Nature, ISSN 0028-0836, 2014, Volume 505, Issue 7483, pp. 412 - 416
Respiratory surfaces are exposed to billions of particulates and pathogens daily. A protective mucus barrier traps and eliminates them through mucociliary... 
CLARA CELLS | LUNG | MUCIN | OTITIS-MEDIA | MULTIDISCIPLINARY SCIENCES | DISEASE | ASTHMA | MICE | CYSTIC-FIBROSIS | EXPRESSION | MUCOCILIARY CLEARANCE | Cilia - physiology | Inflammation - pathology | Lung - microbiology | Asthma - metabolism | Mucin 5AC - deficiency | Mucin-5B - genetics | Pulmonary Disease, Chronic Obstructive - microbiology | Male | Mucin-5B - secretion | Bacterial Infections - immunology | Respiratory Mucosa - immunology | Asthma - immunology | Female | Lung - metabolism | Bacterial Infections - microbiology | Macrophages - immunology | Ear, Middle - microbiology | Ear, Middle - immunology | Macrophages - pathology | Mice, Inbred C57BL | Mice, Transgenic | Mucin-5B - metabolism | Animals | Models, Biological | Survival Analysis | Mucin 5AC - metabolism | Staphylococcus aureus - immunology | Mice | Respiratory Mucosa - metabolism | Pulmonary Disease, Chronic Obstructive - immunology | Lung - immunology | Phagocytosis | Mucin-5B - deficiency | Physiological aspects | Respiratory tract diseases | Research | Mucins | Airway management | Bacterial infections | Lungs | Pathogenesis | Mortality | Ear diseases | Ventilation | Bacteria | Staphylococcus infections | Variance analysis
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9. You will dream new dreams
: inspiring personal stories by parents of children with disabilities
by Klein, Stanley D and Schive, Kim
2001, ISBN 1575665603, xix, 278
Parents of children with disabilities | Children with disabilities | Diabetes in children
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10. Full Text Corrigendum: High-throughput discovery of novel developmental phenotypes (Nature (2016) 537 (508-514) DOI: 10.1038/nature19356)
Nature, ISSN 0028-0836, 11/2017, Volume 551, Issue 7680, p. 398
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11. Full Text The polymeric mucin Muc5ac is required for allergic airway hyperreactivity
by Evans, Christopher M and Raclawska, Dorota S and Ttofali, Fani and Liptzin, Deborah R and Fletcher, Ashley A and Harper, Daniel N and McGing, Maggie A and McElwee, Melissa M and Williams, Olatunji W and Sanchez, Elizabeth and Roy, Michelle G and Kindrachuk, Kristen N and Wynn, Thomas A and Eltzschig, Holger K and Blackburn, Michael R and Tuvim, Michael J and Janssen, William J and Schwartz, David A and Dickey, Burton F
Nature Communications, ISSN 2041-1723, 02/2015, Volume 6, Issue 1, p. 6281
In asthma, airflow obstruction is thought to result primarily from inflammation-triggered airway smooth muscle (ASM) contraction. However, anti-inflammatory... 
GROWTH-FACTOR RECEPTOR | SMOOTH-MUSCLE | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | ASTHMA | GOBLET CELL HYPERPLASIA | N-ACETYLCYSTEINE | MUCUS PRODUCTION | HYPERRESPONSIVENESS | MUCOCILIARY CLEARANCE | MUCOUS METAPLASIA | Immunohistochemistry | Asthma - metabolism | Species Specificity | Mice, Inbred C57BL | Methacholine Chloride - chemistry | Male | Mice, Transgenic | Inflammation | Aspergillus oryzae - chemistry | Animals | Allergens - chemistry | Mucin 5AC - metabolism | Bronchial Hyperreactivity - metabolism | Female | Mucus - metabolism | Lung - metabolism | Mice | Mice, Inbred BALB C | Ovalbumin - chemistry
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12. Full Text Human PI3K gamma deficiency and its microbiota-dependent mouse model reveal immunodeficiency and tissue immunopathology
by Takeda, AJ and Maher, TJ and Zhang, Y and Lanahan, SM and Bucklin, ML and Compton, SR and Tyler, PM and Comrie, WA and Matsuda, M and Olivier, KN and Pittaluga, S and McElwee, JJ and Priel, DAL and Kuhns, DB and Williams, RL and Mustillo, PJ and Wymann, MP and Rao, VK and Lucas, CL
NATURE COMMUNICATIONS, ISSN 2041-1723, 09/2019, Volume 10, Issue 1, pp. 1 - 12
Phosphatidylinositol 3-kinase-gamma (PI3K gamma) is highly expressed in leukocytes and is an attractive drug target for immune modulation. Different... 
IMMUNE DYSREGULATION | PI3K-DELTA | MULTIDISCIPLINARY SCIENCES | T-CELL-ACTIVATION | DELTA SYNDROME | RECEPTOR | PHOSPHOINOSITIDE 3-KINASE GAMMA | MUTATIONS | BETA-SELECTION | INHIBITOR | SUPPRESSION | CD8 antigen | Antibodies | Interleukin 23 | Lymphocytes T | Leukocytes | Macrophages | Kinases | Homing | Microbiota | Lymphocytes | Peripheral blood | Catalysis | Children | Memory cells | Immunoregulation | Immunomodulation | Immunodeficiency | Interleukin 12 | Inflammation | CXCR3 protein | Housing | 1-Phosphatidylinositol 3-kinase | CD4 antigen | Monocytes | Pneumonitis | Mutation | Colitis | Cell migration
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