Nature, ISSN 0028-0836, 09/2016, Volume 537, Issue 7621, pp. 508 - 514
Approximately one-third of all mammalian genes are essential for life. Phenotypes resulting from knockouts of these genes in mice have provided tremendous...
MICRO-CT | MULTIDISCIPLINARY SCIENCES | DISEASE | GENOME-WIDE | MAMMALIAN GENE-FUNCTION | SCREENS | GLYCOGENIN-1 DEFICIENCY | IDENTIFICATION | EXPRESSION | MOUSE EMBRYO | RESOURCE | Genetic research | Phenotype | Research | High-throughput screening (Biochemical assaying) | Methods | Genotype & phenotype | Disease | Developmental biology | Genes | Genomes | Mutation | Embryos | knockout | embryonic lethal | mouse | KOMP | IMPC | EUCOMM
MICRO-CT | MULTIDISCIPLINARY SCIENCES | DISEASE | GENOME-WIDE | MAMMALIAN GENE-FUNCTION | SCREENS | GLYCOGENIN-1 DEFICIENCY | IDENTIFICATION | EXPRESSION | MOUSE EMBRYO | RESOURCE | Genetic research | Phenotype | Research | High-throughput screening (Biochemical assaying) | Methods | Genotype & phenotype | Disease | Developmental biology | Genes | Genomes | Mutation | Embryos | knockout | embryonic lethal | mouse | KOMP | IMPC | EUCOMM
Journal Article
Developmental Biology, ISSN 0012-1606, 11/2016, Volume 419, Issue 2, pp. 229 - 236
In this work, we report the use of iodine-contrast microCT to perform high-throughput 3D morphological analysis of mouse embryos and neonates between embryonic...
MicroCT | IMPC | Embryonic lethal screening | ATLAS | EMBRYO | DNA-DAMAGE | DEVELOPMENTAL BIOLOGY | MICROSCOPY | MORPHOLOGY | TOOL | Animals, Newborn | Staining and Labeling - methods | Yolk Sac - ultrastructure | Genetic Association Studies | Hydrogels | Imaging, Three-Dimensional - methods | Embryonic Development | X-Ray Microtomography - methods | Gestational Age | Mice - embryology | Genes, Lethal | Phenotype | Animals | Contrast Media | Decidua - ultrastructure | Female | Iodine | Physiological aspects | Medical colleges | Infants (Newborn)
MicroCT | IMPC | Embryonic lethal screening | ATLAS | EMBRYO | DNA-DAMAGE | DEVELOPMENTAL BIOLOGY | MICROSCOPY | MORPHOLOGY | TOOL | Animals, Newborn | Staining and Labeling - methods | Yolk Sac - ultrastructure | Genetic Association Studies | Hydrogels | Imaging, Three-Dimensional - methods | Embryonic Development | X-Ray Microtomography - methods | Gestational Age | Mice - embryology | Genes, Lethal | Phenotype | Animals | Contrast Media | Decidua - ultrastructure | Female | Iodine | Physiological aspects | Medical colleges | Infants (Newborn)
Journal Article
Developmental Biology, ISSN 0012-1606, 07/2015, Volume 403, Issue 1, pp. 30 - 42
Programmed capillary regression and remodeling are essential developmental processes. However, the cellular and molecular mechanisms that regulate vessel...
Eye | Macrophages | Pupillary membrane | Endothelial cells | SYSTEM | APOPTOSIS | MOUSE | RECEPTOR | DEATH | DEVELOPMENTAL BIOLOGY | MICROPARTICLES | VASCULAR MORPHOGENESIS | REPORTER | FILOPODIA | MICE | Pupil - physiology | Eye - blood supply | Cell Surface Extensions - metabolism | Mice, Inbred C57BL | Phagocytosis - immunology | Cell Membrane - physiology | Wnt Proteins - metabolism | beta Catenin - metabolism | Mice, Inbred ICR | Mice, Knockout | Animals | Cell-Derived Microparticles - immunology | Endothelial Cells - cytology | Mice | Capillaries | Macrophages - immunology | Embryonic development | Developmental biology | Cell membranes | Genetic engineering | Electron microscopy | Endothelium | eye | pupillary membrane | endothelial cells | macrophages
Eye | Macrophages | Pupillary membrane | Endothelial cells | SYSTEM | APOPTOSIS | MOUSE | RECEPTOR | DEATH | DEVELOPMENTAL BIOLOGY | MICROPARTICLES | VASCULAR MORPHOGENESIS | REPORTER | FILOPODIA | MICE | Pupil - physiology | Eye - blood supply | Cell Surface Extensions - metabolism | Mice, Inbred C57BL | Phagocytosis - immunology | Cell Membrane - physiology | Wnt Proteins - metabolism | beta Catenin - metabolism | Mice, Inbred ICR | Mice, Knockout | Animals | Cell-Derived Microparticles - immunology | Endothelial Cells - cytology | Mice | Capillaries | Macrophages - immunology | Embryonic development | Developmental biology | Cell membranes | Genetic engineering | Electron microscopy | Endothelium | eye | pupillary membrane | endothelial cells | macrophages
Journal Article
Nature, ISSN 0028-0836, 11/2017, Volume 551, Issue 7680, pp. 398 - 398
This corrects the article DOI: 10.1038/nature19356.
Journal Article
Nature, ISSN 0028-0836, 11/2017, Volume 551, Issue 7680, pp. 398 - 398
Journal Article
Cell Reports, ISSN 2211-1247, 02/2016, Volume 14, Issue 7, pp. 1684 - 1697
A fundamental principle governing organ size and function is the fine balance between cell proliferation and cell differentiation. Here, we identify RONIN...
PROGENITORS | APOPTOSIS | SUPERCOMPLEXES | BIOGENESIS | RESPIRATION | EMBRYONIC STEM-CELLS | MOUSE | CELL-CYCLE PROGRESSION | DROSOPHILA | CELL BIOLOGY | Cell Proliferation | Oxidative Stress | Signal Transduction | Embryo, Mammalian | Repressor Proteins - genetics | Mice, Transgenic | Photoreceptor Cells, Vertebrate - cytology | Electron Transport Chain Complex Proteins - genetics | Mitochondria - metabolism | Stem Cells - cytology | Adenosine Triphosphate - biosynthesis | Stem Cells - metabolism | G1 Phase Cell Cycle Checkpoints - genetics | Animals | Gene Expression Regulation, Developmental | Electron Transport Chain Complex Proteins - metabolism | Transcription, Genetic | Cell Differentiation | Mice | Photoreceptor Cells, Vertebrate - metabolism | Repressor Proteins - metabolism
PROGENITORS | APOPTOSIS | SUPERCOMPLEXES | BIOGENESIS | RESPIRATION | EMBRYONIC STEM-CELLS | MOUSE | CELL-CYCLE PROGRESSION | DROSOPHILA | CELL BIOLOGY | Cell Proliferation | Oxidative Stress | Signal Transduction | Embryo, Mammalian | Repressor Proteins - genetics | Mice, Transgenic | Photoreceptor Cells, Vertebrate - cytology | Electron Transport Chain Complex Proteins - genetics | Mitochondria - metabolism | Stem Cells - cytology | Adenosine Triphosphate - biosynthesis | Stem Cells - metabolism | G1 Phase Cell Cycle Checkpoints - genetics | Animals | Gene Expression Regulation, Developmental | Electron Transport Chain Complex Proteins - metabolism | Transcription, Genetic | Cell Differentiation | Mice | Photoreceptor Cells, Vertebrate - metabolism | Repressor Proteins - metabolism
Journal Article
Nature, 09/2016, Volume 537, Issue 7621, p. 508
Approximately one-third of all mammalian genes are essential for life. Phenotypes resulting from knockouts of these genes in mice have provided tremendous...
Conserved Sequence - genetics | Genome-Wide Association Study | Disease | Humans | Mice, Inbred C57BL | Penetrance | Mutation - genetics | Embryo, Mammalian - metabolism | Mice, Knockout | Sequence Homology | Phenotype | Animals | High-Throughput Screening Assays | Embryo, Mammalian - embryology | Genes, Lethal - genetics | Polymorphism, Single Nucleotide - genetics | Mice | Imaging, Three-Dimensional | Genes, Essential - genetics
Conserved Sequence - genetics | Genome-Wide Association Study | Disease | Humans | Mice, Inbred C57BL | Penetrance | Mutation - genetics | Embryo, Mammalian - metabolism | Mice, Knockout | Sequence Homology | Phenotype | Animals | High-Throughput Screening Assays | Embryo, Mammalian - embryology | Genes, Lethal - genetics | Polymorphism, Single Nucleotide - genetics | Mice | Imaging, Three-Dimensional | Genes, Essential - genetics
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 505, Issue 7483, pp. 412 - 416
Respiratory surfaces are exposed to billions of particulates and pathogens daily. A protective mucus barrier traps and eliminates them through mucociliary...
CLARA CELLS | LUNG | MUCIN | OTITIS-MEDIA | MULTIDISCIPLINARY SCIENCES | DISEASE | ASTHMA | MICE | CYSTIC-FIBROSIS | EXPRESSION | MUCOCILIARY CLEARANCE | Cilia - physiology | Inflammation - pathology | Lung - microbiology | Asthma - metabolism | Mucin 5AC - deficiency | Mucin-5B - genetics | Pulmonary Disease, Chronic Obstructive - microbiology | Male | Mucin-5B - secretion | Bacterial Infections - immunology | Respiratory Mucosa - immunology | Asthma - immunology | Female | Lung - metabolism | Bacterial Infections - microbiology | Macrophages - immunology | Ear, Middle - microbiology | Ear, Middle - immunology | Macrophages - pathology | Mice, Inbred C57BL | Mice, Transgenic | Mucin-5B - metabolism | Animals | Models, Biological | Survival Analysis | Mucin 5AC - metabolism | Staphylococcus aureus - immunology | Mice | Respiratory Mucosa - metabolism | Pulmonary Disease, Chronic Obstructive - immunology | Lung - immunology | Phagocytosis | Mucin-5B - deficiency | Physiological aspects | Respiratory tract diseases | Research | Mucins | Airway management | Bacterial infections | Lungs | Pathogenesis | Mortality | Ear diseases | Ventilation | Bacteria | Staphylococcus infections | Variance analysis
CLARA CELLS | LUNG | MUCIN | OTITIS-MEDIA | MULTIDISCIPLINARY SCIENCES | DISEASE | ASTHMA | MICE | CYSTIC-FIBROSIS | EXPRESSION | MUCOCILIARY CLEARANCE | Cilia - physiology | Inflammation - pathology | Lung - microbiology | Asthma - metabolism | Mucin 5AC - deficiency | Mucin-5B - genetics | Pulmonary Disease, Chronic Obstructive - microbiology | Male | Mucin-5B - secretion | Bacterial Infections - immunology | Respiratory Mucosa - immunology | Asthma - immunology | Female | Lung - metabolism | Bacterial Infections - microbiology | Macrophages - immunology | Ear, Middle - microbiology | Ear, Middle - immunology | Macrophages - pathology | Mice, Inbred C57BL | Mice, Transgenic | Mucin-5B - metabolism | Animals | Models, Biological | Survival Analysis | Mucin 5AC - metabolism | Staphylococcus aureus - immunology | Mice | Respiratory Mucosa - metabolism | Pulmonary Disease, Chronic Obstructive - immunology | Lung - immunology | Phagocytosis | Mucin-5B - deficiency | Physiological aspects | Respiratory tract diseases | Research | Mucins | Airway management | Bacterial infections | Lungs | Pathogenesis | Mortality | Ear diseases | Ventilation | Bacteria | Staphylococcus infections | Variance analysis
Journal Article
2001, ISBN 1575665603, xix, 278
Book
Nature, ISSN 0028-0836, 11/2017, Volume 551, Issue 7680, p. 398
Journal Article
Nature Communications, ISSN 2041-1723, 02/2015, Volume 6, Issue 1, p. 6281
In asthma, airflow obstruction is thought to result primarily from inflammation-triggered airway smooth muscle (ASM) contraction. However, anti-inflammatory...
GROWTH-FACTOR RECEPTOR | SMOOTH-MUSCLE | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | ASTHMA | GOBLET CELL HYPERPLASIA | N-ACETYLCYSTEINE | MUCUS PRODUCTION | HYPERRESPONSIVENESS | MUCOCILIARY CLEARANCE | MUCOUS METAPLASIA | Immunohistochemistry | Asthma - metabolism | Species Specificity | Mice, Inbred C57BL | Methacholine Chloride - chemistry | Male | Mice, Transgenic | Inflammation | Aspergillus oryzae - chemistry | Animals | Allergens - chemistry | Mucin 5AC - metabolism | Bronchial Hyperreactivity - metabolism | Female | Mucus - metabolism | Lung - metabolism | Mice | Mice, Inbred BALB C | Ovalbumin - chemistry
GROWTH-FACTOR RECEPTOR | SMOOTH-MUSCLE | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | ASTHMA | GOBLET CELL HYPERPLASIA | N-ACETYLCYSTEINE | MUCUS PRODUCTION | HYPERRESPONSIVENESS | MUCOCILIARY CLEARANCE | MUCOUS METAPLASIA | Immunohistochemistry | Asthma - metabolism | Species Specificity | Mice, Inbred C57BL | Methacholine Chloride - chemistry | Male | Mice, Transgenic | Inflammation | Aspergillus oryzae - chemistry | Animals | Allergens - chemistry | Mucin 5AC - metabolism | Bronchial Hyperreactivity - metabolism | Female | Mucus - metabolism | Lung - metabolism | Mice | Mice, Inbred BALB C | Ovalbumin - chemistry
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 09/2019, Volume 10, Issue 1, pp. 1 - 12
Phosphatidylinositol 3-kinase-gamma (PI3K gamma) is highly expressed in leukocytes and is an attractive drug target for immune modulation. Different...
IMMUNE DYSREGULATION | PI3K-DELTA | MULTIDISCIPLINARY SCIENCES | T-CELL-ACTIVATION | DELTA SYNDROME | RECEPTOR | PHOSPHOINOSITIDE 3-KINASE GAMMA | MUTATIONS | BETA-SELECTION | INHIBITOR | SUPPRESSION | CD8 antigen | Antibodies | Interleukin 23 | Lymphocytes T | Leukocytes | Macrophages | Kinases | Homing | Microbiota | Lymphocytes | Peripheral blood | Catalysis | Children | Memory cells | Immunoregulation | Immunomodulation | Immunodeficiency | Interleukin 12 | Inflammation | CXCR3 protein | Housing | 1-Phosphatidylinositol 3-kinase | CD4 antigen | Monocytes | Pneumonitis | Mutation | Colitis | Cell migration
IMMUNE DYSREGULATION | PI3K-DELTA | MULTIDISCIPLINARY SCIENCES | T-CELL-ACTIVATION | DELTA SYNDROME | RECEPTOR | PHOSPHOINOSITIDE 3-KINASE GAMMA | MUTATIONS | BETA-SELECTION | INHIBITOR | SUPPRESSION | CD8 antigen | Antibodies | Interleukin 23 | Lymphocytes T | Leukocytes | Macrophages | Kinases | Homing | Microbiota | Lymphocytes | Peripheral blood | Catalysis | Children | Memory cells | Immunoregulation | Immunomodulation | Immunodeficiency | Interleukin 12 | Inflammation | CXCR3 protein | Housing | 1-Phosphatidylinositol 3-kinase | CD4 antigen | Monocytes | Pneumonitis | Mutation | Colitis | Cell migration
Journal Article
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