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Science, ISSN 0036-8075, 5/2012, Volume 336, Issue 6082, pp. 717 - 721
Osteoarthritis (OA) is a degenerative joint disease that involves the destruction of articular cartilage and eventually leads to disability. Molecules that... 
Cartilage | Molecules | REPORTS | Chondrocytes | Collagens | Stem cells | Lead | Arthritis | Chondrogenesis | Osteoarthritis | Vehicles | PATHOGENESIS | GENE | ARTICULAR-CARTILAGE | MULTIDISCIPLINARY SCIENCES | FILAMIN | OSTEOARTHRITIS | BONE | TRANSCRIPTION FACTOR | EXPRESSION | CHONDROGENESIS | CHONDROCYTE DIFFERENTIATION | Anilides - therapeutic use | Chondrocytes - cytology | Phthalic Acids - chemistry | Humans | Anilides - chemistry | Structure-Activity Relationship | Osteoarthritis - drug therapy | Osteoarthritis - physiopathology | Chondrocytes - drug effects | Mesenchymal Stromal Cells - cytology | Cell Nucleus - metabolism | Chondrocytes - physiology | Cattle | Microfilament Proteins - metabolism | Osteoarthritis - pathology | Phthalic Acids - pharmacology | Contractile Proteins - metabolism | Chondrocytes - metabolism | Mesenchymal Stromal Cells - physiology | Core Binding Factor beta Subunit - metabolism | Disease Models, Animal | Mesenchymal Stromal Cells - drug effects | Phthalic Acids - therapeutic use | Core Binding Factor Alpha 2 Subunit - metabolism | Cartilage, Articular - cytology | Filamins | Phthalic Acids - administration & dosage | Regeneration | Animals | High-Throughput Screening Assays | Anilides - administration & dosage | Small Molecule Libraries | Anilides - pharmacology | Mice | Care and treatment | Physiological aspects | Transplantation | Methods | Molecular biology | Biomedical materials | Effectiveness | Breakdown | Biocompatibility | Articular | Adults
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 11/2003, Volume 163, Issue 3, pp. 503 - 510
The unit of inheritance for mitochondrial DNA (mtDNA) is a complex nucleoprotein structure termed the nucleoid. The organization of the nucleoid as well as its... 
Yeasts | Haploidy | Mitochondria | Mitochondrial genes | DNA | Antibodies | Mitochondrial DNA | Cell separation | Product labeling | Cells | Nucleoid | Replisome | mtDNA | Membrane-spanning | PROTEIN | NUCLEAR | FUSION | mitochondria | SEGREGATION | SACCHAROMYCES-CEREVISIAE | CELL BIOLOGY | YEAST MITOCHONDRIA | MAINTENANCE | membrane-spanning | TRANSMISSION | DYNAMIN-RELATED GTPASE | replisome | nucleoid | NUCLEOIDS | Green Fluorescent Proteins | Saccharomyces cerevisiae - genetics | Nucleoproteins - genetics | Saccharomyces cerevisiae - ultrastructure | Mitochondrial Proteins | Mitochondria - ultrastructure | DNA-Directed DNA Polymerase - genetics | Intracellular Membranes - ultrastructure | DNA-Binding Proteins - metabolism | DNA, Mitochondrial - genetics | Mitochondria - genetics | Indoles | Nuclear Proteins - genetics | DNA Polymerase I - genetics | Cells, Cultured | Nuclear Proteins - metabolism | Mitochondria - metabolism | Saccharomyces cerevisiae Proteins - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Transcription Factors - metabolism | Nucleoproteins - metabolism | Saccharomyces cerevisiae Proteins - metabolism | DNA Replication - genetics | Luminescent Proteins - genetics | DNA-Directed DNA Polymerase - metabolism | DNA Polymerase I - metabolism | Intracellular Membranes - metabolism | Luminescent Proteins - metabolism | Research | Mip1 protein | mitochondria; mtDNA; nucleoid; replisome; membrane-spanning
Journal Article
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 11/2015, Volume 11, Issue 11, pp. 834 - 836
Journal Article
Cell Metabolism, ISSN 1550-4131, 10/2016, Volume 24, Issue 4, pp. 582 - 592
Using high-throughput screening we identified small molecules that suppress superoxide and/or H O production during reverse electron transport through... 
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 04/2017, Volume 76, Issue 4, pp. 773 - 778
Journal Article
Journal Article
Current Opinion in Cell Biology, ISSN 0955-0674, 2005, Volume 17, Issue 4, pp. 389 - 394
Mitochondrial fusion is unique; no paradigm exists to explain how two sets of compositionally distinct membranes become coordinately fused. Genetic approaches... 
OUTER-MEMBRANE | APOPTOSIS | DOMINANT OPTIC ATROPHY | PROTEIN | DYNAMIN-RELATED GTPASE | FUSION-COMPETENT MITOCHONDRIA | MGM1P | SACCHAROMYCES-CEREVISIAE | MAMMALIAN-CELLS | MORPHOLOGY | CELL BIOLOGY | Membrane Fusion | Mitochondria - metabolism | Animals | Hydrolysis | Mitochondrial DNA
Journal Article
Nature Communications, ISSN 2041-1723, 10/2015, Volume 6, Issue 1, p. 8372
Journal Article
Journal Article
Methods in molecular biology (Clifton, N.J.), ISSN 1064-3745, 2007, Volume 372, pp. 461 - 466
The field of mitochondrial dynamics has received a great deal of attention as a result of a number of studies linking mitochondrial fission and fusion... 
Saccharomyces cerevisiae | Mitochondria - metabolism | Cell Fractionation - methods
Journal Article
Angewandte Chemie, ISSN 1433-7851, 09/2012, Volume 51, Issue 37, p. 9302
  Mitochondrial dynamics: An image-based screen identified a small molecule, M1, that specifically promotes the fusion of fragmented mitochondria and protects... 
Journal Article
Cell Metabolism, ISSN 1550-4131, 10/2016, Volume 24, Issue 4, p. 582
Using high-throughput screening we identified small molecules that suppress superoxide and/or H.sub.2O.sub.2 production during reverse electron transport... 
Protection and preservation | Superoxide | Analysis | Hyperplasia | Reperfusion injury | Stem cells | Medical research | Medicine, Experimental
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 11/2003, Volume 163, Issue 3, p. 503
  The unit of inheritance for mitochondrial DNA (mtDNA) is a complex nucleoprotein structure termed the nucleoid. The organization of the nucleoid as well as... 
Proteins | Membranes | Deoxyribonucleic acid | DNA
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 4/1999, Volume 145, Issue 2, pp. 291 - 304
Maintenance of mitochondrial DNA (mtDNA) during cell division is required for progeny to be respiratory competent. Maintenance involves the replication,... 
Gamma rays | Yeasts | Mitochondria | DNA damage | DNA | Antibodies | Mitochondrial DNA | Genetic mutation | Cells | Radiation damage | MtDNA | Nucleoid | Yeast | Maintenance | DNA repair | OUTER-MEMBRANE | RECOMBINATION | PROTEIN | mtDNA | SEGREGATION | SACCHAROMYCES-CEREVISIAE | MAMMALIAN-CELLS | yeast | CELL BIOLOGY | YEAST MITOCHONDRIA | TRANSMISSION | GENE | MUTATION | maintenance | nucleoid | Genomes | Research | Nucleoproteins
Journal Article
Science (Washington), ISSN 0036-8075, 05/2012, Volume 336, Issue 6082, pp. 717 - 721
Osteoarthritis (OA) is a degenerative joint disease that involves the destruction of articular cartilage and eventually leads to disability. Molecules that... 
Animal models
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 10/2017, Volume 8, Issue 10, pp. 1048 - 1053
NOD2 (nucleotide-binding oligomerization domain-containing protein 2) is an internal pattern recognition receptor that recognizes bacterial peptidoglycan and... 
structure-based drug design | kinase inhibitors | NOD2 | RIPK2 | ACTIVATION | DOMAIN | CHEMISTRY, MEDICINAL | KINASE | BLAU-SYNDROME | MUTATIONS | ARTHRITIS | EARLY-ONSET SARCOIDOSIS
Journal Article