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Journal Article
Lancet Oncology, The, ISSN 1470-2045, 2015, Volume 16, Issue 16, pp. 1659 - 1666
Journal Article
Lancet Oncology, The, ISSN 1470-2045, 2012, Volume 13, Issue 9, pp. 906 - 915
Journal Article
Nature Genetics, ISSN 1061-4036, 08/2017, Volume 49, Issue 8, pp. 1211 - 1218
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 09/2014, Volume 371, Issue 11, pp. 1005 - 1015
About 25% of young adults with ALL have Ph-like genotypes, which are associated with poor outcomes with conventional treatment. In this gene-expression study,... 
MEDICINE, GENERAL & INTERNAL | MODELS | B-CELL PRECURSOR | INHIBITOR THERAPY | IMATINIB | PEDIATRIC ACUTE LEUKEMIAS | GENE FUSION | EXPRESSION | ETV6-NTRK3 FUSION TRANSCRIPTS | CRLF2 | DELETION | Oligonucleotide Array Sequence Analysis | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Humans | Child, Preschool | Infant | Male | Young Adult | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Heterografts | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - mortality | Adult | Female | DNA, Neoplasm - analysis | Receptors, Cytokine - metabolism | Child | Philadelphia Chromosome | Receptors, Cytokine - genetics | Signal Transduction - genetics | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Animals | Protein Kinase Inhibitors - therapeutic use | Adolescent | Survival Analysis | Mice | Polymorphism, Single Nucleotide | Genome, Human | Protein-Tyrosine Kinases - antagonists & inhibitors | Development and progression | Care and treatment | Genetic aspects | Research | Lymphocytic leukemia | Tyrosine metabolism | Cell proliferation | Adolescence | Tyk2 protein | Leukemia | Genes | Clinical trials | Oncology | Genomes | Kinases | Cell activation | Janus kinase 2 | Xenografts | Teenagers | Children | Protein-tyrosine kinase | Age | Tyrosine | Young adults | Genomic analysis | Acute lymphatic leukemia | Stat5 protein | Lymphatic leukemia | Gene expression | Philadelphia chromosome | Interleukin 7 receptors | Thymic stromal lymphopoietin | Lymphocytes B | Cell lines
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 11/2009, Volume 27, Issue 31, pp. 5175 - 5181
Journal Article
Nature, ISSN 0028-0836, 01/2012, Volume 481, Issue 7380, pp. 157 - 163
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 01/2009, Volume 360, Issue 5, pp. 470 - 480
Journal Article
Nature Genetics, ISSN 1061-4036, 09/2009, Volume 41, Issue 9, pp. 1001 - 1005
Using the Affymetrix 500K Mapping array and publicly available genotypes, we identified 18 SNPs whose allele frequency differed significantly(P < 1 x 10(-5))... 
IKAROS GENE ENCODES | POLYMORPHISMS | WIDE ANALYSIS | IN-VIVO | GENETICS & HEREDITY | DNA-BINDING PROTEINS | METHYLENETETRAHYDROFOLATE REDUCTASE MTHFR | NATIONAL-INSTITUTE | BIPOLAR DISORDER | MINIMAL RESIDUAL DISEASE | EXPRESSION | Haplotypes | Humans | Child, Preschool | Methotrexate - therapeutic use | Case-Control Studies | Genetic Variation | Ikaros Transcription Factor - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Germ-Line Mutation | Gene Expression Regulation, Neoplastic - drug effects | Odds Ratio | Child | Antimetabolites, Antineoplastic - metabolism | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Polyglutamic Acid - metabolism | Reproducibility of Results | Methotrexate - metabolism | Gene Frequency | Risk Factors | Trans-Activators | Probability | Gene Dosage | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Germ Cells | Chromosomes, Human, Pair 7 | Linkage Disequilibrium | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Antimetabolites, Antineoplastic - therapeutic use | Dopa Decarboxylase - genetics | Oncogene Proteins, Fusion - genetics | Alleles | Polymorphism, Single Nucleotide | Chromosomes, Human, Pair 10 | Precursor Cell Lymphoblastic Leukemia-Lymphoma - classification | Cohort Studies | Genetic aspects | Single nucleotide polymorphisms | Research | Children | Acute lymphocytic leukemia | Health aspects | Risk factors | Studies | Chemotherapy | Research methodology | Leukemia | Colleges & universities | Cell cycle | Genetics | Bipolar disorder | Gene expression | Drug therapy | Cancer | Index Medicus
Journal Article
Nature Genetics, ISSN 1061-4036, 03/2013, Volume 45, Issue 3, pp. 242 - 252
The genetic basis of hypodiploid acute lymphoblastic leukemia (ALL), a subtype of ALL characterized by aneuploidy and poor outcome, is unknown. Genomic... 
P53 MUTATIONS | NEUROFIBROMATOSIS TYPE-1 GENE | TRANSMEMBRANE ADAPTER | IKAROS | GENETICS & HEREDITY | JUVENILE MYELOMONOCYTIC LEUKEMIA | REGULATORY T-CELLS | MUTANT P53 | HUMAN CANCERS | HEMATOLOGIC MALIGNANCIES | CHILDHOOD | Humans | Gene Expression Regulation, Neoplastic | Molecular Sequence Data | Aneuploidy | Transplantation, Heterologous | Phosphatidylinositol 3-Kinases - metabolism | Tumor Suppressor Protein p53 - genetics | Ikaros Transcription Factor - genetics | Haploidy | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Base Sequence | Ikaros Transcription Factor - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology | Signal Transduction | Retinoblastoma Protein - metabolism | Tumor Suppressor Protein p53 - metabolism | Treatment Outcome | Phosphatidylinositol 3-Kinases - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Animals | Retinoblastoma Protein - genetics | Chromosome Aberrations | Cell Line, Tumor | Mice | Mutation | Care and treatment | Genomics | Physiological aspects | Genetic aspects | Research | Acute lymphocytic leukemia | Cancer | Medical research | Pediatrics | Cloning | Genetics | Genomes | Kinases | Chromosomes | Medicinsk genetik | Basic Medicine | Medical Genetics | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper
Journal Article