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The New England journal of medicine, ISSN 1533-4406, 12/2012, Volume 367, Issue 23, pp. 2204 - 2213
Patients with type 2 diabetes at high risk for cardiovascular disease who were already taking a renin–angiotensin system blocker were randomly assigned to the... 
GLOMERULAR-FILTRATION-RATE | CONVERTING-ENZYME INHIBITORS | LEFT-VENTRICULAR DYSFUNCTION | MYOCARDIAL-INFARCTION | HEART-FAILURE | DOUBLE-BLIND | CARDIOVASCULAR MORTALITY | FOLLOW-UP | SYSTOLIC DYSFUNCTION | UMCG Approved | BLOOD-PRESSURE | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Follow-Up Studies | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Male | Patient Dropouts | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Kidney Diseases - epidemiology | Treatment Failure | Amides - adverse effects | Cardiovascular Diseases - epidemiology | Cardiovascular Diseases - mortality | Hypokalemia | Female | Drug Therapy, Combination | Diabetes Mellitus, Type 2 - complications | Double-Blind Method | Fumarates - therapeutic use | Kidney Diseases - prevention & control | Amides - therapeutic use | Fumarates - adverse effects | Antihypertensive Agents - therapeutic use | Antihypertensive Agents - adverse effects | Renin - antagonists & inhibitors | Hyperkalemia - chemically induced | Aged | Kidney Diseases - etiology | Diabetes Mellitus, Type 2 - drug therapy | Angiotensin Receptor Antagonists - therapeutic use | Myocardial infarction | Women | Creatinine | Cerebral infarction | End-stage renal disease | Stroke | Heart attacks | Kidneys | Diabetes mellitus | Cardiovascular disease | Coronary artery disease | Hypotension | Hyperkalemia | Renin | Angiotensin | Renal failure | Diabetes | Kidney diseases | Cardiovascular diseases | Diabetes mellitus (non-insulin dependent) | Heart diseases | Kidney transplantation | Index Medicus | Abridged Index Medicus
Journal Article
The New England journal of medicine, ISSN 1533-4406, 07/2015, Volume 373, Issue 3, pp. 232 - 242
Journal Article
by Swerdlow, Daniel I and Preiss, David and Kuchenbaecker, Karoline B and Holmes, Michael V and Engmann, Jorgen E L and Shah, Tina and Sofat, Reecha and Stender, Stefan and Johnson, Paul C D and Scott, Robert A and Leusink, Maarten and Verweij, Niek and Sharp, Stephen J and Guo, Yiran and Giambartolomei, Claudia and Chung, Christina and Peasey, Anne and Amuzu, Antoinette and Li, KaWah and Palmen, Jutta and Howard, Philip and Cooper, Jackie A and Drenos, Fotios and Li, Yun R and Lowe, Gordon and Gallacher, John and Stewart, Marlene C W and Tzoulaki, Ioanna and Buxbaum, Sarah G and van der A, Daphne L and Forouhi, Nita G and Onland-Moret, N Charlotte and van der Schouw, Yvonne T and Schnabel, Renate B and Hubacek, Jaroslav A and Kubinova, Ruzena and Baceviciene, Migle and Tamosiunas, Abdonas and Pajak, Andrzej and Topor-Madry, Romanvan and Stepaniak, Urszula and Malyutina, Sofia and Baldassarre, Damiano and Sennblad, Bengt and Tremoli, Elena and de Faire, Ulf and Veglia, Fabrizio and Ford, Ian and Jukema, J Wouter and Westendorp, Rudi G J and de Borst, Gert Jan and de Jong, Pim A and Algra, Ale and Spiering, Wilko and der Zee, Anke H Maitland-van and Klungel, Olaf H and de Boer, Anthonius and Doevendans, Pieter A and Eaton, Charles B and Robinson, Jennifer G and Duggan, David and Kjekshus, John and Downs, John R and Gotto, Antonio M and Keech, Anthony C and Marchioli, Roberto and Tognoni, Gianni and Sever, Peter S and Poulter, Neil R and Waters, David D and Pedersen, Terje R and Amarenco, Pierre and Nakamura, Haruo and McMurray, John J V and Lewsey, James D and Chasman, Daniel I and Ridker, Paul M and Maggioni, Aldo P and Tavazzi, Luigi and Ray, Kausik K and Seshasai, Sreenivasa Rao Kondapally and Manson, JoAnn E and Price, Jackie F and Whincup, Peter H and Morris, Richard W and Lawlor, Debbie A and Smith, George Davey and Ben-Shlomo, Yoav and Schreiner, Pamela J and Fornage, Myriam and Siscovick, David S and Cushman, Mary and Kumari, Meena and Wareham, Nick J and Verschuren, W M Monique and Redline, Susan and Patel, Sanjay R and Whittaker, John C and Hamsten, Anders and Delaney, Joseph A and ... and DIAGRAM Consortium, MAGIC Consortium, InterAct Consortium and MAGIC Consortium and InterAct Consortium and DIAGRAM Consortium
The Lancet (British edition), ISSN 0140-6736, 01/2015, Volume 385, Issue 9965, pp. 351 - 361
Journal Article
The New England journal of medicine, ISSN 1533-4406, 12/2013, Volume 369, Issue 26, pp. 2492 - 2503
Among patients with type 2 diabetes and stage 4 chronic kidney disease, bardoxolone methyl, as compared with placebo, did not reduce the risk of end-stage... 
TRIAL | NRF2 | ANALOGS | RENAL EVENTS BEACON | OUTCOMES | IRBESARTAN | NEPHROPATHY | CKD | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Cardiovascular Diseases - etiology | Glomerular Filtration Rate | Double-Blind Method | Humans | Middle Aged | Oleanolic Acid - analogs & derivatives | Kaplan-Meier Estimate | Diabetic Nephropathies - drug therapy | Male | Weight Loss - drug effects | Renal Insufficiency, Chronic - physiopathology | Renal Insufficiency, Chronic - drug therapy | Kidney Failure, Chronic - prevention & control | NF-E2-Related Factor 2 - metabolism | Treatment Failure | Intention to Treat Analysis | Cardiovascular Diseases - mortality | Female | Oleanolic Acid - adverse effects | Aged | Oleanolic Acid - therapeutic use | Diabetes Mellitus, Type 2 - complications | Kidney Failure, Chronic - etiology | Evaluation | Care and treatment | Dosage and administration | Terpenes | Risk factors | Diabetic nephropathies | Hypertension | Creatinine | End-stage renal disease | Oxidative stress | Kidneys | Diabetes mellitus | Body weight | Clinical trials | Aldosterone | Glomerular filtration rate | Renin | Angiotensin | Blood pressure | Diabetes | Kidney diseases | Diabetes mellitus (non-insulin dependent) | Heart diseases | Index Medicus | Abridged Index Medicus
Journal Article
The New England journal of medicine, ISSN 1533-4406, 10/2019, Volume 381, Issue 17, pp. 1609 - 1620
Patients with heart failure with preserved ejection fraction were assigned to receive sacubitril–valsartan or valsartan. At a median of 35 months, there was no... 
MIDDLE CHILD | MIDRANGE | IMPAIRED SYSTOLIC FUNCTION | SPIRONOLACTONE | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Single-Blind Method | Valsartan - administration & dosage | Follow-Up Studies | Humans | Middle Aged | Heart Failure - physiopathology | Aminobutyrates - adverse effects | Hospitalization - statistics & numerical data | Male | Tetrazoles - administration & dosage | Cardiovascular Diseases - mortality | Female | Aminobutyrates - administration & dosage | Double-Blind Method | Valsartan - adverse effects | Hypotension - chemically induced | Heart Failure - drug therapy | Stroke Volume | Neprilysin - antagonists & inhibitors | Sex Factors | Quality of Life | Angioedema - chemically induced | Aged | Tetrazoles - adverse effects | Angiotensin Receptor Antagonists - administration & dosage | Angiotensin Receptor Antagonists - adverse effects | Heart failure | Treatment outcome | Care and treatment | Usage | Safety and security measures | Hospitals | Patient outcomes | Analysis | Angiotensin | Causes of | Statistics | Admission and discharge | Renal function | Cardiomyopathy | Mortality | Angioedema | Clinical trials | Hospitalization | Coronary artery disease | Hypotension | Heart rate | Hyperkalemia | Patient safety | Death | Neprilysin | Heart diseases | Pharmaceuticals | Ejection fraction | Index Medicus | Abridged Index Medicus
Journal Article
The New England journal of medicine, ISSN 1533-4406, 11/2012, Volume 367, Issue 22, pp. 2089 - 2099
Dalcetrapib, an inhibitor of cholesteryl ester transfer protein, raises HDL cholesterol levels. In this clinical trial involving patients with an acute... 
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Cholesterol Ester Transfer Proteins - antagonists & inhibitors | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Male | Risk | Secondary Prevention | Biomarkers - blood | Apolipoproteins - blood | Anticholesteremic Agents - adverse effects | Acute Coronary Syndrome - drug therapy | Sulfhydryl Compounds - adverse effects | Anticholesteremic Agents - therapeutic use | Triglycerides - blood | Cardiovascular Diseases - mortality | Cholesterol, HDL - blood | Cholesterol, LDL - blood | Female | Aged | Blood Pressure - drug effects | Sulfhydryl Compounds - therapeutic use | C-Reactive Protein - analysis | Measurement | Cholesterol, HDL | Patient outcomes | Dosage and administration | Research | Acute coronary syndrome | Drug therapy | Health aspects | Cardiovascular agents | Myocardial infarction | Cerebral infarction | Lipoproteins (low density) | Stroke | C-reactive protein | Heart attacks | Mortality | Cardiovascular disease | Angina | Coronary artery disease | Cholesterol | Cholesteryl ester transfer protein | Studies | Ischemia | Diet | Biomarkers | Blood pressure | Acute coronary syndromes | Cardiovascular diseases | Heart diseases | Lipoproteins (high density) | Index Medicus | Abridged Index Medicus
Journal Article