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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2016, Volume 113, Issue 16, pp. 4476 - 4481
Inhibition of the vascular endothelial growth factor (VEGF) pathway has failed to improve overall survival of patients with glioblastoma (GBM). We previously... 
Anti-angiogenic therapy | Macrophage polarization | Tumor microenvironment | Microglia reprogramming | Anti-tumor immunity | anti-angiogenic therapy | BEVACIZUMAB | MULTIDISCIPLINARY SCIENCES | macrophage polarization | RANDOMIZED-TRIAL | ANGIOPOIETIN-2 | CANCER | THERAPY | microglia reprogramming | TIE2-EXPRESSING MONOCYTES | BLOOD-VESSELS | TUMOR-ASSOCIATED MACROPHAGES | tumor microenvironment | NORMALIZATION | anti-tumor immunity | ENDOTHELIAL GROWTH-FACTOR | Macrophages - pathology | Antibodies, Bispecific - pharmacology | Vesicular Transport Proteins - metabolism | Humans | Neoplasm Proteins - antagonists & inhibitors | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Neoplasm Proteins - metabolism | Neoplasms, Experimental - pathology | Xenograft Model Antitumor Assays | Macrophages - metabolism | Vesicular Transport Proteins - antagonists & inhibitors | Animals | Antibodies, Neoplasm - pharmacology | Ribonuclease, Pancreatic - metabolism | Glioblastoma - pathology | Cell Line, Tumor | Glioblastoma - metabolism | Antineoplastic Agents - pharmacology | Mice | Neoplasms, Experimental - metabolism | Glioblastoma - drug therapy | Ribonuclease, Pancreatic - antagonists & inhibitors | Neoplasms, Experimental - drug therapy | Viral antibodies | Care and treatment | Antibodies | Physiological aspects | Models | Macrophages | Vascular endothelial growth factor | Health aspects | Glioblastoma multiforme | Genotype & phenotype | Survival analysis | Protein expression | Cells | Tumors | Cancer | Index Medicus | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 04/2018, Volume 115, Issue 17, pp. 4465 - 4470
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2016, Volume 113, Issue 16, pp. 4470 - 4475
Glioblastomas (GBMs) rapidly become refractory to anti-VEGF therapies. We previously demonstrated that ectopic overexpression of angiopoietin-2 (Ang-2)... 
Anti-angiogenic therapy | Colony-stimulating factor 1 | Tumor immunity | Tumor microenvironment | Macrophage | anti-angiogenic therapy | ANGIOPOIETIN-2 FUNCTIONS | ANGIOGENESIS | MULTIDISCIPLINARY SCIENCES | macrophage | BEVACIZUMAB PLUS IRINOTECAN | RANDOMIZED-TRIAL | ANTIBODY | tumor immunity | KINASE INHIBITOR | ANTIANGIOGENIC THERAPY | PHASE-II TRIAL | colony-stimulating factor 1 | tumor microenvironment | EXPRESSION | ENDOTHELIAL GROWTH-FACTOR | Macrophages - pathology | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Neovascularization, Pathologic - pathology | Neoplasms, Experimental - pathology | Macrophages - metabolism | Animals | Antibodies, Neoplasm - pharmacology | Receptors, Vascular Endothelial Growth Factor - metabolism | Ribonuclease, Pancreatic - metabolism | Neovascularization, Pathologic - drug therapy | Glioblastoma - pathology | Cell Line, Tumor | Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors | Glioblastoma - metabolism | Mice | Neovascularization, Pathologic - metabolism | Neoplasms, Experimental - metabolism | Glioblastoma - drug therapy | Quinazolines - pharmacology | Ribonuclease, Pancreatic - antagonists & inhibitors | Neoplasms, Experimental - drug therapy | Drug Screening Assays, Antitumor | Survival analysis | Gene expression | Kinases | Cells | Tumors | Cancer | Index Medicus | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2015, Volume 112, Issue 6, pp. 1827 - 1832
Journal Article
Nature Protocols, ISSN 1754-2189, 05/2018, Volume 13, Issue 5, pp. 1091 - 1105
Journal Article
Chemical Engineering Science, ISSN 0009-2509, 2011, Volume 66, Issue 20, pp. 4510 - 4520
Since the days of the hunter-gatherer, food intake has been limited by its availability, and significant physical effort was involved in bringing it home. For... 
Energy balance | Obesity | Thermogenesis | Diet | Metabolism | Basic metabolic rate | EQUATIONS | BODY-COMPOSITION | MODEL | EXERCISE | ENGINEERING, CHEMICAL | ENERGY-EXPENDITURE | TEMPERATURE | FAT-FREE MASS | WATER-INDUCED THERMOGENESIS | MAMMALS | Physiological aspects | Weight loss maintenance | Analysis | Body weight | Diets | Human | Chemical engineering | Men | Mathematical models | Mice | Foods | Intakes
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2019, Volume 116, Issue 6, pp. 2210 - 2219
In ovarian cancer patients, tumor fibrosis and angiotensin-driven fibrogenic signaling have been shown to inversely correlate with survival. We sought to... 
Angiotensin inhibition | Drug delivery | Ascites | Antifibrotic miRNAs | Ovarian cancer | FIBROSIS | angiotensin inhibition | COLLAGEN EXPRESSION | ovarian cancer | DRUG-DELIVERY | BEVACIZUMAB | MULTIDISCIPLINARY SCIENCES | antifibrotic miRNAs | OPEN-LABEL | drug delivery | BETA | ascites | SOLID STRESS | GROWTH-FACTOR | PARP INHIBITORS | CARCINOMA | Prognosis | Stromal Cells - pathology | Humans | Ovarian Neoplasms - pathology | Extracellular Matrix - metabolism | Ovarian Neoplasms - mortality | Hypoxia - metabolism | Stromal Cells - drug effects | Female | Antineoplastic Agents - pharmacology | Collagen - genetics | Ovarian Neoplasms - metabolism | Stress, Physiological - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Ovarian Neoplasms - drug therapy | Disease Models, Animal | Models, Theoretical | Tumor Microenvironment - drug effects | Stromal Cells - metabolism | Losartan - pharmacology | Treatment Outcome | Ascites - drug therapy | Drug Synergism | Xenograft Model Antitumor Assays | Collagen - metabolism | Animals | Neovascularization, Pathologic - drug therapy | Mice | MicroRNAs - genetics | Neovascularization, Pathologic - metabolism | Neoplasm Staging | Ascites - pathology | Normalizing | Drug delivery systems | Ovarian carcinoma | Antihypertensives | Xenotransplantation | Cancer therapies | Anticancer properties | Paclitaxel | Xenografts | Extracellular matrix | Bioindicators | Effectiveness | Stroma | Patients | Survival | Signaling | Chemotherapy | Perfusion | Fibrosis | Angiotensin | Biomarkers | Cancer | Tumors | Index Medicus | Biological Sciences | Physical Sciences | PNAS Plus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 09/2018, Volume 115, Issue 37, pp. E8717 - E8726
Blood-brain/blood-tumor barriers (BBB and BTB) and interstitial transport may constitute major obstacles to the transport of therapeutics in brain tumors. In... 
Blood–brain/blood–tumor barrier | Brain tumor | Drug transport | Focused ultrasound | Pharmacokinetics | blood-brain/blood-tumor barrier | EFFICACY | MULTIDISCIPLINARY SCIENCES | SIZE | drug transport | brain tumor | EMERGING STRATEGIES | TRASTUZUMAB EMTANSINE | BREAST-CANCER | PRESSURE | TRANSPORT | FLUORESCENCE MICROSCOPY | THERAPY | FLUID | pharmacokinetics | focused ultrasound | Brain - diagnostic imaging | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Trastuzumab - pharmacokinetics | Humans | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Brain Neoplasms - metabolism | Breast Neoplasms - metabolism | Brain - metabolism | Brain Neoplasms - secondary | Microbubbles | Doxorubicin - administration & dosage | Ultrasonography - methods | Maytansine - analogs & derivatives | Trastuzumab - administration & dosage | Brain Neoplasms - drug therapy | Blood-Brain Barrier - drug effects | Breast Neoplasms - drug therapy | Doxorubicin - pharmacokinetics | Blood-Brain Barrier - metabolism | Xenograft Model Antitumor Assays | Maytansine - administration & dosage | Animals | Breast Neoplasms - pathology | Maytansine - pharmacokinetics | Brain - pathology | Cell Line, Tumor | Mice | Drug Delivery Systems - methods | Drugs | Drug delivery systems | Care and treatment | Blood-brain barrier | Brain cancer | Physiological aspects | Metastasis | Drug therapy | Methods | Vehicles | Brain | Brain tumors | Xenotransplantation | Drug delivery | Doxorubicin | Blood | Optimization | Metastases | Anticancer properties | FUS protein | Antitumor agents | Extravasation | Xenografts | Modelling | Ultrasound | Experimental data | Data processing | Breast cancer | Pharmacology | ErbB-2 protein | Endothelial cells | Chemotherapy | Microscopy | Barriers | Disruption | Transport | Trastuzumab | Tumors | Cancer | Index Medicus | Biological Sciences | Physical Sciences | PNAS Plus | blood–tumor barrier | blood–brain
Journal Article
Soft Matter, ISSN 1744-683X, 05/2011, Volume 7, Issue 10, pp. 4735 - 4741
We report experimental studies on a newly synthesised bent-core liquid crystal exhibiting partial bilayer SmA(d)P(R) and SmA(d)P(A) phases. Though the... 
TRANSITION | POLYMER SCIENCE | FLUID | PHYSICS, MULTIDISCIPLINARY | HOMOLOGOUS SERIES | MATERIALS SCIENCE, MULTIDISCIPLINARY | LIQUID-CRYSTALS | CHEMISTRY, PHYSICAL | MODEL | ACHIRAL MOLECULES | Coupling (molecular) | Electric potential | Dielectric strength | Phase transformations | Voltage | Birefringence | Mathematical models | Liquid crystals
Journal Article
Cancer Research, ISSN 0008-5472, 01/2017, Volume 77, Issue 2 Supplement, pp. B59 - B59
Journal Article
Neuro-Oncology, ISSN 1522-8517, 11/2018, Volume 20, Issue suppl_6, pp. vi281 - vi281
Abstract Blood-brain/blood-tumor barriers (BBB and BTB) and interstitial transport may constitute major obstacles to the transport of therapeutics in brain... 
Journal Article