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animals (6) 6
mice (6) 6
biochemistry & molecular biology (3) 3
expression (3) 3
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1. Full Text Inducible nitric oxide synthase, Nos2, does not mediate optic neuropathy and retinopathy in the DBA/2J glaucoma model
by Libby, Richard T and Howell, Gareth R and Pang, Iok-Hou and Savinova, Olga V and Mehalow, Adrienne K and Barter, Joseph W and Smith, Richard S and Clark, Abbot F and John, Simon W.M
BMC Neuroscience, ISSN 1471-2202, 12/2007, Volume 8, Issue 1, pp. 108 - 108
Background: Nitric oxide synthase 2 (NOS2) contributes to neural death in some settings, but its role in glaucoma remains controversial. NOS2 is implicated in... 
RETINAL GANGLION-CELLS | OCULAR HYPERTENSION TREATMENT | IRIS ATROPHY | OPEN-ANGLE GLAUCOMA | RISK-FACTORS | AXONAL-TRANSPORT | NERVE HEAD ASTROCYTES | PIGMENTARY GLAUCOMA | INTRAOCULAR-PRESSURE ELEVATION | NEUROSCIENCES | INHERITED GLAUCOMA | Intraocular Pressure | Optic Nerve Diseases - pathology | Retinal Diseases - enzymology | Animals | Optic Disk - enzymology | Retinal Diseases - pathology | Mice, Inbred DBA | Glaucoma - pathology | Mice | Glaucoma - metabolism | Optic Nerve Diseases - enzymology | Optic Disk - pathology | Disease Models, Animal | Nitric Oxide Synthase Type II - metabolism | Glaucoma | Polymerase chain reaction | Aminoguanidine | Care and treatment | Dosage and administration | Genetic aspects | Diagnosis | Health aspects
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2. Full Text The Classical Complement Cascade Mediates CNS Synapse Elimination
by Stevens, Beth and Allen, Nicola J and Vazquez, Luis E and Howell, Gareth R and Christopherson, Karen S and Nouri, Navid and Micheva, Kristina D and Mehalow, Adrienne K and Huberman, Andrew D and Stafford, Benjamin and Sher, Alexander and Litke, Alan M and Lambris, John D and Smith, Stephen J and John, Simon W.M and Barres, Ben A
Cell, ISSN 0092-8674, 2007, Volume 131, Issue 6, pp. 1164 - 1178
During development, the formation of mature neural circuits requires the selective elimination of inappropriate synaptic connections. Here we show that C1q,... 
HUMDISEASE | MOLNEURO | CELLIMMUNO | DBA/2J MICE | CELLS | C1Q | ACTIVATION | VISUAL-CORTEX | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CENTRAL-NERVOUS-SYSTEM | GLAUCOMA | EXPRESSION | PLASTICITY | CELL BIOLOGY | Animals, Newborn | Up-Regulation | Retina - metabolism | Complement Activation | Complement C3 - metabolism | Complement C1q - genetics | Geniculate Bodies - physiology | RNA, Messenger - metabolism | Retinal Ganglion Cells - metabolism | Complement C1q - metabolism | Long-Term Synaptic Depression | Mice, Knockout | Central Nervous System - physiology | Retina - physiology | Animals | Mice, Inbred DBA | Mice | Glaucoma - metabolism | Synapses | Astrocytes - metabolism | Glaucoma | Ophthalmology | Neurons | Analysis
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3. Full Text High-throughput discovery of novel developmental phenotypes
by Dickinson, Mary E and Flenniken, Ann M and Ji, Xiao and Teboul, Lydia and Wong, Michael D and White, Jacqueline K and Meehan, Terrence F and Weninger, Wolfgang J and Westerberg, Henrik and Adissu, Hibret and Baker, Candice N and Bower, Lynette and Brown, James M and Brianna Caddle, L and Chiani, Francesco and Clary, Dave and Cleak, James and Daly, Mark J and Denegre, James M and Doe, Brendan and Dolan, Mary E and Edie, Sarah M and Fuchs, Helmut and Gailus-Durner, Valerie and Galli, Antonella and Gambadoro, Alessia and Gallegos, Juan and Guo, Shiying and Horner, Neil R and Hsu, Chih-wei and Johnson, Sara J and Kalaga, Sowmya and Keith, Lance C and Lanoue, Louise and Lawson, Thomas N and Lek, Monkol and Mark, Manuel and Marschall, Susan and Mason, Jeremy and McElwee, Melissa L and Newbigging, Susan and Nutter, Lauryl M.J and Peterson, Kevin A and Ramirez-Solis, Ramiro and Rowland, Douglas J and Ryder, Edward and Samocha, Kaitlin E and Seavitt, John R and Selloum, Mohammed and Szoke-Kovacs, Zsombor and Tamura, Masaru and Trainor, Amanda G and Tudose, Ilinca and Wakana, Shigeharu and Warren, Jonathan and Wendling, Olivia and West, David B and Wong, Leeyean and Yoshiki, Atsushi and MacArthur, Daniel G and Tocchini-Valentini, Glauco P and Gao, Xiang and Flicek, Paul and Bradley, Allan and Skarnes, William C and Justice, Monica J and Parkinson, Helen E and Moore, Mark and Wells, Sara and Braun, Robert E and Svenson, Karen L and Hrabe de Angelis, Martin and Herault, Yann and Mohun, Tim and Mallon, Ann-Marie and Mark Henkelman, R and Brown, Steve D.M and Adams, David J and Kent Lloyd, K.C and McKerlie, Colin and Beaudet, Arthur L and Bucan, Maja and Murray, Stephen A and McKay, Matthew and Urban, Barbara and Lund, Caroline and Froeter, Erin and LaCasse, Taylor and Mehalow, Adrienne and Gordon, Emily and Donahue, Leah Rae and Taft, Robert and Kutney, Peter and Dion, Stephanie and Goodwin, Leslie and Kales, Susan and Urban, Rachel and Palmer, Kristina and Pertuy, Fabien and Bitz, Deborah and ... and Int Mouse Phenotyping Consortium and The International Mouse Phenotyping Consortium
Nature, ISSN 0028-0836, 09/2016, Volume 537, Issue 7621, pp. 508 - 514
Approximately one-third of all mammalian genes are essential for life. Phenotypes resulting from knockouts of these genes in mice have provided tremendous... 
MICRO-CT | MULTIDISCIPLINARY SCIENCES | DISEASE | GENOME-WIDE | MAMMALIAN GENE-FUNCTION | SCREENS | GLYCOGENIN-1 DEFICIENCY | IDENTIFICATION | EXPRESSION | MOUSE EMBRYO | RESOURCE | Genetic research | Phenotype | Research | High-throughput screening (Biochemical assaying) | Methods | Genotype & phenotype | Disease | Developmental biology | Genes | Genomes | Mutation | Embryos | knockout | embryonic lethal | mouse | KOMP | IMPC | EUCOMM
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4. Full Text APOBEC1 complementation factor (A1CF) is dispensable for C-to-U RNA editing in vivo
by Snyder, Elizabeth M and McCarty, Christopher and Mehalow, Adrienne and Svenson, Karen L and Murray, Stephen A and Korstanje, Ron and Braun, Robert E
RNA, ISSN 1355-8382, 2017, Volume 23, Issue 4, pp. 457 - 465
Editing of the human and murine ApoB mRNA by APOBEC1, the catalytic enzyme of the protein complex that catalyzes C-to-U RNA editing, creates an internal stop... 
APOBEC1 | RNA editing | ACF | APOB | Kidney | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | B MESSENGER-RNA | IDENTIFICATION | kidney | ENZYME | GENE | MOLECULAR-CLONING | MICE | BINDING | EXPRESSION | REVEALS | Apolipoproteins B - metabolism | RNA Editing | Liver - metabolism | RNA, Messenger - genetics | APOBEC-1 Deaminase - genetics | Water-Electrolyte Imbalance | Male | APOBEC-1 Deaminase - metabolism | Apolipoproteins B - genetics | Kidney Glomerulus - pathology | Organ Specificity | RNA, Messenger - metabolism | Mice, Knockout | Heterogeneous-Nuclear Ribonucleoproteins - genetics | Heterogeneous-Nuclear Ribonucleoproteins - deficiency | Animals | Protein Isoforms - metabolism | Base Sequence | Sex Factors | Kidney Glomerulus - metabolism | Female | Mice | Intestine, Small - metabolism | Protein Isoforms - genetics
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5. Full Text CRB1 is essential for external limiting membrane integrity and photoreceptor morphogenesis in the mammalian retina
by Mehalow, Adrienne K and Kameya, Shuhei and Smith, Richard S and Hawes, Norman L and Denegre, James M and Young, James A and Bechtold, Lesley and Haider, Neena B and Tepass, Ulrich and Heckenlively, John R and Chang, Bo and Naggert, Jürgen K and Nishina, Patsy M
Human Molecular Genetics, ISSN 0964-6906, 09/2003, Volume 12, Issue 17, pp. 2179 - 2189
Mutations within the CRB1 gene have been shown to cause human retinal diseases including retinitis pigmentosa and Leber congenital amaurosis. We have recently... 
LEBER CONGENITAL AMAUROSIS | PROTEIN | GENE | EPITHELIAL-CELL POLARITY | MYOSIN-VIIA | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | HOMOLOG | PIGMENTOSA | MUTATIONS | DROSOPHILA-CRUMBS | DEGENERATION | Frameshift Mutation | Retina - growth & development | Alternative Splicing | Retina - embryology | Retinal Degeneration - metabolism | Morphogenesis | Cell Cycle Proteins - immunology | Gene Expression Regulation, Developmental | Peptide Fragments - immunology | Schizosaccharomyces pombe Proteins - metabolism | Nerve Tissue Proteins - physiology | Nerve Tissue Proteins - immunology | Mice, Inbred C57BL | Cell Cycle Proteins - metabolism | Nuclear Proteins - metabolism | Photoreceptor Cells, Vertebrate - cytology | Chromosome Mapping | Nuclear Proteins - immunology | Basement Membrane - metabolism | Nerve Tissue Proteins - genetics | Schizosaccharomyces pombe Proteins - immunology | Animals | Protein Isoforms | Mice | Photoreceptor Cells, Vertebrate - metabolism | Retinal Degeneration - pathology
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6. Full Text GpnmbR150X allele must be present in bone marrow derived cells to mediate DBA/2J glaucoma
by Anderson, Michael G and Nair, K. Saidas and Amonoo, Leslie A and Mehalow, Adrienne and Trantow, Colleen M and Masli, Sharmila and John, Simon W.M
BMC Genetics, ISSN 1471-2156, 04/2008, Volume 9, Issue 1, pp. 30 - 30
The Gpnmb gene encodes a transmembrane protein whose function(s) remain largely unknown. Here, we assess if a mutant allele of Gpnmb confers susceptibility to... 
Interleukin-18 - immunology | Disease Susceptibility | Mice, Inbred C57BL | Bone Marrow Cells - physiology | Genotype | Antigen-Presenting Cells - immunology | Aqueous Humor - immunology | Membrane Glycoproteins - genetics | Animals | Intraocular Pressure - genetics | Bone Marrow Cells - immunology | Alleles | Glaucoma - immunology | Mice, Inbred DBA | Mice | Mice, Congenic | Eye Proteins - genetics | Mutation | Glaucoma - genetics | Glaucoma - physiopathology
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7. Full Text Gpnmb .sup. R 150 X .sup.allele must be present in bone marrow derived cells to mediate DBA/2J glaucoma
by Anderson, Michael G and Nair, K Saidas and Amonoo, Leslie A and Mehalow, Adrienne and Trantow, Colleen M and Masli, Sharmila and John, Simon WM
BMC Genetics, ISSN 1471-2156, 04/2008, Volume 9, p. 30
The Gpnmb gene encodes a transmembrane protein whose function(s) remain largely unknown. Here, we assess if a mutant allele of Gpnmb confers susceptibility to... 
Glaucoma | Care and treatment | Dendritic cells | Genetic aspects | Research | Gene expression | Health aspects
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8. CRB1 is essential for external limiting membrane integrity and photoreceptor morphogenesis in the mammalian retina
by Adrienne K. Mehalow and Shuhei Kameya and Richard S. Smith and Norman L. Hawes and James M. Denegre and James A. Young and Lesley Bechtold and Neena B. Haider and Ulrich Tepass and John R. Heckenlively and Bo Chang and Jurgen K. Naggert and Patsy M. Nishina
Human Molecular Genetics, ISSN 0964-6906, 09/2003, Volume 12, Issue 17, p. 2179
  Mutations within the CRB1 gene have been shown to cause human retinal diseases including retinitis pigmentosa and Leber congenital amaurosis. We have... 
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