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10/2019
The present invention relates to quinoline derived small molecule inhibitors of nicotinamide N-methyltransferase (NNMT), the preparation thereof and uses... 
HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
The Journal of biological chemistry, ISSN 0021-9258, 09/2019, Volume 294, Issue 41, pp. 15172 - 15175
Proteolysis targeting chimeras (PROTACs) are bivalent molecules that bring a cellular protein to a ubiquitin ligase E3 for ubiquitylation and subsequent... 
Journal Article
10/2019
inibição de atividade olig2 são aqui descritos compostos e composições farmacêuticas contendo tais compostos, que inibem a atividade de olig2. são também aqui... 
METALLURGY | ORGANIC CHEMISTRY | CHEMISTRY | HETEROCYCLIC COMPOUNDS
Patent
09/2019
Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of Olig2. Also described herein are... 
HYGIENE | METALLURGY | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | MEDICAL OR VETERINARY SCIENCE | HETEROCYCLIC COMPOUNDS | HUMAN NECESSITIES
Patent
07/2019
Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of Olig2. Also described herein are... 
METALLURGY | ORGANIC CHEMISTRY | CHEMISTRY | HETEROCYCLIC COMPOUNDS
Patent
06/2019
Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of Olig2. Also described herein are... 
METALLURGY | ORGANIC CHEMISTRY | CHEMISTRY | HETEROCYCLIC COMPOUNDS
Patent
Life science alliance, ISSN 2575-1077, 06/2019, Volume 2, Issue 3, p. e201900439
Shiga toxin 1 (STx1) and 2 (STx2), produced by Shiga toxin-producing , cause lethal untreatable disease. The toxins invade cells via retrograde trafficking.... 
Journal Article
05/2019
Certain embodiments are directed hydrophilic redox substrates for leukocyte esterase (LE). In certain aspects a hydrophilic redox leukocyte esterase substrate... 
HYGIENE | METALLURGY | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | MEDICAL OR VETERINARY SCIENCE | HETEROCYCLIC COMPOUNDS | HUMAN NECESSITIES | ACYCLIC OR CARBOCYCLIC COMPOUNDS
Patent
04/2019
Olig2의 활성을 억제하는 화합물 및 상기 화합물을 함유하는 약제학적 조성물이 본원에서 설명된다. 또한, 암 및 다른 질환을 치료하기 위한, 상기 Olig2 억제제를 단독으로 및 다른 화합물과 조합하여 사용하는 방법이 본원에서 설명된다. 특히, Olig2 억제제는 교모세포종을... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | METALLURGY | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | HETEROCYCLIC COMPOUNDS | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
03/2019
Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of Olig2. Also described herein are... 
METALLURGY | ORGANIC CHEMISTRY | CHEMISTRY | HETEROCYCLIC COMPOUNDS
Patent
03/2019
Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of Olig2. Also described herein are... 
METALLURGY | ORGANIC CHEMISTRY | CHEMISTRY | HETEROCYCLIC COMPOUNDS
Patent
03/2019
Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of Olig2. Also described herein are... 
METALLURGY | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | HETEROCYCLIC COMPOUNDS | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 01/2019, Volume 27, Issue 1, pp. 208 - 215
We previously demonstrated that capsazepine (CPZ), a synthetic transient receptor potential Vanilloid subtype 1 (TRPV1) antagonist, has significant anti-cancer... 
TRPV1 | Solid tumors | Structure-activity relationships | Cancer therapy | Capsazepine | CHEMISTRY, MEDICINAL | ANTAGONIST | MOIETY | TRPA1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | DISCOVERY | RECEPTORS | DERIVATIVES | BRONCHODILATORS | Care and treatment | Squamous cell carcinoma | Drug discovery | Lead compounds | Lung cancer, Non-small cell | Prostate cancer | Cervical cancer | Cancer
Journal Article
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