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Journal Article
Expert Review of Clinical Pharmacology, ISSN 1751-2433, 03/2010, Volume 3, Issue 2, pp. 209 - 229
The microvascular complications of insufficiently controlled diabetes (neuropathy, retinopathy and nephropathy) and the marked increased risk of macrovascular... 
weight loss | β-cell | diabetes | therapy | Therapy | Diabetes | Weight loss | Type 2 diabetes | Diabetics | Glucose metabolism | Type 1 diabetes | Gastrointestinal system | Insulin resistance | Glucose | Drug therapy | Heart attack | Dextrose | Diabetes therapy
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 10/2014, Volume 57, Issue 19, pp. 8180 - 8186
Glucokinase (GK) is the rate-limiting step for insulin release from the pancreas in response to high levels of glucose. Flux through GK also contributes to... 
TYPE-2 DIABETES-MELLITUS | CHEMISTRY, MEDICINAL | THERAPY | Enzyme Activators - pharmacology | Glucose Tolerance Test | Animals | Mice, Inbred C57BL | Urea - analogs & derivatives | Pyridines - chemical synthesis | Pyridines - pharmacology | Glucokinase - metabolism | Drug Discovery | Enzyme Activators - chemical synthesis
Journal Article
International Journal of Toxicology, ISSN 1091-5818, 7/2017, Volume 36, Issue 4, pp. 340 - 349
There are many reasons that molecules fail to progress to market and various principles of risk–benefit decisions that can help drive the molecule through... 
changing indication | FDA | drug development failure | new therapeutic uses | repurpose | TARGET | PREGABALIN | PHASE-II | ATTRITION | LESSONS | DISCOVERY | HEMANGIOSARCOMA | PRODUCTIVITY | PHARMACOLOGY & PHARMACY | MICE | TOXICOLOGY | SUBUNIT | Animals | Therapeutics - standards | Drug Industry - standards | Drug Repositioning | Drug Evaluation, Preclinical | Humans
Journal Article
International Journal of Toxicology, ISSN 1091-5818, 7/2015, Volume 34, Issue 4, pp. 349 - 351
Stem cells have great potential in basic research and are being slowly integrated into toxicological research. This symposium provided an overview of the state... 
advanced therapy medicinal products | induced pluripotent stem cell | stem cell | regenerative medicine | stem cell therapy | LUNGS | RISK | PHARMACOLOGY & PHARMACY | TOXICITY | TOXICOLOGY | Stem Cells | Congresses as Topic | Animals | Humans | Cell Differentiation | Regenerative Medicine | Stem Cell Research | Transplantation, Homologous | Disease Models, Animal | Tissue Engineering
Journal Article
Molecular Carcinogenesis, ISSN 0899-1987, 01/2002, Volume 33, Issue 1, pp. 36 - 43
Apigenin, a nonmutagenic flavonoid, has been shown to inhibit ultraviolet light–induced skin tumorigenesis when topically applied to mouse skin. Our previous... 
apigenin | skin cancer | p21waf1 | chemoprevention | G2/M arrest | M arrest | Apigenin | Chemoprevention | P21 | Skin cancer
Journal Article
Journal of Virology, ISSN 0022-538X, 11/2010, Volume 84, Issue 22, pp. 11898 - 11904
The 2'-5' oligoadenylate synthetase (OAS) proteins are traditionally considered intracellular antiviral proteins. However, several studies demonstrate a... 
Journal Article
Molecular Carcinogenesis, ISSN 0899-1987, 03/1999, Volume 24, Issue 3, pp. 169 - 176
Topical application of α‐tocopherol (αTH), the most prominent naturally occurring form of vitamin E, inhibits ultraviolet (UV) B–induced photocarcinogenesis... 
ultraviolet rays | sunscreen agents | pyrimidine dimers | vitamin E | Ultraviolet rays | Pyrimidine dimers | Vitamin E | Sunscreen agents | HUMAN SKIN | RAT | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | ALPHA-TOCOPHEROL | PENETRATION | GAMMA-TOCOPHEROL | IN-VITRO | INHIBITION | GAS-CHROMATOGRAPHY | ONCOLOGY | BINDING | Keratinocytes - radiation effects | Salicylates - pharmacokinetics | Radiation Tolerance | alpha-Tocopherol - analogs & derivatives | Benzophenones - pharmacology | Cinnamates - pharmacokinetics | Ethers - administration & dosage | Administration, Cutaneous | Sunscreening Agents - administration & dosage | Skin Neoplasms - prevention & control | Biological Transport | Radiation-Protective Agents - pharmacology | Neoplasms, Radiation-Induced - prevention & control | Benzophenones - pharmacokinetics | Anticarcinogenic Agents - pharmacology | Photochemistry | Benzophenones - therapeutic use | Ethers - therapeutic use | Cinnamates - pharmacology | Salicylates - therapeutic use | Benzophenones - administration & dosage | Ultraviolet Rays - adverse effects | Ethers - pharmacology | Keratinocytes - drug effects | Radiation-Protective Agents - therapeutic use | Tocopherols | Mice | Sunscreening Agents - pharmacology | DNA Damage | Vitamin E - pharmacology | Radiation-Protective Agents - pharmacokinetics | Cinnamates - administration & dosage | Radiation-Protective Agents - administration & dosage | Vitamin E - analogs & derivatives | Salicylates - pharmacology | Vitamin E - therapeutic use | Female | Pyrimidine Dimers - analysis | Anticarcinogenic Agents - therapeutic use | Vitamin E - pharmacokinetics | Salicylates - administration & dosage | Cells, Cultured | Cell Nucleus - ultrastructure | Mice, Inbred C3H | Sunscreening Agents - therapeutic use | Animals | Ethers - pharmacokinetics | Skin - radiation effects | Sunscreening Agents - pharmacokinetics | Vitamin E - administration & dosage | Cell Nucleus - chemistry | Cinnamates - therapeutic use | Skin - drug effects
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2002, Volume 12, Issue 9, pp. 1263 - 1267
A series of aromatic substituted diamines was synthesized and characterized for their cytotoxic profiles against human breast and prostate tumor cell lines.... 
BIFUNCTIONAL INTERCALATORS | CELLS | CHEMISTRY, MEDICINAL | RECOGNITION | DNA | DMP-840 | DIACRIDINES | CHEMISTRY, ORGANIC | ZINC(II)-MACROCYCLIC TETRAAMINE COMPLEXES | ANTITUMOR-ACTIVITY | Nitrogen - chemistry | Apoptosis - drug effects | Humans | Diamines - chemistry | Diamines - pharmacology | Tumor Cells, Cultured | Drug Screening Assays, Antitumor
Journal Article
06/2013
The invention describes methods for manufacturing oligoadenylate synthetase (OAS) proteins for use as active pharmaceutical ingredients in pharmaceutical... 
WINE | ENZYMOLOGY | MICROORGANISMS OR ENZYMES | MICROBIOLOGY | BEER | MUTATION OR GENETIC ENGINEERING | SPIRITS | COMPOSITIONS THEREOF | PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS | METALLURGY | BIOCHEMISTRY | CULTURE MEDIA | CHEMISTRY | VINEGAR
Patent
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