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American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, 10/2014, Volume 307, Issue 7, pp. G732 - G740
Activation of the cytosolic inflammasome machinery is responsible for acute and chronic liver inflammation, but little is known about its regulation. The... 
Aspartate | Physiological aspects | Methyl aspartate | Inflammation | Liver diseases | Health aspects
Journal Article
Gastroenterology, ISSN 0016-5085, 2014, Volume 146, Issue 7, pp. 1763 - 1774
Background & Aims The NACHT, LRR, and pyrin domain–containing protein 3 (NLRP3) inflammasome induces inflammation in response to organ injury, but little is... 
Gastroenterology and Hepatology | Innate Immune Response | Immune Regulation | Pancreas | Mouse Model | ACTIVATION | NLRP3 INFLAMMASOME | GPR81 | AGONISTS | GENE | TLR9 | MICE | HEPATOTOXICITY | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | SEVERITY | Liver - pathology | Inflammasomes - metabolism | Receptors, G-Protein-Coupled - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Male | NF-kappa B - metabolism | Monocytes - immunology | Lipopolysaccharides | Liver - immunology | Liver - drug effects | RNA Interference | Interleukin-1beta - metabolism | Toll-Like Receptors - drug effects | Anti-Inflammatory Agents - administration & dosage | Toll-Like Receptors - metabolism | Cytoprotection | Disease Models, Animal | Galactosamine | Chemical and Drug Induced Liver Injury - prevention & control | Anti-Inflammatory Agents - pharmacology | Down-Regulation | Liver - metabolism | Injections, Intraperitoneal | Pancreas - pathology | Pancreas - metabolism | Pancreas - immunology | Toll-Like Receptor 4 - metabolism | Chemical and Drug Induced Liver Injury - immunology | Monocytes - drug effects | Macrophages - metabolism | Signal Transduction - drug effects | Chemical and Drug Induced Liver Injury - metabolism | Sodium Lactate - pharmacology | beta-Arrestins | Mice | Receptors, G-Protein-Coupled - genetics | RNA, Small Interfering - metabolism | Monocytes - metabolism | Pancreatitis - prevention & control | Arrestins - metabolism | Dose-Response Relationship, Drug | Pancreatitis - genetics | Transfection | Inflammasomes - drug effects | Sodium Lactate - administration & dosage | Pancreatitis - immunology | Chemical and Drug Induced Liver Injury - pathology | Chemical and Drug Induced Liver Injury - etiology | Macrophages - immunology | Cell Line | Immunity, Innate - drug effects | Toll-Like Receptor 4 - drug effects | Mice, Inbred C57BL | Pancreas - drug effects | Chemical and Drug Induced Liver Injury - genetics | Pancreatitis - chemically induced | Animals | Carrier Proteins - metabolism | beta-Arrestin 2 | Inflammasomes - immunology | Macrophages - drug effects | Pancreatitis - pathology | Pancreatitis - metabolism | Ceruletide | Lactates | Gastrointestinal diseases | Inflammation
Journal Article
Journal Article
Journal Article
Journal of Hepatology, ISSN 0168-8278, 09/2018, Volume 69, Issue 3, p. 687
Background & Aims Sterile inflammation resulting in alcoholic hepatitis (AH) occurs unpredictably after many years of excess alcohol intake. The factors... 
Phenotypes | G protein-coupled receptors | Liver diseases | Ethanol | Transcription | Genes | Alcohol | Inflammation | Macrophages | Steatosis | Studies | Hepatitis | Mitochondria | Metabolites | Interleukin 1 | Interleukin 10 | Alanine transaminase | Bone marrow | Alcoholic beverages | Membrane potential | Supplementation
Journal Article
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, 06/2009, Volume 296, Issue 6, pp. G1248 - G1257
Watanabe A, Sohail MA, Gomes DA, Hashmi A, Nagata J, Sutterwala FS, Mahmood S, Jhandier MN, Shi Y, Flavell RA, Mehal WZ. Inflammasome-mediated regulation of... 
NLRP3 | Apoptosis-associated speck-like protein containing CARD | FIBROSIS | SIGNAL | APOPTOSIS | PHYSIOLOGY | CHEMOTAXIS | PDGF | DOWN-REGULATION | apoptosis-associated speck-like protein containing CARD | RECEPTORS | GASTROENTEROLOGY & HEPATOLOGY | INSIGHTS | Inflammation - chemically induced | Thioacetamide - pharmacology | Liver - pathology | Carbon Tetrachloride - pharmacology | Gene Expression - drug effects | Cytoskeletal Proteins - genetics | Gene Expression - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Actins - metabolism | Inositol 1,4,5-Trisphosphate - pharmacology | Hepatic Stellate Cells - cytology | Liver Cirrhosis - chemically induced | Inflammation - metabolism | Collagen Type I - genetics | Liver Cirrhosis - metabolism | Inositol 1,4,5-Trisphosphate - analogs & derivatives | Hepatic Stellate Cells - drug effects | Liver Cirrhosis - etiology | Hepatic Stellate Cells - physiology | Liver - metabolism | Mice, Inbred C57BL | Chemotaxis - drug effects | Platelet-Derived Growth Factor - pharmacology | Chemotaxis - genetics | Mice, Knockout | Carrier Proteins - genetics | Animals | Apoptosis Regulatory Proteins | Transforming Growth Factor beta - genetics | Calcium Signaling - drug effects | Uric Acid - pharmacology | CARD Signaling Adaptor Proteins | Liver Cirrhosis - pathology | Mice | Cell Line, Transformed | Inflammation - physiopathology | Index Medicus | Liver and Biliary Tract
Journal Article
Journal of Hepatology, ISSN 0168-8278, 09/2018, Volume 69, Issue 3, pp. 687 - 696
Sterile inflammation resulting in alcoholic hepatitis (AH) occurs unpredictably after many years of excess alcohol intake. The factors responsible for the... 
Therapy | Hcar2 | β-Hydroxybutyrate | Alcohol-induced liver injury | induced liver injury | LIPID-METABOLISM | beta-Hydroxybutyrate | TOLL-LIKE RECEPTOR | GPR109A | Alcohol | NLRP3 INFLAMMASOME | NICOTINIC-ACID | SKELETAL-MUSCLE | INHIBITION | METABOLITE BUTYRATE | DISEASE | MICE | GASTROENTEROLOGY & HEPATOLOGY
Journal Article
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, ISSN 0193-1857, 10/2014, Volume 307, Issue 7, pp. G732 - G740
Activation of the cytosolic inflammasome machinery is responsible for acute and chronic liver inflammation, but little is known about its regulation. The... 
D-AMINO ACIDS | CELLS | PHYSIOLOGY | NMDA RECEPTORS | METABOLISM | MACROPHAGES | DISEASE | NEURONS | aspartate | SENSORS | GASTROENTEROLOGY & HEPATOLOGY | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Receptors, N-Methyl-D-Aspartate - metabolism | Arrestins - genetics | Caspase 1 - metabolism | Male | Interleukin-1beta - genetics | Pancreatitis - prevention & control | Arrestins - metabolism | Liver - immunology | Inflammasomes - drug effects | Liver - drug effects | Time Factors | Interleukin-1beta - metabolism | Pancreatitis - immunology | Macrophages - immunology | Disease Models, Animal | Cell Line | Chemical and Drug Induced Liver Injury - prevention & control | Protein Precursors - genetics | Anti-Inflammatory Agents - pharmacology | Liver - metabolism | Mice, Inbred C57BL | Excitatory Amino Acid Agonists - pharmacology | Chemical and Drug Induced Liver Injury - genetics | Chemical and Drug Induced Liver Injury - immunology | Protein Precursors - metabolism | Carrier Proteins - genetics | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Signal Transduction - drug effects | beta-Arrestin 2 | Caspase 1 - genetics | Chemical and Drug Induced Liver Injury - metabolism | beta-Arrestins | Inflammasomes - immunology | Receptors, N-Methyl-D-Aspartate - agonists | Macrophages - drug effects | Pancreatitis - metabolism | Aspartic Acid - pharmacology | Inflammation | Mediators | Immunity
Journal Article
Cell Metabolism, ISSN 1550-4131, 02/2018, Volume 27, Issue 2, p. 339
Sterile inflammation after tissue damage is a ubiquitous response, yet it has the highest amplitude in the liver. This has major clinical consequences, for... 
Yuan (China) | Chromatin | Liver diseases | Digoxin | Liver | Gastrointestinal diseases | Genetic transcription | DNA binding proteins
Journal Article
Journal Article
Cellular Immunology, ISSN 0008-8749, 11/2005, Volume 238, Issue 1, p. 31
Activated CD8.sup.+ T cells are retained by the healthy liver where the majority undergo apoptosis. The intrahepatic apoptosis of activated CD8.sup.+ T cells... 
Peptides | T cells
Journal Article
The American Journal of Physiology, ISSN 0002-9513, 06/2009, Volume 296, Issue 6, p. G1248
The inflammasome is a cytoplasmic multiprotein complex that has recently been identified in immune cells as an important sensor of signals released by cellular... 
Liver diseases | Messenger RNA | Physiological aspects | Research | Transforming growth factors | Risk factors | Cells
Journal Article
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