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Nature protocols, ISSN 1754-2189, 07/2006, Volume 1, Issue 2, pp. 968 - 971
...Author(s): C James Hastie [1, 3]; Hilary J McLauchlan [1, 3]; Philip Cohen (corresponding author) [2] Introduction The attachment and removal of phosphate... 
FLUORESCENCE | BIOCHEMICAL RESEARCH METHODS | INHIBITORS | Protein Kinases - metabolism | Adenosine Triphosphate - metabolism | Sensitivity and Specificity | Phosphorus - chemistry | Isotope Labeling | Phosphorus Radioisotopes | Adenosine Triphosphate - chemistry
Journal Article
Journal Article
Biochemical journal, ISSN 1470-8728, 2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Biochemical journal, ISSN 1470-8728, 2003, Volume 371, Issue 1, pp. 199 - 204
We have previously examined the specificities of 28 commercially available compounds, reported to be relatively selective inhibitors of particular... 
SELECTIVE-INHIBITION | ACTIVATION | VIVO | Src | protein kinase inhibitors | TYROSINE KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | protein phosphorylation | CYCLIN-DEPENDENT KINASES | GLYCOGEN-SYNTHASE KINASE-3-BETA | IN-VITRO | POTENT | SP 600125 | Roscovitine | Kenpaullone | LITHIUM | SMOOTH-MUSCLE CELLS
Journal Article
Journal of neurochemistry, ISSN 0022-3042, 2010, Volume 115, Issue 4, pp. 974 - 983
Journal Article
Journal of neurochemistry, ISSN 1471-4159, 2004, Volume 90, Issue 2, pp. 352 - 358
Microtubule‐associated protein tau in a hyperphosphorylated state is the major component of the filamentous lesions that define a number of neurodegenerative... 
stress‐activated protein kinase | tauopathy | tau protein | c‐Jun N‐terminal kinase | c-Jun N-terminal kinase | Stress-activated protein kinase | Tau protein | Tauopathy | NEUROFIBRILLARY TANGLES | NERVOUS-SYSTEM | ALZHEIMERS-DISEASE BRAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | FRONTOTEMPORAL DEMENTIA | DEPENDENT MONOCLONAL-ANTIBODY | NEUROSCIENCES | GLYCOGEN-SYNTHASE KINASE-3-BETA | FTDP-17 MUTATIONS | stress-activated protein kinase | PAIRED HELICAL FILAMENTS | SITES | NANOELECTROSPRAY MASS-SPECTROMETRY | Phosphorylation | Epitopes - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Cyclic AMP-Dependent Protein Kinases - chemistry | tau Proteins - metabolism | Glycogen Synthase Kinase 3 beta | Immunoblotting | Isoenzymes - chemistry | Recombinant Fusion Proteins - metabolism | tau Proteins - chemistry | Mitogen-Activated Protein Kinases - chemistry | Mitogen-Activated Protein Kinase 1 - chemistry | Protein-Tyrosine Kinases - genetics | Cyclic AMP-Dependent Protein Kinases - genetics | tau Proteins - genetics | Isoenzymes - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Protein-Tyrosine Kinases - chemistry | JNK Mitogen-Activated Protein Kinases | Protein-Serine-Threonine Kinases - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Glycogen Synthase Kinase 3 - chemistry | Isoenzymes - genetics | Protein-Serine-Threonine Kinases - genetics | Recombinant Fusion Proteins - chemistry | Epitopes - genetics | Glycogen Synthase Kinase 3 - metabolism | Animals | Mitogen-Activated Protein Kinase 10 | Mitogen-Activated Protein Kinase 8 | Glycogen Synthase Kinase 3 - genetics | Mitogen-Activated Protein Kinase 9 | Recombinant Fusion Proteins - genetics | Mitogen-Activated Protein Kinases - genetics | Mice | Protein-Serine-Threonine Kinases - chemistry | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinases - metabolism
Journal Article
Cell biology international, ISSN 1065-6995, 08/2001, Volume 25, Issue 8, pp. 705 - 713
Transport vesicles or containers (TCs) mediate constitutive protein transport between the trans -Golgi network (TGN) and the plasma membrane. A key question is... 
transport container, TC | polymeric Ig receptor, plgR | β1,4-galactosyltransferase, GalT | trans -Golgi network, TGN | trans -Golgi network protein 38 kDa, TGN38 | protein kinase C, PKC | 1,4-galactosyltransferase, GalT | trans ‐Golgi network, TGN | trans ‐Golgi network protein 38kDa, TGN38 | β1,4‐galactosyltransferase, GalT | Trans-Golgi network protein 38 kDa, TGN38 | Protein kinase C, PKC | Trans-Golgi network, TGN | Polymeric Ig receptor, plgR | Transport container, TC | PLASMA-MEMBRANE PROTEINS | MDCK CELLS | FUSION | COATED VESICLES | trans-Golgi network, TGN | CELL-SURFACE | MICROSCOPY | TGN38/41 | CELL BIOLOGY | beta 1.4-galactosyltransferase, GalT | trans-Golgi network protein 38 kDa, TGN38 | TGN | Okadaic Acid - pharmacology | Guanosine 5'-O-(3-Thiotriphosphate) - pharmacology | Liver - ultrastructure | Membrane Glycoproteins - metabolism | Golgi Apparatus - drug effects | Rats | Glycoproteins | Microscopy, Immunoelectron | Intracellular Membranes - ultrastructure | Brain - metabolism | Dose-Response Relationship, Drug | Membrane Proteins | Animals | Cattle | Cytosol - metabolism | Golgi Apparatus - metabolism | Biological Transport - drug effects | Biological Transport - physiology | Intracellular Membranes - drug effects | N-Acetyllactosamine Synthase - metabolism | Golgi Apparatus - ultrastructure | Intracellular Membranes - metabolism
Journal Article