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British Journal of Pharmacology, ISSN 0007-1188, 08/2017, Volume 174, Issue 15, p. 2444
Background and purpose The [kappa] receptor has a central role in modulating neurotransmission in central and peripheral neuronal circuits that subserve pain... 
GTP | Pain perception | Circuits | Selectivity | Recruitment | Proteins | Signal transduction | Signaling | Side effects | Receptors | Liability | Pain | Rodents | Aversion | Liabilities | Ligands | Neurotransmission | Locomotor activity
Journal Article
FRONTIERS IN PHARMACOLOGY, ISSN 1663-9812, 06/2019, Volume 10, p. 678
Sigma-1 receptors (SIR) and sigma-2 receptors (S2R) may modulate nociception without the liabilities of opioids, offering a promising therapeutic target to... 
MECHANICAL ALLODYNIA | chronic pain | ANESTHETIC POTENCY | CONDITIONED PLACE PREFERENCE | Sigma | analgesia | addiction | SPINAL-CORD | S1RA | TANDEM MASS-SPECTROMETRY | ANTINOCICEPTION | sedation | NEUROPATHIC PAIN | allodynia | NMDA-INDUCED PAIN | PHARMACOLOGY & PHARMACY | NR1 SUBUNIT | Care and treatment | Pain
Journal Article
Drug and Alcohol Dependence, ISSN 0376-8716, 2015, Volume 156, pp. e147 - e147
Journal Article
Drug and Alcohol Dependence, ISSN 0376-8716, 2013, Volume 140, pp. e168 - e168
Journal Article
Drug and Alcohol Dependence, ISSN 0376-8716, 2013, Volume 140, pp. e141 - e142
Journal Article
Journal Article
Alcohol, ISSN 0741-8329, 2012, Volume 46, Issue 4, pp. 359 - 370
Abstract This review represents the focus of a symposium that was presented at the “Alcoholism and Stress: A Framework for Future Treatment Strategies”... 
Psychiatry | Self-administration | Impulsivity | Orbitofrontal cortex | Decision making | Withdrawal | Kappa opioid receptor | Nor-binaltorphimine (nor-BNI) | Opioid | Alcohol | Depression | Central nucleus of the amygdala | Prefrontal cortex | Stress | Nucleus accumbens | Place preference | Dependence | Dynorphin | Anxiety | Negative reinforcement | Cognitive dysfunction | Extended amygdala | Negative affect | CONDITIONED PLACE PREFERENCE | FORCED SWIM TEST | RAT NUCLEUS-ACCUMBENS | ANXIETY-RELATED BEHAVIOR | PHARMACOLOGY & PHARMACY | TOXICOLOGY | ACTIVATED PROTEIN-KINASE | SUBSTANCE ABUSE | STRIATAL BDNF REGULATION | VENTRAL TEGMENTAL AREA | CORTICOTROPIN-RELEASING-FACTOR | POSITRON-EMISSION-TOMOGRAPHY | ETHANOL-CONSUMPTION | Amygdala - physiopathology | Amygdala - drug effects | Humans | Receptors, Opioid, kappa - agonists | Substance Withdrawal Syndrome - drug therapy | Dynorphins - physiology | Dynorphins - therapeutic use | Receptors, Opioid, kappa - physiology | Ethanol - pharmacology | Animals | Neurotransmitter Agents - therapeutic use | Neurotransmitter Agents - pharmacology | Dynorphins - pharmacology | Alcoholism - drug therapy | Alcoholism - physiopathology | Substance Withdrawal Syndrome - physiopathology | Alcoholism - psychology | Neurotransmitter Agents - physiology | Stress, Psychological - complications | Disease Models, Animal | Drug abuse | Care and treatment | Neurosciences | Alcoholism | Alcoholics | Substance abuse | Health/Alcohol and other Drugs | Universities and colleges | Drinking of alcoholic beverages | Stress (Psychology) | Neurodegeneration | Addictive behaviors | Ligands | Behavior | Grants | Alcohol use | Decision Making | Central Nucleus of the Amygdala | Nucleus Accumbens | Place Preference | Negative Affect | Orbitofrontal Cortex | Cognitive Dysfunction | Kappa Opioid Receptor | norbinaltorphimine (nor-BNI) | Prefrontal Cortex | Negative Reinforcement | Medical and Health Sciences | Medicin och hälsovetenskap
Journal Article
Drug Discovery Today: Technologies, ISSN 1740-6749, 2012, Volume 9, Issue 1, pp. e23 - e31
Opioid receptors are important targets for the treatment of pain and potentially for other disease states ( mood disorders and drug abuse) as well. Significant... 
Journal Article
ISSN 1477-0520, 5/2019, Volume 17, Issue 21, pp. 535 - 5315
Numerous studies demonstrate the promise of opioid peptides as analgesics, but poor oral bioavailability has limited their therapeutic development. This study... 
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 09/2010, Volume 51, Issue 38, p. 5020
A strategy to select linear precursor peptides favoring cyclization was developed and cyclization conditions were optimized. 
Peptides
Journal Article
Journal Article