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PLoS ONE, ISSN 1932-6203, 12/2013, Volume 8, Issue 12, p. e83830
CLL cell trafficking between blood and tissue compartments is an integral part of the disease process. Idelalisib, a phosphoinositide 3-kinase delta (PI3K... 
B-CELLS | SURVIVAL | MIGRATION | APOPTOSIS | CAL-101 | MICROENVIRONMENT | MULTIDISCIPLINARY SCIENCES | MOLECULE-1 | TYROSINE KINASE INHIBITOR | RECEPTOR | EXPRESSION | Cell Survival - drug effects | Integrin alpha4beta1 - metabolism | Purines - pharmacology | Stromal Cells - pathology | Bone Marrow Cells - pathology | Enzyme Inhibitors - pharmacology | Cell Adhesion - drug effects | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Integrins - metabolism | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Animals | Signal Transduction - drug effects | Stromal Cells - drug effects | Cell Line, Tumor | Mice | Gene Expression Regulation, Neoplastic - drug effects | Endothelial Cells - pathology | Vascular Cell Adhesion Molecule-1 - metabolism | Quinazolinones - pharmacology | Endothelial Cells - drug effects | B cells | Analysis | Integrins | Endothelium | Cell culture | Vascular cell adhesion molecule 1 | Phosphorylation | Pathogenesis | Leukemia | Shear flow | Trafficking | AKT protein | Kinases | Tissues | VLA-4 antigen | Blood | Lymph nodes | Cell adhesion & migration | Atrophy | Cell growth | Immunology | Lymphocytes | Compartments | Cell adhesion | Bone marrow | Inhibition | Antigens | Chronic lymphatic leukemia | CD49d antigen | Hematology | Internal medicine | Shrinkage | Lymphatic leukemia | Tumor necrosis factor-α | Adhesion | 1-Phosphatidylinositol 3-kinase | Inhibitors | Stromal cells | Lymphomas | Lymphocytosis | Binding sites | Chemokines | Apoptosis | Cancer
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2014, Volume 289, Issue 33, pp. 23141 - 23153
Journal Article
Journal Article
Bioconjugate Chemistry, ISSN 1043-1802, 08/2011, Volume 22, Issue 8, p. 1706
A key issue regarding the use of stem cells in cardiovascular regenerative medicine is their retention in target tissues. Here, we have generated and assessed... 
Immunohistochemistry | Flow cytometry | Heart attacks | Stem cells | Monoclonal antibodies | Binding sites
Journal Article
Biochemical Journal, ISSN 0264-6021, 08/2013, Volume 454, Issue 1, pp. 109 - 121
Distinct signalling pathways producing diverse cellular outcomes can utilize similar subsets of proteins. For example, proteins from the TCR (T-cell receptor)... 
Integrin | Outside-in signalling | Extracellular-signal-regulated kinase (ERK) | T-cell co-stimulation | Early signalling complex | Time Factors | Antigens, CD - biosynthesis | Integrin alpha4beta1 - physiology | Jurkat Cells | Humans | Interleukin-2 Receptor alpha Subunit - biosynthesis | Signal Transduction - physiology | Lectins, C-Type - biosynthesis | Antigens, Differentiation, T-Lymphocyte - biosynthesis | Receptors, Antigen, T-Cell - physiology | Lck, lymphocyte-specific kinase | MEK, MAPK | TCR, T-cell receptor | ESC, early signalling complex | ECM, extracellular matrix | GDS, guanine nucleotide dissociation stimulator | ZAP-70, ζ-chain-associated protein of 70 kDa | ERK kinase | extracellular-signal-regulated kinase (ERK) | ERK, extracellular-signal-regulated kinase | HRP, horseradish peroxidase | CXCR4, CXC chemokine receptor 4 | SLP-76, SH2-domain-containing leukocyte protein of 76 kDa | FTI, farnesyl transferase inhibitor | integrin | PBMC, peripheral blood mononuclear cell | LFA-1, lymphocyte-function-associated antigen 1 | VCAM-1, vascular cell adhesion molecule-1 | IFNαR, interferon-α receptor | early signalling complex | outside-in signalling | RBD, Rap1-binding domain | LAT, linker for activation of T-cells | SH2, Src homology 2 | VLA-4, very late antigen-4 | MAPK, mitogen-activated protein kinase
Journal Article
Immunology and Cell Biology, ISSN 0818-9641, 06/2008, Volume 86, Issue 4, pp. 381 - 384
  CD45RA T cells are fully co-activated by natural β1 integrin ligands fibronectin (FN) and VCAM-1, as well as monoclonal antibody (mAb) 19H8, which binds a... 
Journal Article
Human Immunology, ISSN 0198-8859, 2010, Volume 71, Issue 1, pp. 23 - 28
Abstract The α4 β1 integrin VLA-4 (very-late activation antigen–4) and the lineage-specific CD4 and CD8 receptors have been proposed as putative co-stimulatory... 
Allergy and Immunology
Journal Article
Human Immunology, ISSN 0198-8859, 2010, Volume 71, Issue 1, pp. 23 - 28
The α β integrin VLA-4 (very-late activation antigen–4) and the lineage-specific CD4 and CD8 receptors have been proposed as putative co-stimulatory receptors... 
Human | CD4 | Integrin | Co-stimulation | CD8 | T lymphocyte
Journal Article
Human Immunology, ISSN 0198-8859, 01/2010, Volume 71, Issue 1, p. 23
The [alpha].sub.4[beta].sub.1 integrin VLA-4 (very-late activation antigen-4) and the lineage-specific CD4 and CD8 receptors have been proposed as putative... 
Cytokines | Stem cells | Transplantation | Universities and colleges | T cells | Integrins
Journal Article
Human Immunology, ISSN 0198-8859, 01/2010, Volume 71, Issue 1, pp. 23 - 28
The alpha 4 beta 1 integrin VLA-4 (very-late activation antigen-4) and the lineage-specific CD4 and CD8 receptors have been proposed as putative co-stimulatory... 
Journal Article
Immunology and Cell Biology, ISSN 0818-9641, 06/2008, Volume 86, Issue 4, pp. 381 - 384
CD45RA T cells are fully co‐activated by natural β1 integrin ligands fibronectin (FN) and VCAM‐1, as well as monoclonal antibody (mAb) 19H8, which binds a... 
T lymphocyte | costimulation | integrin | human | CD45 | Human | Integrin | Costimulation
Journal Article
European Journal of Cancer, ISSN 0959-8049, 2006, Volume 42, Issue 10, pp. 1491 - 1500
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 2002, Volume 110, Issue 10, pp. 1461 - 1471
Journal Article