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Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2014, Volume 134, Issue 2, pp. 276 - 284
Next-generation DNA sequencing has accelerated the genetic characterization of many human primary immunodeficiency diseases (PIDs). These discoveries can be... 
Allergy and Immunology | nuclear factor κB | next-generation sequencing | CARMA1 | primary immunodeficiency diseases | CARD11-BCL10-MALT1 signalosome complex | paracaspase | congenital B-cell lymphocytosis | combined immunodeficiency | nuclear factor kappa B | IMMUNE-DEFICIENCY | T-CELL | BCL10 | IMMUNOLOGY | CLEAVAGE | MALT LYMPHOMA | JNK ACTIVATION | ALLERGY | ECTODERMAL DYSPLASIA | CARD11 MUTATIONS | NF-KAPPA-B | Immunologic Deficiency Syndromes - pathology | Caspases - immunology | Humans | NF-kappa B - immunology | Neoplasm Proteins - immunology | CARD Signaling Adaptor Proteins - genetics | Adaptor Proteins, Signal Transducing - immunology | Germ-Line Mutation | B-Lymphocytes - pathology | Immunologic Deficiency Syndromes - diagnosis | Immunologic Deficiency Syndromes - immunology | Neoplasm Proteins - genetics | CARD Signaling Adaptor Proteins - immunology | Guanylate Cyclase - immunology | Signal Transduction | Caspases - genetics | Gene Expression Regulation | Receptors, Antigen, B-Cell - immunology | B-Lymphocytes - immunology | NF-kappa B - genetics | B-Cell CLL-Lymphoma 10 Protein | Adaptor Proteins, Signal Transducing - genetics | Immunologic Deficiency Syndromes - genetics | Guanylate Cyclase - genetics | Receptors, Antigen, B-Cell - genetics | High-Throughput Nucleotide Sequencing | Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein | Lymphomas | Immunodeficiency | Primary immunodeficiency diseases | Congenital B cell lymphocytosis | NF-κB | Combined immunodeficiency | CARD11–BCL10–MALT1 (CBM) signalosome complex | Paracaspase | Next generation sequencing
Journal Article
Brain, ISSN 0006-8950, 2014, Volume 137, Issue 3, pp. 819 - 833
Journal Article
Cancer Letters, ISSN 0304-3835, 2014, Volume 356, Issue 2, pp. 994 - 1006
Highlights • Lobatin B inhibited NPM/ALK protein expression at the transcriptional level. • Consequently, the cascade of downstream signalling to JunB and... 
Hematology, Oncology and Palliative Medicine | Lobatin | NPM/ALK | 3D-compound testing | ALCL | Lymphendothelial intravasation | NPM-ALK | ANTIINFLAMMATORY ACTIVITY | QEQCHI MAYA | TRADITIONAL MEDICINE | SESQUITERPENE LACTONES | IN-VITRO | JUNB TRANSCRIPTION | NEUROLAENA-LOBATA | ONCOLOGY | C-JUN | EXPRESSION | Leukocytes, Mononuclear - metabolism | Apoptosis - drug effects | Plant Extracts - pharmacology | Protein-Tyrosine Kinases - metabolism | Humans | NF-kappa B - metabolism | Asteraceae - chemistry | Protein-Tyrosine Kinases - genetics | Caspases - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Endothelium, Lymphatic - drug effects | Tumor Cells, Cultured | Real-Time Polymerase Chain Reaction | Lymphoma, Large-Cell, Anaplastic - metabolism | Endothelium, Lymphatic - pathology | NF-kappa B - antagonists & inhibitors | Leukocytes, Mononuclear - drug effects | Caspases - genetics | Neoplasm Invasiveness | Proto-Oncogene Proteins c-jun - genetics | RNA, Messenger - genetics | Mitochondria - metabolism | Mitochondria - drug effects | Mitochondria - pathology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Leukocytes, Mononuclear - pathology | NF-kappa B - genetics | Proto-Oncogene Proteins c-jun - metabolism | Lymphoma, Large-Cell, Anaplastic - drug therapy | Cell Proliferation - drug effects | Lymphoma, Large-Cell, Anaplastic - pathology | Sesquiterpenes - pharmacology | Antineoplastic Agents, Phytogenic - pharmacology | Cell Cycle - drug effects | Protein-Tyrosine Kinases - antagonists & inhibitors
Journal Article
Phytomedicine, ISSN 0944-7113, 08/2015, Volume 22, Issue 9, pp. 862 - 874
Journal Article
by Stern, S.A and Bagenal, F and Ennico, K and Gladstone, G.R and Grundy, W.M and McKinnon, W.B and Moore, J.M and Olkin, C.B and Spencer, J.R and Weaver, H.A and Young, L.A and Andert, T and Andrews, J and Banks, M and Bauer, B and Bauman, J and Barnouin, O.S and Bedini, P and Beisser, K and Beyer, R.A and Bhaskaran, S and Binzel, R.P and Birath, E and Bird, M and Bogan, D.J and Bowman, A and Bray, V.J and Brozovic, M and Bryan, C and Buckley, M.R and Buie, M.W and Buratti, B.J and Bushman, S.S and Calloway, A and Carcich, B and Cheng, A.F and Conard, S and Conrad, C.A and Cook, J.C and Cruikshank, D.P and Custodio, O.S and Dalle Ore, C.M and Deboy, C and Dischner, Z.J.B and Dumont, P and Earle, A.M and Elliott, H.A and Ercol, J and Ernst, C.M and Finley, T and Flanigan, S.H and Fountain, G and Freeze, M.J and Greathouse, T and Green, J.L and Guo, Y and Hahn, M and Hamilton, D.P and Hamilton, S.A and Hanley, J and Harch, A and Hart, H.M and Hersman, C.B and Hill, A and Hill, M.E and Hinson, D.P and Holdridge, M.E and Horanyi, M and Howard, A.D and Howett, C.J.A and Jackman, C and Jacobson, R.A and Jennings, D.E and Kammer, J.A and Kang, H.K and Kaufmann, D.E and Kollmann, P and Krimigis, S.M and Kusnierkiewicz, D and Lauer, T.R and Lee, J.E and Lindstrom, K.L and Linscott, I.R and Lisse, C.M and Lunsford, A.W and Mallder, V.A and Martin, N and McComas, D.J and McNutt, R.L and Mehoke, D and Mehoke, T and Melin, E.D and Mutchler, M and Nelson, D and Nimmo, F and Nunez, J.I and Ocampo, A and Owen, W.M and Paetzold, M and Page, B and ...
Science, ISSN 0036-8075, 10/2015, Volume 350, Issue 6258, pp. aad1815 - aad1815
The Pluto system was recently explored by NASA's New Horizons spacecraft, making closest approach on 14 July 2015. Pluto's surface displays diverse landforms,... 
ORIGIN | N-2 | METHANE | COLLAPSE | MULTIDISCIPLINARY SCIENCES | STELLAR OCCULTATIONS | NITROGEN | ICES | SATELLITES | ATMOSPHERE | Moons | Space exploration | Pluto | Astronomy | Pluto (dwarf planet) | Pluto satellites | Albedo | New Horizons mission | Spacecraft | Surface chemistry | Displays | Charon | Physics - Earth and Planetary Astrophysics
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2009, Volume 19, Issue 10, pp. 2646 - 2649
A new series of tricyclic-based inhibitors of IKK have been derived from an earlier lead compound. The synthesis and structure–activity relationships (SAR) are... 
IKK | SAR | TNF | LPS | CELLS | CHEMISTRY, MEDICINAL | COLLAGEN | INFLAMMATORY RESPONSES | TRANSCRIPTION | CHEMISTRY, ORGANIC | ALPHA | PROLIFERATION | ARTHRITIS | POTENT | GENE-EXPRESSION | MICE
Journal Article
Cancer Letters, ISSN 0304-3835, 01/2015, Volume 356, Issue 2, p. 994
* Lobatin B inhibited NPM/ALK protein expression at the transcriptional level. * Consequently, the cascade of downstream signalling to JunB and PDGFR-[beta]... 
Tumors | Cell culture | Medical research | Lymphomas | Metastasis
Journal Article
Journal Article