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American Journal of Physiology: Lung Cellular and Molecular Physiology, ISSN 1040-0605, 08/2016, Volume 311, Issue 2, pp. L328 - L328
The proteasome system degrades more than 80% of intracellular proteins into small peptides. Accordingly, the proteasome is involved in many essential cellular... 
Journal Article
European Respiratory Journal, ISSN 0903-1936, 10/2014, Volume 44, Issue 4, pp. 846 - 849
Journal Article
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 11/2014, Volume 307, Issue 11, pp. L895 - L907
Journal Article
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 11/2012, Volume 303, Issue 9, pp. 814 - 823
Cigarette smoke mediates DNA damage, lipid peroxidation, and modification and misfolding of proteins, thereby inducing severe cellular damage. The ubiquitin... 
Oxidative stress | Chronic obstructive pulmonary disease | Protein quality control | Ubiquitin proteasome system | Cigarette smoke | SYSTEM | PHYSIOLOGY | UBIQUITIN | ubiquitin proteasome system | ANTIGEN PRESENTATION | cigarette smoke | 20S PROTEASOME | CARDIOMYOPATHIES | OBSTRUCTIVE PULMONARY-DISEASE | RESPIRATORY SYSTEM | protein quality control | DEGRADATION | INHIBITORS | PROTEINS | oxidative stress | chronic obstructive pulmonary disease | Smoking - adverse effects | Protein Carbonylation | Oxidative Stress | Apoptosis - drug effects | Humans | Smoke | Polyubiquitin | Lung - enzymology | Protein Processing, Post-Translational - drug effects | Plant Preparations - pharmacology | Female | Ubiquitinated Proteins - metabolism | Gene Expression | Oxidation-Reduction | Proteasome Inhibitors - pharmacology | Cell Survival | Mice, Inbred C57BL | Alveolar Epithelial Cells - metabolism | Alveolar Epithelial Cells - drug effects | Proteasome Inhibitors - toxicity | Proteasome Endopeptidase Complex - physiology | Tobacco - toxicity | Proteasome Endopeptidase Complex - genetics | Plant Preparations - toxicity | Animals | Lung - drug effects | Cell Line, Tumor | Mice | Proteasome Endopeptidase Complex - metabolism | Alveolar Epithelial Cells - physiology | Glutathione - blood | Physiological aspects | Lungs | Ubiquitin-proteasome system | Health aspects | DNA damage | Rodents | Lipids | Oxidation | Cells | Smoking
Journal Article
European Respiratory Journal, ISSN 0903-1936, 11/2012, Volume 40, Issue 5, pp. 1260 - 1268
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 402 - 9
Accounting for about 1.5 million deaths annually, lung cancer is the prevailing cause of cancer deaths worldwide, mostly associated with long-term smoking... 
SIGNAL | NODULES | ALVEOLI | MULTIDISCIPLINARY SCIENCES | CONTRAST | CHEST RADIOGRAPHS | RIB SUPPRESSION | Lung - pathology | Animals | Radiography - methods | Mice, Mutant Strains | X-Rays | Lung Neoplasms - diagnostic imaging | Lung Neoplasms - pathology | Lung - diagnostic imaging | Mice | Disease Models, Animal | Radiography | Animal models | Lung cancer | Tumors | Smoking | Nodules
Journal Article
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 10/2014, Volume 51, Issue 4, pp. 526 - 535
In inhalation therapy, drugs are deposited as aerosols onto the air-facing lung epithelium. The currently used in vitro cell assays for drug testing, however,... 
Lung epithelial cell | Aerosolized drug delivery | Inflammation | Comparison of air-liquid interface and submerged cell culture | Proteasome inhibitor | SYSTEM | RESPIRATORY-TRACT | PARTICLES | DEPOSITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MONOLAYERS | CELL BIOLOGY | HUMAN LUNG-CELLS | proteasome inhibitor | SURFACTANT | inflammation | RESPIRATORY SYSTEM | aerosolized drug delivery | comparison of air-liquid interface and submerged cell culture | IN-VITRO MODEL | lung epithelial cell | PROTEASOME INHIBITORS | EXPOSURE | Tumor Necrosis Factor-alpha - metabolism | Interleukin-8 - genetics | Up-Regulation | Epithelial Cells - metabolism | Respiratory Mucosa - drug effects | Boronic Acids - metabolism | Epithelial Cells - drug effects | Humans | Pyrazines - administration & dosage | Transcriptional Activation - drug effects | Proteasome Inhibitors - metabolism | Pyrazines - metabolism | Anti-Inflammatory Agents - metabolism | Dose-Response Relationship, Drug | Blood-Air Barrier - drug effects | Respiratory Mucosa - immunology | Anti-Inflammatory Agents - administration & dosage | Boronic Acids - administration & dosage | Cell Culture Techniques | Interleukin-8 - metabolism | Promoter Regions, Genetic | Reproducibility of Results | Bortezomib | Proteasome Inhibitors - administration & dosage | Administration, Inhalation | Blood-Air Barrier - immunology | Blood-Air Barrier - metabolism | Epithelial Cells - immunology | Aerosols | Cell Line, Tumor | Kinetics | Respiratory Mucosa - metabolism | Respiratory therapy | Cell culture | Microscopy | Efficiency | Colleges & universities | Pharmaceutical industry | Surfactants | Drug testing
Journal Article
Molecular and Cellular Pediatrics, ISSN 2194-7791, 12/2016, Volume 3, Issue 1, pp. 1 - 7
Chronic lung disease of the newborn, also known as bronchopulmonary dysplasia (BPD), is the most common chronic lung disease in early infancy and results in an... 
Pediatrics | Immature lung | Medicine & Public Health | BPD premature aging | Hyperoxia | Oncology | Diabetes | Early injury | Endocrinology | Neonates | Dysplasia | Hypotheses | Immune response | Toxicity | Lung diseases | Fibrosis | Aging | Ventilation | Extracellular matrix | Inflammation | Saccule
Journal Article
ACS Nano, ISSN 1936-0851, 03/2015, Volume 9, Issue 3, pp. 2377 - 2389
Journal Article
American Journal of Physiology (Consolidated), ISSN 0002-9513, 08/2016, Volume 311, Issue 2, p. L328
The proteasome system degrades more than 80% of intracellular proteins into small peptides. Accordingly, the proteasome is involved in many essential cellular... 
Physiological aspects | Ubiquitin-proteasome system | Immune response
Journal Article
Nature Communications, ISSN 2041-1723, 05/2017, Volume 8, Issue 1, pp. 15205 - 15205
Journal Article
Medicinal Research Reviews, ISSN 0198-6325, 03/2008, Volume 28, Issue 2, pp. 309 - 327
The proteasome inhibitor bortezomib has been approved as a cytostatic drug for the therapy of multiple myeloma, and is currently being tested in clinical... 
proteasome inhibition | apoptosis | protection | cell type and dose dependency | substrate specificity | Protection | Proteasome inhibition | Substrate specificity | Cell type and dose dependency | Apoptosis | SALT HYPERTENSIVE-RATS | CHEMISTRY, MEDICINAL | TISSUE-PLASMINOGEN ACTIVATOR | ACUTE-RENAL-FAILURE | MULTIPLE-MYELOMA CELLS |