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TOXICOLOGICAL SCIENCES, ISSN 1096-6080, 09/2018, Volume 165, Issue 1, pp. 3 - 4
Journal Article
CLINICAL CHEMISTRY, ISSN 0009-9147, 01/2018, Volume 64, Issue 1, pp. 242 - 243
Four of 10 healthy volunteers in the control group had increased serum C-reactive protein (CRP) concentrations (reference interval: 10 mg/L; non-high... 
MEDICAL LABORATORY TECHNOLOGY | Case studies | Health aspects | C-reactive protein | Proteins | Laboratories | Low density lipoprotein
Journal Article
Biochimica et Biophysica Acta - Molecular Basis of Disease, ISSN 0925-4439, 2018, Volume 1865, Issue 5, pp. 1031 - 1039
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 9/2013, Volume 30, Issue 9, pp. 2174 - 2187
Acetaminophen (APAP) is one of the most widely used drugs. Though safe at therapeutic doses, overdose causes mitochondrial dysfunction and centrilobular... 
Biochemistry, general | Biomedical Engineering | drug transporters | nuclear receptors | acetaminophen | Biomedicine | Pharmacy | hepatotoxicity | drug metabolism | Medical Law | Pharmacology/Toxicology | ACUTE LIVER-FAILURE | PREGNANE-X RECEPTOR | APOPTOSIS-INDUCING FACTOR | COVALENT BINDING | MITOCHONDRIAL OXIDANT STRESS | CHEMISTRY, MULTIDISCIPLINARY | S-TRANSFERASE-PI | INDUCED HEPATIC-NECROSIS | CULTURED MOUSE HEPATOCYTES | BILIARY-EXCRETION | PHARMACOLOGY & PHARMACY | GLUTATHIONE DEPLETION | Acetaminophen - metabolism | Analgesics, Non-Narcotic - blood | Analgesics, Non-Narcotic - pharmacokinetics | Acetaminophen - toxicity | Humans | Liver - metabolism | Antipyretics - toxicity | Cytochrome P-450 Enzyme System - metabolism | Glutathione Transferase - metabolism | Analgesics, Non-Narcotic - metabolism | Chemical and Drug Induced Liver Injury - diagnosis | Acetaminophen - blood | Animals | Antipyretics - pharmacokinetics | Analgesics, Non-Narcotic - toxicity | Liver - drug effects | Chemical and Drug Induced Liver Injury - metabolism | Protein Binding | Acetaminophen - pharmacokinetics | Antipyretics - blood | Antipyretics - metabolism | Cellular proteins | Metabolites | Acetaminophen | Transferases | Cytochrome P-450 | Physiological aspects | Sulfates | Protein binding | Metabolism | Medical diagnosis | Hepatology | Index Medicus
Journal Article
Hearing Research, ISSN 0378-5955, 08/2019, Volume 379, pp. 98 - 102
Inner ear drug delivery is a major area of research and development, but relatively little is known about basic drug metabolism in the cochlea. Additionally,... 
Deafness | Cytochrome P450 | Drug toxicity | Drug metabolism | Drug delivery | Hearing loss | Ototoxicity | PERSPECTIVE | AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY | RISK | NEUROSCIENCES | VARIABILITY | HEARING-LOSS | ACETAMINOPHEN | OTORHINOLARYNGOLOGY | ANALGESIC USE | STRESS | Drugs | Drug delivery systems | Liver | Transferases | Cytochrome P-450 | Physiological aspects | Enzyme kinetics | Biopharmaceutics | Vehicles | Index Medicus
Journal Article
Advances in pharmacology (San Diego, Calif.), 2019, Volume 85, p. 221
Drug-induced liver injury (DILI) is a major clinical and regulatory challenge. As a result, interest in DILI biomarkers is growing. So far, considerable... 
Journal Article
Food and Chemical Toxicology, ISSN 0278-6915, 03/2019, Volume 125, p. 279
Repair mechanisms after acetaminophen (APAP) hepatotoxicity are poorly understood. We recently discovered that phosphatidic acid (PA) increases in mice and... 
Glycerin | Phosphates | Drugs | Medical colleges | Synthesis | Glycogen | Acetaminophen | Liver | Physiological aspects | Glycerol | Lipids | Overdose
Journal Article
MOLECULAR NEUROBIOLOGY, ISSN 0893-7648, 08/2019, Volume 56, Issue 8, pp. 5917 - 5933
As mitochondrial dysfunction is evident in neurodegenerative disorders that are accompanied by pain, we generated inducible mutant mice with disruption of... 
Pain hypersensitivity | RAT SPINAL-CORD | OXIDATIVE STRESS | PHOSPHOLIPASE-D | PHARMACOLOGICAL CHARACTERIZATION | DORSAL-ROOT GANGLIA | Energy deficiency | NEUROSCIENCES | KAINATE RECEPTORS | Mitochondria | GLUTAMATE RECEPTORS | P2Y receptor | PERIPHERAL NEUROPATHY | Mutation | INDUCED INFLAMMATORY PAIN | ELECTRON-TRANSPORT
Journal Article
Journal Article
Advances in Pharmacology, ISSN 1054-3589, 2019, Volume 85, p. 241
Liver, the major metabolic organ in the body, is known for its remarkable capacity to regenerate. Whereas partial hepatectomy (PHx) is a popular model for the... 
Acute liver failure | Hepatocyte proliferation | Cytokines | Acetaminophen | Carbon tetrachloride | Alcohol | Drug-induced liver injury | Liver repair | Growth factors | Ischemic hepatitis
Journal Article
JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES, ISSN 1482-1826, 07/2019, Volume 22, Issue 1, pp. 301 - 312
Purpose: Methamphetamine (METH) abuse is associated with hepatic dysfunction related comorbidities such as HIV, hepatitis C, and polysubstance abuse with... 
PHARMACOLOGY & PHARMACY | MONOCLONAL-ANTIBODY | HIV | BEHAVIOR | (+)-METHAMPHETAMINE | BRAIN
Journal Article
Journal Article
ISSN 1611-2156, 2016
Laboratory testing is important in the diagnosis and monitoring of liver injury and disease. Current liver tests include plasma markers of injury (e.g.... 
liver injury | diagnostics | liver disease | biomarkers | mechanistic biomarkers
Journal Article
Hepatology, ISSN 0270-9139, 01/2013, Volume 57, Issue 1, p. 419
Journal Article
EXCLI JOURNAL, ISSN 1611-2156, 2016, Volume 15, pp. 817 - 828
Laboratory testing is important in the diagnosis and monitoring of liver injury and disease. Current liver tests include plasma markers of injury (e.g.... 
liver disease | ASPARTATE | MITOCHONDRIAL | biomarkers | mechanistic biomarkers | ALANINE AMINOTRANSFERASE | GLUTAMIC-PYRUVIC TRANSAMINASE | Liver injury | CELL-DEATH | diagnostics | BIOLOGY | ACETAMINOPHEN OVERDOSE | GENE-EXPRESSION | HEPATOTOXICITY | PROTEIN ADDUCTS
Journal Article