X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Patent (1582) 1582
Journal Article (319) 319
Publication (20) 20
Book Chapter (16) 16
Book / eBook (5) 5
Conference Proceeding (5) 5
Web Resource (4) 4
Book Review (2) 2
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
chemistry (1563) 1563
metallurgy (1552) 1552
organic chemistry (1548) 1548
human necessities (1440) 1440
hygiene (1439) 1439
medical or veterinary science (1439) 1439
preparations for medical, dental, or toilet purposes (1427) 1427
heterocyclic compounds (1285) 1285
specific therapeutic activity of chemical compounds ormedicinal preparations (1104) 1104
steroids (247) 247
acyclic, carbocyclic or heterocyclic compounds containingelements other than carbon, hydrogen, halogen, oxygen, nitrogen,sulfur, selenium or tellurium (194) 194
peptides (127) 127
acyclic or carbocyclic compounds (120) 120
chemistry, medicinal (113) 113
humans (92) 92
index medicus (91) 91
chemistry, organic (84) 84
animals (75) 75
microbiology (68) 68
biochemistry (63) 63
structure-activity relationship (63) 63
enzymology (57) 57
beer (56) 56
mutation or genetic engineering (56) 56
spirits (56) 56
vinegar (56) 56
wine (56) 56
compositions thereof (51) 51
culture media (51) 51
microorganisms or enzymes (51) 51
propagating, preserving or maintaining microorganisms (51) 51
antiviral agents - pharmacology (47) 47
rats (46) 46
physics (40) 40
measuring (39) 39
testing (39) 39
antiviral agents - chemistry (32) 32
pharmacology & pharmacy (31) 31
viral nonstructural proteins - antagonists & inhibitors (31) 31
antiviral agents (30) 30
molecular structure (28) 28
hiv (27) 27
investigating or analysing materials by determining theirchemical or physical properties (27) 27
hiv-1 - drug effects (26) 26
infection (25) 25
discovery (24) 24
hepacivirus - drug effects (24) 24
potent (24) 24
dogs (23) 23
drug discovery (23) 23
drug design (22) 22
derivatives (21) 21
general tagging of cross-sectional technologies spanning over several sections of the ipc (20) 20
general tagging of new technological developments (20) 20
technical subjects covered by former uspc cross-reference art collections [xracs] and digests (20) 20
anti-hiv agents - chemistry (19) 19
models, molecular (19) 19
analysis (18) 18
anti-hiv agents - pharmacology (18) 18
cell line (17) 17
hepatitis c virus (17) 17
imidazoles - pharmacology (17) 17
antiviral agents - pharmacokinetics (16) 16
electric communication technique (16) 16
electricity (16) 16
male (16) 16
telephonic communication (16) 16
binding (15) 15
research (15) 15
virus diseases (15) 15
virus replication - drug effects (15) 15
agriculture (14) 14
animal husbandry (14) 14
anti-hiv agents - chemical synthesis (14) 14
anti-hiv agents - pharmacokinetics (14) 14
antiviral agents - therapeutic use (14) 14
biocides, e.g. as disinfectants, as pesticides, as herbicides (14) 14
fishing (14) 14
forestry (14) 14
hunting (14) 14
mice (14) 14
pest repellants or attractants (14) 14
plant growth regulators (14) 14
preservation of bodies of humans or animals or plants or partsthereof (14) 14
replication (14) 14
trapping (14) 14
administration, oral (13) 13
antiviral activity (13) 13
dose-response relationship, drug (13) 13
entry (13) 13
hiv-1 (13) 13
indoles - chemistry (13) 13
inhibitors (13) 13
biochemistry & molecular biology (12) 12
design (12) 12
genotype (12) 12
half-life (12) 12
hepatitis-c virus (12) 12
measuring electric variables (12) 12
measuring magnetic variables (12) 12
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (1558) 1558
French (382) 382
German (212) 212
Spanish (184) 184
Chinese (105) 105
Portuguese (75) 75
Norwegian (40) 40
Danish (32) 32
Russian (28) 28
Korean (26) 26
Greek (19) 19
Finnish (18) 18
Croatian (17) 17
Slovenian (16) 16
Hungarian (15) 15
Icelandic (11) 11
Polish (10) 10
Serbian (9) 9
Swedish (7) 7
Czech (5) 5
Italian (3) 3
Bulgarian (2) 2
Estonian (2) 2
Japanese (2) 2
Lithuanian (2) 2
Ukrainian (2) 2
Arabic (1) 1
Slovak (1) 1
Turkish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


2013, RSC drug discovery series, ISBN 184973657X, Volume no. 32., xvi, 534 pages
The antiviral therapeutic area continues to rapidly generate meaningful new chemical entities; for example, for HIV alone more than 25 drugs have been... 
Virus diseases | Development | Antiviral agents | Chemotherapy | Drug development | Organic chemistry
Book
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2018, Volume 61, Issue 14, pp. 5822 - 5880
The electronic properties and relatively small size of fluorine endow it with considerable versatility as a bioisostere and it has found application as a... 
PEPTIDASE-IV INHIBITOR | CHEMISTRY, MEDICINAL | MECHANISM-BASED INHIBITION | HUMAN CATHEPSIN-L | KINASE BTK INHIBITOR | SMALL-MOLECULE INHIBITORS | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | PROTEIN KSP INHIBITORS | HUMAN LIVER-MICROSOMES | GENERATION DOPAMINERGIC AGENTS | ORTHOGONAL MULTIPOLAR INTERACTIONS
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 10/2019, Volume 62, Issue 1, pp. 1 - 2
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2020, Volume 186, p. 111826
Fluorine-containing amino acids are becoming increasingly prominent in new drugs due to two general trends in the modern pharmaceutical industry. Firstly, the... 
Tailor-made amino acids | Pharmaceuticals and medicinal formulations | Drug design | Fluorine | Fluorinated amino acids
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 02/2019, Volume 62, Issue 3, pp. 1348 - 1361
A series of 5,6,7,8-tetrahydro-1,6-naphthyridine derivatives targeting the allosteric lens-epithelium-derived growth-factor-p75 (LEDGF/p75)-binding site on... 
BI 224436 | CHEMISTRY, MEDICINAL | RALTEGRAVIR | HIV-1 INTEGRASE | ACIDS | NCINI | RESISTANCE | LEDGF/P75 | INTEGRASE INHIBITOR | ALLOSTERIC INHIBITORS | DISCOVERY
Journal Article
Synthesis, ISSN 0039-7881, 02/2020, Volume 52, Issue 3, pp. 441 - 449
Abstract An efficient and practical synthetic protocol for the synthesis of 1,4-disubstituted pyrrolo[1,2- a ]pyrazine derivatives is described that originates... 
paper | aromatization | POTENT | SERIES | alpha-aminoacetonitriles | CHEMISTRY, ORGANIC | Clauson-Kass reaction | PYRROLES | cyclization | pyrrolo[1,2,a]pyrazine
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2017, Volume 60, Issue 1, pp. 1 - 3
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 02/2019, Volume 29, Issue 4, pp. 659 - 663
Screening of 100 acylsulfonamides from the Bristol-Myers Squibb compound collection identified the C3-cyclohexyl indole as a potent Na 1.7 inhibitor.... 
Acyl sulfonamide | Pain | Indole-based | Nav1.7 inhibitor | 1.7 inhibitor
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 01/2020
We describe the synthesis through visible-light photocatalysis of novel functionalized tetracyclic scaffolds that incorporate a fused... 
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 06/2019, Volume 29, Issue 11, pp. 1423 - 1429
Indole- and azaindole-based glyoxylyl amide derivatives have been described as HIV-1 attachment inhibitors (AIs) that act by blocking the interaction between... 
HIV-1 | Bicyclic | Tricyclic | Indole | Azaindole | Heteroaryl | Attachment Inhibitor | Replacement | Heterocycle | CHEMISTRY, MEDICINAL | CHEMISTRY, ORGANIC | Surveys | Quinoline | Antiviral agents | HIV (Viruses)
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 03/2018, Volume 28, Issue 5, pp. 958 - 962
Replacement of the piperidine ring in the lead benzenesulfonamide Na 1.7 inhibitor with a weakly basic morpholine core resulted in a significant reduction in... 
Pain | Aryl sulfonamides | Nav1.7 inhibitor | Morpholine-based | 1.7 inhibitor
Journal Article
ACS MEDICINAL CHEMISTRY LETTERS, ISSN 1948-5875, 08/2019, Volume 10, Issue 8, pp. 1094 - 1097
While biological medications have addressed many important and challenging therapeutic targets, the pharmacopeia is still dominated by centamolecules. In this... 
MORTALITY | CHEMISTRY, MEDICINAL | INHIBITORS | HEPATITIS-C
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 02/2020, Volume 30, Issue 3, p. 126784
A series of heterocyclic pyrimidinedione-based HIV-1 integrase inhibitors was prepared and screened for activity against purified integrase enzyme and/or... 
HIV Integrase | Pyrimidinedione | Integrase inhibitor | HIV | Strand transfer inhibitor | DESIGN | CHEMISTRY, MEDICINAL | SERIES | RALTEGRAVIR | CHEMISTRY, ORGANIC | MECHANISMS | DISCOVERY | BINDING
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2018, Volume 61, Issue 14, pp. 6308 - 6327
The optimization of the 4-methoxy-6-azaindole series of HIV-1 attachment inhibitors (AIs) that originated with 1 to deliver temsavir (3, BMS-626529) is... 
SUBSTITUTION PATTERNS | CROSS-COUPLING REACTIONS | CHEMISTRY, MEDICINAL | ENTRY INHIBITORS | CONFORMATIONAL-CHANGES | PHOSPHATE PRODRUGS | CENTER-DOT-O | ANTIRETROVIRAL DRUG-RESISTANCE | ANTIVIRAL ACTIVITY | RANDOMIZED CONTROLLED-TRIAL | HYDROGEN-BONDS
Journal Article
No results were found for your search.

Cannot display more than 1000 results, please narrow the terms of your search.