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Cancer Cell, ISSN 1535-6108, 2011, Volume 19, Issue 4, pp. 484 - 497
Journal Article
PLoS Medicine, ISSN 1549-1277, 12/2016, Volume 13, Issue 12, p. e1002200
Journal Article
Nature Medicine, ISSN 1078-8956, 11/2010, Volume 16, Issue 11, pp. 1321 - 1327
Journal Article
Haematologica, ISSN 0390-6078, 09/2012, Volume 97, Issue 9, pp. 1405 - 1413
Journal Article
Nature Communications, ISSN 2041-1723, 01/2015, Volume 6, Issue 1, p. 5794
Journal Article
PLoS Biology, ISSN 1544-9173, 2012, Volume 10, Issue 11, p. e1001430
The HMG-box factor Tcf1 is required during T-cell development in the thymus and mediates the nuclear response to Wnt signals. Tcf1(-/-) mice have previously... 
DEFECTS | FACTOR-1 | NOTCH1 | HEMATOPOIESIS | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOLOGY | MUTATIONS | BETA-CATENIN | EXPRESSION | LEF-1 | Axin Protein - genetics | Hepatocyte Nuclear Factor 1-alpha - genetics | Oligonucleotide Array Sequence Analysis | Thymocytes - metabolism | Lymphoid Enhancer-Binding Factor 1 - genetics | Transcriptional Activation | Gene Expression Regulation, Neoplastic | Hepatocyte Nuclear Factor 1-alpha - metabolism | Axin Protein - metabolism | Lymphoma - metabolism | Protein Isoforms - metabolism | Transfection | T-Lymphocytes - metabolism | Thymus Gland - pathology | Lymphoma - pathology | T-Lymphocytes - pathology | Thymus Gland - metabolism | Genes, Tumor Suppressor | Genes, Reporter | Wnt Signaling Pathway | Green Fluorescent Proteins - metabolism | Promoter Regions, Genetic | Genetic Predisposition to Disease | Mice, Inbred C57BL | Cells, Cultured | Receptor, Notch1 - metabolism | Lymphoid Enhancer-Binding Factor 1 - metabolism | Neoplasm Metastasis - genetics | Animals | Neoplasm Metastasis - pathology | Mice | Receptor, Notch1 - genetics | Thymocytes - pathology | Protein Isoforms - genetics | Proteins | Medical research | Statistical analysis | Research & development--R&D | Lymphocytes | Rodents | Leukemia | Cell cycle | Mutation | Experiments | Tumors | Research & development | R&D
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2016, Volume 11, Issue 5, p. e0155408
Trib2 is highly expressed in human T cell acute lymphoblastic leukemia (T-ALL) and is a direct transcriptional target of the oncogenic drivers Notch and TAL1.... 
BINDING PROTEIN-ALPHA | C/EBP-ALPHA | ACTIVATION | TRIBBLES HOMOLOG | MULTIDISCIPLINARY SCIENCES | ACUTE LYMPHOBLASTIC-LEUKEMIA | ACUTE MYELOGENOUS LEUKEMIA | GENE-EXPRESSION | ACUTE MYELOID-LEUKEMIA | MUTATIONS | CELL LEUKEMIA | CCAAT-Enhancer-Binding Proteins - metabolism | Gene Targeting | Gene Expression | Signal Transduction | Receptors, Notch - metabolism | Protein-Serine-Threonine Kinases - genetics | Penetrance | Intracellular Signaling Peptides and Proteins - metabolism | Genetic Loci | Cell Transformation, Neoplastic - metabolism | Mice, Knockout | Animals | Cell Transformation, Neoplastic - genetics | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Line, Tumor | Mice | CCAAT-Enhancer-Binding Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | Physiological aspects | Development and progression | Tumor suppressor genes | Genetic aspects | Research | Acute lymphocytic leukemia | T cells | Cell proliferation | Pediatrics | Biotechnology | Phosphorylation | Transcription | Laboratories | Pathogenesis | Leukemia | Immunoblotting | AKT protein | Lymphocytes T | Genomes | Proteins | Engineering | Cell growth | Immunology | Clonal deletion | Lymphocytes | Hematopoiesis | Cell cycle | Deletion | Tumorigenesis | Medical research | Acute lymphatic leukemia | Cell survival | Hematology | Cortex | Extracellular signal-regulated kinase | Lymphatic leukemia | Gene expression | Survival | Hemopoiesis | Latency | Medicine | Pathology | Tlx1 protein | Cell lines | Stem cells | Leukemogenesis | In vivo methods and tests | Survival factor | Notch protein | Mutation | Cancer
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2014, Volume 9, Issue 8, pp. e105642 - e105642
textabstractAllogeneic hematopoietic stem cell (HSC) transplantations from umbilical cord blood or autologous HSCs for gene therapy purposes are hampered by... 
PROGENITOR CELLS | CD34(+)THY-1(+)LIN(-) CELLS | LENTIVIRUS VECTOR | MULTIDISCIPLINARY SCIENCES | SERUM-FREE CULTURES | SELF-RENEWAL | TERM REPOPULATING CELLS | GENE-THERAPY | FLT3 LIGAND | STIMULATES PROLIFERATION | GROWTH-FACTOR-I | Angiopoietins - pharmacology | Humans | Male | Green Fluorescent Proteins - genetics | Proto-Oncogene Proteins c-kit - metabolism | Flow Cytometry | Transfection | Angiopoietin-like Proteins | Stem Cell Factor - pharmacology | HEK293 Cells | Insulin-Like Growth Factor II - pharmacology | Antigens, Ly - metabolism | Female | Lentivirus - genetics | Membrane Proteins - metabolism | Hematopoietic Stem Cells - drug effects | Green Fluorescent Proteins - metabolism | Angiopoietins - metabolism | Cell Proliferation - genetics | Cells, Cultured | Hematopoietic Stem Cells - metabolism | Thrombopoietin - pharmacology | Genetic Vectors - genetics | Animals | Hematopoietic Stem Cells - cytology | Fibroblast Growth Factor 1 - pharmacology | Cell Proliferation - drug effects | Mice, Inbred BALB C | HeLa Cells | Hematopoietic Stem Cell Transplantation - methods | Angiopoietins - genetics | Pediatrics | Fibroblast growth factor | Populations | Toxicity | Angiopoietin | Leukemia | Stem cell transplantation | Oncology | Transplantation | Insulin-like growth factors | Kinases | Experiments | Blood | Hematopoietic stem cells | Thrombopoietin | Stem cell factor | Proteins | Allografts | Cord blood | Rodents | Bone marrow | Biocompatibility | Accessory cells | Protein-tyrosine kinase | Expansion | Tyrosine | Autografts | Immunoglobulins | Cytokines | Hematology | Preservation | Insulin | c-Kit protein | Medical prognosis | Stem cells | Ligands | In vivo methods and tests | Umbilical cord | Gene therapy | Index Medicus
Journal Article
Nature Genetics, ISSN 1061-4036, 06/2010, Volume 42, Issue 6, pp. 530 - 535
Journal Article